KDM2B_MOUSE - dbPTM
KDM2B_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KDM2B_MOUSE
UniProt AC Q6P1G2
Protein Name Lysine-specific demethylase 2B
Gene Name Kdm2b
Organism Mus musculus (Mouse).
Sequence Length 1309
Subcellular Localization Nucleus, nucleolus.
Protein Description Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex..
Protein Sequence MEAEKDSGRRLRAIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAMEGKDFNYEYVQREALRVPLVFRDKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQRDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNALAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYYEMCWYVLERYVYCVTQRSYLTQEYQRELMLIDAPRKTSVDGFSSDSWLDMEEESCEQQPQEEEEEEEDKEEEGDGADKTPKPPTDDPTSPTSTPPEDQDSTGKKPKAPAIRFLKRTLSNESEESVKSTSMPTDDPKTPTGSPATEVSTKWTHLTEFELKGLKALVEKLESLPENKKCVPEGIEDPQALLEGVKNVLKEHVDDDPTLAITGVPVVSWPKKTAKNRVVGRPKGKLGPASAVKLAANRTTAGARRRRTRCRKCEACLRTECGECHFCKDMKKFGGPGRMKQSCIMRQCIAPVLPHTAVCLVCGEAGKEDTVEEEEGKFNLMLMECSICNEIIHPGCLKIKESEGVVNDELPNCWECPKCNHAGKTGKQKRGPGFKYASNLPGSLLKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHPKKVPADGILRRKSDDVHLRRKRKYEKPQELSGRKRASSLQTSPGSSSHLSPRPPLGSSLSPWWRSSLTYFQQQLKPGKEDKLFRKKRRSWKNAEDRLSLANKPLRRFKQEPEDDLPEAPPKTRESDQSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLVNKELSKELSKELNHEIQKTESTLAHESQQPIKSEPESENDEPKRPLSHCERPHRFSKGLNGTPRELRHSLGPGLRSPPRVMSRPPPSASPPKCIQMERHVIRPPPISPPPDSLPLDDGAAHVMHREVWMAVFSYLSHRDLCVCMRVCRTWNRWCCDKRLWTRIDLNRCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDVSLRLIIRHMPLLSKLQLSYCNHINDQSINLLTAVGTTTRDSLTEVNLSDCNKVTDLCLSFFKRCGNICHIDLRYCKQVTKEGCEQFIAEMSVSVQFGQVEEKLLQKLS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6 (in isoform 2)Phosphorylation-48.0723375375
14 (in isoform 2)Phosphorylation-3.4725266776
19PhosphorylationRAIDRQRYDENEDLS
HHHHHHCCCCCCCCC		21.1923984901
26PhosphorylationYDENEDLSDVEEIVS
CCCCCCCCCHHHHHH		52.5121082442
33PhosphorylationSDVEEIVSVRGFSLE
CCHHHHHHHCCCCHH		16.26-
202PhosphorylationVKKYCLMSVKGCFTD
HHHEEEEECCCCEEE		14.0227357545
408PhosphorylationEGDGADKTPKPPTDD
CCCCCCCCCCCCCCC		36.7729472430
413PhosphorylationDKTPKPPTDDPTSPT
CCCCCCCCCCCCCCC		62.6529550500
417PhosphorylationKPPTDDPTSPTSTPP
CCCCCCCCCCCCCCC		55.0929550500
418PhosphorylationPPTDDPTSPTSTPPE
CCCCCCCCCCCCCCC		31.4125521595
420PhosphorylationTDDPTSPTSTPPEDQ
CCCCCCCCCCCCCCC		45.0329550500
421PhosphorylationDDPTSPTSTPPEDQD
CCCCCCCCCCCCCCC		42.1529550500
422PhosphorylationDPTSPTSTPPEDQDS
CCCCCCCCCCCCCCC		45.3929472430
445PhosphorylationAIRFLKRTLSNESEE
HHHHHHHHCCCCCHH		32.7128833060
447PhosphorylationRFLKRTLSNESEESV
HHHHHHCCCCCHHHH		37.6325521595
450PhosphorylationKRTLSNESEESVKST
HHHCCCCCHHHHHHC		51.4128833060
453PhosphorylationLSNESEESVKSTSMP
CCCCCHHHHHHCCCC		30.6928833060
457PhosphorylationSEESVKSTSMPTDDP
CHHHHHHCCCCCCCC		24.2723375375
461PhosphorylationVKSTSMPTDDPKTPT
HHHCCCCCCCCCCCC		44.3829514104
466PhosphorylationMPTDDPKTPTGSPAT
CCCCCCCCCCCCCCC		31.3223375375
468PhosphorylationTDDPKTPTGSPATEV
CCCCCCCCCCCCCCC		56.3723375375
470PhosphorylationDPKTPTGSPATEVST
CCCCCCCCCCCCCCC		17.5323375375
