HNRLL_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HNRLL_MOUSE
• UniProt AC: Q921F4
• Protein Name: Heterogeneous nuclear ribonucleoprotein L-like
• Gene Name: Hnrnpll
• Organism: Mus musculus (Mouse).
• Sequence Length: 591
• Protein Description: RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC..
• Protein Sequence: MSSSSSSSPKEETYEEDREFESQAKRLKTEEGEIVYSAEESENRQEATPQAGSDSDSGGGDGGDGDGGSGGGGDGEEGEGGEEGDEGDGDEGGSGGDEGGSGGGPRSMPLSTEGGGSHHKVSVSPVVHVRGLCESVVEADLVEALEKFGTICYVMMMPFKRQALVEFENIDSAKECVTFAADVPVYIAGQQAFFNYSTSKRITRPGNTDDPSGGNKVLLLSIQNPLYPITVDVLYTVCNPVGKVQRIVIFKRNGIQAMVEFESVLCAQKAKAALNGADIYAGCCTLKIEYARPTRLNVIRNDNDSWDYTKPYLGRRDRGKGRQRQAILGDHPSSFRHDGYGSHGPLLPLPSRYRMGSRDTPELVAYPLPQASSSYMHGGSPSGSVVMVSGLHQLKMNCSRVFNLFCLYGNIEKVKFMKTIPGTALVEMGDEYAVERAVTHLNNVKLFGKRLNVCVSKQHSVVPSQIFELEDGTSSYKDFAMSKNNRFTSAGQASKNIIQPPSCVLHYYNVPLCVTEETFTKLCNDHEVLPFIKYKVFDAKASAKTLSGLLEWKCKTDAVEALTALNHYQIRVPNGSNPYTLKLCFSTSSHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSSSSSSP ------CCCCCCCCC	38.64	23684622
3	Phosphorylation	-----MSSSSSSSPK -----CCCCCCCCCC	32.70	23684622
4	Phosphorylation	----MSSSSSSSPKE ----CCCCCCCCCCC	27.25	23684622
5	Phosphorylation	---MSSSSSSSPKEE ---CCCCCCCCCCCC	35.87	23684622
6	Phosphorylation	--MSSSSSSSPKEET --CCCCCCCCCCCCC	36.46	23684622
7	Phosphorylation	-MSSSSSSSPKEETY -CCCCCCCCCCCCCH	53.24	23684622
8	Phosphorylation	MSSSSSSSPKEETYE CCCCCCCCCCCCCHH	41.77	23684622
13	Phosphorylation	SSSPKEETYEEDREF CCCCCCCCHHHHHHH	37.01	23429704
14	Phosphorylation	SSPKEETYEEDREFE CCCCCCCHHHHHHHH	22.17	21149613
22	Phosphorylation	EEDREFESQAKRLKT HHHHHHHHHHHHHHC	40.53	21183079
29	Phosphorylation	SQAKRLKTEEGEIVY HHHHHHHCCCCCEEE	43.81	25619855
36	Phosphorylation	TEEGEIVYSAEESEN CCCCCEEEEHHHCCC	14.07	25521595
37	Phosphorylation	EEGEIVYSAEESENR CCCCEEEEHHHCCCC	20.50	25521595
41	Phosphorylation	IVYSAEESENRQEAT EEEEHHHCCCCCCCC	31.51	25619855
48	Phosphorylation	SENRQEATPQAGSDS CCCCCCCCCCCCCCC	18.38	-
55	Phosphorylation	TPQAGSDSDSGGGDG CCCCCCCCCCCCCCC	35.06	25338131
57 (in isoform 5)	Phosphorylation	-	43.20	17242355
64 (in isoform 5)	Phosphorylation	-	58.50	17242355
65 (in isoform 5)	Phosphorylation	-	38.44	17242355
107	Phosphorylation	GSGGGPRSMPLSTEG CCCCCCCCCCCCCCC	28.08	29472430
111	Phosphorylation	GPRSMPLSTEGGGSH CCCCCCCCCCCCCCC	20.67	25338131
117	Phosphorylation	LSTEGGGSHHKVSVS CCCCCCCCCCEEEEC	26.20	24899341
122	Phosphorylation	GGSHHKVSVSPVVHV CCCCCEEEECCEEEH	22.98	28833060
124	Phosphorylation	SHHKVSVSPVVHVRG CCCEEEECCEEEHHH	12.41	28833060
133	S-palmitoylation	VVHVRGLCESVVEAD EEEHHHHHCHHHHHH	4.00	28526873
133	Glutathionylation	VVHVRGLCESVVEAD EEEHHHHHCHHHHHH	4.00	24333276
305	Phosphorylation	VIRNDNDSWDYTKPY EEECCCCCCCCCCCC	28.27	26370283
310	Ubiquitination	NDSWDYTKPYLGRRD CCCCCCCCCCCCCCC	25.99	27667366
310	Acetylation	NDSWDYTKPYLGRRD CCCCCCCCCCCCCCC	25.99	23236377
333	Phosphorylation	AILGDHPSSFRHDGY HHHCCCCHHHCCCCC	38.39	29176673
334	Phosphorylation	ILGDHPSSFRHDGYG HHCCCCHHHCCCCCC	30.65	29176673
357	Phosphorylation	PSRYRMGSRDTPELV CCCCCCCCCCCCHHE	20.03	26060331
360	Phosphorylation	YRMGSRDTPELVAYP CCCCCCCCCHHEEEE	19.97	26060331
366	Phosphorylation	DTPELVAYPLPQASS CCCHHEEEECCCCCC	9.60	26643407
372	Phosphorylation	AYPLPQASSSYMHGG EEECCCCCCCCCCCC	17.99	26643407
373	Phosphorylation	YPLPQASSSYMHGGS EECCCCCCCCCCCCC	28.62	26643407
374	Phosphorylation	PLPQASSSYMHGGSP ECCCCCCCCCCCCCC	24.79	26643407
375	Phosphorylation	LPQASSSYMHGGSPS CCCCCCCCCCCCCCC	8.62	26643407
380	Phosphorylation	SSYMHGGSPSGSVVM CCCCCCCCCCCCEEE	22.08	26643407
382	Phosphorylation	YMHGGSPSGSVVMVS CCCCCCCCCCEEEEE	45.45	26643407
384	Phosphorylation	HGGSPSGSVVMVSGL CCCCCCCCEEEEECC	18.84	26643407
389	Phosphorylation	SGSVVMVSGLHQLKM CCCEEEEECCEEHHH	19.96	26643407
464	Phosphorylation	KQHSVVPSQIFELED CCCCCCHHHEEEECC	25.05	25338131
483	Ubiquitination	YKDFAMSKNNRFTSA HHHHHHHCCCCCCCC	45.19	22790023
533	Acetylation	HEVLPFIKYKVFDAK CCCCCEEEEEEECCH	39.12	22826441
542	Phosphorylation	KVFDAKASAKTLSGL EEECCHHCCHHHHHH	29.59	25338131
544	Acetylation	FDAKASAKTLSGLLE ECCHHCCHHHHHHHH	47.72	23806337
553	Ubiquitination	LSGLLEWKCKTDAVE HHHHHHCEECCCHHH	19.24	22790023
556	Phosphorylation	LLEWKCKTDAVEALT HHHCEECCCHHHHHH	38.37	21082442
576	Phosphorylation	QIRVPNGSNPYTLKL EEECCCCCCCEEEEE	41.07	25338131
579	Phosphorylation	VPNGSNPYTLKLCFS CCCCCCCEEEEEEEE	29.02	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HNRLL_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HNRLL_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HNRLL_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of HNRLL_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.