dbPTM

VIME_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	VIME_MOUSE
UniProt AC	P20152
Protein Name	Vimentin
Gene Name	Vim
Organism	Mus musculus (Mouse).
Sequence Length	466
Subcellular Localization	Cytoplasm . Cytoplasm, cytoskeleton . Nucleus matrix .
Protein Description	Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.; Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2..
Protein Sequence	MSTRSVSSSSYRRMFGGSGTSSRPSSNRSYVTTSTRTYSLGSALRPSTSRSLYSSSPGGAYVTRSSAVRLRSSVPGVRLLQDSVDFSLADAINTEFKNTRTNEKVELQELNDRFANYIDKVRFLEQQNKILLAELEQLKGQGKSRLGDLYEEEMRELRRQVDQLTNDKARVEVERDNLAEDIMRLREKLQEEMLQREEAESTLQSFRQDVDNASLARLDLERKVESLQEEIAFLKKLHDEEIQELQAQIQEQHVQIDVDVSKPDLTAALRDVRQQYESVAAKNLQEAEEWYKSKFADLSEAANRNNDALRQAKQESNEYRRQVQSLTCEVDALKGTNESLERQMREMEENFALEAANYQDTIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESRISLPLPTFSSLNLRETNLESLPLVDTHSKRTLLIKTVETRDGQVINETSQHHDDLE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSTRSVSSS ------CCCCCCCCH	32.31	-
2	Phosphorylation	------MSTRSVSSS ------CCCCCCCCH	32.31	26745281
3	Phosphorylation	-----MSTRSVSSSS -----CCCCCCCCHH	26.18	26745281
5	Phosphorylation	---MSTRSVSSSSYR ---CCCCCCCCHHCH	26.83	27087446
7	Phosphorylation	-MSTRSVSSSSYRRM -CCCCCCCCHHCHHH	26.25	27087446
7	O-linked_Glycosylation	-MSTRSVSSSSYRRM -CCCCCCCCHHCHHH	26.25	-
8	Phosphorylation	MSTRSVSSSSYRRMF CCCCCCCCHHCHHHC	22.58	23684622
9	Phosphorylation	STRSVSSSSYRRMFG CCCCCCCHHCHHHCC	24.71	23684622
10	Phosphorylation	TRSVSSSSYRRMFGG CCCCCCHHCHHHCCC	25.30	27149854
11	Nitrated tyrosine	RSVSSSSYRRMFGGS CCCCCHHCHHHCCCC	12.27	-
11	Phosphorylation	RSVSSSSYRRMFGGS CCCCCHHCHHHCCCC	12.27	24899341
18	Phosphorylation	YRRMFGGSGTSSRPS CHHHCCCCCCCCCCC	39.00	26824392
20	Phosphorylation	RMFGGSGTSSRPSSN HHCCCCCCCCCCCCC	25.81	23684622
21	Phosphorylation	MFGGSGTSSRPSSNR HCCCCCCCCCCCCCC	28.07	23684622
21	O-linked_Glycosylation	MFGGSGTSSRPSSNR HCCCCCCCCCCCCCC	28.07	21540332
22	Phosphorylation	FGGSGTSSRPSSNRS CCCCCCCCCCCCCCC	48.31	24899341
25	Phosphorylation	SGTSSRPSSNRSYVT CCCCCCCCCCCCEEE	38.85	22942356
26	Phosphorylation	GTSSRPSSNRSYVTT CCCCCCCCCCCEEEE	38.66	7530295
29	Phosphorylation	SRPSSNRSYVTTSTR CCCCCCCCEEEEECC	28.36	25263469
30	Phosphorylation	RPSSNRSYVTTSTRT CCCCCCCEEEEECCE	9.89	26160508
32	O-linked_Glycosylation	SSNRSYVTTSTRTYS CCCCCEEEEECCEEE	13.54	21540332
32	Phosphorylation	SSNRSYVTTSTRTYS CCCCCEEEEECCEEE	13.54	24453211
33	Phosphorylation	SNRSYVTTSTRTYSL CCCCEEEEECCEEEC	20.32	26160508
33	O-linked_Glycosylation	SNRSYVTTSTRTYSL CCCCEEEEECCEEEC	20.32	-
34	Phosphorylation	NRSYVTTSTRTYSLG CCCEEEEECCEEECC	13.41	27149854
34	O-linked_Glycosylation	NRSYVTTSTRTYSLG CCCEEEEECCEEECC	13.41	21540332
35	Phosphorylation	RSYVTTSTRTYSLGS CCEEEEECCEEECCC	25.57	26160508
37	Phosphorylation	YVTTSTRTYSLGSAL EEEEECCEEECCCCC	19.97	27087446
38	Phosphorylation	VTTSTRTYSLGSALR EEEECCEEECCCCCC	9.90	26060331
39	Phosphorylation	TTSTRTYSLGSALRP EEECCEEECCCCCCC	26.16	27087446
39	O-linked_Glycosylation	TTSTRTYSLGSALRP EEECCEEECCCCCCC	26.16	21540332
