KIF23_HUMAN - dbPTM
KIF23_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KIF23_HUMAN
UniProt AC Q02241
Protein Name Kinesin-like protein KIF23
Gene Name KIF23
Organism Homo sapiens (Human).
Sequence Length 960
Subcellular Localization Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody, Midbody ring . Localizes to the interzone of mitotic spindles. Detected at the midbody during later stages of mitotic cytokinesis.
Protein Description Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro..
Protein Sequence MKSARAKTPRKPTVKKGSQTNLKDPVGVYCRVRPLGFPDQECCIEVINNTTVQLHTPEGYRLNRNGDYKETQYSFKQVFGTHTTQKELFDVVANPLVNDLIHGKNGLLFTYGVTGSGKTHTMTGSPGEGGLLPRCLDMIFNSIGSFQAKRYVFKSNDRNSMDIQCEVDALLERQKREAMPNPKTSSSKRQVDPEFADMITVQEFCKAEEVDEDSVYGVFVSYIEIYNNYIYDLLEEVPFDPIKPKPPQSKLLREDKNHNMYVAGCTEVEVKSTEEAFEVFWRGQKKRRIANTHLNRESSRSHSVFNIKLVQAPLDADGDNVLQEKEQITISQLSLVDLAGSERTNRTRAEGNRLREAGNINQSLMTLRTCMDVLRENQMYGTNKMVPYRDSKLTHLFKNYFDGEGKVRMIVCVNPKAEDYEENLQVMRFAEVTQEVEVARPVDKAICGLTPGRRYRNQPRGPVGNEPLVTDVVLQSFPPLPSCEILDINDEQTLPRLIEALEKRHNLRQMMIDEFNKQSNAFKALLQEFDNAVLSKENHMQGKLNEKEKMISGQKLEIERLEKKNKTLEYKIEILEKTTTIYEEDKRNLQQELETQNQKLQRQFSDKRRLEARLQGMVTETTMKWEKECERRVAAKQLEMQNKLWVKDEKLKQLKAIVTEPKTEKPERPSRERDREKVTQRSVSPSPVPLSSNYIAQISNGQQLMSQPQLHRRSNSCSSISVASCISEWEQKIPTYNTPLKVTSIARRRQQEPGQSKTCIVSDRRRGMYWTEGREVVPTFRNEIEIEEDHCGRLLFQPDQNAPPIRLRHRRSRSAGDRWVDHKPASNMQTETVMQPHVPHAITVSVANEKALAKCEKYMLTHQELASDGEIETKLIKGDIYKTRGGGQSVQFTDIETLKQESPNGSRKRRSSTVAPAQPDGAESEWTDVETRCSVAVEMRAGSQLGPGYQHHAQPKRKKP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Ubiquitination------MKSARAKTP
------CCCCCCCCC		53.4723503661
7Ubiquitination-MKSARAKTPRKPTV
-CCCCCCCCCCCCCC		54.2123503661
7 (in isoform 2)Ubiquitination-54.21-
8PhosphorylationMKSARAKTPRKPTVK
CCCCCCCCCCCCCCC		27.6015282614
11UbiquitinationARAKTPRKPTVKKGS
CCCCCCCCCCCCCCC		46.3623503661
11 (in isoform 2)Ubiquitination-46.36-
13PhosphorylationAKTPRKPTVKKGSQT
CCCCCCCCCCCCCCC		48.2524719451
15UbiquitinationTPRKPTVKKGSQTNL
CCCCCCCCCCCCCCC		54.6223503661
16UbiquitinationPRKPTVKKGSQTNLK
CCCCCCCCCCCCCCC		60.5023503661
18PhosphorylationKPTVKKGSQTNLKDP
CCCCCCCCCCCCCCC		42.5922617229
20PhosphorylationTVKKGSQTNLKDPVG
CCCCCCCCCCCCCCE		44.1922617229
20UbiquitinationTVKKGSQTNLKDPVG
CCCCCCCCCCCCCCE		44.1921890473
23UbiquitinationKGSQTNLKDPVGVYC
CCCCCCCCCCCEEEE		63.1523000965
28UbiquitinationNLKDPVGVYCRVRPL
CCCCCCEEEEEECCC		4.0823000965
29PhosphorylationLKDPVGVYCRVRPLG
CCCCCEEEEEECCCC		2.9128152594
33UbiquitinationVGVYCRVRPLGFPDQ
CEEEEEECCCCCCCC		11.0223000965
54 (in isoform 3)Phosphorylation-4.1725849741
56PhosphorylationNTTVQLHTPEGYRLN
CCEEEEECCCCEECC		31.4625159151
69UbiquitinationLNRNGDYKETQYSFK
CCCCCCCCCCEEEHH		60.0532015554
81PhosphorylationSFKQVFGTHTTQKEL
EHHHHHCCCCCHHHH		12.4621406692
83PhosphorylationKQVFGTHTTQKELFD
HHHHCCCCCHHHHHH		30.6621406692
84PhosphorylationQVFGTHTTQKELFDV
HHHCCCCCHHHHHHH		30.0021406692
86AcetylationFGTHTTQKELFDVVA
HCCCCCHHHHHHHHH		55.0526051181
86UbiquitinationFGTHTTQKELFDVVA
HCCCCCHHHHHHHHH		55.0529967540
104UbiquitinationVNDLIHGKNGLLFTY
HHHHHCCCCCEEEEE		33.4132015554
111PhosphorylationKNGLLFTYGVTGSGK
