CDKAL_HUMAN - dbPTM
CDKAL_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CDKAL_HUMAN
UniProt AC Q5VV42
Protein Name Threonylcarbamoyladenosine tRNA methylthiotransferase
Gene Name CDKAL1
Organism Homo sapiens (Human).
Sequence Length 579
Subcellular Localization Endoplasmic reticulum membrane
Single-pass membrane protein . Is a tail-anchored protein that exploits the TCR40 pathway for insertion into the endoplasmic reticulum.
Protein Description Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine..
Protein Sequence MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAYGYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGTNLPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDLSRVFHSYSPYDHKIGERQQVLVTEESFDSKFYVAHNQFYEQVLVPKNPAFMGKMVEVDIYESGKHFMKGQPVSDAKVYTPSISKPLAKGEVSGLTKDFRNGLGNQLSSGSHTSAASQCDSASSRMVLPMPRLHQDCALRMSVGLALLGLLFAFFVKVYN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MPSASCDTLL
-----CCCCCHHHHH		31.3623663014
5Phosphorylation---MPSASCDTLLDD
---CCCCCHHHHHHH		19.5023663014
6Glutathionylation--MPSASCDTLLDDI
--CCCCCHHHHHHHH		4.6622555962
8PhosphorylationMPSASCDTLLDDIED
CCCCCHHHHHHHHHH		33.2823663014
18PhosphorylationDDIEDIVSQEDSKPQ
HHHHHHHHCCCCCCC		28.3423401153
22PhosphorylationDIVSQEDSKPQDRHF
HHHHCCCCCCCCCCC		45.5423401153
37UbiquitinationVRKDVVPKVRRRNTQ
CCCCHHHHHHHHHHH		36.4429967540
43PhosphorylationPKVRRRNTQKYLQEE
HHHHHHHHHHHHHHH		25.3222817900
45UbiquitinationVRRRNTQKYLQEEEN
HHHHHHHHHHHHHHC		45.9821906983
45 (in isoform 3)Ubiquitination-45.9821906983
45 (in isoform 1)Ubiquitination-45.9821890473
46PhosphorylationRRRNTQKYLQEEENS
HHHHHHHHHHHHHCC		12.1029978859
53PhosphorylationYLQEEENSPPSDSTI
HHHHHHCCCCCCCCC		41.2825159151
56PhosphorylationEEENSPPSDSTIPGI
HHHCCCCCCCCCCCC		47.8022199227
58PhosphorylationENSPPSDSTIPGIQK
HCCCCCCCCCCCCEE		32.3529978859
59PhosphorylationNSPPSDSTIPGIQKI
CCCCCCCCCCCCEEE		35.8629978859
65UbiquitinationSTIPGIQKIWIRTWG
CCCCCCEEEEEEEEC		37.7823503661
65 (in isoform 3)Ubiquitination-37.78-
70 (in isoform 3)Phosphorylation-19.6422210691
80 (in isoform 2)Ubiquitination-27.9621890473
95PhosphorylationAAYGYKITENASDAD
HHHCCEECCCCCCCC		21.0226074081
95 (in isoform 3)Phosphorylation-21.0222210691
99PhosphorylationYKITENASDADLWLL
CEECCCCCCCCEEEE		44.9328464451
112UbiquitinationLLNSCTVKNPAEDHF
EEECCCCCCHHHHHH		38.7729967540
122PhosphorylationAEDHFRNSIKKAQEE
HHHHHHHHHHHHHHH		31.3723401153
124UbiquitinationDHFRNSIKKAQEENK
HHHHHHHHHHHHHHC		41.7129967540
127UbiquitinationRNSIKKAQEENKKIV
HHHHHHHHHHHCCEE		68.3724816145
131UbiquitinationKKAQEENKKIVLAGC
HHHHHHHCCEEEEEC		47.35-
132UbiquitinationKAQEENKKIVLAGCV
HHHHHHCCEEEEECC		50.0229967540
148PhosphorylationQAQPRQDYLKGLSII
CCCCCCHHHHCCEEE		11.2822817900
150 (in isoform 1)Ubiquitination-52.1321890473
150UbiquitinationQPRQDYLKGLSIIGV
CCCCHHHHCCEEEEE		52.1321906983
170PhosphorylationVVEVVEETIKGHSVR
HHHHHHHHHCCCCEE		17.9324719451
172UbiquitinationEVVEETIKGHSVRLL
HHHHHHHCCCCEEEC		58.9729967540
175PhosphorylationEETIKGHSVRLLGQK
HHHHCCCCEEECEEE		20.0126434776
183UbiquitinationVRLLGQKKDNGRRLG
EEECEEECCCCCCCC		48.8424816145
198UbiquitinationGARLDLPKIRKNPLI
CEECCCCHHCCCCCE		63.54-
202UbiquitinationDLPKIRKNPLIEIIS
CCCHHCCCCCEEEEE		27.1127667366
220PhosphorylationGCLNACTYCKTKHAR
CCHHHHHHHCCCCCC		7.5728387310
230UbiquitinationTKHARGNLASYPIDE