42	Phosphorylation	TRTYSLGSALRPSTS CCEEECCCCCCCCCC	29.44	28725479
47	Phosphorylation	LGSALRPSTSRSLYS CCCCCCCCCCCCCCC	32.36	22942356
48	Phosphorylation	GSALRPSTSRSLYSS CCCCCCCCCCCCCCC	30.73	22942356
48	O-linked_Glycosylation	GSALRPSTSRSLYSS CCCCCCCCCCCCCCC	30.73	21540332
49	Phosphorylation	SALRPSTSRSLYSSS CCCCCCCCCCCCCCC	24.98	22942356
49	O-linked_Glycosylation	SALRPSTSRSLYSSS CCCCCCCCCCCCCCC	24.98	21540332
51	Phosphorylation	LRPSTSRSLYSSSPG CCCCCCCCCCCCCCC	31.27	27087446
53	Phosphorylation	PSTSRSLYSSSPGGA CCCCCCCCCCCCCCE	14.04	28725479
54	Phosphorylation	STSRSLYSSSPGGAY CCCCCCCCCCCCCEE	29.63	23527152
54	O-linked_Glycosylation	STSRSLYSSSPGGAY CCCCCCCCCCCCCEE	29.63	21540332
55	Phosphorylation	TSRSLYSSSPGGAYV CCCCCCCCCCCCEEE	27.31	27087446
55	O-linked_Glycosylation	TSRSLYSSSPGGAYV CCCCCCCCCCCCEEE	27.31	21540332
56	Phosphorylation	SRSLYSSSPGGAYVT CCCCCCCCCCCEEEE	22.94	27087446
61	Phosphorylation	SSSPGGAYVTRSSAV CCCCCCEEEECCCCC	12.96	27149854
63	Phosphorylation	SPGGAYVTRSSAVRL CCCCEEEECCCCCCC	16.50	27742792
65	Phosphorylation	GGAYVTRSSAVRLRS CCEEEECCCCCCCCC	17.18	21454597
66	Phosphorylation	GAYVTRSSAVRLRSS CEEEECCCCCCCCCC	27.74	7530295
72	Phosphorylation	SSAVRLRSSVPGVRL CCCCCCCCCCCCCHH	40.03	7530295
73	Phosphorylation	SAVRLRSSVPGVRLL CCCCCCCCCCCCHHC	26.37	26824392
83	Phosphorylation	GVRLLQDSVDFSLAD CCHHCCCCCCHHHHH	15.60	15140879
87	Phosphorylation	LQDSVDFSLADAINT CCCCCCHHHHHHHCC	20.41	26824392
94	Phosphorylation	SLADAINTEFKNTRT HHHHHHCCCCCCCCC	36.36	29119230
97	Ubiquitination	DAINTEFKNTRTNEK HHHCCCCCCCCCCCC	51.70	-
104	Ubiquitination	KNTRTNEKVELQELN CCCCCCCCEEHHHHH	42.98	-
104	Acetylation	KNTRTNEKVELQELN CCCCCCCCEEHHHHH	42.98	23806337
104	Succinylation	KNTRTNEKVELQELN CCCCCCCCEEHHHHH	42.98	23806337
117	Phosphorylation	LNDRFANYIDKVRFL HHHHHHHHHHHHHHH	13.68	26824392
120	Methylation	RFANYIDKVRFLEQQ HHHHHHHHHHHHHHH	26.25	-
120	Acetylation	RFANYIDKVRFLEQQ HHHHHHHHHHHHHHH	26.25	23806337
120	Succinylation	RFANYIDKVRFLEQQ HHHHHHHHHHHHHHH	26.25	-
120	Ubiquitination	RFANYIDKVRFLEQQ HHHHHHHHHHHHHHH	26.25	-
120	Succinylation	RFANYIDKVRFLEQQ HHHHHHHHHHHHHHH	26.25	23806337
129	Acetylation	RFLEQQNKILLAELE HHHHHHCHHHHHHHH	30.32	23806337
129	Succinylation	RFLEQQNKILLAELE HHHHHHCHHHHHHHH	30.32	-
129	Succinylation	RFLEQQNKILLAELE HHHHHHCHHHHHHHH	30.32	23806337
139	Acetylation	LAELEQLKGQGKSRL HHHHHHHCCCCCCCH	49.21	23806337
139	Ubiquitination	LAELEQLKGQGKSRL HHHHHHHCCCCCCCH	49.21	-
139	Succinylation	LAELEQLKGQGKSRL HHHHHHHCCCCCCCH	49.21	23806337
143	Ubiquitination	EQLKGQGKSRLGDLY HHHCCCCCCCHHHHH	25.23	22790023
144	Phosphorylation	QLKGQGKSRLGDLYE HHCCCCCCCHHHHHH	39.29	26824392
150	Phosphorylation	KSRLGDLYEEEMREL CCCHHHHHHHHHHHH	26.49	19854140
168	Acetylation	VDQLTNDKARVEVER HHHHHCCHHHHHHCC	39.91	23806337
168	Ubiquitination	VDQLTNDKARVEVER HHHHHCCHHHHHHCC	39.91	-
168	Succinylation	VDQLTNDKARVEVER HHHHHCCHHHHHHCC	39.91	23806337
188	Acetylation	DIMRLREKLQEEMLQ HHHHHHHHHHHHHHH	49.38	23806337
