CAZA2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAZA2_MOUSE
• UniProt AC: P47754
• Protein Name: F-actin-capping protein subunit alpha-2
• Gene Name: Capza2
• Organism: Mus musculus (Mouse).
• Sequence Length: 286
• Protein Description: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments..
• Protein Sequence: MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEDQVLITEHGDLGNGKFLDPKNRICFKFDHLRKEATDPRPYEAENAIESWRTSVETALRAYVKEHYPNGVCTVYGKKVDGQQTIIACIESHQFQAKNFWNGRWRSEWKFTVTPSTTQVVGILKIQVHYYEDGNVQLVSHKDIQDSLTVSNEVQTAKEFIKIVEAAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADLEEQLS ------CCCHHHHCC	30.05	-
9	Phosphorylation	ADLEEQLSDEEKVRI CCHHHHCCHHHHHHH	42.54	26824392
63	Phosphorylation	QYNLDQFTPVKIEGY HCCCCCCCCEEEECC	22.87	25521595
86	Acetylation	HGDLGNGKFLDPKNR CCCCCCCCCCCCCCC	46.91	22826441
86	Ubiquitination	HGDLGNGKFLDPKNR CCCCCCCCCCCCCCC	46.91	22790023
97	Acetylation	PKNRICFKFDHLRKE CCCCEEEEHHHHHHC	45.53	22826441
126	Phosphorylation	SWRTSVETALRAYVK HHHHHHHHHHHHHHH	28.92	28464351
133	Ubiquitination	TALRAYVKEHYPNGV HHHHHHHHHHCCCCE	26.54	22790023
141	S-nitrosocysteine	EHYPNGVCTVYGKKV HHCCCCEEEEEEEEE	1.95	-
141	S-nitrosylation	EHYPNGVCTVYGKKV HHCCCCEEEEEEEEE	1.95	20925432
157	S-palmitoylation	GQQTIIACIESHQFQ CCEEEEEEEECCEEE	2.21	28680068
157	S-nitrosylation	GQQTIIACIESHQFQ CCEEEEEEEECCEEE	2.21	20925432
157	S-nitrosocysteine	GQQTIIACIESHQFQ CCEEEEEEEECCEEE	2.21	-
180	Phosphorylation	WRSEWKFTVTPSTTQ CCCEEEEEECCCCEE	21.53	28576409
182	Phosphorylation	SEWKFTVTPSTTQVV CEEEEEECCCCEEEE	14.41	25521595
184	Phosphorylation	WKFTVTPSTTQVVGI EEEEECCCCEEEEEE	34.42	29514104
185	Phosphorylation	KFTVTPSTTQVVGIL EEEECCCCEEEEEEE	23.58	29472430
186	Phosphorylation	FTVTPSTTQVVGILK EEECCCCEEEEEEEE	24.57	29472430
198	Phosphorylation	ILKIQVHYYEDGNVQ EEEEEEEEEECCCEE	15.08	-
215	Phosphorylation	SHKDIQDSLTVSNEV EECCCCCCEEECHHH	15.01	28464351
217	Phosphorylation	KDIQDSLTVSNEVQT CCCCCCEEECHHHHH	26.32	28464351
226	Succinylation	SNEVQTAKEFIKIVE CHHHHHHHHHHHHHH	57.45	23954790
268	Ubiquitination	QLPVTRTKIDWNKIL HCCCCCCEECHHHHH	35.06	-
268	Malonylation	QLPVTRTKIDWNKIL HCCCCCCEECHHHHH	35.06	26320211
273	Ubiquitination	RTKIDWNKILSYKIG CCEECHHHHHHHHCH	40.55	22790023
273	Acetylation	RTKIDWNKILSYKIG CCEECHHHHHHHHCH	40.55	132803
277	Phosphorylation	DWNKILSYKIGKEMQ CHHHHHHHHCHHHHC	11.81	29514104
278	Malonylation	WNKILSYKIGKEMQN HHHHHHHHCHHHHCC	41.42	26320211
278	Ubiquitination	WNKILSYKIGKEMQN HHHHHHHHCHHHHCC	41.42	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAZA2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAZA2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAZA2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CAZA2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.