dbPTM

LAS1L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LAS1L_HUMAN
UniProt AC	Q9Y4W2
Protein Name	Ribosomal biogenesis protein LAS1L
Gene Name	LAS1L
Organism	Homo sapiens (Human).
Sequence Length	734
Subcellular Localization	Nucleus, nucleolus . Nucleus, nucleoplasm. Cytoplasm. Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity). Localizes mainly to the granular component, the region implicated in the later
Protein Description	Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes..
Protein Sequence	MSWESGAGPGLGSQGMDLVWSAWYGKCVKGKGSLPLSAHGIVVAWLSRAEWDQVTVYLFCDDHKLQRYALNRITVWRSRSGNELPLAVASTADLIRCKLLDVTGGLGTDELRLLYGMALVRFVNLISERKTKFAKVPLKCLAQEVNIPDWIVDLRHELTHKKMPHINDCRRGCYFVLDWLQKTYWCRQLENSLRETWELEEFREGIEEEDQEEDKNIVVDDITEQKPEPQDDGKSTESDVKADGDSKGSEEVDSHCKKALSHKELYERARELLVSYEEEQFTVLEKFRYLPKAIKAWNNPSPRVECVLAELKGVTCENREAVLDAFLDDGFLVPTFEQLAALQIEYEDGQTEVQRGEGTDPKSHKNVDLNDVLVPKPFSQFWQPLLRGLHSQNFTQALLERMLSELPALGISGIRPTYILRWTVELIVANTKTGRNARRFSAGQWEARRGWRLFNCSASLDWPRMVESCLGSPCWASPQLLRIIFKAMGQGLPDEEQEKLLRICSIYTQSGENSLVQEGSEASPIGKSPYTLDSLYWSVKPASSSFGSEAKAQQQEEQGSVNDVKEEEKEEKEVLPDQVEEEEENDDQEEEEEDEDDEDDEEEDRMEVGPFSTGQESPTAENARLLAQKRGALQGSAWQVSSEDVRWDTFPLGRMPGQTEDPAELMLENYDTMYLLDQPVLEQRLEPSTCKTDTLGLSCGVGSGNCSNSSSSNFEGLLWSQGQLHGLKTGLQLF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSWESGAGP ------CCCCCCCCC	39.28	28348404
5	Phosphorylation	---MSWESGAGPGLG ---CCCCCCCCCCCC	27.90	28348404
13	Phosphorylation	GAGPGLGSQGMDLVW CCCCCCCHHCCHHHH	28.71	28348404
21	Phosphorylation	QGMDLVWSAWYGKCV HCCHHHHHEECCCCC	11.05	28674151
24	Phosphorylation	DLVWSAWYGKCVKGK HHHHHEECCCCCCCC	13.36	28674151
31	Acetylation	YGKCVKGKGSLPLSA CCCCCCCCCCCCCCC	39.34	26051181
31	Ubiquitination	YGKCVKGKGSLPLSA CCCCCCCCCCCCCCC	39.34	-
60	Ubiquitination	QVTVYLFCDDHKLQR EEEEEEEECCHHHHH	5.77	22817900
63	Ubiquitination	VYLFCDDHKLQRYAL EEEEECCHHHHHHHH	21.34	21890473
64	Ubiquitination	YLFCDDHKLQRYALN EEEECCHHHHHHHHH	54.00	21963094
80	Phosphorylation	ITVWRSRSGNELPLA EEEEECCCCCCCCEE	47.41	20068231
90	Phosphorylation	ELPLAVASTADLIRC CCCEEEEHHHHHHHC	19.96	20068231
91	Phosphorylation	LPLAVASTADLIRCK CCEEEEHHHHHHHCE	17.91	20068231
93	Ubiquitination	LAVASTADLIRCKLL EEEEHHHHHHHCEEC	42.59	29901268
97	Ubiquitination	STADLIRCKLLDVTG HHHHHHHCEECCCCC	2.63	21963094
97 (in isoform 3)	Ubiquitination	-	2.63	21890473
98	Ubiquitination	TADLIRCKLLDVTGG HHHHHHCEECCCCCC	42.08	21963094
115	Phosphorylation	TDELRLLYGMALVRF HHHHHHHHHHHHHHH	14.94	-
119	Ubiquitination	RLLYGMALVRFVNLI HHHHHHHHHHHHHHH	1.79	29967540
