dbPTM

SYNEM_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SYNEM_HUMAN
UniProt AC	O15061
Protein Name	Synemin
Gene Name	SYNM
Organism	Homo sapiens (Human).
Sequence Length	1565
Subcellular Localization	Cytoplasm, cytoskeleton. Cell junction, adherens junction. There are at least two distinct SYNM subpopulations, one in which SYMN interacts with DES within the Z-lines, and another in which it interacts with both DTNA and DES at the costamere.
Protein Description	Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteropolymeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteropolymeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells..
Protein Sequence	MLSWRLQTGPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARCAEEARSLRQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQEALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRLREVHDSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALGLEQLRARLEDALLRMREEYGIQAEERQRAIDCLEDEKATLTLAMADWLRDYQDLLQVKTGLSLEVATYRALLEGESNPEIVIWAEHVENMPSEFRNKSYHYTDSLLQRENERNLFSRQKAPLASFNHSSALYSNLSGHRGSQTGTSIGGDARRGFLGSGYSSSATTQQENSYGKAVSSQTNVRTFSPTYGLLRNTEAQVKTFPDRPKAGDTREVPVYIGEDSTIARESYRDRRDKVAAGASESTRSNERTVILGKKTEVKATREQERNRPETIRTKPEEKMFDSKEKASEERNLRWEELTKLDKEARQRESQQMKEKAKEKDSPKEKSVREREVPISLEVSQDRRAEVSPKGLQTPVKDAGGGTGREAEARELRFRLGTSDATGSLQGDSMTETVAENIVTSILKQFTQSPETEASADSFPDTKVTYVDRKELPGERKTKTEIVVESKLTEDVDVSDEAGLDYLLSKDIKEVGLKGKSAEQMIGDIINLGLKGREGRAKVVNVEIVEEPVSYVSGEKPEEFSVPFKVEEVEDVSPGPWGLVKEEEGYGESDVTFSVNQHRRTKQPQENTTHVEEVTEAGDSEGEQSYFVSTPDEHPGGHDRDDGSVYGQIHIEEESTIRYSWQDEIVQGTRRRTQKDGAVGEKVVKPLDVPAPSLEGDLGSTHWKEQARSGEFHAEPTVIEKEIKIPHEFHTSMKGISSKEPRQQLVEVIGQLEETLPERMREELSALTREGQGGPGSVSVDVKKVQGAGGSSVTLVAEVNVSQTVDADRLDLEELSKDEASEMEKAVESVVRESLSRQRSPAPGSPDEEGGAEAPAAGIRFRRWATRELYIPSGESEVAGGASHSSGQRTPQGPVSATVEVSSPTGFAQSQVLEDVSQAARHIKLGPSEVWRTERMSYEGPTAEVVEVSAGGDLSQAASPTGASRSVRHVTLGPGQSPLSREVIFLGPAPACPEAWGSPEPGPAESSADMDGSGRHSTFGCRQFHAEKEIIFQGPISAAGKVGDYFATEESVGTQTSVRQLQLGPKEGFSGQIQFTAPLSDKVELGVIGDSVHMEGLPGSSTSIRHISIGPQRHQTTQQIVYHGLVPQLGESGDSESTVHGEGSADVHQATHSHTSGRQTVMTEKSTFQSVVSESPQEDSAGDTSGAEMTSGVSRSFRHIRLGPTETETSEHIAIRGPVSRTFVLAGSADSPELGKLADSSRTLRHIAPGPKETSFTFQMDVSNVEAIRSRTQEAGALGVSDRGSWRDADSRNDQAVGVSFKASAGEGDQAHREQGKEQAMFDKKVQLQRMVDQRSVISDEKKVALLYLDNEEEENDGHWF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MLSWRLQTGP -----CCCCCCCCCC	23.24	24719451
