dbPTM

TRPS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TRPS1_HUMAN
UniProt AC	Q9UHF7
Protein Name	Zinc finger transcription factor Trps1
Gene Name	TRPS1
Organism	Homo sapiens (Human).
Sequence Length	1281
Subcellular Localization	Nucleus .
Protein Description	Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes..
Protein Sequence	MVRKKNPPLRNVASEGEGQILEPIGTESKVSGKNKEFSADQMSENTDQSDAAELNHKEEHSLHVQDPSSSSKKDLKSAVLSEKAGFNYESPSKGGNFPSFPHDEVTDRNMLAFSSPAAGGVCEPLKSPQRAEADDPQDMACTPSGDSLETKEDQKMSPKATEETGQAQSGQANCQGLSPVSVASKNPQVPSDGGVRLNKSKTDLLVNDNPDPAPLSPELQDFKCNICGYGYYGNDPTDLIKHFRKYHLGLHNRTRQDAELDSKILALHNMVQFSHSKDFQKVNRSVFSGVLQDINSSRPVLLNGTYDVQVTSGGTFIGIGRKTPDCQGNTKYFRCKFCNFTYMGNSSTELEQHFLQTHPNKIKASLPSSEVAKPSEKNSNKSIPALQSSDSGDLGKWQDKITVKAGDDTPVGYSVPIKPLDSSRQNGTEATSYYWCKFCSFSCESSSSLKLLEHYGKQHGAVQSGGLNPELNDKLSRGSVINQNDLAKSSEGETMTKTDKSSSGAKKKDFSSKGAEDNMVTSYNCQFCDFRYSKSHGPDVIVVGPLLRHYQQLHNIHKCTIKHCPFCPRGLCSPEKHLGEITYPFACRKSNCSHCALLLLHLSPGAAGSSRVKHQCHQCSFTTPDVDVLLFHYESVHESQASDVKQEANHLQGSDGQQSVKESKEHSCTKCDFITQVEEEISRHYRRAHSCYKCRQCSFTAADTQSLLEHFNTVHCQEQDITTANGEEDGHAISTIKEEPKIDFRVYNLLTPDSKMGEPVSESVVKREKLEEKDGLKEKVWTESSSDDLRNVTWRGADILRGSPSYTQASLGLLTPVSGTQEQTKTLRDSPNVEAAHLARPIYGLAVETKGFLQGAPAGGEKSGALPQQYPASGENKSKDESQSLLRRRRGSGVFCANCLTTKTSLWRKNANGGYVCNACGLYQKLHSTPRPLNIIKQNNGEQIIRRRTRKRLNPEALQAEQLNKQQRGSNEEQVNGSPLERRSEDHLTESHQREIPLPSLSKYEAQGSLTKSHSAQQPVLVSQTLDIHKRMQPLHIQIKSPQESTGDPGNSSSVSEGKGSSERGSPIEKYMRPAKHPNYSPPGSPIEKYQYPLFGLPFVHNDFQSEADWLRFWSKYKLSVPGNPHYLSHVPGLPNPCQNYVPYPTFNLPPHFSAVGSDNDIPLDLAIKHSRPGPTANGASKEKTKAPPNVKNEGPLNVVKTEKVDRSTQDELSTKCVHCGIVFLDEVMYALHMSCHGDSGPFQCSICQHLCTDKYDFTTHIQRGLHRNNAQVEKNGKPKE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	PPLRNVASEGEGQIL CCCCCCCCCCCCCEE	41.68	28555341
27	Phosphorylation	ILEPIGTESKVSGKN EEECCCCCCCCCCCC	43.26	24719451
29	Sumoylation	EPIGTESKVSGKNKE ECCCCCCCCCCCCCC	33.90	28112733
29	Ubiquitination	EPIGTESKVSGKNKE ECCCCCCCCCCCCCC	33.90	32015554
33	Ubiquitination	TESKVSGKNKEFSAD CCCCCCCCCCCCCHH	58.29	32015554
35	Acetylation	SKVSGKNKEFSADQM CCCCCCCCCCCHHHH	64.72	26051181
35	Ubiquitination	SKVSGKNKEFSADQM CCCCCCCCCCCHHHH	64.72	32015554