120	Ubiquitination	LLYGMALVRFVNLIS HHHHHHHHHHHHHHC	3.03	27667366
127	O-linked_Glycosylation	VRFVNLISERKTKFA HHHHHHHCCCCCCCC	34.22	30379171
127	Phosphorylation	VRFVNLISERKTKFA HHHHHHHCCCCCCCC	34.22	20068231
135	Acetylation	ERKTKFAKVPLKCLA CCCCCCCCCCHHHHH	47.74	26051181
135	Ubiquitination	ERKTKFAKVPLKCLA CCCCCCCCCCHHHHH	47.74	27667366
139	Methylation	KFAKVPLKCLAQEVN CCCCCCHHHHHHHCC	22.57	30783411
139	Ubiquitination	KFAKVPLKCLAQEVN CCCCCCHHHHHHHCC	22.57	21906983
139 (in isoform 1)	Ubiquitination	-	22.57	21890473
139 (in isoform 2)	Ubiquitination	-	22.57	21890473
139 (in isoform 4)	Ubiquitination	-	22.57	21890473
140	Glutathionylation	FAKVPLKCLAQEVNI CCCCCHHHHHHHCCC	5.12	22555962
161	Ubiquitination	LRHELTHKKMPHIND HHHHHHCCCCCCHHH	45.60	29967540
162	Ubiquitination	RHELTHKKMPHINDC HHHHHCCCCCCHHHH	50.49	27667366
167	Ubiquitination	HKKMPHINDCRRGCY CCCCCCHHHHHHCHH	39.02	27667366
173	Ubiquitination	INDCRRGCYFVLDWL HHHHHHCHHHHHHHH	1.95	29967540
180	Ubiquitination	CYFVLDWLQKTYWCR HHHHHHHHHHHHHHH	3.60	21963094
184	Ubiquitination	LDWLQKTYWCRQLEN HHHHHHHHHHHHHHH	15.00	27667366
184 (in isoform 3)	Ubiquitination	-	15.00	21890473
192	Ubiquitination	WCRQLENSLRETWEL HHHHHHHHHHHHCHH	21.30	29967540
197	Ubiquitination	ENSLRETWELEEFRE HHHHHHHCHHHHHHH	11.92	21890473
199	Ubiquitination	SLRETWELEEFREGI HHHHHCHHHHHHHCC	6.03	33845483
199 (in isoform 3)	Ubiquitination	-	6.03	21890473
205	Ubiquitination	ELEEFREGIEEEDQE HHHHHHHCCCHHHHH	28.49	27667366
215	Sumoylation	EEDQEEDKNIVVDDI HHHHHHHCCCEEEEH	52.43	28112733
215	Ubiquitination	EEDQEEDKNIVVDDI HHHHHHHCCCEEEEH	52.43	29967540
215 (in isoform 3)	Ubiquitination	-	52.43	21890473
216	Ubiquitination	EDQEEDKNIVVDDIT HHHHHHCCCEEEEHH	44.61	22817900
221	Ubiquitination	DKNIVVDDITEQKPE HCCCEEEEHHCCCCC	37.79	27667366
221 (in isoform 3)	Ubiquitination	-	37.79	21890473
223	Phosphorylation	NIVVDDITEQKPEPQ CCEEEEHHCCCCCCC	39.08	30576142
226	Sumoylation	VDDITEQKPEPQDDG EEEHHCCCCCCCCCC	45.15	-
226	Sumoylation	VDDITEQKPEPQDDG EEEHHCCCCCCCCCC	45.15	28112733
226	Ubiquitination	VDDITEQKPEPQDDG EEEHHCCCCCCCCCC	45.15	21906983
226 (in isoform 1)	Ubiquitination	-	45.15	21890473
226 (in isoform 2)	Ubiquitination	-	45.15	21890473
226 (in isoform 4)	Ubiquitination	-	45.15	21890473
234	Ubiquitination	PEPQDDGKSTESDVK CCCCCCCCCCHHHHH	62.29	29967540
235	Phosphorylation	EPQDDGKSTESDVKA CCCCCCCCCHHHHHC	42.83	23927012
236	Phosphorylation	PQDDGKSTESDVKAD CCCCCCCCHHHHHCC	42.89	25159151
238	Phosphorylation	DDGKSTESDVKADGD CCCCCCHHHHHCCCC	48.03	23401153
238	Ubiquitination	DDGKSTESDVKADGD CCCCCCHHHHHCCCC	48.03	21963094