188	Succinylation	DIMRLREKLQEEMLQ HHHHHHHHHHHHHHH	49.38	-
188	Ubiquitination	DIMRLREKLQEEMLQ HHHHHHHHHHHHHHH	49.38	-
188	Succinylation	DIMRLREKLQEEMLQ HHHHHHHHHHHHHHH	49.38	23806337
201	Phosphorylation	LQREEAESTLQSFRQ HHHHHHHHHHHHHHH	41.27	26824392
202	Phosphorylation	QREEAESTLQSFRQD HHHHHHHHHHHHHHH	21.96	26824392
205	Phosphorylation	EAESTLQSFRQDVDN HHHHHHHHHHHHHCH	26.05	26824392
214	Phosphorylation	RQDVDNASLARLDLE HHHHCHHHHHHHHHH	28.90	27087446
223	Acetylation	ARLDLERKVESLQEE HHHHHHHHHHHHHHH	40.76	23806337
223	Ubiquitination	ARLDLERKVESLQEE HHHHHHHHHHHHHHH	40.76	-
223	Succinylation	ARLDLERKVESLQEE HHHHHHHHHHHHHHH	40.76	23806337
226	Phosphorylation	DLERKVESLQEEIAF HHHHHHHHHHHHHHH	38.04	27180971
235	Acetylation	QEEIAFLKKLHDEEI HHHHHHHHHHCHHHH	47.00	23806337
235	Ubiquitination	QEEIAFLKKLHDEEI HHHHHHHHHHCHHHH	47.00	-
235	Succinylation	QEEIAFLKKLHDEEI HHHHHHHHHHCHHHH	47.00	23806337
236	Ubiquitination	EEIAFLKKLHDEEIQ HHHHHHHHHCHHHHH	53.88	-
261	Phosphorylation	VQIDVDVSKPDLTAA CEEEECCCCHHHHHH	33.73	26824392
276	Phosphorylation	LRDVRQQYESVAAKN HHHHHHHHHHHHHHC	11.22	22817900
278	Phosphorylation	DVRQQYESVAAKNLQ HHHHHHHHHHHHCHH	16.48	24899341
282	Ubiquitination	QYESVAAKNLQEAEE HHHHHHHHCHHHHHH	48.75	22790023
291	Phosphorylation	LQEAEEWYKSKFADL HHHHHHHHHHHHHHH	14.52	25367039
292	Acetylation	QEAEEWYKSKFADLS HHHHHHHHHHHHHHH	48.52	134195
292	Ubiquitination	QEAEEWYKSKFADLS HHHHHHHHHHHHHHH	48.52	22790023
293	Phosphorylation	EAEEWYKSKFADLSE HHHHHHHHHHHHHHH	19.80	25367039
294	Acetylation	AEEWYKSKFADLSEA HHHHHHHHHHHHHHH	40.18	23806337
294	Succinylation	AEEWYKSKFADLSEA HHHHHHHHHHHHHHH	40.18	-
294	Ubiquitination	AEEWYKSKFADLSEA HHHHHHHHHHHHHHH	40.18	-
294	Succinylation	AEEWYKSKFADLSEA HHHHHHHHHHHHHHH	40.18	23806337
299	Phosphorylation	KSKFADLSEAANRNN HHHHHHHHHHHHHCH	26.24	26824392
325	Phosphorylation	EYRRQVQSLTCEVDA HHHHHHHHHHHHHHH	27.13	25521595
327	Phosphorylation	RRQVQSLTCEVDALK HHHHHHHHHHHHHHH	16.33	27742792
328	S-nitrosocysteine	RQVQSLTCEVDALKG HHHHHHHHHHHHHHC	6.10	-
328	Glutathionylation	RQVQSLTCEVDALKG HHHHHHHHHHHHHHC	6.10	24333276
328	S-nitrosylation	RQVQSLTCEVDALKG HHHHHHHHHHHHHHC	6.10	20925432
328	S-palmitoylation	RQVQSLTCEVDALKG HHHHHHHHHHHHHHC	6.10	28526873
334	Ubiquitination	TCEVDALKGTNESLE HHHHHHHHCCCHHHH	66.46	22790023
334	Acetylation	TCEVDALKGTNESLE HHHHHHHHCCCHHHH	66.46	22826441
336	Phosphorylation	EVDALKGTNESLERQ HHHHHHCCCHHHHHH	33.94	25619855
339	Phosphorylation	ALKGTNESLERQMRE HHHCCCHHHHHHHHH	37.29	27087446
358	Phosphorylation	FALEAANYQDTIGRL HHHHHHHHHHHHHHH	11.75	30635358
361	Phosphorylation	EAANYQDTIGRLQDE HHHHHHHHHHHHHHH	15.14	30635358
373	Acetylation	QDEIQNMKEEMARHL HHHHHHHHHHHHHHH	59.06	23806337
373	Ubiquitination	QDEIQNMKEEMARHL HHHHHHHHHHHHHHH	59.06	-
373	Succinylation	QDEIQNMKEEMARHL HHHHHHHHHHHHHHH	59.06	23806337
383	Nitrated tyrosine	MARHLREYQDLLNVK HHHHHHHHHHHHCHH	10.82	-
383	Phosphorylation	MARHLREYQDLLNVK HHHHHHHHHHHHCHH	10.82	25367039
