OASL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OASL_HUMAN
• UniProt AC: Q15646
• Protein Name: 2'-5'-oligoadenylate synthase-like protein
• Gene Name: OASL
• Organism: Homo sapiens (Human).
• Sequence Length: 514
• Subcellular Localization: Isoform p56: Nucleus, nucleolus. Cytoplasm.; Isoform p30: Cytoplasm.
• Protein Description: Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L..
• Protein Sequence: MALMQELYSTPASRLDSFVAQWLQPHREWKEEVLDAVRTVEEFLRQEHFQGKRGLDQDVRVLKVVKVGSFGNGTVLRSTREVELVAFLSCFHSFQEAAKHHKDVLRLIWKTMWQSQDLLDLGLEDLRMEQRVPDALVFTIQTRGTAEPITVTIVPAYRALGPSLPNSQPPPEVYVSLIKACGGPGNFCPSFSELQRNFVKHRPTKLKSLLRLVKHWYQQYVKARSPRANLPPLYALELLTIYAWEMGTEEDENFMLDEGFTTVMDLLLEYEVICIYWTKYYTLHNAIIEDCVRKQLKKERPIILDPADPTLNVAEGYRWDIVAQRASQCLKQDCCYDNRENPISSWNVKRARDIHLTVEQRGYPDFNLIVNPYEPIRKVKEKIRRTRGYSGLQRLSFQVPGSERQLLSSRCSLAKYGIFSHTHIYLLETIPSEIQVFVKNPDGGSYAYAINPNSFILGLKQQIEDQQGLPKKQQQLEFQGQVLQDWLGLGIYGIQDSDTLILSKKKGEALFPAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MALMQELYS ------CCCHHHHHC	16.25	22814378
8	Phosphorylation	MALMQELYSTPASRL CCCHHHHHCCCHHHH	15.11	29083192
9	Phosphorylation	ALMQELYSTPASRLD CCHHHHHCCCHHHHH	40.31	29083192
10	Phosphorylation	LMQELYSTPASRLDS CHHHHHCCCHHHHHH	14.87	29083192
30	Ubiquitination	LQPHREWKEEVLDAV HHHCHHHHHHHHHHH	38.96	29967540
52	Ubiquitination	RQEHFQGKRGLDQDV HHHHHCCCCCCCCCC	32.29	29967540
102	Ubiquitination	QEAAKHHKDVLRLIW HHHHHHHHHHHHHHH	49.61	29967540
176	Phosphorylation	PPPEVYVSLIKACGG CCCHHHHHHHHHCCC	13.49	24719451
179	Ubiquitination	EVYVSLIKACGGPGN HHHHHHHHHCCCCCC	42.81	21963094
200	Ubiquitination	ELQRNFVKHRPTKLK HHHHHHHHCCCHHHH	29.74	29967540
208	Phosphorylation	HRPTKLKSLLRLVKH CCCHHHHHHHHHHHH	42.97	24719451
214	Ubiquitination	KSLLRLVKHWYQQYV HHHHHHHHHHHHHHH	32.77	29967540
298	Ubiquitination	CVRKQLKKERPIILD HHHHHHHCCCCEEEC	68.50	29967540
317	Phosphorylation	TLNVAEGYRWDIVAQ CCCHHCCCCHHHHHH	10.47	20068231
330	Ubiquitination	AQRASQCLKQDCCYD HHHHHHHHHCCCCCC	4.29	29967540
331	Ubiquitination	QRASQCLKQDCCYDN HHHHHHHHCCCCCCC	52.28	21963094
349	Ubiquitination	PISSWNVKRARDIHL CCCCCHHHCCEEEEE	36.81	21963094
363	Phosphorylation	LTVEQRGYPDFNLIV EEEHHCCCCCCCEEC	11.21	-
375	Ubiquitination	LIVNPYEPIRKVKEK EECCCCHHHHHHHHH	26.33	29967540
376	Ubiquitination	IVNPYEPIRKVKEKI ECCCCHHHHHHHHHH	4.44	29967540
389	Phosphorylation	KIRRTRGYSGLQRLS HHHHHCCCCCCCEEE	9.04	-
396	Phosphorylation	YSGLQRLSFQVPGSE CCCCCEEEEECCCHH	18.80	27067055
408	Phosphorylation	GSERQLLSSRCSLAK CHHHHHHHHHHHHHH	25.08	24719451
409	Phosphorylation	SERQLLSSRCSLAKY HHHHHHHHHHHHHHH	36.96	24719451
420	Phosphorylation	LAKYGIFSHTHIYLL HHHHCCCCCCEEEEE	26.09	24719451
460	Ubiquitination	NSFILGLKQQIEDQQ CCEEEHHHHHHHHHC	38.06	29967540
505	Ubiquitination	DTLILSKKKGEALFP CEEEEECCCCCCCCC	63.74	29967540
506	Ubiquitination	TLILSKKKGEALFPA EEEEECCCCCCCCCC	66.76	29967540
514	Phosphorylation	GEALFPAS------- CCCCCCCC-------	40.78	26425664

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OASL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OASL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OASL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SE6L2_HUMAN	SEZ6L2	physical	21988832

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.