TPM4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TPM4_MOUSE
• UniProt AC: Q6IRU2
• Protein Name: Tropomyosin alpha-4 chain
• Gene Name: Tpm4
• Organism: Mus musculus (Mouse).
• Sequence Length: 248
• Subcellular Localization: Cytoplasm, cytoskeleton . Associates with F-actin stress fibers.
• Protein Description: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium..
• Protein Sequence: MAGLNSLEAVKRKIQALQQQADDAEDRAQGLQRELDGERERREKAEGDAAALNRRIQLLEEELDRAQEQLATALQNLEEAEKAADESERGMKVIENRAMKDEEKMEILEMQLKEAKHITDEADRKYEEVARKLVILEGELKRAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVSKLEKTIDDLEEKLAQAKEENVGLHQTLDQTLNELNCI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGLNSLEA ------CCCHHHHHH	31.05	-
6	Phosphorylation	--MAGLNSLEAVKRK --CCCHHHHHHHHHH	32.40	26824392
11	Ubiquitination	LNSLEAVKRKIQALQ HHHHHHHHHHHHHHH	55.83	22790023
11	Acetylation	LNSLEAVKRKIQALQ HHHHHHHHHHHHHHH	55.83	23236377
13	Acetylation	SLEAVKRKIQALQQQ HHHHHHHHHHHHHHH	33.19	22826441
82	Acetylation	QNLEEAEKAADESER HHHHHHHHHHHHHHH	56.79	88219
82	Ubiquitination	QNLEEAEKAADESER HHHHHHHHHHHHHHH	56.79	-
87	Phosphorylation	AEKAADESERGMKVI HHHHHHHHHHHHHHH	32.89	29899451
92	Ubiquitination	DESERGMKVIENRAM HHHHHHHHHHHHHCC	42.77	27667366
113	Ubiquitination	EILEMQLKEAKHITD HHHHHHHHHHHCCCH	38.44	22790023
113	Acetylation	EILEMQLKEAKHITD HHHHHHHHHHHCCCH	38.44	23236377
116	Acetylation	EMQLKEAKHITDEAD HHHHHHHHCCCHHHH	36.31	7719619
125	Acetylation	ITDEADRKYEEVARK CCHHHHHHHHHHHHH	58.52	23236377
126	Phosphorylation	TDEADRKYEEVARKL CHHHHHHHHHHHHHH	20.44	28542873
132	Acetylation	KYEEVARKLVILEGE HHHHHHHHHHHHHHH	37.05	7719629
153	Acetylation	RAEVSELKCGDLEEE HHHHHHCCCCCHHHH	31.92	23806337
153	Succinylation	RAEVSELKCGDLEEE HHHHHHCCCCCHHHH	31.92	23806337
154	S-nitrosocysteine	AEVSELKCGDLEEEL HHHHHCCCCCHHHHH	8.84	-
154	S-nitrosylation	AEVSELKCGDLEEEL HHHHHCCCCCHHHHH	8.84	20925432
169	Acetylation	KNVTNNLKSLEAASE HHHHHHHHHHHHHHH	55.93	23806337
169	Succinylation	KNVTNNLKSLEAASE HHHHHHHHHHHHHHH	55.93	23806337
169	Ubiquitination	KNVTNNLKSLEAASE HHHHHHHHHHHHHHH	55.93	-
170	Phosphorylation	NVTNNLKSLEAASEK HHHHHHHHHHHHHHH	34.31	26824392
177	Ubiquitination	SLEAASEKYSEKEDK HHHHHHHHHHHHHHH	52.13	22790023
177	Acetylation	SLEAASEKYSEKEDK HHHHHHHHHHHHHHH	52.13	22826441
179	Phosphorylation	EAASEKYSEKEDKYE HHHHHHHHHHHHHHH	53.94	25338131
181	Acetylation	ASEKYSEKEDKYEEE HHHHHHHHHHHHHHH	66.33	22826441
184	Acetylation	KYSEKEDKYEEEIKL HHHHHHHHHHHHHHH	56.50	21728379
185	Phosphorylation	YSEKEDKYEEEIKLL HHHHHHHHHHHHHHH	40.68	22210690
197	Ubiquitination	KLLSDKLKEAETRAE HHHHHHHHHHHHHHH	61.70	22790023
201	Phosphorylation	DKLKEAETRAEFAER HHHHHHHHHHHHHHH	42.08	22210690
211	Phosphorylation	EFAERTVSKLEKTID HHHHHHHHHHHHHHH	30.80	24719451
215	Acetylation	RTVSKLEKTIDDLEE HHHHHHHHHHHHHHH	62.31	23236377
216	Phosphorylation	TVSKLEKTIDDLEEK HHHHHHHHHHHHHHH	21.91	26824392
228	Ubiquitination	EEKLAQAKEENVGLH HHHHHHHHHHCCCHH	54.18	-
247	Glutathionylation	QTLNELNCI------ HHHHHHCCC------	6.45	24333276

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TPM4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TPM4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TPM4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ADDA_HUMAN	ADD1	physical	26496610
DPH1_HUMAN	DPH1	physical	26496610
GELS_HUMAN	GSN	physical	26496610
SVIL_HUMAN	SVIL	physical	26496610
TMOD1_HUMAN	TMOD1	physical	26496610
TPM1_HUMAN	TPM1	physical	26496610
TPM2_HUMAN	TPM2	physical	26496610
TPM3_HUMAN	TPM3	physical	26496610
HYOU1_HUMAN	HYOU1	physical	26496610
EHMT2_HUMAN	EHMT2	physical	26496610
TMOD3_HUMAN	TMOD3	physical	26496610
CYTSB_HUMAN	SPECC1	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.