241	Phosphorylation	KSTESDVKADGDSKG CCCHHHHHCCCCCCC	45.83	32142685
241	Ubiquitination	KSTESDVKADGDSKG CCCHHHHHCCCCCCC	45.83	21906983
241 (in isoform 1)	Ubiquitination	-	45.83	21890473
241 (in isoform 2)	Ubiquitination	-	45.83	21890473
241 (in isoform 4)	Ubiquitination	-	45.83	21890473
244	Ubiquitination	ESDVKADGDSKGSEE HHHHHCCCCCCCHHH	46.05	21963094
244 (in isoform 3)	Ubiquitination	-	46.05	21890473
246	Phosphorylation	DVKADGDSKGSEEVD HHHCCCCCCCHHHHH	44.43	28985074
246	Ubiquitination	DVKADGDSKGSEEVD HHHCCCCCCCHHHHH	44.43	27667366
247	Ubiquitination	VKADGDSKGSEEVDS HHCCCCCCCHHHHHH	71.80	27667366
249	Phosphorylation	ADGDSKGSEEVDSHC CCCCCCCHHHHHHHH	34.03	25849741
250	Ubiquitination	DGDSKGSEEVDSHCK CCCCCCHHHHHHHHH	71.37	29901268
253	Ubiquitination	SKGSEEVDSHCKKAL CCCHHHHHHHHHHHH	35.62	21963094
253 (in isoform 3)	Ubiquitination	-	35.62	21890473
254	Phosphorylation	KGSEEVDSHCKKALS CCHHHHHHHHHHHHC	35.64	28985074
257	Ubiquitination	EEVDSHCKKALSHKE HHHHHHHHHHHCHHH	35.34	21906983
257 (in isoform 1)	Ubiquitination	-	35.34	21890473
257 (in isoform 2)	Ubiquitination	-	35.34	21890473
257 (in isoform 4)	Ubiquitination	-	35.34	21890473
258	Ubiquitination	EVDSHCKKALSHKEL HHHHHHHHHHCHHHH	61.01	22817900
261	Phosphorylation	SHCKKALSHKELYER HHHHHHHCHHHHHHH	37.06	-
263	Ubiquitination	CKKALSHKELYERAR HHHHHCHHHHHHHHH	46.14	21890473
263	Acetylation	CKKALSHKELYERAR HHHHHCHHHHHHHHH	46.14	26051181
263	Ubiquitination	CKKALSHKELYERAR HHHHHCHHHHHHHHH	46.14	27667366
263 (in isoform 1)	Ubiquitination	-	46.14	21890473
263 (in isoform 2)	Ubiquitination	-	46.14	21890473
263 (in isoform 4)	Ubiquitination	-	46.14	21890473
270	Ubiquitination	KELYERARELLVSYE HHHHHHHHHHHHCCC	41.12	21963094
270 (in isoform 3)	Ubiquitination	-	41.12	21890473
286	Ubiquitination	EQFTVLEKFRYLPKA HHHHHHHHHCCHHHH	30.86	21906983
286 (in isoform 1)	Ubiquitination	-	30.86	21890473
286 (in isoform 2)	Ubiquitination	-	30.86	21890473
292	Malonylation	EKFRYLPKAIKAWNN HHHCCHHHHHHHHCC	61.21	32601280
292	Ubiquitination	EKFRYLPKAIKAWNN HHHCCHHHHHHHHCC	61.21	29901268
295	Sumoylation	RYLPKAIKAWNNPSP CCHHHHHHHHCCCCH	52.81	-
295	Malonylation	RYLPKAIKAWNNPSP CCHHHHHHHHCCCCH	52.81	26320211
295	Sumoylation	RYLPKAIKAWNNPSP CCHHHHHHHHCCCCH	52.81	-
295	Ubiquitination	RYLPKAIKAWNNPSP CCHHHHHHHHCCCCH	52.81	21906983
295 (in isoform 1)	Ubiquitination	-	52.81	21890473
295 (in isoform 2)	Ubiquitination	-	52.81	21890473
298	Phosphorylation	PKAIKAWNNPSPRVE HHHHHHHCCCCHHHH	56.23	33259812
301	Phosphorylation	IKAWNNPSPRVECVL HHHHCCCCHHHHHHH	27.71	25159151
