FHL1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FHL1_MOUSE
• UniProt AC: P97447
• Protein Name: Four and a half LIM domains protein 1
• Gene Name: Fhl1
• Organism: Mus musculus (Mouse).
• Sequence Length: 280
• Subcellular Localization: Isoform 1: Cytoplasm.; Isoform 2: Nucleus.
• Protein Description: May have an involvement in muscle development or hypertrophy. Isoform 2 binds to RBP-J and plays a negative regulatory role in the RBP-J-mediated transcription in mammalian systems..
• Protein Sequence: MSEKFDCHYCRDPLQGKKYVQKDGRHCCLKCFDKFCANTCVDCRKPISADAKEVHYKNRYWHDNCFRCAKCLHPLASETFVSKDGKILCNKCATREDSPRCKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQDQPWHAECFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHNEQVYCPDCAKKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSEKFDCHY ------CCCCCCCCC	49.87	27742792
2	Acetylation	------MSEKFDCHY ------CCCCCCCCC	49.87	23806337
4	Acetylation	----MSEKFDCHYCR ----CCCCCCCCCCC	38.91	23806337
22	Acetylation	QGKKYVQKDGRHCCL CCCCEEEECCCCEEH	52.70	23806337
48	Phosphorylation	VDCRKPISADAKEVH CCCCCCCCCCCCHHH	28.73	26824392
65	S-nitrosocysteine	NRYWHDNCFRCAKCL CCCCCCCCHHHHHHH	2.57	-
65	S-nitrosylation	NRYWHDNCFRCAKCL CCCCCCCCHHHHHHH	2.57	21278135
71	S-nitrosocysteine	NCFRCAKCLHPLASE CCHHHHHHHHHHHCC	1.93	-
71	S-nitrosylation	NCFRCAKCLHPLASE CCHHHHHHHHHHHCC	1.93	21278135
77	Phosphorylation	KCLHPLASETFVSKD HHHHHHHCCEEECCC	44.87	28464351
79	Phosphorylation	LHPLASETFVSKDGK HHHHHCCEEECCCCE	27.17	28464351
82	Phosphorylation	LASETFVSKDGKILC HHCCEEECCCCEEEE	22.34	28542873
83	Ubiquitination	ASETFVSKDGKILCN HCCEEECCCCEEEEC	66.26	-
98	Phosphorylation	KCATREDSPRCKGCF CCCCCCCCCCCCCCC	14.97	26824392
118	Acetylation	GDQNVEYKGTVWHKD CCCCCEECCEEEECC	34.30	23236377
140	Phosphorylation	KQVIGTGSFFPKGED CEEEECCCCCCCCCC	24.45	28464351
144	Acetylation	GTGSFFPKGEDFYCV ECCCCCCCCCCEEEE	70.54	22826441
144 (in isoform 2)	Sumoylation	-	70.54	-
157	Acetylation	CVTCHETKFAKHCVK EEEECCCCCHHHHHH	40.10	23806337
171 (in isoform 2)	Sumoylation	-	28.98	-
255	S-nitrosocysteine	YCFHCKKCSVNLANK EEEECCCCEEEECCC	3.16	-
255	S-nitrosylation	YCFHCKKCSVNLANK EEEECCCCEEEECCC	3.16	21278135
256	Phosphorylation	CFHCKKCSVNLANKR EEECCCCEEEECCCE	23.95	26824392
278	Ubiquitination	VYCPDCAKKL----- EECCCHHHCC-----	62.02	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FHL1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FHL1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FHL1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CBX4_HUMAN	CBX4	physical	15710417
RET3_HUMAN	RBP3	physical	15710417
RING1_HUMAN	RING1	physical	15710417
TLN1_MOUSE	Tln1	physical	18725486

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.