RL6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RL6_MOUSE
• UniProt AC: P47911
• Protein Name: 60S ribosomal protein L6
• Gene Name: Rpl6
• Organism: Mus musculus (Mouse).
• Sequence Length: 296
• Subcellular Localization: Cytoplasm, cytosol . Cytoplasm . Rough endoplasmic reticulum . Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).
• Protein Description: Component of the large ribosomal subunit..
• Protein Sequence: MAGEKAPDTKEKKPAAKKAGSDAAASRPRAAKVAKKVHPKGKKPKKAKPHCSRNPVLVRGIGRYSRSAMYSRKALYKRKYSAAKTKVEKKKKKEKVLATVTKTVGGDKNGGTRVVKLRKMPRYYPTEDVPRKLLSHGKKPFSQHVRRLRSSITPGTVLIILTGRHRGKRVVFLKQLDSGLLLVTGPLVINRVPLRRTHQKFVIATSTKVDISDVKIPKHLTDAYFKKKQLRKPRHQEGEIFDTEKEKYEITEQRKADQKAVDLQILPKIKAVPQLQGYLRSQFSLTNGMYPHKLVF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Acetylation	APDTKEKKPAAKKAG CCCCCCCCHHHHHHC	40.77	23201123
18	Ubiquitination	EKKPAAKKAGSDAAA CCCHHHHHHCCHHHH	53.93	-
21	Phosphorylation	PAAKKAGSDAAASRP HHHHHHCCHHHHCCH	29.01	26824392
26	Phosphorylation	AGSDAAASRPRAAKV HCCHHHHCCHHHHHH	37.78	26824392
51	S-palmitoylation	PKKAKPHCSRNPVLV CCCCCCCCCCCCCCH	5.76	26165157
51	Glutathionylation	PKKAKPHCSRNPVLV CCCCCCCCCCCCCCH	5.76	24333276
59	Methylation	SRNPVLVRGIGRYSR CCCCCCHHCCCCCCH	27.18	16188905
65	Phosphorylation	VRGIGRYSRSAMYSR HHCCCCCCHHHHHCH	20.56	24719451
80	Phosphorylation	KALYKRKYSAAKTKV HHHHHHHHHHHHHHH	13.94	23140645
81	Phosphorylation	ALYKRKYSAAKTKVE HHHHHHHHHHHHHHH	25.45	23140645
95	Ubiquitination	EKKKKKEKVLATVTK HHHHHHHHEEEEEEE	51.97	-
95	Malonylation	EKKKKKEKVLATVTK HHHHHHHHEEEEEEE	51.97	26320211
95	Acetylation	EKKKKKEKVLATVTK HHHHHHHHEEEEEEE	51.97	23201123
102	Ubiquitination	KVLATVTKTVGGDKN HEEEEEEEECCCCCC	36.56	-
102	Acetylation	KVLATVTKTVGGDKN HEEEEEEEECCCCCC	36.56	23806337
102	Malonylation	KVLATVTKTVGGDKN HEEEEEEEECCCCCC	36.56	26320211
102	Succinylation	KVLATVTKTVGGDKN HEEEEEEEECCCCCC	36.56	23806337
108	Ubiquitination	TKTVGGDKNGGTRVV EEECCCCCCCCEEEE	61.85	-
108	Acetylation	TKTVGGDKNGGTRVV EEECCCCCCCCEEEE	61.85	23201123
123	Phosphorylation	KLRKMPRYYPTEDVP EECCCCCCCCCCCCC	14.13	26239621
132	Ubiquitination	PTEDVPRKLLSHGKK CCCCCCHHHHHCCCC	47.94	-
135	Phosphorylation	DVPRKLLSHGKKPFS CCCHHHHHCCCCCHH	40.40	-
138	Ubiquitination	RKLLSHGKKPFSQHV HHHHHCCCCCHHHHH	52.42	-
139	Succinylation	KLLSHGKKPFSQHVR HHHHCCCCCHHHHHH	56.75	23806337
139	Acetylation	KLLSHGKKPFSQHVR HHHHCCCCCHHHHHH	56.75	23806337
139	Ubiquitination	KLLSHGKKPFSQHVR HHHHCCCCCHHHHHH	56.75	-
142	Phosphorylation	SHGKKPFSQHVRRLR HCCCCCHHHHHHHHH	28.09	24899341