CCCEEEEEEECCCCC		11.41-
116PhosphorylationFTYGVTGSGKTHTMT
EEEEECCCCCEEECC		27.96-
121PhosphorylationTGSGKTHTMTGSPGE
CCCCCEEECCCCCCC		22.9729214152
125PhosphorylationKTHTMTGSPGEGGLL
CEEECCCCCCCCCCH		22.1425159151
139UbiquitinationLPRCLDMIFNSIGSF
HHHHHHHHHHCCCHH		2.7021890473
149UbiquitinationSIGSFQAKRYVFKSN
CCCHHHHHEEEEECC		33.2223000965
153UbiquitinationFQAKRYVFKSNDRNS
HHHHEEEEECCCCCC		5.4923000965
154UbiquitinationQAKRYVFKSNDRNSM
HHHEEEEECCCCCCC		38.0023000965
155PhosphorylationAKRYVFKSNDRNSMD
HHEEEEECCCCCCCE		32.2822167270
155 (in isoform 2)Phosphorylation-32.2818669648
159UbiquitinationVFKSNDRNSMDIQCE
EEECCCCCCCEEEHH		44.5421890473
160PhosphorylationFKSNDRNSMDIQCEV
EECCCCCCCEEEHHH		20.8022167270
160 (in isoform 2)Phosphorylation-20.8018669648
172UbiquitinationCEVDALLERQKREAM
HHHHHHHHHHHHHCC		54.6522817900
183AcetylationREAMPNPKTSSSKRQ
HHCCCCCCCCCCCCC		68.6211789809
188AcetylationNPKTSSSKRQVDPEF
CCCCCCCCCCCCHHH		49.1211789821
201UbiquitinationEFADMITVQEFCKAE
HHHHHHHHHHHHCCC		3.38-
202UbiquitinationFADMITVQEFCKAEE
HHHHHHHHHHHCCCC		29.4221890473
207UbiquitinationTVQEFCKAEEVDEDS
HHHHHHCCCCCCCCC		21.2621890473
213UbiquitinationKAEEVDEDSVYGVFV
CCCCCCCCCCEEEEE		38.6522817900
215UbiquitinationEEVDEDSVYGVFVSY
CCCCCCCCEEEEEEE		8.1429967540
235UbiquitinationNYIYDLLEEVPFDPI
CHHHHHHHCCCCCCC		65.3321890473
260UbiquitinationREDKNHNMYVAGCTE
CCCCCCCEEEECCEE		1.9021890473
263UbiquitinationKNHNMYVAGCTEVEV
CCCCEEEECCEEEEE		7.0021890473
272UbiquitinationCTEVEVKSTEEAFEV
CEEEEECCHHHHHHH		46.3423000965
274UbiquitinationEVEVKSTEEAFEVFW
EEEECCHHHHHHHHH		55.1921890473
279UbiquitinationSTEEAFEVFWRGQKK
CHHHHHHHHHCHHHC		4.5021890473
286UbiquitinationVFWRGQKKRRIANTH
HHHCHHHCHHCCCCC		38.7323000965
288UbiquitinationWRGQKKRRIANTHLN
HCHHHCHHCCCCCCC		41.0521890473
291UbiquitinationQKKRRIANTHLNRES
HHCHHCCCCCCCCHH		26.1723000965
292PhosphorylationKKRRIANTHLNRESS
HCHHCCCCCCCCHHH		20.7924719451
296UbiquitinationIANTHLNRESSRSHS
CCCCCCCCHHHCCCC		52.0829967540
298PhosphorylationNTHLNRESSRSHSVF
CCCCCCHHHCCCCCE		28.0223186163
299PhosphorylationTHLNRESSRSHSVFN
CCCCCHHHCCCCCEE		32.8023186163
301PhosphorylationLNRESSRSHSVFNIK
CCCHHHCCCCCEEEE		23.2823312004
303PhosphorylationRESSRSHSVFNIKLV
CHHHCCCCCEEEEEE		29.6530576142
320UbiquitinationPLDADGDNVLQEKEQ
CCCCCCCCCHHHHHE		41.76-
325UbiquitinationGDNVLQEKEQITISQ
CCCCHHHHHEEEEEH		41.7929967540
334UbiquitinationQITISQLSLVDLAGS
EEEEEHHEEHHHCCC		20.7932015554
340UbiquitinationLSLVDLAGSERTNRT
HEEHHHCCCCCCCCC		37.02-
353UbiquitinationRTRAEGNRLREAGNI
CCHHCHHHHHHCCCC		46.08-
363PhosphorylationEAGNINQSLMTLRTC
HCCCCCHHHHHHHHH		18.6727050516
365SulfoxidationGNINQSLMTLRTCMD
CCCCHHHHHHHHHHH		3.9321406390
372UbiquitinationMTLRTCMDVLRENQM
HHHHHHHHHHHHCCC		38.15-
377UbiquitinationCMDVLRENQMYGTNK
HHHHHHHCCCCCCCC		26.0321890473
380PhosphorylationVLRENQMYGTNKMVP
HHHHCCCCCCCCCCC		15.8425003641
382PhosphorylationRENQMYGTNKMVPYR
HHCCCCCCCCCCCCC		17.7425003641
382UbiquitinationRENQMYGTNKMVPYR
HHCCCCCCCCCCCCC		17.7421890473
383UbiquitinationENQMYGTNKMVPYRD
HCCCCCCCCCCCCCC		26.51-
384UbiquitinationNQMYGTNKMVPYRDS
CCCCCCCCCCCCCCH		40.9021890473
384UbiquitinationNQMYGTNKMVPYRDS
