CTBP2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CTBP2_MOUSE
• UniProt AC: P56546
• Protein Name: C-terminal-binding protein 2
• Gene Name: Ctbp2
• Organism: Mus musculus (Mouse).
• Sequence Length: 445
• Subcellular Localization: Nucleus . Cell junction, synapse.
• Protein Description: Corepressor targeting diverse transcription regulators. Isoform 2 probably acts as a scaffold for specialized synapses (By similarity). Functions in brown adipose tissue (BAT) differentiation..
• Protein Sequence: MALVDKHKVKRQRLDRICEGIRPQIMNGPLHPRPLVALLDGRDCTVEMPILKDLATVAFCDAQSTQEIHEKVLNEAVGAMMYHTITLTREDLEKFKALRVIVRIGSGYDNVDIKAAGELGIAVCNIPSAAVEETADSTVCHILNLYRRNTWLYQALREGTRVQSVEQIREVASGAARIRGETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIERSLGVQRVYTLQDLLYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKALAQALKEGRIRGAALDVHESEPFSFAQGPLKDAPNLICTPHTAWYSEQASLEMREAAATEIRRAITGRIPESLRNCVNKEFFVTSAPWSVIDQQAIHPELNGATYRYPPGIVGVAPGGLPPAMEGIIPGGIPVTHNLPTVAHPSQAPSPNQPTKHGDNREHPNEQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Asymmetric dimethylarginine	DRICEGIRPQIMNGP HHHHHCCCHHHHCCC	28.11	-
22	Methylation	DRICEGIRPQIMNGP HHHHHCCCHHHHCCC	28.11	24129315
44	S-nitrosylation	ALLDGRDCTVEMPIL EEECCCCCEEECCHH	4.41	20925432
44	S-nitrosocysteine	ALLDGRDCTVEMPIL EEECCCCCEEECCHH	4.41	-
164	Phosphorylation	REGTRVQSVEQIREV HCCCCCCCHHHHHHH	25.43	-
279	Ubiquitination	RGGLVDEKALAQALK CCCCCCHHHHHHHHH	44.21	-
286	Ubiquitination	KALAQALKEGRIRGA HHHHHHHHHCCCCCE	62.23	-
364	Phosphorylation	VNKEFFVTSAPWSVI CCCCCEEECCCCCEE	17.64	23649490
365	Phosphorylation	NKEFFVTSAPWSVID CCCCEEECCCCCEEC	27.34	26239621
369	Phosphorylation	FVTSAPWSVIDQQAI EEECCCCCEECHHHC	14.24	23649490
387	Phosphorylation	LNGATYRYPPGIVGV HCCCEEECCCCEEEE	11.90	25777480
414	Phosphorylation	IPGGIPVTHNLPTVA CCCCCCCCCCCCCCC	10.33	25159016
419	Phosphorylation	PVTHNLPTVAHPSQA CCCCCCCCCCCCCCC	33.23	25159016
424	Phosphorylation	LPTVAHPSQAPSPNQ CCCCCCCCCCCCCCC	29.16	25159016
428	Phosphorylation	AHPSQAPSPNQPTKH CCCCCCCCCCCCCCC	39.23	22942356
433	Phosphorylation	APSPNQPTKHGDNRE CCCCCCCCCCCCCCC	26.38	25159016
559 (in isoform 2)	Phosphorylation	-		21454597
563 (in isoform 2)	Phosphorylation	-		21454597

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
428	S	Phosphorylation	Kinase	HIPK2	Q9QZR5	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
428	S	Phosphorylation	Phosphorylation by HIPK2 on Ser-428 induces proteasomal degradation.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CTBP2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CTBP2_MOUSE	Ctbp2	physical	16940173
KLF3_MOUSE	Klf3	physical	16940173
UBC9_MOUSE	Ube2i	physical	16940173
FHL3_MOUSE	Fhl3	physical	16940173
HIPK1_MOUSE	Hipk1	physical	16940173
HIPK2_MOUSE	Hipk2	physical	16940173
TRPS1_HUMAN	TRPS1	physical	16940173
PRD16_HUMAN	PRDM16	physical	21516122
FOG1_MOUSE	Zfpm1	physical	11940669

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.