RET3_HUMAN - dbPTM
RET3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RET3_HUMAN
UniProt AC P10745
Protein Name Retinol-binding protein 3
Gene Name RBP3
Organism Homo sapiens (Human).
Sequence Length 1247
Subcellular Localization Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix. Interphotoreceptor matrix that permeates the space between the retina and the contiguous layer of pigment epithelium cells.
Protein Description IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina..
Protein Sequence MMREWVLLMSVLLCGLAGPTHLFQPSLVLDMAKVLLDNYCFPENLLGMQEAIQQAIKSHEILSISDPQTLASVLTAGVQSSLNDPRLVISYEPSTPEPPPQVPALTSLSEEELLAWLQRGLRHEVLEGNVGYLRVDSVPGQEVLSMMGEFLVAHVWGNLMGTSALVLDLRHCTGGQVSGIPYIISYLHPGNTILHVDTIYNRPSNTTTEIWTLPQVLGERYGADKDVVVLTSSQTRGVAEDIAHILKQMRRAIVVGERTGGGALDLRKLRIGESDFFFTVPVSRSLGPLGGGSQTWEGSGVLPCVGTPAEQALEKALAILTLRSALPGVVHCLQEVLKDYYTLVDRVPTLLQHLASMDFSTVVSEEDLVTKLNAGLQAASEDPRLLVRAIGPTETPSWPAPDAAAEDSPGVAPELPEDEAIRQALVDSVFQVSVLPGNVGYLRFDSFADASVLGVLAPYVLRQVWEPLQDTEHLIMDLRHNPGGPSSAVPLLLSYFQGPEAGPVHLFTTYDRRTNITQEHFSHMELPGPRYSTQRGVYLLTSHRTATAAEEFAFLMQSLGWATLVGEITAGNLLHTRTVPLLDTPEGSLALTVPVLTFIDNHGEAWLGGGVVPDAIVLAEEALDKAQEVLEFHQSLGALVEGTGHLLEAHYARPEVVGQTSALLRAKLAQGAYRTAVDLESLASQLTADLQEVSGDHRLLVFHSPGELVVEEAPPPPPAVPSPEELTYLIEALFKTEVLPGQLGYLRFDAMAELETVKAVGPQLVRLVWQQLVDTAALVIDLRYNPGSYSTAIPLLCSYFFEAEPRQHLYSVFDRATSKVTEVWTLPQVAGQRYGSHKDLYILMSHTSGSAAEAFAHTMQDLQRATVIGEPTAGGALSVGIYQVGSSPLYASMPTQMAMSATTGKAWDLAGVEPDITVPMSEALSIAQDIVALRAKVPTVLQTAGKLVADNYASAELGAKMATKLSGLQSRYSRVTSEVALAEILGADLQMLSGDPHLKAAHIPENAKDRIPGIVPMQIPSPEVFEELIKFSFHTNVLEDNIGYLRFDMFGDGELLTQVSRLLVEHIWKKIMHTDAMIIDMRFNIGGPTSSIPILCSYFFDEGPPVLLDKIYSRPDDSVSELWTHAQVVGERYGSKKSMVILTSSVTAGTAEEFTYIMKRLGRALVIGEVTSGGCQPPQTYHVDDTNLYLTIPTARSVGASDGSSWEGVGVTPHVVVPAEEALARAKEMLQHNQLRVKRSPGLQDHL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
205N-linked_GlycosylationTIYNRPSNTTTEIWT
ECCCCCCCCCCEEEE		44.09UniProtKB CARBOHYD
259PhosphorylationAIVVGERTGGGALDL
HHCCCCCCCCCCCCC		35.56-
515N-linked_GlycosylationTTYDRRTNITQEHFS
EECCCCCCCCHHHHC		33.23UniProtKB CARBOHYD
532PhosphorylationELPGPRYSTQRGVYL
CCCCCCCCCCCCEEE		21.2421712546
541PhosphorylationQRGVYLLTSHRTATA
CCCEEEEECCCCCHH		21.6421712546
547PhosphorylationLTSHRTATAAEEFAF
EECCCCCHHHHHHHH		26.2829970186
558PhosphorylationEFAFLMQSLGWATLV
HHHHHHHHCCHHHHC		18.1929970186
563PhosphorylationMQSLGWATLVGEITA
HHHCCHHHHCEEECC		18.5729970186
576PhosphorylationTAGNLLHTRTVPLLD
CCCCCCCCEEEECCC		28.1829970186
756PhosphorylationDAMAELETVKAVGPQ
HHHHHHHHHHHHCHH		39.6724888630
821PhosphorylationDRATSKVTEVWTLPQ
HHHCCCCEEEEECCC		28.6723312004
825PhosphorylationSKVTEVWTLPQVAGQ
CCCEEEEECCCCCCC		33.4623312004
952PhosphorylationGKLVADNYASAELGA
CHHHHCCHHHHHHHH		11.5029759185
972PhosphorylationLSGLQSRYSRVTSEV
HHHHHHHHHHHHHHH		13.1822210691
976PhosphorylationQSRYSRVTSEVALAE
HHHHHHHHHHHHHHH		20.3322210691
977PhosphorylationSRYSRVTSEVALAEI
HHHHHHHHHHHHHHH		27.5022210691
993PhosphorylationGADLQMLSGDPHLKA
CCCHHHHCCCCCCHH		35.4922210691
1070MethylationLVEHIWKKIMHTDAM
HHHHHHHHHHCCCCE		30.2023644510
1070TrimethylationLVEHIWKKIMHTDAM
HHHHHHHHHHCCCCE		30.20-
1113PhosphorylationVLLDKIYSRPDDSVS
EEEHHHCCCCCCCHH		40.5924719451
1133PhosphorylationAQVVGERYGSKKSMV
HHHHHHHHCCCCEEE		22.8124461736
1135PhosphorylationVVGERYGSKKSMVIL
HHHHHHCCCCEEEEE		28.1624461736
1147PhosphorylationVILTSSVTAGTAEEF
EEEEECCCCCCHHHH		22.7124461736
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RET3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RET3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RET3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of RET3_HUMAN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RET3_HUMAN

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Related Literatures of Post-Translational Modification

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