8	Phosphorylation	MLSWRLQTGPEKAEL CCCCCCCCCCCHHHH	60.33	20068231
23	Phosphorylation	QELNARLYDYVCRVR HHHHHHHHHHHHHHH	10.32	-
161	Phosphorylation	ELRARAASLTMHFRA HHHHHHHHHHEEEHH	24.32	28857561
163	Phosphorylation	RARAASLTMHFRARA HHHHHHHHEEEHHHC	13.20	27251275
171	Phosphorylation	MHFRARATGPAAPPP EEEHHHCCCCCCCCC	37.84	23403867
262	Phosphorylation	LLRMREEYGIQAEER HHHHHHHHCCCHHHH	18.12	-
294	Phosphorylation	MADWLRDYQDLLQVK HHHHHHHHHHHHHHH	9.48	20068231
341	Phosphorylation	PSEFRNKSYHYTDSL CHHHCCCCCCCHHHH	22.23	23403867
342	Phosphorylation	SEFRNKSYHYTDSLL HHHCCCCCCCHHHHH	10.64	29214152
344	Phosphorylation	FRNKSYHYTDSLLQR HCCCCCCCHHHHHHH	12.19	23403867
347	Phosphorylation	KSYHYTDSLLQRENE CCCCCHHHHHHHHHH	24.15	28555341
367	Phosphorylation	RQKAPLASFNHSSAL CCCCCHHHCCCCHHH	33.97	25002506
371	Phosphorylation	PLASFNHSSALYSNL CHHHCCCCHHHHCCC	20.57	25002506
372	Phosphorylation	LASFNHSSALYSNLS HHHCCCCHHHHCCCC	18.10	25002506
375	Phosphorylation	FNHSSALYSNLSGHR CCCCHHHHCCCCCCC	8.67	21945579
376	Phosphorylation	NHSSALYSNLSGHRG CCCHHHHCCCCCCCC	31.95	21945579
379	Phosphorylation	SALYSNLSGHRGSQT HHHHCCCCCCCCCCC	36.48	28857561
384	Phosphorylation	NLSGHRGSQTGTSIG CCCCCCCCCCCCCCC	25.24	26657352
386	Phosphorylation	SGHRGSQTGTSIGGD CCCCCCCCCCCCCCC	44.09	29255136
388	Phosphorylation	HRGSQTGTSIGGDAR CCCCCCCCCCCCCCC	22.13	30242111
389	O-linked_Glycosylation	RGSQTGTSIGGDARR CCCCCCCCCCCCCCC	22.15	30059200
389	Phosphorylation	RGSQTGTSIGGDARR CCCCCCCCCCCCCCC	22.15	28857561
401	Phosphorylation	ARRGFLGSGYSSSAT CCCCCCCCCCCCCCC	36.38	28857561
403	Phosphorylation	RGFLGSGYSSSATTQ CCCCCCCCCCCCCCC	13.69	-
405	Phosphorylation	FLGSGYSSSATTQQE CCCCCCCCCCCCCCC	18.60	-
409	Phosphorylation	GYSSSATTQQENSYG CCCCCCCCCCCCCCC	28.15	-
415	Phosphorylation	TTQQENSYGKAVSSQ CCCCCCCCCCCCCCC	33.94	-
421	Phosphorylation	SYGKAVSSQTNVRTF CCCCCCCCCCCCCEE	34.13	26437602
423	Phosphorylation	GKAVSSQTNVRTFSP CCCCCCCCCCCEECC	37.31	27251275
427	Phosphorylation	SSQTNVRTFSPTYGL CCCCCCCEECCCCCH	24.96	23403867
429	Phosphorylation	QTNVRTFSPTYGLLR CCCCCEECCCCCHHC	18.73	17001009
431	Phosphorylation	NVRTFSPTYGLLRNT CCCEECCCCCHHCCC	29.08	19691289
432	Phosphorylation	VRTFSPTYGLLRNTE CCEECCCCCHHCCCC	14.79	23403867
454	Phosphorylation	DRPKAGDTREVPVYI CCCCCCCCCEECEEE	28.01	22210691
460	Phosphorylation	DTREVPVYIGEDSTI CCCEECEEECCCCCC	9.35	24927040