CCCCCCCCCCCCCCH		40.9023000965
384 (in isoform 1)Ubiquitination-40.9021890473
384 (in isoform 2)Ubiquitination-40.9021890473
388UbiquitinationGTNKMVPYRDSKLTH
CCCCCCCCCCHHHHH		18.68-
388PhosphorylationGTNKMVPYRDSKLTH
CCCCCCCCCCHHHHH		18.6828348404
391PhosphorylationKMVPYRDSKLTHLFK
CCCCCCCHHHHHHHH		22.1428348404
393UbiquitinationVPYRDSKLTHLFKNY
CCCCCHHHHHHHHHH		4.1723000965
394UbiquitinationPYRDSKLTHLFKNYF
CCCCHHHHHHHHHHC		21.92-
396UbiquitinationRDSKLTHLFKNYFDG
CCHHHHHHHHHHCCC		5.7223000965
398UbiquitinationSKLTHLFKNYFDGEG
HHHHHHHHHHCCCCC		58.0321890473
402UbiquitinationHLFKNYFDGEGKVRM
HHHHHHCCCCCEEEE		43.8221890473
403UbiquitinationLFKNYFDGEGKVRMI
HHHHHCCCCCEEEEE		35.34-
406UbiquitinationNYFDGEGKVRMIVCV
HHCCCCCEEEEEEEE		23.5129967540
407UbiquitinationYFDGEGKVRMIVCVN
HCCCCCEEEEEEEEC		8.0521890473
413UbiquitinationKVRMIVCVNPKAEDY
EEEEEEEECCCCCHH		10.7321890473
415UbiquitinationRMIVCVNPKAEDYEE
EEEEEECCCCCHHHH		19.4822817900
416UbiquitinationMIVCVNPKAEDYEEN
EEEEECCCCCHHHHH		60.24-
421UbiquitinationNPKAEDYEENLQVMR
CCCCCHHHHHHHHHH		53.3723000965
426UbiquitinationDYEENLQVMRFAEVT
HHHHHHHHHHHHHHC		3.1532015554
427UbiquitinationYEENLQVMRFAEVTQ
HHHHHHHHHHHHHCC		1.5621890473
433UbiquitinationVMRFAEVTQEVEVAR
HHHHHHHCCEEEECC		15.5429901268
440UbiquitinationTQEVEVARPVDKAIC
CCEEEECCCCCHHHH		36.6322817900
441UbiquitinationQEVEVARPVDKAICG
CEEEECCCCCHHHHC		28.99-
444AcetylationEVARPVDKAICGLTP
EECCCCCHHHHCCCC		39.6326051181
444UbiquitinationEVARPVDKAICGLTP
EECCCCCHHHHCCCC		39.6332015554
445UbiquitinationVARPVDKAICGLTPG
ECCCCCHHHHCCCCC		9.6121890473
450PhosphorylationDKAICGLTPGRRYRN
CHHHHCCCCCCCCCC		14.6930266825
450UbiquitinationDKAICGLTPGRRYRN
CHHHHCCCCCCCCCC		14.6921890473
450 (in isoform 2)Phosphorylation-14.6918669648
453UbiquitinationICGLTPGRRYRNQPR
HHCCCCCCCCCCCCC		33.39-
456UbiquitinationLTPGRRYRNQPRGPV
CCCCCCCCCCCCCCC		33.2333845483
458UbiquitinationPGRRYRNQPRGPVGN
CCCCCCCCCCCCCCC		21.7733845483
460UbiquitinationRRYRNQPRGPVGNEP
CCCCCCCCCCCCCCC		52.89-
461UbiquitinationRYRNQPRGPVGNEPL
CCCCCCCCCCCCCCC		28.1121890473
464UbiquitinationNQPRGPVGNEPLVTD
CCCCCCCCCCCCCCC		35.60-
467UbiquitinationRGPVGNEPLVTDVVL
CCCCCCCCCCCCHHH		35.81-
467UbiquitinationRGPVGNEPLVTDVVL
CCCCCCCCCCCCHHH		35.8133845483
470UbiquitinationVGNEPLVTDVVLQSF
CCCCCCCCCHHHHCC		30.6621890473
472UbiquitinationNEPLVTDVVLQSFPP
CCCCCCCHHHHCCCC		3.19-
475UbiquitinationLVTDVVLQSFPPLPS
CCCCHHHHCCCCCCC		31.2721890473
476UbiquitinationVTDVVLQSFPPLPSC
CCCHHHHCCCCCCCC		35.2432015554
478UbiquitinationDVVLQSFPPLPSCEI
CHHHHCCCCCCCCEE		34.4621890473
481UbiquitinationLQSFPPLPSCEILDI
HHCCCCCCCCEEECC		42.5822817900
489UbiquitinationSCEILDINDEQTLPR
CCEEECCCCHHHHHH		46.5723000965
496 (in isoform 3)Phosphorylation-51.9528450419
499 (in isoform 3)Phosphorylation-52.3622167270
501 (in isoform 3)Phosphorylation-5.3122167270
503UbiquitinationRLIEALEKRHNLRQM
HHHHHHHHHHCHHHH		60.8621890473
503UbiquitinationRLIEALEKRHNLRQM
HHHHHHHHHHCHHHH		60.8623000965
503 (in isoform 1)Ubiquitination-60.8621890473
503 (in isoform 2)Ubiquitination-60.8621890473
503 (in isoform 3)Phosphorylation-60.8622167270
