SYNCI_HUMAN - dbPTM
SYNCI_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SYNCI_HUMAN
UniProt AC Q9H7C4
Protein Name Syncoilin
Gene Name SYNC
Organism Homo sapiens (Human).
Sequence Length 482
Subcellular Localization Cytoplasm, perinuclear region . In skeletal muscle, colocalizes with DES and DTNA, and is localized at the myotendinous and neuromuscular junctions, sarcolemma and Z-lines. In myotubes, detected in a punctate cytoplasmic pattern (By similarity).
Protein Description Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facilitate lateral force transmission during skeletal muscle contraction. Does not form homofilaments nor heterofilaments with other IF proteins..
Protein Sequence MASPEPRRGGDGAAQAARKTRVEANSPLPKNSGSLNEAEALNPEVTLSSEGSLNLEDILYLEDTGDLDETLYVQETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQFVEGPVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSMEENLSIEDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKAMLLPKSLEQADAPTSQAGGMETQSQGAV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
20PhosphorylationAAQAARKTRVEANSP
HHHHHHHHCCCCCCC
34.1023403867
26PhosphorylationKTRVEANSPLPKNSG
HHCCCCCCCCCCCCC
34.5625159151
34PhosphorylationPLPKNSGSLNEAEAL
CCCCCCCCCCHHHHH
28.04-
131PhosphorylationPVEPGKPTSPEHVVY
CCCCCCCCCCCEEEE
61.4722167270
132PhosphorylationVEPGKPTSPEHVVYE
CCCCCCCCCCEEEEE
36.5022167270
138PhosphorylationTSPEHVVYEGETVTR
CCCCEEEEECEECEE
19.6827642862
142PhosphorylationHVVYEGETVTRAEKS
EEEEECEECEEHHHC
37.7320068231
144PhosphorylationVYEGETVTRAEKSNP
EEECEECEEHHHCCH
31.4220068231
325PhosphorylationLQESRRLSAQFENLM
HHHHHHHHHHHHHHH
20.4322167270
335PhosphorylationFENLMAESRQDLEEE
HHHHHHHHHHHHHHH
26.2122617229
343PhosphorylationRQDLEEEYEPQFLRL
HHHHHHHHCHHHHHH
35.8727642862
450PhosphorylationLSLAEELSTYKAMLL
HHHHHHHHHHHHHHC
32.7326074081
451PhosphorylationSLAEELSTYKAMLLP
HHHHHHHHHHHHHCC
41.4826074081
452PhosphorylationLAEELSTYKAMLLPK
HHHHHHHHHHHHCCC
8.0626074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SYNCI_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SYNCI_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SYNCI_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DESM_HUMANDESphysical
11694502
PERI_HUMANPRPHphysical
28514442
DESM_HUMANDESphysical
28514442
CC136_HUMANCCDC136physical
28514442
TJAP1_HUMANTJAP1physical
28514442
M3K7_HUMANMAP3K7physical
28514442
APC_HUMANAPCphysical
28514442
CEP55_HUMANCEP55physical
28514442
AINX_HUMANINAphysical
28514442
SYNEM_HUMANSYNMphysical
28514442
NFM_HUMANNEFMphysical
28514442
CRCM_HUMANMCCphysical
28514442
NEMO_HUMANIKBKGphysical
28514442
GOGA3_HUMANGOLGA3physical
28514442
TNIP1_HUMANTNIP1physical
28514442
CP250_HUMANCEP250physical
28514442
SLMAP_HUMANSLMAPphysical
28514442
TAB1_HUMANTAB1physical
28514442
NFL_HUMANNEFLphysical
28514442
RUFY1_HUMANRUFY1physical
28514442
ARHG6_HUMANARHGEF6physical
28514442
GIT2_HUMANGIT2physical
28514442
GCC2_HUMANGCC2physical
28514442
GIT1_HUMANGIT1physical
28514442
UACA_HUMANUACAphysical
28514442
CACO2_HUMANCALCOCO2physical
28514442
CASC4_HUMANCASC4physical
28514442
KIF15_HUMANKIF15physical
28514442
THA11_HUMANTHAP11physical
28514442
VIME_HUMANVIMphysical
28514442
NEST_HUMANNESphysical
28514442
ARHG7_HUMANARHGEF7physical
28514442
NDC80_HUMANNDC80physical
28514442
GFAP_HUMANGFAPphysical
28514442
RABE1_HUMANRABEP1physical
28514442
GAN_HUMANGANphysical
28514442
KLH42_HUMANKLHL42physical
28514442
IPYR2_HUMANPPA2physical
28514442
GOGA5_HUMANGOLGA5physical
28514442
C102A_HUMANCCDC102Aphysical
28514442

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SYNCI_HUMAN

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Related Literatures of Post-Translational Modification

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