402	Ubiquitination	IEIATYRKLLEGEES HHHHHHHHHHCCCCC	47.19	22790023
409	Phosphorylation	KLLEGEESRISLPLP HHHCCCCCCCCCCCC	30.52	24899341
412	Phosphorylation	EGEESRISLPLPTFS CCCCCCCCCCCCCCC	23.87	7530295
417	Phosphorylation	RISLPLPTFSSLNLR CCCCCCCCCCCCCCC	43.78	26824392
419	Phosphorylation	SLPLPTFSSLNLRET CCCCCCCCCCCCCCC	36.07	27087446
420	Phosphorylation	LPLPTFSSLNLRETN CCCCCCCCCCCCCCC	19.65	27087446
426	Phosphorylation	SSLNLRETNLESLPL CCCCCCCCCCHHCCC	38.37	26824392
430	Phosphorylation	LRETNLESLPLVDTH CCCCCCHHCCCCCCC	38.15	25521595
436	Phosphorylation	ESLPLVDTHSKRTLL HHCCCCCCCCCCEEE	22.14	25521595
438	Phosphorylation	LPLVDTHSKRTLLIK CCCCCCCCCCEEEEE	26.40	26824392
439	Acetylation	PLVDTHSKRTLLIKT CCCCCCCCCEEEEEE	41.62	23806337
439	Ubiquitination	PLVDTHSKRTLLIKT CCCCCCCCCEEEEEE	41.62	-
439	Succinylation	PLVDTHSKRTLLIKT CCCCCCCCCEEEEEE	41.62	23806337
441	Phosphorylation	VDTHSKRTLLIKTVE CCCCCCCEEEEEEEE	29.65	29514104
445	Acetylation	SKRTLLIKTVETRDG CCCEEEEEEEECCCC	46.62	23806337
445	Succinylation	SKRTLLIKTVETRDG CCCEEEEEEEECCCC	46.62	-
445	Ubiquitination	SKRTLLIKTVETRDG CCCEEEEEEEECCCC	46.62	-
445	Succinylation	SKRTLLIKTVETRDG CCCEEEEEEEECCCC	46.62	23806337
446	Phosphorylation	KRTLLIKTVETRDGQ CCEEEEEEEECCCCC	19.31	26824392
449	Phosphorylation	LLIKTVETRDGQVIN EEEEEEECCCCCEEC	29.71	29550500
458	Phosphorylation	DGQVINETSQHHDDL CCCEECCCCCCCCCC	29.24	27087446
459	Phosphorylation	GQVINETSQHHDDLE CCEECCCCCCCCCCC	22.72	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
5	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
5	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM
5	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
5	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
7	S	Phosphorylation	Kinase	PRKCA	P20444	GPS
7	S	Phosphorylation	Kinase	PRKACA	P05132	GPS
7	S	Phosphorylation	Kinase	AURKB	O70126	GPS
7	S	Phosphorylation	Kinase	PKC	-	Uniprot
7	S	Phosphorylation	Kinase	PKA	-	Uniprot
7	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
7	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
8	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM
8	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
9	S	Phosphorylation	Kinase	PKC	-	Uniprot
9	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
9	S	Phosphorylation	Kinase	PRKCA	P20444	GPS
10	S	Phosphorylation	Kinase	PRKCA	P20444	GPS
10	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
10	S	Phosphorylation	Kinase	PKC	-	Uniprot
21	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
21	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM
21	S	Phosphorylation	Kinase	PKC	-	Uniprot
21	S	Phosphorylation	Kinase	PRKCA	P20444	GPS
25	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
25	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
25	S	Phosphorylation	Kinase	PKA	-	Uniprot
25	S	Phosphorylation	Kinase	PRKCA	P20444	GPS
25	S	Phosphorylation	Kinase	PKC	-	Uniprot
25	S	Phosphorylation	Kinase	AURKB	O70126	GPS
25	S	Phosphorylation	Kinase	PRKACA	P05132	GPS