510UbiquitinationKRHNLRQMMIDEFNK
HHHCHHHHHHHHHHH		1.7423000965
513UbiquitinationNLRQMMIDEFNKQSN
CHHHHHHHHHHHHCH		36.2223000965
514UbiquitinationLRQMMIDEFNKQSNA
HHHHHHHHHHHHCHH		39.9521890473
515UbiquitinationRQMMIDEFNKQSNAF
HHHHHHHHHHHCHHH		14.1923000965
517UbiquitinationMMIDEFNKQSNAFKA
HHHHHHHHHCHHHHH		61.5023000965
518UbiquitinationMIDEFNKQSNAFKAL
HHHHHHHHCHHHHHH		42.9223000965
522UbiquitinationFNKQSNAFKALLQEF
HHHHCHHHHHHHHHH		5.7921890473
523UbiquitinationNKQSNAFKALLQEFD
HHHCHHHHHHHHHHH		35.4021890473
523UbiquitinationNKQSNAFKALLQEFD
HHHCHHHHHHHHHHH		35.4023000965
523 (in isoform 1)Ubiquitination-35.4021890473
523 (in isoform 2)Ubiquitination-35.4021890473
526UbiquitinationSNAFKALLQEFDNAV
CHHHHHHHHHHHHHH		5.6823000965
528UbiquitinationAFKALLQEFDNAVLS
HHHHHHHHHHHHHHC		55.7421890473
529UbiquitinationFKALLQEFDNAVLSK
HHHHHHHHHHHHHCC		5.9123000965
531UbiquitinationALLQEFDNAVLSKEN
HHHHHHHHHHHCCHH		36.9523000965
533UbiquitinationLQEFDNAVLSKENHM
HHHHHHHHHCCHHHH		8.5421890473
534UbiquitinationQEFDNAVLSKENHMQ
HHHHHHHHCCHHHHC		5.8623000965
536UbiquitinationFDNAVLSKENHMQGK
HHHHHHCCHHHHCCC		59.3721906983
536 (in isoform 1)Ubiquitination-59.3721890473
536 (in isoform 2)Ubiquitination-59.3721890473
537UbiquitinationDNAVLSKENHMQGKL
HHHHHCCHHHHCCCC		49.3321890473
540UbiquitinationVLSKENHMQGKLNEK
HHCCHHHHCCCCCHH		9.4223000965
542UbiquitinationSKENHMQGKLNEKEK
CCHHHHCCCCCHHHH		28.9223000965
543UbiquitinationKENHMQGKLNEKEKM
CHHHHCCCCCHHHHH		31.1129901268
545UbiquitinationNHMQGKLNEKEKMIS
HHHCCCCCHHHHHHH		62.8823000965
547UbiquitinationMQGKLNEKEKMISGQ
HCCCCCHHHHHHHCC		62.6521890473
550UbiquitinationKLNEKEKMISGQKLE
CCCHHHHHHHCCEEE		2.8633845483
552PhosphorylationNEKEKMISGQKLEIE
CHHHHHHHCCEEEHH		31.50-
552UbiquitinationNEKEKMISGQKLEIE
CHHHHHHHCCEEEHH		31.5029967540
554UbiquitinationKEKMISGQKLEIERL
HHHHHHCCEEEHHHH		40.1323000965
555UbiquitinationEKMISGQKLEIERLE
HHHHHCCEEEHHHHH		52.1733845483
556UbiquitinationKMISGQKLEIERLEK
HHHHCCEEEHHHHHH		6.5223000965
557UbiquitinationMISGQKLEIERLEKK
HHHCCEEEHHHHHHH		50.2529901268
559UbiquitinationSGQKLEIERLEKKNK
HCCEEEHHHHHHHCC		41.6723000965
566UbiquitinationERLEKKNKTLEYKIE
HHHHHHCCCHHHHHH		64.4621890473
566UbiquitinationERLEKKNKTLEYKIE
HHHHHHCCCHHHHHH		64.4633845483
566 (in isoform 1)Ubiquitination-64.4621890473
566 (in isoform 2)Ubiquitination-64.4621890473
569UbiquitinationEKKNKTLEYKIEILE
HHHCCCHHHHHHHHH		50.4333845483
570PhosphorylationKKNKTLEYKIEILEK
HHCCCHHHHHHHHHH		22.0028152594
571UbiquitinationKNKTLEYKIEILEKT
HCCCHHHHHHHHHHH		25.2021890473
571SumoylationKNKTLEYKIEILEKT
HCCCHHHHHHHHHHH		25.2028112733
571UbiquitinationKNKTLEYKIEILEKT
HCCCHHHHHHHHHHH		25.2033845483
571 (in isoform 1)Ubiquitination-25.2021890473
571 (in isoform 2)Ubiquitination-25.2021890473
577UbiquitinationYKIEILEKTTTIYEE
HHHHHHHHHCCHHHH		47.9621906983
577 (in isoform 1)Ubiquitination-47.9621890473
577 (in isoform 2)Ubiquitination-47.9621890473
580PhosphorylationEILEKTTTIYEEDKR
HHHHHHCCHHHHHHH		27.13-
580UbiquitinationEILEKTTTIYEEDKR
HHHHHHCCHHHHHHH		27.1321890473
582PhosphorylationLEKTTTIYEEDKRNL
HHHHCCHHHHHHHHH		15.9220007894
585UbiquitinationTTTIYEEDKRNLQQE