42	Ubiquitination	KEFSADQMSENTDQS CCCCHHHHCCCCCHH	5.81	32015554
61	Phosphorylation	LNHKEEHSLHVQDPS HCHHHHHCCCCCCCC	24.37	25849741
68	Phosphorylation	SLHVQDPSSSSKKDL CCCCCCCCCCCHHHH	51.66	25159151
69	Phosphorylation	LHVQDPSSSSKKDLK CCCCCCCCCCHHHHH	43.98	25159151
70	Phosphorylation	HVQDPSSSSKKDLKS CCCCCCCCCHHHHHH	50.98	28555341
71	Phosphorylation	VQDPSSSSKKDLKSA CCCCCCCCHHHHHHH	45.75	28555341
76	Sumoylation	SSSKKDLKSAVLSEK CCCHHHHHHHHHHHH	46.64	28112733
77	Phosphorylation	SSKKDLKSAVLSEKA CCHHHHHHHHHHHHC	30.79	24719451
82	Phosphorylation	LKSAVLSEKAGFNYE HHHHHHHHHCCCCCC	42.64	27251275
88	Phosphorylation	SEKAGFNYESPSKGG HHHCCCCCCCCCCCC	18.60	29396449
90	Phosphorylation	KAGFNYESPSKGGNF HCCCCCCCCCCCCCC	24.90	23401153
92	Phosphorylation	GFNYESPSKGGNFPS CCCCCCCCCCCCCCC	53.89	30266825
99	Phosphorylation	SKGGNFPSFPHDEVT CCCCCCCCCCCCCCC	47.47	19276368
103	Phosphorylation	NFPSFPHDEVTDRNM CCCCCCCCCCCCCCC	52.91	24719451
105	Phosphorylation	PSFPHDEVTDRNMLA CCCCCCCCCCCCCEE	9.33	-
112	Phosphorylation	VTDRNMLAFSSPAAG CCCCCCEEECCCCCC	7.48	-
114	Phosphorylation	DRNMLAFSSPAAGGV CCCCEEECCCCCCCC	29.79	30108239
115	Phosphorylation	RNMLAFSSPAAGGVC CCCEEECCCCCCCCC	16.47	30278072
127	Phosphorylation	GVCEPLKSPQRAEAD CCCCCCCCCCCCCCC	33.67	30278072
128	Phosphorylation	VCEPLKSPQRAEADD CCCCCCCCCCCCCCC	26.53	24719451
140	Phosphorylation	ADDPQDMACTPSGDS CCCCCCCCCCCCCCC	11.43	24719451
142	Phosphorylation	DPQDMACTPSGDSLE CCCCCCCCCCCCCCC	15.79	25849741
144	Phosphorylation	QDMACTPSGDSLETK CCCCCCCCCCCCCCC	36.76	28857561
147	Phosphorylation	ACTPSGDSLETKEDQ CCCCCCCCCCCCCCC	31.46	22210691
150	Phosphorylation	PSGDSLETKEDQKMS CCCCCCCCCCCCCCC	45.05	28857561
155	Phosphorylation	LETKEDQKMSPKATE CCCCCCCCCCCHHCH	54.38	24719451
157	Phosphorylation	TKEDQKMSPKATEET CCCCCCCCCHHCHHH	30.22	30278072
159	"N6,N6-dimethyllysine"	EDQKMSPKATEETGQ CCCCCCCHHCHHHCC	61.71	-
159	Methylation	EDQKMSPKATEETGQ CCCCCCCHHCHHHCC	61.71	-
160	Phosphorylation	DQKMSPKATEETGQA CCCCCCHHCHHHCCC	24.51	27251275
164	Phosphorylation	SPKATEETGQAQSGQ CCHHCHHHCCCCCCC	28.50	27251275
169	Phosphorylation	EETGQAQSGQANCQG HHHCCCCCCCCCCCC	35.57	30266825
170	Phosphorylation	ETGQAQSGQANCQGL HHCCCCCCCCCCCCC	20.66	24719451