465	Phosphorylation	PVYIGEDSTIARESY CEEECCCCCCCCHHH	19.87	26657352
466	Phosphorylation	VYIGEDSTIARESYR EEECCCCCCCCHHHH	30.86	28857561
471	Phosphorylation	DSTIARESYRDRRDK CCCCCCHHHHHHHHH	21.66	22210691
472	Phosphorylation	STIARESYRDRRDKV CCCCCHHHHHHHHHH	16.27	22210691
484	Phosphorylation	DKVAAGASESTRSNE HHHCCCCCCCCCCCC	31.03	20860994
486	Phosphorylation	VAAGASESTRSNERT HCCCCCCCCCCCCCE	26.99	20860994
487	Phosphorylation	AAGASESTRSNERTV CCCCCCCCCCCCCEE	33.78	29759185
489	Phosphorylation	GASESTRSNERTVIL CCCCCCCCCCCEEEE	43.03	25159151
498	2-Hydroxyisobutyrylation	ERTVILGKKTEVKAT CCEEEECCCCCCHHH	53.74	-
500	Phosphorylation	TVILGKKTEVKATRE EEEECCCCCCHHHHH	49.88	-
515	Phosphorylation	QERNRPETIRTKPEE HHHCCCCHHCCCHHH	20.60	24719451
527	Phosphorylation	PEEKMFDSKEKASEE HHHHCCCCHHHHHHH	31.30	25072903
544	Acetylation	LRWEELTKLDKEARQ CCHHHHHHHHHHHHH	68.28	12432283
547	Acetylation	EELTKLDKEARQRES HHHHHHHHHHHHHHH	64.80	12432295
566	Phosphorylation	EKAKEKDSPKEKSVR HHHHHCCCCCHHCHH	49.27	26657352
580	Phosphorylation	REREVPISLEVSQDR HHCCCCEEEEECCCC	16.65	26657352
584	Phosphorylation	VPISLEVSQDRRAEV CCEEEEECCCCCCCC	19.58	26657352
592	Phosphorylation	QDRRAEVSPKGLQTP CCCCCCCCCCCCCCC	16.64	26437602
598	Phosphorylation	VSPKGLQTPVKDAGG CCCCCCCCCCCCCCC	34.78	26055452
628	Phosphorylation	GTSDATGSLQGDSMT CCCCCCCCCCCCCCH	17.11	26657352
633	Phosphorylation	TGSLQGDSMTETVAE CCCCCCCCCHHHHHH	34.13	26657352
635	Phosphorylation	SLQGDSMTETVAENI CCCCCCCHHHHHHHH	32.24	27732954
637	Phosphorylation	QGDSMTETVAENIVT CCCCCHHHHHHHHHH	18.82	22199227
645	Phosphorylation	VAENIVTSILKQFTQ HHHHHHHHHHHHHHC	18.28	24719451
651	Phosphorylation	TSILKQFTQSPETEA HHHHHHHHCCCCCHH	26.16	29255136
653	Phosphorylation	ILKQFTQSPETEASA HHHHHHCCCCCHHCC	22.96	29255136
656	Phosphorylation	QFTQSPETEASADSF HHHCCCCCHHCCCCC	39.99	29255136
659	Phosphorylation	QSPETEASADSFPDT CCCCCHHCCCCCCCC	26.78	23663014
662	Phosphorylation	ETEASADSFPDTKVT CCHHCCCCCCCCEEE	38.09	23663014
684	Phosphorylation	PGERKTKTEIVVESK CCCCCCCCEEEEEEE	35.85	29759185
690	Phosphorylation	KTEIVVESKLTEDVD CCEEEEEEECCCCCC	22.73	29759185
699	Phosphorylation	LTEDVDVSDEAGLDY CCCCCCCCCHHCHHH	25.85	27251275
721	Phosphorylation	EVGLKGKSAEQMIGD HHCCCCCCHHHHHHH	45.78	20068231
754	Phosphorylation	EIVEEPVSYVSGEKP EEEECCCCCCCCCCC	30.45	26657352
757	Phosphorylation	EEPVSYVSGEKPEEF ECCCCCCCCCCCCHH	32.76	26657352