HCCHHHHHHHHHHHH		43.1821890473
5862-HydroxyisobutyrylationTTIYEEDKRNLQQEL
CCHHHHHHHHHHHHH		46.60-
586SumoylationTTIYEEDKRNLQQEL
CCHHHHHHHHHHHHH		46.6028112733
586UbiquitinationTTIYEEDKRNLQQEL
CCHHHHHHHHHHHHH		46.6033845483
590UbiquitinationEEDKRNLQQELETQN
HHHHHHHHHHHHHHH		37.95-
591UbiquitinationEDKRNLQQELETQNQ
HHHHHHHHHHHHHHH		61.4829901268
595PhosphorylationNLQQELETQNQKLQR
HHHHHHHHHHHHHHH		45.50-
599UbiquitinationELETQNQKLQRQFSD
HHHHHHHHHHHHHCH		54.8821890473
599UbiquitinationELETQNQKLQRQFSD
HHHHHHHHHHHHHCH		54.8823000965
599 (in isoform 1)Ubiquitination-54.8821890473
599 (in isoform 2)Ubiquitination-54.8821890473
600UbiquitinationLETQNQKLQRQFSDK
HHHHHHHHHHHHCHH		3.5033845483
605PhosphorylationQKLQRQFSDKRRLEA
HHHHHHHCHHHHHHH		33.6128355574
613UbiquitinationDKRRLEARLQGMVTE
HHHHHHHHHHHHCHH		20.4023000965
620UbiquitinationRLQGMVTETTMKWEK
HHHHHCHHHHHHHHH		30.7621890473
621PhosphorylationLQGMVTETTMKWEKE
HHHHCHHHHHHHHHH		23.8729083192
622PhosphorylationQGMVTETTMKWEKEC
HHHCHHHHHHHHHHH		15.5529083192
624UbiquitinationMVTETTMKWEKECER
HCHHHHHHHHHHHHH		50.5421890473
624SumoylationMVTETTMKWEKECER
HCHHHHHHHHHHHHH		50.5428112733
624UbiquitinationMVTETTMKWEKECER
HCHHHHHHHHHHHHH		50.5432015554
624 (in isoform 1)Ubiquitination-50.5421890473
624 (in isoform 2)Ubiquitination-50.5421890473
631UbiquitinationKWEKECERRVAAKQL
HHHHHHHHHHHHHHH		50.4621890473
636UbiquitinationCERRVAAKQLEMQNK
HHHHHHHHHHHHHHC		45.7523000965
636 (in isoform 1)Ubiquitination-45.7521890473
636 (in isoform 2)Ubiquitination-45.7521890473
638UbiquitinationRRVAAKQLEMQNKLW
HHHHHHHHHHHHCCC		6.1221890473
643UbiquitinationKQLEMQNKLWVKDEK
HHHHHHHCCCCCHHH		27.1721890473
643UbiquitinationKQLEMQNKLWVKDEK
HHHHHHHCCCCCHHH		27.1732015554
643 (in isoform 1)Ubiquitination-27.1721890473
643 (in isoform 2)Ubiquitination-27.1721890473
645UbiquitinationLEMQNKLWVKDEKLK
HHHHHCCCCCHHHHH		9.2021890473
647SumoylationMQNKLWVKDEKLKQL
HHHCCCCCHHHHHHH		48.89-
647SumoylationMQNKLWVKDEKLKQL
HHHCCCCCHHHHHHH		48.8928112733
647UbiquitinationMQNKLWVKDEKLKQL
HHHCCCCCHHHHHHH		48.8933845483
650UbiquitinationKLWVKDEKLKQLKAI
CCCCCHHHHHHHHHH		71.7323000965
652UbiquitinationWVKDEKLKQLKAIVT
CCCHHHHHHHHHHHC		65.7323000965
655UbiquitinationDEKLKQLKAIVTEPK
HHHHHHHHHHHCCCC		33.3123000965
657UbiquitinationKLKQLKAIVTEPKTE
HHHHHHHHHCCCCCC		3.6321890473
661UbiquitinationLKAIVTEPKTEKPER
HHHHHCCCCCCCCCC		39.2333845483
662SumoylationKAIVTEPKTEKPERP
HHHHCCCCCCCCCCC		64.18-
662SumoylationKAIVTEPKTEKPERP
HHHHCCCCCCCCCCC		64.1828112733
662UbiquitinationKAIVTEPKTEKPERP
HHHHCCCCCCCCCCC		64.1829967540
663PhosphorylationAIVTEPKTEKPERPS
HHHCCCCCCCCCCCC		61.0228555341
664UbiquitinationIVTEPKTEKPERPSR
HHCCCCCCCCCCCCC		73.1323000965
665AcetylationVTEPKTEKPERPSRE
HCCCCCCCCCCCCCH		58.3625953088
665SumoylationVTEPKTEKPERPSRE
HCCCCCCCCCCCCCH		58.3628112733
666UbiquitinationTEPKTEKPERPSRER
CCCCCCCCCCCCCHH		36.2723000965
669UbiquitinationKTEKPERPSRERDRE
CCCCCCCCCCHHHHH		35.76-
669UbiquitinationKTEKPERPSRERDRE
CCCCCCCCCCHHHHH		35.7623000965
670PhosphorylationTEKPERPSRERDREK
CCCCCCCCCHHHHHH		53.6620860994
674UbiquitinationERPSRERDREKVTQR