310	Ubiquitination	RVECVLAELKGVTCE HHHHHHHHHCCCCCC	47.02	27667366
312	Acetylation	ECVLAELKGVTCENR HHHHHHHCCCCCCCH	42.72	25953088
312	Ubiquitination	ECVLAELKGVTCENR HHHHHHHCCCCCCCH	42.72	21906983
312 (in isoform 1)	Ubiquitination	-	42.72	21890473
312 (in isoform 2)	Ubiquitination	-	42.72	21890473
320	Ubiquitination	GVTCENREAVLDAFL CCCCCCHHHHHHHHC	55.50	22817900
323	Ubiquitination	CENREAVLDAFLDDG CCCHHHHHHHHCCCC	5.18	21890473
327	Ubiquitination	EAVLDAFLDDGFLVP HHHHHHHCCCCCCCC	6.68	27667366
362	Ubiquitination	RGEGTDPKSHKNVDL CCCCCCCCCCCCCCH	68.92	22817900
363	Phosphorylation	GEGTDPKSHKNVDLN CCCCCCCCCCCCCHH	45.11	-
365	Ubiquitination	GTDPKSHKNVDLNDV CCCCCCCCCCCHHHC	66.80	21890473
365	Ubiquitination	GTDPKSHKNVDLNDV CCCCCCCCCCCHHHC	66.80	21890473
365 (in isoform 1)	Ubiquitination	-	66.80	21890473
372	Ubiquitination	KNVDLNDVLVPKPFS CCCCHHHCCCCCCHH	5.89	21963094
373 (in isoform 3)	Ubiquitination	-	6.43	21890473
376	Ubiquitination	LNDVLVPKPFSQFWQ HHHCCCCCCHHHHHH	51.74	33845483
389	Ubiquitination	WQPLLRGLHSQNFTQ HHHHHHHHHCCCHHH	2.58	21963094
404	Phosphorylation	ALLERMLSELPALGI HHHHHHHHHCHHHCC	27.95	20068231
412	Phosphorylation	ELPALGISGIRPTYI HCHHHCCCCCCCCEE	26.77	20068231
415 (in isoform 2)	Ubiquitination	-	22.49	21890473
417	Phosphorylation	GISGIRPTYILRWTV CCCCCCCCEEHHEEE	17.22	20068231
418	Phosphorylation	ISGIRPTYILRWTVE CCCCCCCEEHHEEEE	10.71	22210691
427	Ubiquitination	LRWTVELIVANTKTG HHEEEEEEEEECCCC	1.41	27667366
427 (in isoform 3)	Ubiquitination	-	1.41	21890473
432	Ubiquitination	ELIVANTKTGRNARR EEEEEECCCCCCCHH	49.11	21906983
432 (in isoform 1)	Ubiquitination	-	49.11	21890473
440	Ubiquitination	TGRNARRFSAGQWEA CCCCCHHCCCCCCHH	4.97	21963094
440 (in isoform 3)	Ubiquitination	-	4.97	21890473
441	Phosphorylation	GRNARRFSAGQWEAR CCCCHHCCCCCCHHH	29.67	28450419
444	Ubiquitination	ARRFSAGQWEARRGW CHHCCCCCCHHHCCE	34.26	27667366
457	Ubiquitination	GWRLFNCSASLDWPR CEEEEEEEECCCHHH	23.23	21890473
469	Ubiquitination	WPRMVESCLGSPCWA HHHHHHHHHCCCCCC	2.93	27667366
469 (in isoform 2)	Ubiquitination	-	2.93	21890473
477	Phosphorylation	LGSPCWASPQLLRII HCCCCCCCHHHHHHH	6.67	21815630
481	Ubiquitination	CWASPQLLRIIFKAM CCCCHHHHHHHHHHH	2.88	21963094
481 (in isoform 3)	Ubiquitination	-	2.88	21890473
482	Ubiquitination	WASPQLLRIIFKAMG CCCHHHHHHHHHHHC	28.66	21963094
482 (in isoform 2)	Ubiquitination	-	28.66	21890473
486	Ubiquitination	QLLRIIFKAMGQGLP HHHHHHHHHHCCCCC	27.36	21890473
486	Acetylation	QLLRIIFKAMGQGLP HHHHHHHHHHCCCCC	27.36	26051181
