| UniProt ID | PAGR1_HUMAN | |
|---|---|---|
| UniProt AC | Q9BTK6 | |
| Protein Name | PAXIP1-associated glutamate-rich protein 1 | |
| Gene Name | PAGR1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 254 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex. [PubMed: 19124460 However, its function in DNA damage has been questioned (By similarity During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex (By similarity Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition] | |
| Protein Sequence | MSLARGHGDTAASTAAPLSEEGEVTSGLQALAVEDTGGPSASAGKAEDEGEGGREETEREGSGGEEAQGEVPSAGGEEPAEEDSEDWCVPCSDEEVELPADGQPWMPPPSEIQRLYELLAAHGTLELQAEILPRRPPTPEAQSEEERSDEEPEAKEEEEEKPHMPTEFDFDDEPVTPKDSLIDRRRTPGSSARSQKREARLDKVLSDMKRHKKLEEQILRTGRDLFSLDSEDPSPASPPLRSSGSSLFPRQRKY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 13 | Phosphorylation | GHGDTAASTAAPLSE CCCCCCHHCCCCCCC | 28348404 | ||
| 14 | Phosphorylation | HGDTAASTAAPLSEE CCCCCHHCCCCCCCC | 28348404 | ||
| 19 | Phosphorylation | ASTAAPLSEEGEVTS HHCCCCCCCCCCCCC | 28348404 | ||
| 42 | Phosphorylation | DTGGPSASAGKAEDE ECCCCCCCCCCCCCC | - | ||
| 45 | Acetylation | GPSASAGKAEDEGEG CCCCCCCCCCCCCCC | 26051181 | ||
| 92 | Phosphorylation | EDWCVPCSDEEVELP CCCCCCCCCCCEECC | 26074081 | ||
| 138 | Phosphorylation | ILPRRPPTPEAQSEE ECCCCCCCHHHCCHH | 29255136 | ||
| 143 | Phosphorylation | PPTPEAQSEEERSDE CCCHHHCCHHHHCCC | 29255136 | ||
| 148 | Phosphorylation | AQSEEERSDEEPEAK HCCHHHHCCCCCHHH | 29255136 | ||
| 166 | Phosphorylation | EEKPHMPTEFDFDDE HHCCCCCCCCCCCCC | 29978859 | ||
| 176 | Phosphorylation | DFDDEPVTPKDSLID CCCCCCCCCCCCHHC | 29978859 | ||
| 187 | Phosphorylation | SLIDRRRTPGSSARS CHHCCCCCCCCCHHH | 23312004 | ||
| 190 | Phosphorylation | DRRRTPGSSARSQKR CCCCCCCCCHHHHHH | 23312004 | ||
| 191 | Phosphorylation | RRRTPGSSARSQKRE CCCCCCCCHHHHHHH | 23312004 | ||
| 194 | Phosphorylation | TPGSSARSQKREARL CCCCCHHHHHHHHHH | 23312004 | ||
| 203 | Ubiquitination | KREARLDKVLSDMKR HHHHHHHHHHHHHHH | 24816145 | ||
| 203 | Acetylation | KREARLDKVLSDMKR HHHHHHHHHHHHHHH | 19608861 | ||
| 206 | Phosphorylation | ARLDKVLSDMKRHKK HHHHHHHHHHHHHHH | 23927012 | ||
| 209 | Acetylation | DKVLSDMKRHKKLEE HHHHHHHHHHHHHHH | 25953088 | ||
| 209 | Methylation | DKVLSDMKRHKKLEE HHHHHHHHHHHHHHH | 90943 | ||
| 227 | Phosphorylation | RTGRDLFSLDSEDPS HHCHHHHCCCCCCCC | 23927012 | ||
| 230 | Phosphorylation | RDLFSLDSEDPSPAS HHHHCCCCCCCCCCC | 23927012 | ||
| 234 | Phosphorylation | SLDSEDPSPASPPLR CCCCCCCCCCCCCCC | 30266825 | ||
| 237 | Phosphorylation | SEDPSPASPPLRSSG CCCCCCCCCCCCCCC | 19664994 | ||
| 242 | Phosphorylation | PASPPLRSSGSSLFP CCCCCCCCCCCCCCC | 28450419 | ||
| 242 | O-linked_Glycosylation | PASPPLRSSGSSLFP CCCCCCCCCCCCCCC | 31373491 | ||
| 243 | Phosphorylation | ASPPLRSSGSSLFPR CCCCCCCCCCCCCCC | 28450419 | ||
| 245 | Phosphorylation | PPLRSSGSSLFPRQR CCCCCCCCCCCCCCC | 21712546 | ||
| 246 | Phosphorylation | PLRSSGSSLFPRQRK CCCCCCCCCCCCCCC | 28450419 | ||
| 254 | Phosphorylation | LFPRQRKY------- CCCCCCCC------- | 26074081 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PAGR1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PAGR1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PAGR1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| PAXI1_HUMAN | PAXIP1 | physical | 17500065 | |
| RBBP5_HUMAN | RBBP5 | physical | 17500065 | |
| ASH2L_HUMAN | ASH2L | physical | 17500065 | |
| KMT2B_HUMAN | KMT2B | physical | 17500065 | |
| KMT2C_HUMAN | KMT2C | physical | 17500065 | |
| NCOA6_HUMAN | NCOA6 | physical | 17500065 | |
| WDR5_HUMAN | WDR5 | physical | 17500065 | |
| A4_HUMAN | APP | physical | 21832049 | |
| RO60_HUMAN | TROVE2 | physical | 22939629 | |
| ESR1_HUMAN | ESR1 | physical | 19039327 | |
| NCOA1_HUMAN | NCOA1 | physical | 19039327 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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