777	Phosphorylation	VEEVEDVSPGPWGLV EEEEECCCCCCCCEE	36.14	25159151
819	Phosphorylation	TTHVEEVTEAGDSEG CCCCEEEHHCCCCCC	24.33	26657352
824	Phosphorylation	EVTEAGDSEGEQSYF EEHHCCCCCCCEEEE	46.73	26657352
829	Phosphorylation	GDSEGEQSYFVSTPD CCCCCCEEEEEECCC	19.08	26657352
830	Phosphorylation	DSEGEQSYFVSTPDE CCCCCEEEEEECCCC	14.01	26657352
833	Phosphorylation	GEQSYFVSTPDEHPG CCEEEEEECCCCCCC	25.07	26657352
834	Phosphorylation	EQSYFVSTPDEHPGG CEEEEEECCCCCCCC	29.47	26657352
877	Phosphorylation	VQGTRRRTQKDGAVG CCCCCCCCCCCCCCC	37.85	-
897	Phosphorylation	PLDVPAPSLEGDLGS CCCCCCCCCCCCCCC	40.95	26657352
904	Phosphorylation	SLEGDLGSTHWKEQA CCCCCCCCHHHHHHH	25.13	26657352
905	Phosphorylation	LEGDLGSTHWKEQAR CCCCCCCHHHHHHHH	29.92	24076635
908	Acetylation	DLGSTHWKEQARSGE CCCCHHHHHHHHCCC	32.13	30588207
913	Phosphorylation	HWKEQARSGEFHAEP HHHHHHHCCCCCCCC	45.77	26657352
921	Phosphorylation	GEFHAEPTVIEKEIK CCCCCCCEEEEEEEC	26.14	28857561
925	Acetylation	AEPTVIEKEIKIPHE CCCEEEEEEECCCHH	54.32	25953088
935	Phosphorylation	KIPHEFHTSMKGISS CCCHHHHCCCCCCCC	35.52	25002506
936	Phosphorylation	IPHEFHTSMKGISSK CCHHHHCCCCCCCCC	15.21	23312004
941	Phosphorylation	HTSMKGISSKEPRQQ HCCCCCCCCCCHHHH	43.98	23403867
942	Phosphorylation	TSMKGISSKEPRQQL CCCCCCCCCCHHHHH	38.83	23403867
969	Phosphorylation	ERMREELSALTREGQ HHHHHHHHHHHCCCC	25.22	23828894
981	Phosphorylation	EGQGGPGSVSVDVKK CCCCCCCCEEEEEEE	17.85	26437602
983	Phosphorylation	QGGPGSVSVDVKKVQ CCCCCCEEEEEEEEC	17.81	27251275
1033	Phosphorylation	EMEKAVESVVRESLS HHHHHHHHHHHHHHH	21.22	26657352
1038	Phosphorylation	VESVVRESLSRQRSP HHHHHHHHHHCCCCC	22.53	29507054
1040	Phosphorylation	SVVRESLSRQRSPAP HHHHHHHHCCCCCCC	35.33	27422710
1044	Phosphorylation	ESLSRQRSPAPGSPD HHHHCCCCCCCCCCC	19.64	29255136
1049	Phosphorylation	QRSPAPGSPDEEGGA CCCCCCCCCCCCCCC	28.28	29255136
1070	Phosphorylation	IRFRRWATRELYIPS CEEEEEEEEEEECCC	20.09	26437602
1077	Phosphorylation	TRELYIPSGESEVAG EEEEECCCCCCCCCC	45.71	26437602
1087	Phosphorylation	SEVAGGASHSSGQRT CCCCCCCCCCCCCCC	27.46	26657352
1089	Phosphorylation	VAGGASHSSGQRTPQ CCCCCCCCCCCCCCC	33.40	28348404
1090	Phosphorylation	AGGASHSSGQRTPQG CCCCCCCCCCCCCCC	33.26	28348404
1094	Phosphorylation	SHSSGQRTPQGPVSA CCCCCCCCCCCCCEE	16.45	23663014
1100	Phosphorylation	RTPQGPVSATVEVSS CCCCCCCEEEEEECC	22.73	30206219
1102	Phosphorylation	PQGPVSATVEVSSPT CCCCCEEEEEECCCC	15.08	30206219