486	Ubiquitination	QLLRIIFKAMGQGLP HHHHHHHHHHCCCCC	27.36	27667366
486 (in isoform 1)	Ubiquitination	-	27.36	21890473
492	Ubiquitination	FKAMGQGLPDEEQEK HHHHCCCCCHHHHHH	3.57	29967540
498	Ubiquitination	GLPDEEQEKLLRICS CCCHHHHHHHHHHHH	49.29	21963094
499	Ubiquitination	LPDEEQEKLLRICSI CCHHHHHHHHHHHHH	53.14	21890473
499	Acetylation	LPDEEQEKLLRICSI CCHHHHHHHHHHHHH	53.14	26051181
499	Ubiquitination	LPDEEQEKLLRICSI CCHHHHHHHHHHHHH	53.14	21963094
499 (in isoform 1)	Ubiquitination	-	53.14	21890473
501	Phosphorylation	DEEQEKLLRICSIYT HHHHHHHHHHHHHHC	5.27	32142685
505	Phosphorylation	EKLLRICSIYTQSGE HHHHHHHHHHCCCCC	19.09	29255136
506	Ubiquitination	KLLRICSIYTQSGEN HHHHHHHHHCCCCCC	3.60	27667366
506 (in isoform 3)	Ubiquitination	-	3.60	21890473
507	Phosphorylation	LLRICSIYTQSGENS HHHHHHHHCCCCCCC	5.17	29255136
508	Phosphorylation	LRICSIYTQSGENSL HHHHHHHCCCCCCCC	18.00	29255136
510	Phosphorylation	ICSIYTQSGENSLVQ HHHHHCCCCCCCCCC	40.03	29255136
514	Phosphorylation	YTQSGENSLVQEGSE HCCCCCCCCCCCCCC	26.14	29255136
520	Phosphorylation	NSLVQEGSEASPIGK CCCCCCCCCCCCCCC	29.27	30266825
523	Phosphorylation	VQEGSEASPIGKSPY CCCCCCCCCCCCCCC	17.01	29255136
523	Ubiquitination	VQEGSEASPIGKSPY CCCCCCCCCCCCCCC	17.01	27667366
523 (in isoform 2)	Ubiquitination	-	17.01	21890473
528	Phosphorylation	EASPIGKSPYTLDSL CCCCCCCCCCCHHHH	20.23	21945579
530	Phosphorylation	SPIGKSPYTLDSLYW CCCCCCCCCHHHHEE	27.33	21945579
531	Phosphorylation	PIGKSPYTLDSLYWS CCCCCCCCHHHHEEE	27.72	21945579
534	Phosphorylation	KSPYTLDSLYWSVKP CCCCCHHHHEEECCC	26.86	21945579
534	Ubiquitination	KSPYTLDSLYWSVKP CCCCCHHHHEEECCC	26.86	29967540
536	Phosphorylation	PYTLDSLYWSVKPAS CCCHHHHEEECCCCC	10.29	21945579
538	Phosphorylation	TLDSLYWSVKPASSS CHHHHEEECCCCCCC	13.50	21945579
540	Acetylation	DSLYWSVKPASSSFG HHHEEECCCCCCCCC	29.38	26051181
540	Ubiquitination	DSLYWSVKPASSSFG HHHEEECCCCCCCCC	29.38	21906983
540 (in isoform 1)	Ubiquitination	-	29.38	21890473
543	Phosphorylation	YWSVKPASSSFGSEA EEECCCCCCCCCHHH	34.73	25159151
544	Phosphorylation	WSVKPASSSFGSEAK EECCCCCCCCCHHHH	31.62	26074081
545	Phosphorylation	SVKPASSSFGSEAKA ECCCCCCCCCHHHHH	31.00	21945579
548	Phosphorylation	PASSSFGSEAKAQQQ CCCCCCCHHHHHHHH	32.16	25159151
548	Ubiquitination	PASSSFGSEAKAQQQ CCCCCCCHHHHHHHH	32.16	27667366
548 (in isoform 2)	Ubiquitination	-	32.16	21890473
551	Ubiquitination	SSFGSEAKAQQQEEQ CCCCHHHHHHHHHHC	42.55	29967540
558	Phosphorylation	KAQQQEEQGSVNDVK HHHHHHHCCCCCHHH	49.02	33259812
560	Phosphorylation	QQQEEQGSVNDVKEE HHHHHCCCCCHHHHH	19.90	29255136
565	Sumoylation	QGSVNDVKEEEKEEK CCCCCHHHHHHHHHH	63.37	-
