FBX46_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FBX46_MOUSE
• UniProt AC: Q8BG80
• Protein Name: F-box only protein 46
• Gene Name: Fbxo46
• Organism: Mus musculus (Mouse).
• Sequence Length: 603
• Protein Description: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex..
• Protein Sequence: MDRGSLLPFQLWCPRPFSKYSQNQPRPPSTALKPPVCPDTSSGTEPDHRPAHLESTPPAVAAEAPTSQPAPLLSTAASGDEGRVLLDTWYVIKPGNTKEKVAFFVAHQCGGSSRASSMKVKGHWGSDSSKAKRRRRCLEPTKAPPDQGGREGTPATEVTPTSSGDDVDLVSVAEMVALVEQRAALALQSYPRPSTPAPVVFVSADQGGPAKGLGSERRSGGGDCSRVAEAVAHFEAQRDSPPTKGLRKEERPGPGPGEVRIAFRISNVREPHSPDGNLPNGGGGRPGCAYPGSPGPGTRAKDKITCDLYQLISPSRDALPSNVEFLLARADEASEGETPAPTRPEDTPPAPPPPPARDCGASGFHVDVVVTGVVDACIFFGKDGTKNVKEETVCLTVSPEEPPPPGQLFFLQSRGPEGPPEPPPADIPSTVPGPDDSEGTTDTSLCRLYRHVSHDFLEIRFKIQRLLEPRQYMLLLPEHVLVKIFSFLPTRALAALKCTCHHFKGIIEAFGVRATDSRWSRDPLYRDDPCKQCRKRYEKGDVSLCRWHPKPYHHDLPYGRSYWMCCRRADRETPGCRLGLHDNNWVLPCNGVGGGRAGREEGR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
189	Phosphorylation	RAALALQSYPRPSTP HHHHHHHCCCCCCCC	37.64	26643407
190	Phosphorylation	AALALQSYPRPSTPA HHHHHHCCCCCCCCC	7.12	26643407
194	Phosphorylation	LQSYPRPSTPAPVVF HHCCCCCCCCCCEEE	48.58	26643407
195	Phosphorylation	QSYPRPSTPAPVVFV HCCCCCCCCCCEEEE	26.59	26643407
240	Phosphorylation	HFEAQRDSPPTKGLR HHHHHCCCCCCCCCC	34.66	28507225
243	Phosphorylation	AQRDSPPTKGLRKEE HHCCCCCCCCCCCCC	40.92	28066266
273	Phosphorylation	SNVREPHSPDGNLPN CCCCCCCCCCCCCCC	35.09	25266776
293	Phosphorylation	PGCAYPGSPGPGTRA CCCCCCCCCCCCCCC	23.37	29514104
334	Phosphorylation	LARADEASEGETPAP HHCCHHHCCCCCCCC	44.05	25338131
342	Phosphorylation	EGETPAPTRPEDTPP CCCCCCCCCCCCCCC	62.05	25338131
347	Phosphorylation	APTRPEDTPPAPPPP CCCCCCCCCCCCCCC	29.52	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FBX46_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FBX46_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FBX46_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of FBX46_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.