CCCCCHHHHHHHHHC		59.3423000965
679PhosphorylationERDREKVTQRSVSPS
HHHHHHHHHCCCCCC		29.3620068231
679 (in isoform 2)Phosphorylation-29.3628450419
682PhosphorylationREKVTQRSVSPSPVP
HHHHHHCCCCCCCCC		19.6822167270
682 (in isoform 2)Phosphorylation-19.6822167270
684PhosphorylationKVTQRSVSPSPVPLS
HHHHCCCCCCCCCCC		22.4022167270
684 (in isoform 2)Phosphorylation-22.4022167270
686PhosphorylationTQRSVSPSPVPLSSN
HHCCCCCCCCCCCCC		30.9022167270
686 (in isoform 2)Phosphorylation-30.9022167270
691PhosphorylationSPSPVPLSSNYIAQI
CCCCCCCCCCEEEEE		15.5222115753
692PhosphorylationPSPVPLSSNYIAQIS
CCCCCCCCCEEEEEC		41.1423663014
694PhosphorylationPVPLSSNYIAQISNG
CCCCCCCEEEEECCC		10.2823663014
705UbiquitinationISNGQQLMSQPQLHR
ECCCCCHHCCCCHHC		2.8032015554
708PhosphorylationGQQLMSQPQLHRRSN
CCCHHCCCCHHCCCC		31.2432645325
712PhosphorylationMSQPQLHRRSNSCSS
HCCCCHHCCCCCCCC		52.9233259812
714PhosphorylationQPQLHRRSNSCSSIS
CCCHHCCCCCCCCCC		32.8125159151
716PhosphorylationQLHRRSNSCSSISVA
CHHCCCCCCCCCCHH		19.3421712546
718PhosphorylationHRRSNSCSSISVASC
HCCCCCCCCCCHHHH		30.4421712546
719PhosphorylationRRSNSCSSISVASCI
CCCCCCCCCCHHHHH		24.1823663014
721PhosphorylationSNSCSSISVASCISE
CCCCCCCCHHHHHHH		17.3623663014
724PhosphorylationCSSISVASCISEWEQ
CCCCCHHHHHHHHHH		15.1630576142
735PhosphorylationEWEQKIPTYNTPLKV
HHHHHCCCCCCCCHH		32.6430266825
736PhosphorylationWEQKIPTYNTPLKVT
HHHHCCCCCCCCHHH		16.2225159151
738PhosphorylationQKIPTYNTPLKVTSI
HHCCCCCCCCHHHHH		21.4230266825
741SumoylationPTYNTPLKVTSIARR
CCCCCCCHHHHHHHH		44.6728112733
741UbiquitinationPTYNTPLKVTSIARR
CCCCCCCHHHHHHHH		44.6723000965
741 (in isoform 1)Ubiquitination-44.6721890473
743PhosphorylationYNTPLKVTSIARRRQ
CCCCCHHHHHHHHHC		16.9021712546
744PhosphorylationNTPLKVTSIARRRQQ
CCCCHHHHHHHHHCC		19.7626055452
753UbiquitinationARRRQQEPGQSKTCI
HHHHCCCCCCCCEEE		41.6123000965
755UbiquitinationRRQQEPGQSKTCIVS
HHCCCCCCCCEEEEE		53.0921890473
756UbiquitinationRQQEPGQSKTCIVSD
HCCCCCCCCEEEEEC		35.5323000965
757UbiquitinationQQEPGQSKTCIVSDR
CCCCCCCCEEEEECC		39.26-
758O-linked_GlycosylationQEPGQSKTCIVSDRR
CCCCCCCEEEEECCC		16.8330379171
761UbiquitinationGQSKTCIVSDRRRGM
CCCCEEEEECCCCCE		5.4623000965
762PhosphorylationQSKTCIVSDRRRGMY
CCCEEEEECCCCCEE		12.8921815630
762UbiquitinationQSKTCIVSDRRRGMY
CCCEEEEECCCCCEE		12.8929967540
763PhosphorylationSKTCIVSDRRRGMYW
CCEEEEECCCCCEEE		36.8932142685
770UbiquitinationDRRRGMYWTEGREVV
CCCCCEEECCCCEEC		4.5123000965
773UbiquitinationRGMYWTEGREVVPTF
CCEEECCCCEECCCC		24.5523000965
778UbiquitinationTEGREVVPTFRNEIE
CCCCEECCCCCCCEE		30.8723000965
781UbiquitinationREVVPTFRNEIEIEE
CEECCCCCCCEEECC		42.2123000965
784UbiquitinationVPTFRNEIEIEEDHC
CCCCCCCEEECCCCC		8.0423000965
786UbiquitinationTFRNEIEIEEDHCGR
CCCCCEEECCCCCCC		9.6223000965
787UbiquitinationFRNEIEIEEDHCGRL
CCCCEEECCCCCCCE		44.5823000965
792UbiquitinationEIEEDHCGRLLFQPD
EECCCCCCCEEECCC		21.6123000965
795UbiquitinationEDHCGRLLFQPDQNA
CCCCCCEEECCCCCC		3.4532015554
798PhosphorylationCGRLLFQPDQNAPPI
CCCEEECCCCCCCCC		37.5132645325
802PhosphorylationLFQPDQNAPPIRLRH
EECCCCCCCCCCCCC		12.9533259812
812PhosphorylationIRLRHRRSRSAGDRW
CCCCCCCCCCCCCCC		30.4620068231