26	S	Phosphorylation	Kinase	PRKCA	P20444	GPS
26	S	Phosphorylation	Kinase	PKC	-	Uniprot
26	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
34	S	Phosphorylation	Kinase	PRKCA	P20444	GPS
34	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
34	S	Phosphorylation	Kinase	PKC	-	Uniprot
34	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM
39	S	Phosphorylation	Kinase	PKC	-	Uniprot
39	S	Phosphorylation	Kinase	AURKB	O70126	GPS
39	S	Phosphorylation	Kinase	CAM-KII_GROUP	-	PhosphoELM
39	S	Phosphorylation	Kinase	PRKACA	P05132	GPS
39	S	Phosphorylation	Kinase	PRKCA	P20444	GPS
39	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
39	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP
39	S	Phosphorylation	Kinase	CAMK2B	P28652	GPS
39	S	Phosphorylation	Kinase	ROCK2	P70336	Uniprot
39	S	Phosphorylation	Kinase	PKA	-	Uniprot
39	S	Phosphorylation	Kinase	CAMK2-FAMILY	-	GPS
39	S	Phosphorylation	Kinase	CAMK2	-	Uniprot
39	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
42	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM
42	S	Phosphorylation	Kinase	PRKCA	P20444	GPS
42	S	Phosphorylation	Kinase	PKC	-	Uniprot
42	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
47	S	Phosphorylation	Kinase	PKA	-	Uniprot
47	S	Phosphorylation	Kinase	AURKB	O70126	GPS
47	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
47	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
47	S	Phosphorylation	Kinase	PRKACA	P05132	GPS
51	S	Phosphorylation	Kinase	PRKACA	P05132	GPS
51	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM
51	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
51	S	Phosphorylation	Kinase	PKACA	P17612	PSP
51	S	Phosphorylation	Kinase	PRKCA	P20444	GPS
51	S	Phosphorylation	Kinase	PKC	-	Uniprot
51	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
51	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
51	S	Phosphorylation	Kinase	PKA	-	Uniprot
56	S	Phosphorylation	Kinase	CDK_GROUP	-	PhosphoELM
56	S	Phosphorylation	Kinase	CDK-FAMILY	-	GPS
56	S	Phosphorylation	Kinase	CDK1	P11440	PSP
56	S	Phosphorylation	Kinase	CDK1	P06493	PSP
65	S	Phosphorylation	Kinase	AURKB	O70126	GPS
66	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
66	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
66	S	Phosphorylation	Kinase	PRKCA	P20444	GPS
66	S	Phosphorylation	Kinase	PRKACA	P05132	GPS
66	S	Phosphorylation	Kinase	PKA	-	Uniprot
66	S	Phosphorylation	Kinase	PKC	-	Uniprot
66	S	Phosphorylation	Kinase	AURKB	O70126	GPS
72	S	Phosphorylation	Kinase	ROCK2	P70336	Uniprot
72	S	Phosphorylation	Kinase	ROCK1	P70335	PSP
72	S	Phosphorylation	Kinase	ROCK1	Q13464	PSP
72	S	Phosphorylation	Kinase	AURKB	O70126	Uniprot
73	S	Phosphorylation	Kinase	AURKB	O70126	PhosphoELM
83	S	Phosphorylation	Kinase	CAMK2	-	Uniprot
83	S	Phosphorylation	Kinase	CAMK2-FAMILY	-	GPS
83	S	Phosphorylation	Kinase	PLK1	P53350	PSP
83	S	Phosphorylation	Kinase	CAMK2B	P28652	GPS
83	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP
83	S	Phosphorylation	Kinase	CAMK2A	P11798	PSP
83	S	Phosphorylation	Kinase	CAM-KII_GROUP	-	PhosphoELM
87	S	Phosphorylation	Kinase	AURKB	O70126	GPS
459	S	Phosphorylation	Kinase	PLK1	P53350	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
55	S	Phosphorylation	-
Filament disassembly during mitosis is promoted by phosphorylation at Ser-55 as well as by nestin.
56	S	Phosphorylation	17242355
Phosphorylated at Ser-56 by CDK5 during neutrophil secretion in the cytoplasm.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of VIME_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PPARG_MOUSE	Pparg	physical	23297177
RAB7A_HUMAN	RAB7A	physical	26496610
PHB2_HUMAN	PHB2	physical	26496610
ZBT11_HUMAN	ZBTB11	physical	26496610
CENPJ_HUMAN	CENPJ	physical	26496610
SYNCI_HUMAN	SYNC	physical	26496610

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of VIME_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39; SER-49; SER-56;SER-66; SER-419; SER-420; SER-430 AND SER-459, AND MASS SPECTROMETRY.	19131326 [Abstract]
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7 AND SER-214, AND MASSSPECTROMETRY.	19144319 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39; SER-72; SER-73;SER-144; SER-226; SER-430 AND SER-459, AND MASS SPECTROMETRY.	19367708 [Abstract]
"Identification of phosphoproteins and their phosphorylation sites inthe WEHI-231 B lymphoma cell line."; Shu H., Chen S., Bi Q., Mumby M., Brekken D.L.; Mol. Cell. Proteomics 3:279-286(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-72 AND SER-73, AND MASSSPECTROMETRY.	14729942 [Abstract]
"Phosphorylation of vimentin by Rho-associated kinase at a uniqueamino-terminal site that is specifically phosphorylated duringcytokinesis."; Goto H., Kosako H., Tanabe K., Yanagida M., Sakurai M., Amano M.,Kaibuchi K., Inagaki M.; J. Biol. Chem. 273:11728-11736(1998). Cited for: PHOSPHORYLATION AT SER-39 AND SER-72.	9565595 [Abstract]
"Evidence that Ser-82 is a unique phosphorylation site on vimentin forCa2(+)-calmodulin-dependent protein kinase II."; Ando S., Tokui T., Yamauchi T., Sugiura H., Tanabe K., Inagaki M.; Biochem. Biophys. Res. Commun. 175:955-962(1991). Cited for: PHOSPHORYLATION AT SER-39 AND SER-83.	1850997 [Abstract]
"Domain- and sequence-specific phosphorylation of vimentin inducesdisassembly of the filament structure."; Ando S., Tanabe K., Gonda Y., Sato C., Inagaki M.; Biochemistry 28:2974-2979(1989). Cited for: PROTEIN SEQUENCE OF 5-69, AND PHOSPHORYLATION AT SER-7; SER-9; SER-10;SER-21; SER-25; SER-26; SER-34; SER-39; SER-42; SER-47; SER-51 ANDSER-66.	2500966 [Abstract]
"Quantitative time-resolved phosphoproteomic analysis of mast cellsignaling."; Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y.,Kawakami T., Salomon A.R.; J. Immunol. 179:5864-5876(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-53 AND TYR-61, AND MASSSPECTROMETRY.	17947660 [Abstract]

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