178	Phosphorylation	QANCQGLSPVSVASK CCCCCCCCCCCCCCC	30.04	30266825
181	Phosphorylation	CQGLSPVSVASKNPQ CCCCCCCCCCCCCCC	18.49	30266825
182	Phosphorylation	QGLSPVSVASKNPQV CCCCCCCCCCCCCCC	7.69	33259812
184	Phosphorylation	LSPVSVASKNPQVPS CCCCCCCCCCCCCCC	30.70	30266825
191	Phosphorylation	SKNPQVPSDGGVRLN CCCCCCCCCCCCCCC	50.46	33259812
197	Phosphorylation	PSDGGVRLNKSKTDL CCCCCCCCCCCCCCE	9.82	19413330
200	Phosphorylation	GGVRLNKSKTDLLVN CCCCCCCCCCCEECC	39.45	30278072
202	Phosphorylation	VRLNKSKTDLLVNDN CCCCCCCCCEECCCC	38.68	21712546
213	Phosphorylation	VNDNPDPAPLSPELQ CCCCCCCCCCCHHHC	25.66	27251275
215	Phosphorylation	DNPDPAPLSPELQDF CCCCCCCCCHHHCCC	16.91	24719451
216	Phosphorylation	NPDPAPLSPELQDFK CCCCCCCCHHHCCCC	18.44	23401153
229	Phosphorylation	FKCNICGYGYYGNDP CCCCCCCCCCCCCCH	9.50	20068231
242	Phosphorylation	DPTDLIKHFRKYHLG CHHHHHHHHHHHHCC	22.28	18452278
262	Phosphorylation	RQDAELDSKILALHN HHHHHHHHHHHHHHH	33.93	23403867
263	Sumoylation	QDAELDSKILALHNM HHHHHHHHHHHHHHH	41.21	28112733
274	Phosphorylation	LHNMVQFSHSKDFQK HHHHHHHCCCCCHHH	15.12	22468782
276	Phosphorylation	NMVQFSHSKDFQKVN HHHHHCCCCCHHHHC	32.49	28348404
289	Phosphorylation	VNRSVFSGVLQDINS HCHHHHHHHHCCCCC	16.82	27251275
365	Phosphorylation	HPNKIKASLPSSEVA CCCCHHCCCCHHHCC	35.49	25072903
368	Phosphorylation	KIKASLPSSEVAKPS CHHCCCCHHHCCCCC	44.41	29255136
369	Phosphorylation	IKASLPSSEVAKPSE HHCCCCHHHCCCCCC	33.86	29255136
373	Acetylation	LPSSEVAKPSEKNSN CCHHHCCCCCCCCCC	55.01	26051181
375	Phosphorylation	SSEVAKPSEKNSNKS HHHCCCCCCCCCCCC	61.57	29255136
379	Phosphorylation	AKPSEKNSNKSIPAL CCCCCCCCCCCCCCH	57.62	29978859
382	Phosphorylation	SEKNSNKSIPALQSS CCCCCCCCCCCHHCC	37.75	29978859
388	Phosphorylation	KSIPALQSSDSGDLG CCCCCHHCCCCCCCC	36.64	29978859
389	Phosphorylation	SIPALQSSDSGDLGK CCCCHHCCCCCCCCC	23.88	30278072
391	Phosphorylation	PALQSSDSGDLGKWQ CCHHCCCCCCCCCCC	35.83	25159151
401	Phosphorylation	LGKWQDKITVKAGDD CCCCCCEEEEEECCC	7.82	27251275
404	Phosphorylation	WQDKITVKAGDDTPV CCCEEEEEECCCCCC	37.69	24719451
404	Ubiquitination	WQDKITVKAGDDTPV CCCEEEEEECCCCCC	37.69	-
413	Phosphorylation	GDDTPVGYSVPIKPL CCCCCCCEEEECCCC	13.51	30576142