150	Phosphorylation	QHVRRLRSSITPGTV HHHHHHHHCCCCCEE	30.59	26824392
151	Phosphorylation	HVRRLRSSITPGTVL HHHHHHHCCCCCEEE	24.85	26239621
153	Phosphorylation	RRLRSSITPGTVLII HHHHHCCCCCEEEEE	20.01	26239621
156	Phosphorylation	RSSITPGTVLIILTG HHCCCCCEEEEEEEC	17.22	26643407
174	Ubiquitination	GKRVVFLKQLDSGLL CEEEEEEEECCCCEE	37.03	-
200	Acetylation	PLRRTHQKFVIATST CCCCCCCEEEEEECC	33.71	22826441
200	Ubiquitination	PLRRTHQKFVIATST CCCCCCCEEEEEECC	33.71	-
208	Ubiquitination	FVIATSTKVDISDVK EEEEECCCCCHHHCC	37.36	22790023
215	Malonylation	KVDISDVKIPKHLTD CCCHHHCCCCHHHHH	59.28	32601280
215	Acetylation	KVDISDVKIPKHLTD CCCHHHCCCCHHHHH	59.28	23806337
215	Succinylation	KVDISDVKIPKHLTD CCCHHHCCCCHHHHH	59.28	23806337
215	Ubiquitination	KVDISDVKIPKHLTD CCCHHHCCCCHHHHH	59.28	-
218	Malonylation	ISDVKIPKHLTDAYF HHHCCCCHHHHHHHH	55.51	32601280
218	Ubiquitination	ISDVKIPKHLTDAYF HHHCCCCHHHHHHHH	55.51	22790023
218	Acetylation	ISDVKIPKHLTDAYF HHHCCCCHHHHHHHH	55.51	22826441
224	Phosphorylation	PKHLTDAYFKKKQLR CHHHHHHHHHHHHCC	20.81	29514104
226	Succinylation	HLTDAYFKKKQLRKP HHHHHHHHHHHCCCC	46.51	23954790
226	Ubiquitination	HLTDAYFKKKQLRKP HHHHHHHHHHHCCCC	46.51	-
226	Acetylation	HLTDAYFKKKQLRKP HHHHHHHHHHHCCCC	46.51	22826441
243	Phosphorylation	QEGEIFDTEKEKYEI CCCCCCCCHHHHEEC	37.90	26525534
245	Acetylation	GEIFDTEKEKYEITE CCCCCCHHHHEECCH	62.69	23864654
245	Ubiquitination	GEIFDTEKEKYEITE CCCCCCHHHHEECCH	62.69	22790023
247	Acetylation	IFDTEKEKYEITEQR CCCCHHHHEECCHHH	60.29	23806337
247	Ubiquitination	IFDTEKEKYEITEQR CCCCHHHHEECCHHH	60.29	-
255	Ubiquitination	YEITEQRKADQKAVD EECCHHHHHHHHHHH	56.88	-
259	Succinylation	EQRKADQKAVDLQIL HHHHHHHHHHHCHHH	51.42	23954790
259	Acetylation	EQRKADQKAVDLQIL HHHHHHHHHHHCHHH	51.42	23864654
259	Ubiquitination	EQRKADQKAVDLQIL HHHHHHHHHHHCHHH	51.42	-
268	Succinylation	VDLQILPKIKAVPQL HHCHHHHHHCCHHHH	54.09	23806337
268	Acetylation	VDLQILPKIKAVPQL HHCHHHHHHCCHHHH	54.09	23806337
270	Ubiquitination	LQILPKIKAVPQLQG CHHHHHHCCHHHHHH	49.83	22790023
281	Phosphorylation	QLQGYLRSQFSLTNG HHHHHHHHHHCCCCC	32.74	29514104
284	Phosphorylation	GYLRSQFSLTNGMYP HHHHHHHCCCCCCCC	27.01	29514104
293	Ubiquitination	TNGMYPHKLVF---- CCCCCCCCCCC----	41.67	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RL6_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RL6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RL6_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RL6_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.