499PhosphorylationALVEKLESLPENKKC
HHHHHHHCCCCCCCC		60.7128066266
618PhosphorylationGPGRMKQSCIMRQCI
CCCHHHHHHHHHHCC		10.4925159016
712PhosphorylationKRGPGFKYASNLPGS
CCCCCCCCCCCCCHH		17.01-
741PhosphorylationQEPAKRRSECEEAPR
CCCHHHHHHHHHCCC		51.1126824392
751PhosphorylationEEAPRRRSDEHPKKV
HHCCCCCCCCCCCCC		45.6022802335
768PhosphorylationDGILRRKSDDVHLRR
CCHHCCCCCCHHHHH		36.9126824392
823PhosphorylationPWWRSSLTYFQQQLK
HHHHHHHHHHHHHCC		25.0029899451
853PhosphorylationKNAEDRLSLANKPLR
CCHHHHHHHCCHHHH		26.7428066266
857AcetylationDRLSLANKPLRRFKQ
HHHHHCCHHHHHHHC		39.5623806337
883PhosphorylationKTRESDQSRSSSPTA
CCCCCCCCCCCCCCC		38.8421082442
885PhosphorylationRESDQSRSSSPTAGP
CCCCCCCCCCCCCCC		40.1825159016
886PhosphorylationESDQSRSSSPTAGPS
CCCCCCCCCCCCCCC		38.9525159016
887PhosphorylationSDQSRSSSPTAGPST
CCCCCCCCCCCCCCC		27.7626824392
889PhosphorylationQSRSSSPTAGPSTEG
CCCCCCCCCCCCCCC		46.3125159016
893PhosphorylationSSPTAGPSTEGAEGP
CCCCCCCCCCCCCCH		37.8730635358
894PhosphorylationSPTAGPSTEGAEGPE
CCCCCCCCCCCCCHH		41.3930635358
920PhosphorylationRLVNKELSKELSKEL
HHHCHHHHHHHHHHH		25.7729176673
924PhosphorylationKELSKELSKELNHEI
HHHHHHHHHHHHHHH		25.77-
934PhosphorylationLNHEIQKTESTLAHE
HHHHHHHHHHHHHHH		20.8425159016
936PhosphorylationHEIQKTESTLAHESQ
HHHHHHHHHHHHHCC		33.6725159016
937PhosphorylationEIQKTESTLAHESQQ
HHHHHHHHHHHHCCC		23.0225159016
948PhosphorylationESQQPIKSEPESEND
HCCCCCCCCCCCCCC		60.1327087446
952PhosphorylationPIKSEPESENDEPKR
CCCCCCCCCCCCCCC		53.0327087446
984PhosphorylationTPRELRHSLGPGLRS
CHHHHHHCCCCCCCC		28.7025159016
991PhosphorylationSLGPGLRSPPRVMSR
CCCCCCCCCCCCCCC		44.2826824392
997PhosphorylationRSPPRVMSRPPPSAS
CCCCCCCCCCCCCCC		38.4925159016
1002PhosphorylationVMSRPPPSASPPKCI
CCCCCCCCCCCCCCE		47.3423684622
1004PhosphorylationSRPPPSASPPKCIQM
CCCCCCCCCCCCEEE		46.1826824392
1022PhosphorylationVIRPPPISPPPDSLP
ECCCCCCCCCCCCCC		36.8126824392
1087PhosphorylationLNRCKSITPLMLSGI
HHHCCCCCHHHHHCH		19.9122871156
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KDM2B_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KDM2B_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KDM2B_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BCOR_MOUSEBcorphysical
17296600
RING2_MOUSERnf2physical
17296600
CSK21_MOUSECsnk2a1physical
17296600
HSP7C_MOUSEHspa8physical
17296600
SKP1_MOUSESkp1aphysical
17296600
RBBP4_MOUSERbbp4physical
17296600
CBX8_MOUSECbx8physical
17296600
PCGF1_MOUSEPcgf1physical
17296600
RING1_MOUSERing1physical
17296600
CSK22_MOUSECsnk2a2physical
17296600
WDR5_MOUSEWdr5physical
17296600
BMI1_MOUSEBmi1physical
17296600
YAF2_MOUSEYaf2physical
17296600
CTBP1_MOUSECtbp1physical
17296600
CTBP2_MOUSECtbp2physical
17296600
KDM1A_MOUSEKdm1aphysical
17296600
RING2_MOUSERnf2physical
23395003
PCGF1_MOUSEPcgf1physical
23395003
RYBP_MOUSERybpphysical
23395003
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KDM2B_MOUSE

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Related Literatures of Post-Translational Modification

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