ACTN1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACTN1_MOUSE
• UniProt AC: Q7TPR4
• Protein Name: Alpha-actinin-1
• Gene Name: Actn1
• Organism: Mus musculus (Mouse).
• Sequence Length: 892
• Subcellular Localization: Cytoplasm, cytoskeleton . Cytoplasm, myofibril, sarcomere, Z line . Cell membrane . Cell junction . Cell projection, ruffle . Colocalizes with MYOZ2 and PPP3CA at the Z-line of heart and skeletal muscle (PubMed:11114196). Colocalizes with PSD in memb
• Protein Description: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity)..
• Protein Sequence: MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAERFLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLECDHQLIQEALIFDNKHTNYNMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITEDELRRELPPDQAEYCIARMAPYAGPDSVPGALDYMSFSTALYGESDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDHYDSQQ -------CCCCCCCC	6.90	-
6	Phosphorylation	--MDHYDSQQTNDYM --CCCCCCCCCCCCC	19.61	26370283
9	Phosphorylation	DHYDSQQTNDYMQPE CCCCCCCCCCCCCCH	23.55	24224561
12	Phosphorylation	DSQQTNDYMQPEEDW CCCCCCCCCCCHHHC	10.34	29514104
31	Ubiquitination	LLDPAWEKQQRKTFT CCCHHHHHHHHHHHH	40.82	-
35	Ubiquitination	AWEKQQRKTFTAWCN HHHHHHHHHHHHHHH	43.59	-
38	Phosphorylation	KQQRKTFTAWCNSHL HHHHHHHHHHHHHHH	25.20	28542873
43	Phosphorylation	TFTAWCNSHLRKAGT HHHHHHHHHHHHHCH	22.29	28542873
50	Phosphorylation	SHLRKAGTQIENIEE HHHHHHCHHHHCHHH	31.10	22210690
91	Phosphorylation	KMRVHKISNVNKALD CCCEEECCCHHHHHH	39.26	54885909
95	Acetylation	HKISNVNKALDFIAS EECCCHHHHHHHHHH	46.15	22826441
102	Phosphorylation	KALDFIASKGVKLVS HHHHHHHHCCCEEEE	25.73	28542873
106	Ubiquitination	FIASKGVKLVSIGAE HHHHCCCEEEEECCH	52.41	-
140	Phosphorylation	RFAIQDISVEETSAK HHHHHCCCCCCCCHH	31.59	26824392
144	Phosphorylation	QDISVEETSAKEGLL HCCCCCCCCHHHCCH	22.07	27742792
145	Phosphorylation	DISVEETSAKEGLLL CCCCCCCCHHHCCHH	40.39	27742792
154	S-palmitoylation	KEGLLLWCQRKTAPY HHCCHHHHCCCCCCC	2.57	28526873
162	Acetylation	QRKTAPYKNVNIQNF CCCCCCCCCCCCCEE	54.05	22826441
180	S-palmitoylation	WKDGLGFCALIHRHR ECCCCHHHHHHHHCC	2.60	26165157
193	Phosphorylation	HRPELIDYGKLRKDD CCHHHHCCCCCCCCC	14.79	26824392
195	Acetylation	PELIDYGKLRKDDPL HHHHCCCCCCCCCCC	38.60	23236377
195	Ubiquitination	PELIDYGKLRKDDPL HHHHCCCCCCCCCCC	38.60	-
198	Ubiquitination	IDYGKLRKDDPLTNL HCCCCCCCCCCCCCH	76.54	-
198	Acetylation	IDYGKLRKDDPLTNL HCCCCCCCCCCCCCH	76.54	23236377
230	Phosphorylation	DAEDIVGTARPDEKA CHHHHCCCCCCCHHH	14.48	26824392
241	Phosphorylation	DEKAIMTYVSSFYHA CHHHHHHHHHHHHHH	4.87	23984901
243	Phosphorylation	KAIMTYVSSFYHAFS HHHHHHHHHHHHHHH	12.33	22499769
244	Phosphorylation	AIMTYVSSFYHAFSG HHHHHHHHHHHHHHC	21.56	22499769
246	Phosphorylation	MTYVSSFYHAFSGAQ HHHHHHHHHHHHCHH	8.32	26824392
250	Phosphorylation	SSFYHAFSGAQKAET HHHHHHHHCHHHHHH	33.72	22499769
279	Phosphorylation	NEQLMEDYEKLASDL HHHHHHHHHHHHHHH	11.14	15879432
284	Phosphorylation	EDYEKLASDLLEWIR HHHHHHHHHHHHHHH	38.95	73665943
312	Acetylation	TMHAMQQKLEDFRDY HHHHHHHHHHHHHHH	36.63	22826441
