SERPH_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SERPH_MOUSE
• UniProt AC: P19324
• Protein Name: Serpin H1
• Gene Name: Serpinh1
• Organism: Mus musculus (Mouse).
• Sequence Length: 417
• Subcellular Localization: Endoplasmic reticulum lumen.
• Protein Description: Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen..
• Protein Sequence: MRSLLLGTLCLLAVALAAEVKKPLEAAAPGTAEKLSSKATTLAERSTGLAFSLYQAMAKDQAVENILLSPLVVASSLGLVSLGGKATTASQAKAVLSAEKLRDEEVHTGLGELLRSLSNSTARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDKRSALQSINEWASQTTDGKLPEVTKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVTMMHRTGLYNYYDDEKEKLQMVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKAWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFEWDTEGNPFDQDIYGREELRSPKLFYADHPFIFLVRDNQSGSLLFIGRLVRPKGDKMRDEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Acetylation	ALAAEVKKPLEAAAP HHHHHCCCHHHHCCC	61.07	22826441
38	Succinylation	TAEKLSSKATTLAER CHHHHHHHHHHHHHH	46.51	23806337
38	Acetylation	TAEKLSSKATTLAER CHHHHHHHHHHHHHH	46.51	23806337
69	Phosphorylation	AVENILLSPLVVASS HHHHHHHHHHHHHHH	16.85	-
93	Succinylation	ATTASQAKAVLSAEK CCHHHHHHHHHHHHH	31.24	23806337
93	Acetylation	ATTASQAKAVLSAEK CCHHHHHHHHHHHHH	31.24	23806337
93	Succinylation	ATTASQAKAVLSAEK CCHHHHHHHHHHHHH	31.24	-
100	Succinylation	KAVLSAEKLRDEEVH HHHHHHHHHCCCHHH	48.84	23806337
100	Acetylation	KAVLSAEKLRDEEVH HHHHHHHHHCCCHHH	48.84	23806337
119	N-linked_Glycosylation	ELLRSLSNSTARNVT HHHHHHCCCCCCCCC	48.99	-
120	O-linked_Glycosylation	LLRSLSNSTARNVTW HHHHHCCCCCCCCCE	21.77	30059200
124	N-linked_Glycosylation	LSNSTARNVTWKLGS HCCCCCCCCCEECCC	32.86	-
138	Phosphorylation	SRLYGPSSVSFADDF CCCCCCCCCHHHHHH	25.55	26824392
140	Phosphorylation	LYGPSSVSFADDFVR CCCCCCCHHHHHHHH	19.37	27180971
159	Acetylation	HYNCEHSKINFRDKR HHCCCCCCCCHHHHH	43.51	22826441
189	Acetylation	GKLPEVTKDVERTDG CCCCCCCCCCHHCCC	66.02	22826441
206	Acetylation	LVNAMFFKPHWDEKF EEEEEEECCCCCHHH	25.38	23806337
212	Acetylation	FKPHWDEKFHHKMVD ECCCCCHHHHHHEEC	47.74	22826441
216	Acetylation	WDEKFHHKMVDNRGF CCHHHHHHEECCCCE	31.86	22826441
249	Acetylation	YNYYDDEKEKLQMVE CCCCCCHHHHHHEEH	68.12	23806337
290	Acetylation	LLTKEQLKAWMGKMQ HCCHHHHHHHHHHHH	39.43	23806337
290	Succinylation	LLTKEQLKAWMGKMQ HCCHHHHHHHHHHHH	39.43	23806337
295	Acetylation	QLKAWMGKMQKKAVA HHHHHHHHHHHHHHE	23.27	23806337
295	Succinylation	QLKAWMGKMQKKAVA HHHHHHHHHHHHHHE	23.27	-
295	Succinylation	QLKAWMGKMQKKAVA HHHHHHHHHHHHHHE	23.27	23806337
299	Succinylation	WMGKMQKKAVAISLP HHHHHHHHHHEEECC	31.07	23806337
299	Acetylation	WMGKMQKKAVAISLP HHHHHHHHHHEEECC	31.07	23806337
318	Acetylation	EVTHDLQKHLAGLGL EHHHHHHHHHCCCCH	48.13	23806337
331	Acetylation	GLTEAIDKNKADLSR CHHHHHHHCHHHHHH	54.99	22826441
379	Acetylation	REELRSPKLFYADHP CHHHCCCCEEECCCC	53.10	22826441
379	Ubiquitination	REELRSPKLFYADHP CHHHCCCCEEECCCC	53.10	-
394	N-linked_Glycosylation	FIFLVRDNQSGSLLF EEEEEECCCCCCEEE	27.61	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SERPH_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SERPH_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SERPH_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SERPH_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.