414	Phosphorylation	DDTPVGYSVPIKPLD CCCCCCEEEECCCCC	18.58	30576142
418	Sumoylation	VGYSVPIKPLDSSRQ CCEEEECCCCCCCCC	33.20	28112733
418	Ubiquitination	VGYSVPIKPLDSSRQ CCEEEECCCCCCCCC	33.20	-
423	Phosphorylation	PIKPLDSSRQNGTEA ECCCCCCCCCCCCCC	37.24	30576142
440	Phosphorylation	YYWCKFCSFSCESSS EEEEECCCCCCCCHH	24.27	28348404
457	Sumoylation	KLLEHYGKQHGAVQS HHHHHHHHHCCCHHC	31.77	28112733
474	Acetylation	LNPELNDKLSRGSVI CCHHHCCHHHCCCCC	47.49	26051181
474	Sumoylation	LNPELNDKLSRGSVI CCHHHCCHHHCCCCC	47.49	28112733
476	Phosphorylation	PELNDKLSRGSVINQ HHHCCHHHCCCCCCH	40.09	28348404
479	Phosphorylation	NDKLSRGSVINQNDL CCHHHCCCCCCHHHH	20.79	28348404
488	Sumoylation	INQNDLAKSSEGETM CCHHHHHHCCCCCCC	62.91	28112733
489	Phosphorylation	NQNDLAKSSEGETMT CHHHHHHCCCCCCCC	28.19	28348404
492	Phosphorylation	DLAKSSEGETMTKTD HHHHCCCCCCCCCCC	37.31	27251275
573	Phosphorylation	FCPRGLCSPEKHLGE CCCCCCCCCCCCCCC	40.93	21712546
586	Phosphorylation	GEITYPFACRKSNCS CCCCCCCCCCCCCCC	6.41	24719451
603	Phosphorylation	ALLLLHLSPGAAGSS HHHHHHCCCCCCCCH	15.56	25849741
616	Phosphorylation	SSRVKHQCHQCSFTT CHHHHHCCCCCCCCC	2.09	24719451
635	Phosphorylation	VLLFHYESVHESQAS EEEEEECCCCHHHHH	22.93	22468782
645	Sumoylation	ESQASDVKQEANHLQ HHHHHHHHHHHHHHC	47.62	28112733
654	Phosphorylation	EANHLQGSDGQQSVK HHHHHCCCCCCHHHH	26.13	22468782
659	Phosphorylation	QGSDGQQSVKESKEH CCCCCCHHHHHHHHC	27.54	22468782
667	Phosphorylation	VKESKEHSCTKCDFI HHHHHHCCCCCCCHH	25.27	27251275
682	Phosphorylation	TQVEEEISRHYRRAH HHHHHHHHHHHHHHH	19.11	27251275
695	Phosphorylation	AHSCYKCRQCSFTAA HHHCHHCCCCCCCHH	36.07	27251275
737	Sumoylation	GHAISTIKEEPKIDF CCCCCCCCCCCCCCE	56.99	28112733
751	Phosphorylation	FRVYNLLTPDSKMGE EEEEECCCCCCCCCC	28.37	30266825
754	Phosphorylation	YNLLTPDSKMGEPVS EECCCCCCCCCCCCC	26.24	30266825
755	Sumoylation	NLLTPDSKMGEPVSE ECCCCCCCCCCCCCH	59.30	28112733
761	Phosphorylation	SKMGEPVSESVVKRE CCCCCCCCHHHHCHH	34.56	24719451
763	Phosphorylation	MGEPVSESVVKREKL CCCCCCHHHHCHHHH	25.38	21712546
764	Phosphorylation	GEPVSESVVKREKLE CCCCCHHHHCHHHHH	5.30	24719451
766	Sumoylation	PVSESVVKREKLEEK CCCHHHHCHHHHHCC	53.32	-