CCCCCCCCCCCCHHH		3.5921890473
243UbiquitinationDELVDRAKQSFQEGV
HHHHHHHHHHHHHCC		47.58-
287SulfoxidationEVIPEGAMLRLGMTN
HHCCCCCCHHCCCCC		3.0921406390
307UbiquitinationEHLEEMAKILNHPRV
HHHHHHHHHHCCCEE		46.55-
315PhosphorylationILNHPRVYAFLHIPV
HHCCCEEEEEEECCC		7.91-
343UbiquitinationEYCVADFKRVVDFLK
HHHHHHHHHHHHHHH		44.8429967540
350UbiquitinationKRVVDFLKEKVPGIT
HHHHHHHHHHCCCEE		56.3229967540
352UbiquitinationVVDFLKEKVPGITIA
HHHHHHHHCCCEEEE		52.7429967540
400PhosphorylationQFYPRPGTPAAKMEQ
CCCCCCCCCCHHHHH		16.6728555341
404UbiquitinationRPGTPAAKMEQVPAQ
CCCCCCHHHHHCCHH		45.1129967540
405SulfoxidationPGTPAAKMEQVPAQV
CCCCCHHHHHCCHHH		3.6021406390
413UbiquitinationEQVPAQVKKQRTKDL
HHCCHHHHHHHHHHH		30.9824816145
414UbiquitinationQVPAQVKKQRTKDLS
HCCHHHHHHHHHHHH		46.27-
425 (in isoform 2)Ubiquitination-23.9921890473
433UbiquitinationSYSPYDHKIGERQQV
HCCCCCCCCCCCEEE		49.8929967540
446PhosphorylationQVLVTEESFDSKFYV
EEEEEECCCCCCEEE		28.2825690035
449PhosphorylationVTEESFDSKFYVAHN
EEECCCCCCEEEECC		23.7425690035
452PhosphorylationESFDSKFYVAHNQFY
CCCCCCEEEECCCHH		10.6427642862
459PhosphorylationYVAHNQFYEQVLVPK
EEECCCHHEEECCCC		8.8328796482
466UbiquitinationYEQVLVPKNPAFMGK
HEEECCCCCCCCCCC		68.99-
467UbiquitinationEQVLVPKNPAFMGKM
EEECCCCCCCCCCCE		27.3627667366
484UbiquitinationVDIYESGKHFMKGQP
EEEECCCCCCCCCCC		42.84-
488UbiquitinationESGKHFMKGQPVSDA
CCCCCCCCCCCCCCC		54.1527667366
495UbiquitinationKGQPVSDAKVYTPSI
CCCCCCCCEEECCCC		8.8421890473
496UbiquitinationGQPVSDAKVYTPSIS
CCCCCCCEEECCCCC		40.5433845483
498PhosphorylationPVSDAKVYTPSISKP
CCCCCEEECCCCCCC		16.5429978859
499PhosphorylationVSDAKVYTPSISKPL
CCCCEEECCCCCCCC		17.3421712546
501PhosphorylationDAKVYTPSISKPLAK
CCEEECCCCCCCCCC		31.5223186163
503PhosphorylationKVYTPSISKPLAKGE
EEECCCCCCCCCCCC		32.3424719451
504UbiquitinationVYTPSISKPLAKGEV
EECCCCCCCCCCCCC		42.2433845483
508UbiquitinationSISKPLAKGEVSGLT
CCCCCCCCCCCCCCC		64.3933845483
516UbiquitinationGEVSGLTKDFRNGLG
CCCCCCCHHHHCCCC		60.9723000965
516 (in isoform 1)Ubiquitination-60.9721890473
527PhosphorylationNGLGNQLSSGSHTSA
CCCCCCCCCCCCCCH		23.9228450419
528PhosphorylationGLGNQLSSGSHTSAA
CCCCCCCCCCCCCHH		53.5628450419
530PhosphorylationGNQLSSGSHTSAASQ
CCCCCCCCCCCHHHH		26.0728450419
532PhosphorylationQLSSGSHTSAASQCD
CCCCCCCCCHHHHCC		23.0429978859
533PhosphorylationLSSGSHTSAASQCDS
CCCCCCCCHHHHCCC		19.2023186163
536PhosphorylationGSHTSAASQCDSASS
CCCCCHHHHCCCCCC		30.9328450419
543PhosphorylationSQCDSASSRMVLPMP
HHCCCCCCCCEECCC		24.9030576142
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CDKAL_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CDKAL_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CDKAL_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TTYH3_HUMANTTYH3physical
28514442
BPIB1_HUMANBPIFB1physical
28514442
DYN1_HUMANDNM1physical
28514442
CIAO1_HUMANCIAO1physical
28514442
TYW3_HUMANTYW3physical
28514442
DYN3_HUMANDNM3physical
28514442
TYW1B_HUMANTYW1Bphysical
28514442
Drug and Disease Associations
Kegg Disease
H00409 Type II diabetes mellitus
OMIM Disease
125853Diabetes mellitus, non-insulin-dependent (NIDDM)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CDKAL_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-499, AND MASSSPECTROMETRY.

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