1106	Phosphorylation	VSATVEVSSPTGFAQ CEEEEEECCCCCCCH	19.66	30175587
1107	Phosphorylation	SATVEVSSPTGFAQS EEEEEECCCCCCCHH	31.49	26055452
1109	Phosphorylation	TVEVSSPTGFAQSQV EEEECCCCCCCHHHH	47.05	30206219
1114	Phosphorylation	SPTGFAQSQVLEDVS CCCCCCHHHHHHHHH	20.87	30206219
1121	Phosphorylation	SQVLEDVSQAARHIK HHHHHHHHHHHHHHC	26.82	23663014
1132	Phosphorylation	RHIKLGPSEVWRTER HHHCCCHHHHHHCCC	42.88	28857561
1137	Phosphorylation	GPSEVWRTERMSYEG CHHHHHHCCCCCCCC	16.54	21712546
1141	Phosphorylation	VWRTERMSYEGPTAE HHHCCCCCCCCCCEE	26.67	26657352
1141 (in isoform 2)	Phosphorylation	-	26.67	26657352
1142	Phosphorylation	WRTERMSYEGPTAEV HHCCCCCCCCCCEEE	18.63	26657352
1142 (in isoform 2)	Phosphorylation	-	18.63	26657352
1146	Phosphorylation	RMSYEGPTAEVVEVS CCCCCCCCEEEEEEE	46.43	26657352
1153	Phosphorylation	TAEVVEVSAGGDLSQ CEEEEEEECCCCHHH	14.00	27251275
1159	Phosphorylation	VSAGGDLSQAASPTG EECCCCHHHCCCCCC	23.63	26657352
1163	Phosphorylation	GDLSQAASPTGASRS CCHHHCCCCCCCCCC	26.47	26657352
1165	Phosphorylation	LSQAASPTGASRSVR HHHCCCCCCCCCCEE	42.77	27732954
1168	Phosphorylation	AASPTGASRSVRHVT CCCCCCCCCCEEEEE	26.83	27732954
1175	Phosphorylation	SRSVRHVTLGPGQSP CCCEEEEEECCCCCC	21.63	24732914
1181	Phosphorylation	VTLGPGQSPLSREVI EEECCCCCCCCCEEE	33.45	29255136
1184	Phosphorylation	GPGQSPLSREVIFLG CCCCCCCCCEEEEEE	29.76	22617229
1202	Phosphorylation	ACPEAWGSPEPGPAE CCHHHCCCCCCCCCC	18.52	29449344
1210	Phosphorylation	PEPGPAESSADMDGS CCCCCCCCCCCCCCC	32.69	27251275
1211	Phosphorylation	EPGPAESSADMDGSG CCCCCCCCCCCCCCC	21.57	27251275
1217	Phosphorylation	SSADMDGSGRHSTFG CCCCCCCCCCCCCCC	28.52	26657352
1234 (in isoform 2)	Ubiquitination	-	5.91	21906983
1241	Phosphorylation	IIFQGPISAAGKVGD EEEECCCCCCCCCCC	18.39	26657352
1274	Phosphorylation	LGPKEGFSGQIQFTA CCCCCCCCCEEEEEE	40.42	23403867
1280	Phosphorylation	FSGQIQFTAPLSDKV CCCEEEEEEECCCCE	15.81	23403867
1284	Phosphorylation	IQFTAPLSDKVELGV EEEEEECCCCEEEEE	34.03	23403867
1304	Phosphorylation	HMEGLPGSSTSIRHI ECCCCCCCCCEEEEE	28.62	25159151
1305	Phosphorylation	MEGLPGSSTSIRHIS CCCCCCCCCEEEEEE	31.89	27251275
1306	Phosphorylation	EGLPGSSTSIRHISI CCCCCCCCEEEEEEE	29.85	23403867
1307	Phosphorylation	GLPGSSTSIRHISIG CCCCCCCEEEEEEEC	21.41	26657352
1312	Phosphorylation	STSIRHISIGPQRHQ CCEEEEEEECCCCCC	18.50	28857561
1370	Phosphorylation	QTVMTEKSTFQSVVS CEEECCHHHHHHHHC	28.37	27732954