814PhosphorylationLRHRRSRSAGDRWVD
CCCCCCCCCCCCCCC		37.5425159151
823AcetylationGDRWVDHKPASNMQT
CCCCCCCCCCCCCCC		37.5026051181
823SumoylationGDRWVDHKPASNMQT
CCCCCCCCCCCCCCC		37.5028112733
826PhosphorylationWVDHKPASNMQTETV
CCCCCCCCCCCCCCC		41.1720068231
830PhosphorylationKPASNMQTETVMQPH
CCCCCCCCCCCCCCC		23.9021406692
832PhosphorylationASNMQTETVMQPHVP
CCCCCCCCCCCCCCC		25.3521406692
843PhosphorylationPHVPHAITVSVANEK
CCCCCEEEEEECCHH		13.9121406692
845PhosphorylationVPHAITVSVANEKAL
CCCEEEEEECCHHHH		13.5821406692
852UbiquitinationSVANEKALAKCEKYM
EECCHHHHHHHHHHC		7.4829967540
854SumoylationANEKALAKCEKYMLT
CCHHHHHHHHHHCHH		43.7228112733
857AcetylationKALAKCEKYMLTHQE
HHHHHHHHHCHHHHH		45.4926051181
858PhosphorylationALAKCEKYMLTHQEL
HHHHHHHHCHHHHHH		3.8123403867
861PhosphorylationKCEKYMLTHQELASD
HHHHHCHHHHHHHCC		12.6523927012
867PhosphorylationLTHQELASDGEIETK
HHHHHHHCCCCEEEE		59.7929255136
873PhosphorylationASDGEIETKLIKGDI
HCCCCEEEEEEECCE		36.4930278072
874SumoylationSDGEIETKLIKGDIY
CCCCEEEEEEECCEE		35.1128112733
874UbiquitinationSDGEIETKLIKGDIY
CCCCEEEEEEECCEE		35.1123000965
877SumoylationEIETKLIKGDIYKTR
CEEEEEEECCEEECC		62.05-
877SumoylationEIETKLIKGDIYKTR
CEEEEEEECCEEECC		62.0528112733
877UbiquitinationEIETKLIKGDIYKTR
CEEEEEEECCEEECC		62.0523000965
881PhosphorylationKLIKGDIYKTRGGGQ
EEEECCEEECCCCCC		15.8525839225
882UbiquitinationLIKGDIYKTRGGGQS
EEECCEEECCCCCCE		31.8923000965
883PhosphorylationIKGDIYKTRGGGQSV
EECCEEECCCCCCEE		19.9926074081
884MethylationKGDIYKTRGGGQSVQ
ECCEEECCCCCCEEE		37.29115481213
888UbiquitinationYKTRGGGQSVQFTDI
EECCCCCCEEEEECH		43.6423000965
889PhosphorylationKTRGGGQSVQFTDIE
ECCCCCCEEEEECHH		22.5923927012
891UbiquitinationRGGGQSVQFTDIETL
CCCCCEEEEECHHHH		40.5523000965
893PhosphorylationGGQSVQFTDIETLKQ
CCCEEEEECHHHHCC		20.9830266825
896UbiquitinationSVQFTDIETLKQESP
EEEEECHHHHCCCCC		51.3923000965
897PhosphorylationVQFTDIETLKQESPN
EEEECHHHHCCCCCC		39.3230266825
899SumoylationFTDIETLKQESPNGS
EECHHHHCCCCCCCC		60.4828112733
899UbiquitinationFTDIETLKQESPNGS
EECHHHHCCCCCCCC		60.4832015554
902PhosphorylationIETLKQESPNGSRKR
HHHHCCCCCCCCCCC		22.6029255136
906PhosphorylationKQESPNGSRKRRSST
CCCCCCCCCCCCCCC		41.0730266825
911PhosphorylationNGSRKRRSSTVAPAQ
CCCCCCCCCCCCCCC		34.1022167270
912PhosphorylationGSRKRRSSTVAPAQP
CCCCCCCCCCCCCCC		25.7022167270
913PhosphorylationSRKRRSSTVAPAQPD
CCCCCCCCCCCCCCC		23.1822167270
913UbiquitinationSRKRRSSTVAPAQPD
CCCCCCCCCCCCCCC		23.1832015554
916PhosphorylationRRSSTVAPAQPDGAE
CCCCCCCCCCCCCCC		27.3932645325
920PhosphorylationTVAPAQPDGAESEWT
CCCCCCCCCCCCCCC		57.7833259812
924PhosphorylationAQPDGAESEWTDVET
CCCCCCCCCCCCCCH		37.5930266825
927PhosphorylationDGAESEWTDVETRCS
CCCCCCCCCCCHHHE		26.5623927012
931PhosphorylationSEWTDVETRCSVAVE
CCCCCCCHHHEEEEE		36.5030108239
934PhosphorylationTDVETRCSVAVEMRA
CCCCHHHEEEEEECC		15.1519007248
943PhosphorylationAVEMRAGSQLGPGYQ
EEEECCCCCCCCCCC		22.6530266825
949PhosphorylationGSQLGPGYQHHAQPK
CCCCCCCCCCCCCCC		14.0630266825
956SumoylationYQHHAQPKRKKP---
CCCCCCCCCCCC---		65.8428112733
956UbiquitinationYQHHAQPKRKKP---
CCCCCCCCCCCC---		65.8429967540