312	Ubiquitination	TMHAMQQKLEDFRDY HHHHHHHHHHHHHHH	36.63	-
331	Ubiquitination	KPPKVQEKCQLEINF CCCCHHHCEEEEEEC	15.36	-
332	S-nitrosylation	PPKVQEKCQLEINFN CCCHHHCEEEEEECC	5.70	20925432
332	S-nitrosocysteine	PPKVQEKCQLEINFN CCCHHHCEEEEEECC	5.70	-
340	Phosphorylation	QLEINFNTLQTKLRL EEEEECCHHHHHHHH	18.99	28464351
343	Phosphorylation	INFNTLQTKLRLSNR EECCHHHHHHHHHCC	34.85	28464351
348	Phosphorylation	LQTKLRLSNRPAFMP HHHHHHHHCCCCCCC	25.10	24899341
356	Phosphorylation	NRPAFMPSEGRMVSD CCCCCCCCCCCCCCC	40.68	28638064
362	Phosphorylation	PSEGRMVSDINNAWG CCCCCCCCCHHHHHH	24.35	57405025
398	Acetylation	RLDHLAEKFRQKASI HHHHHHHHHHHHHHH	39.99	130095
398	Ubiquitination	RLDHLAEKFRQKASI HHHHHHHHHHHHHHH	39.99	-
402	Ubiquitination	LAEKFRQKASIHEAW HHHHHHHHHHHHHHC	39.58	-
404	Phosphorylation	EKFRQKASIHEAWTD HHHHHHHHHHHHCCC	31.36	25521595
410	Phosphorylation	ASIHEAWTDGKEAML HHHHHHCCCHHHHHH	41.75	23684622
420	Malonylation	KEAMLRQKDYETATL HHHHHHHCCHHHCHH	56.71	26320211
420	Acetylation	KEAMLRQKDYETATL HHHHHHHCCHHHCHH	56.71	23806337
426	Phosphorylation	QKDYETATLSEIKAL HCCHHHCHHHHHHHH	37.93	26824392
431	Acetylation	TATLSEIKALLKKHE HCHHHHHHHHHHHHH	29.00	22826441
436	Acetylation	EIKALLKKHEAFESD HHHHHHHHHHHHHHH	46.80	23806337
436	Succinylation	EIKALLKKHEAFESD HHHHHHHHHHHHHHH	46.80	23806337
442	Phosphorylation	KKHEAFESDLAAHQD HHHHHHHHHHHHCHH	31.32	27742792
471	Phosphorylation	LDYYDSPSVNARCQK CCCCCCCCHHHHHHH	31.77	-
490	Phosphorylation	WDNLGALTQKRREAL HHHHHHHHHHHHHHH	31.35	37009265
492	Acetylation	NLGALTQKRREALER HHHHHHHHHHHHHHH	48.46	130091
516	Acetylation	QLYLEYAKRAAPFNN HHHHHHHHHHCCCCH	41.49	30985427
633	Ubiquitination	QHNERLRKQFGAQAN HHHHHHHHHHCCCCC	55.35	-
649	Acetylation	IGPWIQTKMEEIGRI CCHHHHHHHHHHHCC	28.12	23954790
676	Acetylation	SHLRQYEKSIVNYKP HHHHHHHHHHHCCCC	40.32	22826441
677	Phosphorylation	HLRQYEKSIVNYKPK HHHHHHHHHHCCCCC	21.59	26824392
681	Phosphorylation	YEKSIVNYKPKIDQL HHHHHHCCCCCCCCC	20.13	7122847
682	Acetylation	EKSIVNYKPKIDQLE HHHHHCCCCCCCCCC	34.33	23806337
690	Glutathionylation	PKIDQLECDHQLIQE CCCCCCCCCHHHHHH	8.44	24333276
741	Ubiquitination	QILTRDAKGISQEQM HHHCCCCCCCCHHHH	62.15	-
754	Phosphorylation	QMNEFRASFNHFDRD HHHHHHHHHCCCCCC	23.48	24899341
763	Phosphorylation	NHFDRDHSGTLGPEE CCCCCCCCCCCCHHH	37.45	28066266
765	Phosphorylation	FDRDHSGTLGPEEFK CCCCCCCCCCHHHHH	31.40	26824392
881	Phosphorylation	PGALDYMSFSTALYG CCHHHHHCHHHHHHC	15.15	29895711
883	Phosphorylation	ALDYMSFSTALYGES HHHHHCHHHHHHCCC	12.88	29472430
884	Phosphorylation	LDYMSFSTALYGESD HHHHCHHHHHHCCCC	20.76	29472430
887	Phosphorylation	MSFSTALYGESDL-- HCHHHHHHCCCCC--	19.18	29472430
890	Phosphorylation	STALYGESDL----- HHHHHCCCCC-----	39.59	29895711

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
12	Y	Phosphorylation	Kinase	FAK1	P34152	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACTN1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACTN1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ACTN1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.