CNN2_MOUSE - dbPTM
CNN2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CNN2_MOUSE
UniProt AC Q08093
Protein Name Calponin-2
Gene Name Cnn2
Organism Mus musculus (Mouse).
Sequence Length 305
Subcellular Localization
Protein Description Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity..
Protein Sequence MSSTQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRSWIEGLTGLSIGPDFQKGLKDGVILCTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGNMTQVQVSLLALAGKAKTKGLQSGVDIGVKYSEKQERNFDDATMKAGQCVIGLQMGTNKCASQSGMTAYGTRRHLYDPKNHILPPMDHCTISLQMGTNKCASQVGMTAPGTRRHIYDTKLGTDKCDNSSMSLQMGYTQGANQSGQVFGLGRQIYDPKYCPQGSAADGAPAGDGQGEAPEYLAYCQEEAGY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSSTQFNKG
------CCCCCCCCC		41.9327742792
2Acetylation------MSSTQFNKG
------CCCCCCCCC		41.9323806337
4Phosphorylation----MSSTQFNKGPS
----CCCCCCCCCCC		29.8528576409
8AcetylationMSSTQFNKGPSYGLS
CCCCCCCCCCCCCCC		73.7623806337
11PhosphorylationTQFNKGPSYGLSAEV
CCCCCCCCCCCCHHH		40.2728833060
12PhosphorylationQFNKGPSYGLSAEVK
CCCCCCCCCCCHHHH		25.8129514104
15PhosphorylationKGPSYGLSAEVKNRL
CCCCCCCCHHHHHHH		20.3028833060
25AcetylationVKNRLLSKYDPQKEA
HHHHHHHCCCHHHHH		54.3522826441
30AcetylationLSKYDPQKEAELRSW
HHCCCHHHHHHHHHH		65.3722826441
52AcetylationSIGPDFQKGLKDGVI
CCCCCHHHCCCCCEE		67.2322826441
55AcetylationPDFQKGLKDGVILCT
CCHHHCCCCCEEEEE		62.1922826441
138PhosphorylationAKTKGLQSGVDIGVK
HHHCCCCCCCCEECC		45.9129514104
146PhosphorylationGVDIGVKYSEKQERN
CCCEECCCCHHCCCC		21.4729514104
177PhosphorylationMGTNKCASQSGMTAY
CCCCHHHCCCCCCCC		34.06-
184PhosphorylationSQSGMTAYGTRRHLY
CCCCCCCCCCCHHCC		15.1822817900
186PhosphorylationSGMTAYGTRRHLYDP
CCCCCCCCCHHCCCC		16.3218563927
217PhosphorylationMGTNKCASQVGMTAP
CCCCCCHHHCCCCCC		34.5629514104
231PhosphorylationPGTRRHIYDTKLGTD
CCCCCEEEECCCCCC		16.0729514104
234AcetylationRRHIYDTKLGTDKCD
CCEEEECCCCCCCCC		41.8622826441
298PhosphorylationEAPEYLAYCQEEAGY
CCCHHHHHHHHHHCC		7.6522817900
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CNN2_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CNN2_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CNN2_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of CNN2_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CNN2_MOUSE

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Related Literatures of Post-Translational Modification

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