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
708SPhosphorylationKinaseAURKBQ96GD4
GPS
714SPhosphorylationKinaseAURKBQ96GD4
PhosphoELM
716SPhosphorylationKinaseLATS1O95835
PSP
716SPhosphorylationKinaseLATS2Q9NRM7
PSP
716SPhosphorylationKinaseSTK38Q15208
GPS
814SPhosphorylationKinaseLATS1O95835
PSP
814SPhosphorylationKinaseLATS2Q9NRM7
PSP
814SPhosphorylationKinaseSTK38Q15208
GPS
911SPhosphorylationKinaseAURKBQ96GD4
GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KIF23_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KIF23_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ARF3_HUMANARF3physical
10506747
BIRC6_HUMANBIRC6physical
18329369
PRC1_HUMANPRC1physical
15297875
RGAP1_HUMANRACGAP1physical
22939629
XRCC6_HUMANXRCC6physical
22939629
ARF6_MOUSEArf6physical
22522702
ARF6_HUMANARF6physical
22522702
DNLI3_HUMANLIG3physical
26344197
RGAP1_HUMANRACGAP1physical
26344197
SPF30_HUMANSMNDC1physical
26344197
TCEA1_HUMANTCEA1physical
26344197
AT2A2_HUMANATP2A2physical
26496610
HD_HUMANHTTphysical
26496610
M3K4_HUMANMAP3K4physical
26496610
1433B_HUMANYWHABphysical
26496610
1433G_HUMANYWHAGphysical
26496610
1433F_HUMANYWHAHphysical
26496610
UBP7_HUMANUSP7physical
26496610
RB6I2_HUMANERC1physical
26496610
CD2AP_HUMANCD2APphysical
26496610
RGAP1_HUMANRACGAP1physical
26496610
CEP55_HUMANCEP55physical
26496610
MICA3_HUMANMICAL3physical
26496610
SHCBP_HUMANSHCBP1physical
26496610
PHLB2_HUMANPHLDB2physical
26496610
LIMK1_HUMANLIMK1physical
25786116
Drug and Disease Associations
Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KIF23_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-867, AND MASSSPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-160; THR-450; THR-738;THR-861; SER-867 AND SER-902, AND MASS SPECTROMETRY.
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-682; SER-684; SER-686;SER-911; SER-912 AND THR-913, AND MASS SPECTROMETRY.
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-682; SER-684; SER-867AND SER-934, AND MASS SPECTROMETRY.
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-686, AND MASSSPECTROMETRY.
"Phosphoproteome analysis of the human mitotic spindle.";
Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.;
Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-160; SER-682; SER-684;SER-911 AND SER-912, AND MASS SPECTROMETRY.
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-155; SER-814; SER-867AND SER-902, AND MASS SPECTROMETRY.
"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-684, AND MASSSPECTROMETRY.
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-738, AND MASSSPECTROMETRY.
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization.";
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
Nat. Biotechnol. 24:1285-1292(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-450 AND THR-738, ANDMASS SPECTROMETRY.
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells.";
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.;
Nat. Biotechnol. 23:94-101(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-29, AND MASSSPECTROMETRY.

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