1371	Phosphorylation	TVMTEKSTFQSVVSE EEECCHHHHHHHHCC	36.44	27732954
1374	Phosphorylation	TEKSTFQSVVSESPQ CCHHHHHHHHCCCCC	21.94	27732954
1377	Phosphorylation	STFQSVVSESPQEDS HHHHHHHCCCCCCCC	30.15	27732954
1379	Phosphorylation	FQSVVSESPQEDSAG HHHHHCCCCCCCCCC	25.11	26657352
1384	Phosphorylation	SESPQEDSAGDTSGA CCCCCCCCCCCCCCC	33.14	26657352
1388	Phosphorylation	QEDSAGDTSGAEMTS CCCCCCCCCCCCCCC	28.30	27732954
1389	Phosphorylation	EDSAGDTSGAEMTSG CCCCCCCCCCCCCCC	40.52	26657352
1400	Phosphorylation	MTSGVSRSFRHIRLG CCCCCCCCCCEEEEC	21.08	29507054
1432	Phosphorylation	RTFVLAGSADSPELG EEEEEEECCCCHHHH	24.24	26657352
1435	Phosphorylation	VLAGSADSPELGKLA EEEECCCCHHHHHHC	21.71	25159151
1474	Phosphorylation	SNVEAIRSRTQEAGA CCHHHHHHHCHHCCC	33.30	23312004
1476	Phosphorylation	VEAIRSRTQEAGALG HHHHHHHCHHCCCCC	31.82	26437602
1485	Phosphorylation	EAGALGVSDRGSWRD HCCCCCCCCCCCCCC	21.57	23312004
1487	Methylation	GALGVSDRGSWRDAD CCCCCCCCCCCCCCC	33.27	-
1489	Phosphorylation	LGVSDRGSWRDADSR CCCCCCCCCCCCCCC	21.60	23312004
1504	Phosphorylation	NDQAVGVSFKASAGE CCCEEEEEEEECCCC	18.33	28857561
1540	Phosphorylation	QRMVDQRSVISDEKK HHHHHHCCCCCCCCE	20.40	26657352
1543	Phosphorylation	VDQRSVISDEKKVAL HHHCCCCCCCCEEEE	37.25	29507054
1546	Ubiquitination	RSVISDEKKVALLYL CCCCCCCCEEEEEEC	58.50	2190698
1546 (in isoform 1)	Ubiquitination	-	58.50	21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SYNEM_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SYNEM_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SYNEM_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DTNA_HUMAN	DTNA	physical	11353857
DESM_HUMAN	DES	physical	11353857
PACN1_HUMAN	PACSIN1	physical	17437541
SH3G2_HUMAN	SH3GL2	physical	17437541
AMPH_HUMAN	AMPH	physical	17437541
GRB2_HUMAN	GRB2	physical	17437541
P85A_HUMAN	PIK3R1	physical	17437541
CBL_HUMAN	CBL	physical	15872089
2ABB_HUMAN	PPP2R2B	physical	22337773
2AAA_HUMAN	PPP2R1A	physical	22337773

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SYNEM_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-429; THR-598; SER-1044;SER-1049 AND SER-1181, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1044; SER-1049; SER-1181AND SER-1435, AND MASS SPECTROMETRY.	18691976 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-653; SER-1044; SER-1049AND SER-1184, AND MASS SPECTROMETRY.	17081983 [Abstract]