RAP2C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RAP2C_HUMAN
• UniProt AC: Q9Y3L5
• Protein Name: Ras-related protein Rap-2c
• Gene Name: RAP2C
• Organism: Homo sapiens (Human).
• Sequence Length: 183
• Subcellular Localization: Cytoplasm . Recycling endosome membrane; Lipid-anchor; Cytoplasmic side.
• Protein Description: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription..
• Protein Sequence: MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIVRVKRYEKVPLILVGNKVDLEPEREVMSSEGRALAQEWGCPFMETSAKSKSMVDELFAEIVRQMNYSSLPEKQDQCCTTCVVQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MREYKVVVLGS ----CCEEEEEEECC	9.94	-
5	Ubiquitination	---MREYKVVVLGSG ---CCEEEEEEECCC	24.65	21890473
11	Phosphorylation	YKVVVLGSGGVGKSA EEEEEECCCCCCCCC	28.36	20068231
17	Phosphorylation	GSGGVGKSALTVQFV CCCCCCCCCEEEEEE	23.68	20068231
20	Phosphorylation	GVGKSALTVQFVTGT CCCCCCEEEEEEEEC	16.39	20068231
25	Phosphorylation	ALTVQFVTGTFIEKY CEEEEEEEECHHHHC	31.62	20068231
27	Phosphorylation	TVQFVTGTFIEKYDP EEEEEEECHHHHCCC	16.45	20068231
31	Ubiquitination	VTGTFIEKYDPTIED EEECHHHHCCCCHHH	50.57	-
40	Phosphorylation	DPTIEDFYRKEIEVD CCCHHHHHHCCCCCC	32.85	-
42	Ubiquitination	TIEDFYRKEIEVDSS CHHHHHHCCCCCCCC	52.22	-
48	Phosphorylation	RKEIEVDSSPSVLEI HCCCCCCCCHHHHHH	49.69	28060719
49	Phosphorylation	KEIEVDSSPSVLEIL CCCCCCCCHHHHHHH	19.41	20068231
51	Phosphorylation	IEVDSSPSVLEILDT CCCCCCHHHHHHHHC	41.08	20068231
58	Phosphorylation	SVLEILDTAGTEQFA HHHHHHHCCCCHHHH	24.44	28060719
61	Phosphorylation	EILDTAGTEQFASMR HHHHCCCCHHHHHHH	24.93	30108239
66	Phosphorylation	AGTEQFASMRDLYIK CCCHHHHHHHHEEEE	18.68	30108239
71	Phosphorylation	FASMRDLYIKNGQGF HHHHHHEEEECCCEE	17.71	28270605
106	Phosphorylation	QIVRVKRYEKVPLIL HEEEEEECCCCCEEE	17.87	24248375
108	Ubiquitination	VRVKRYEKVPLILVG EEEEECCCCCEEEEC	39.97	21890473
117	Ubiquitination	PLILVGNKVDLEPER CEEEECCCCCCCHHH	31.06	-
127	Sulfoxidation	LEPEREVMSSEGRAL CCHHHHHHCHHHHHH	2.90	21406390
140	S-palmitoylation	ALAQEWGCPFMETSA HHHHHHCCCCHHCCC	2.16	19801377
148	Ubiquitination	PFMETSAKSKSMVDE CCHHCCCCCHHHHHH	59.17	-
149	Phosphorylation	FMETSAKSKSMVDEL CHHCCCCCHHHHHHH	29.67	24719451
151	Phosphorylation	ETSAKSKSMVDELFA HCCCCCHHHHHHHHH	31.00	28348404
166	Phosphorylation	EIVRQMNYSSLPEKQ HHHHHCCCCCCCHHH	8.36	25884760
167	Phosphorylation	IVRQMNYSSLPEKQD HHHHCCCCCCCHHHC	22.01	28442448
168	Phosphorylation	VRQMNYSSLPEKQDQ HHHCCCCCCCHHHCC	37.27	28442448
176	S-palmitoylation	LPEKQDQCCTTCVVQ CCHHHCCCCCEEEEC	2.75	19061864
177	S-palmitoylation	PEKQDQCCTTCVVQ- CHHHCCCCCEEEEC-	2.68	19061864
180	Methylation	QDQCCTTCVVQ---- HCCCCCEEEEC----	1.20	-
180	Geranylgeranylation	QDQCCTTCVVQ---- HCCCCCEEEEC----	1.20	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RAP2C_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RAP2C_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RAP2C_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TCPZ_HUMAN	CCT6A	physical	26344197
DX39A_HUMAN	DDX39A	physical	26344197
RAB1A_HUMAN	RAB1A	physical	26344197
RAB1B_HUMAN	RAB1B	physical	26344197
RS10_HUMAN	RPS10	physical	26344197
M4K4_HUMAN	MAP4K4	physical	28514442
GDS1_HUMAN	RAP1GDS1	physical	28514442
TCPB_HUMAN	CCT2	physical	28514442
TCPG_HUMAN	CCT3	physical	28514442
TCPD_HUMAN	CCT4	physical	28514442
TCPA_HUMAN	TCP1	physical	28514442
TCPZ_HUMAN	CCT6A	physical	28514442
TCPH_HUMAN	CCT7	physical	28514442
TCPW_HUMAN	CCT6B	physical	28514442
PHLP_HUMAN	PDCL	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.