| UniProt ID | SPRY3_HUMAN | |
|---|---|---|
| UniProt AC | Q8NCJ5 | |
| Protein Name | SPRY domain-containing protein 3 | |
| Gene Name | SPRYD3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 442 | |
| Subcellular Localization | ||
| Protein Description | ||
| Protein Sequence | MRRTRRPRFVLMNKMDDLNLHYRFLNWRRRIREIREVRAFRYQERFKHILVDGDTLSYHGNSGEVGCYVASRPLTKDSNYFEVSIVDSGVRGTIAVGLVPQYYSLDHQPGWLPDSVAYHADDGKLYNGRAKGRQFGSKCNSGDRIGCGIEPVSFDVQTAQIFFTKNGKRVGSTIMPMSPDGLFPAVGMHSLGEEVRLHLNAELGREDDSVMMVDSYEDEWGRLHDVRVCGTLLEYLGKGKSIVDVGLAQARHPLSTRSHYFEVEIVDPGEKCYIALGLARKDYPKNRHPGWSRGSVAYHADDGKIFHGSGVGDPFGPRCYKGDIMGCGIMFPRDYILDSEGDSDDSCDTVILSPTARAVRNVRNVMYLHQEGEEEEEEEEEEEDGEEIEPEHEGRKVVVFFTRNGKIIGKKDAVVPSGGFFPTIGMLSCGEKVKVDLHPLSG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 14 | Ubiquitination | PRFVLMNKMDDLNLH CEEEEEECCCCCCHH | 29.73 | 21890473 | |
| 22 | Phosphorylation | MDDLNLHYRFLNWRR CCCCCHHHHHHHHHH | 13.26 | 22817900 | |
| 138 | Ubiquitination | KGRQFGSKCNSGDRI CCCCCCCCCCCCCCC | 37.50 | - | |
| 240 | Sumoylation | LEYLGKGKSIVDVGL HHHHCCCCCEEEHHH | 40.26 | - | |
| 240 | Ubiquitination | LEYLGKGKSIVDVGL HHHHCCCCCEEEHHH | 40.26 | 21890473 | |
| 240 | Sumoylation | LEYLGKGKSIVDVGL HHHHCCCCCEEEHHH | 40.26 | - | |
| 304 | Ubiquitination | AYHADDGKIFHGSGV EEECCCCCCCCCCCC | 49.55 | - | |
| 321 | Ubiquitination | PFGPRCYKGDIMGCG CCCCCCCCCCCCCCE | 54.45 | - | |
| 335 | Phosphorylation | GIMFPRDYILDSEGD EEECCCCEEECCCCC | 12.50 | 23663014 | |
| 339 | Phosphorylation | PRDYILDSEGDSDDS CCCEEECCCCCCCCC | 39.78 | 23663014 | |
| 343 | Phosphorylation | ILDSEGDSDDSCDTV EECCCCCCCCCCCEE | 54.92 | 23663014 | |
| 346 | Phosphorylation | SEGDSDDSCDTVILS CCCCCCCCCCEEEEC | 20.91 | 23663014 | |
| 349 | Phosphorylation | DSDDSCDTVILSPTA CCCCCCCEEEECHHH | 17.48 | 23663014 | |
| 353 | Phosphorylation | SCDTVILSPTARAVR CCCEEEECHHHHHHH | 14.74 | 21712546 | |
| 355 | Phosphorylation | DTVILSPTARAVRNV CEEEECHHHHHHHHH | 25.96 | 30177828 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SPRY3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SPRY3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SPRY3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of SPRY3_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-22, AND MASSSPECTROMETRY. | |