565	Sumoylation	QGSVNDVKEEEKEEK CCCCCHHHHHHHHHH	63.37	-
565	Ubiquitination	QGSVNDVKEEEKEEK CCCCCHHHHHHHHHH	63.37	27667366
565 (in isoform 1)	Ubiquitination	-	63.37	21890473
570	Ubiquitination	DVKEEEKEEKEVLPD HHHHHHHHHHCCCCH	77.05	27667366
587	Ubiquitination	EEEEENDDQEEEEED HHHHHCCCHHHHHCC	70.17	27667366
600	Phosphorylation	EDEDDEDDEEEDRME CCCCCCCCCHHHHHC	64.26	33259812
612	Phosphorylation	RMEVGPFSTGQESPT HHCCCCCCCCCCCCC	34.46	22167270
612	Ubiquitination	RMEVGPFSTGQESPT HHCCCCCCCCCCCCC	34.46	27667366
613	Phosphorylation	MEVGPFSTGQESPTA HCCCCCCCCCCCCCH	43.17	22167270
617	Phosphorylation	PFSTGQESPTAENAR CCCCCCCCCCHHHHH	21.47	19664994
619	Phosphorylation	STGQESPTAENARLL CCCCCCCCHHHHHHH	56.75	30266825
629	Ubiquitination	NARLLAQKRGALQGS HHHHHHHHHCCCCCC	47.38	27667366
632	Ubiquitination	LLAQKRGALQGSAWQ HHHHHHCCCCCCCEE	10.76	21963094
641	Phosphorylation	QGSAWQVSSEDVRWD CCCCEECCCCCCCCC	16.95	29449344
642	Phosphorylation	GSAWQVSSEDVRWDT CCCEECCCCCCCCCC	38.67	28985074
649	Ubiquitination	SEDVRWDTFPLGRMP CCCCCCCCCCCCCCC	21.86	21963094
673	Ubiquitination	MLENYDTMYLLDQPV HHHCCCCEEECCCHH	1.71	21963094
674	Ubiquitination	LENYDTMYLLDQPVL HHCCCCEEECCCHHH	13.25	21963094
690	Ubiquitination	QRLEPSTCKTDTLGL HHCCCCCCCCCCCCC	5.39	21963094
691	Ubiquitination	RLEPSTCKTDTLGLS HCCCCCCCCCCCCCC	49.91	21963094

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of LAS1L_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LAS1L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LAS1L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PELP1_HUMAN	PELP1	physical	20442285
PELP1_HUMAN	PELP1	physical	22939629
TEX10_HUMAN	TEX10	physical	22939629
PELP1_HUMAN	PELP1	physical	22190735
IPO5_HUMAN	IPO5	physical	22190735
TEX10_HUMAN	TEX10	physical	22190735
NOL9_HUMAN	NOL9	physical	22190735
SENP3_HUMAN	SENP3	physical	22190735
WDR18_HUMAN	WDR18	physical	22190735
NOL9_HUMAN	NOL9	physical	26344197
PELP1_HUMAN	PELP1	physical	26344197
TEX10_HUMAN	TEX10	physical	26344197
WDR18_HUMAN	WDR18	physical	26344197
RAF1_HUMAN	RAF1	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LAS1L_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-617, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-560, AND MASSSPECTROMETRY.	19413330 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-523, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-523 AND SER-560, ANDMASS SPECTROMETRY.	19007248 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-523, AND MASSSPECTROMETRY.	16964243 [Abstract]