766	Sumoylation	PVSESVVKREKLEEK CCCHHHHCHHHHHCC	53.32	25114211
774	Phosphorylation	REKLEEKDGLKEKVW HHHHHCCCCCCCCEE	71.57	24719451
779	Sumoylation	EKDGLKEKVWTESSS CCCCCCCCEECCCCC	41.29	-
784	Phosphorylation	KEKVWTESSSDDLRN CCCEECCCCCHHHHC	27.97	28348404
785	Phosphorylation	EKVWTESSSDDLRNV CCEECCCCCHHHHCC	31.39	28348404
786	Phosphorylation	KVWTESSSDDLRNVT CEECCCCCHHHHCCH	44.41	28102081
799	Phosphorylation	VTWRGADILRGSPSY CHHCCHHHHCCCCCC	2.54	24719451
803	Phosphorylation	GADILRGSPSYTQAS CHHHHCCCCCCCCCC	12.30	30266825
805	Phosphorylation	DILRGSPSYTQASLG HHHCCCCCCCCCCCC	42.37	30266825
806	Phosphorylation	ILRGSPSYTQASLGL HHCCCCCCCCCCCCC	13.27	30266825
807	Phosphorylation	LRGSPSYTQASLGLL HCCCCCCCCCCCCCE	23.23	30266825
810	Phosphorylation	SPSYTQASLGLLTPV CCCCCCCCCCCEECC	17.10	30266825
815	Phosphorylation	QASLGLLTPVSGTQE CCCCCCEECCCCCHH	27.04	30278072
816	Phosphorylation	ASLGLLTPVSGTQEQ CCCCCEECCCCCHHH	20.46	24719451
818	Phosphorylation	LGLLTPVSGTQEQTK CCCEECCCCCHHHHC	37.01	22199227
819	Phosphorylation	GLLTPVSGTQEQTKT CCEECCCCCHHHHCC	31.48	24719451
820	Phosphorylation	LLTPVSGTQEQTKTL CEECCCCCHHHHCCC	22.79	22199227
824	Phosphorylation	VSGTQEQTKTLRDSP CCCCHHHHCCCCCCC	25.83	27080861
825	Sumoylation	SGTQEQTKTLRDSPN CCCHHHHCCCCCCCC	45.30	28112733
826	Phosphorylation	GTQEQTKTLRDSPNV CCHHHHCCCCCCCCH	30.34	30266825
828	Phosphorylation	QEQTKTLRDSPNVEA HHHHCCCCCCCCHHH	47.82	24719451
830	Phosphorylation	QTKTLRDSPNVEAAH HHCCCCCCCCHHHHH	16.37	30266825
831	Phosphorylation	TKTLRDSPNVEAAHL HCCCCCCCCHHHHHH	53.85	-
834	Phosphorylation	LRDSPNVEAAHLARP CCCCCCHHHHHHHHC	46.94	32142685
836	Phosphorylation	DSPNVEAAHLARPIY CCCCHHHHHHHHCHH	5.68	32142685
839	Phosphorylation	NVEAAHLARPIYGLA CHHHHHHHHCHHEEE	12.82	-
843	Phosphorylation	AHLARPIYGLAVETK HHHHHCHHEEEEEEC	14.58	23927012
850	Sumoylation	YGLAVETKGFLQGAP HEEEEEECCCCCCCC	33.87	-
850	Sumoylation	YGLAVETKGFLQGAP HEEEEEECCCCCCCC	33.87	28112733
856	Phosphorylation	TKGFLQGAPAGGEKS ECCCCCCCCCCCCCC	4.27	27642862
863	Sumoylation	APAGGEKSGALPQQY CCCCCCCCCCCCCCC	25.62	-
873	Phosphorylation	LPQQYPASGENKSKD CCCCCCCCCCCCCHH	41.98	25159151
877	Sumoylation	YPASGENKSKDESQS CCCCCCCCCHHHHHH	55.36	28112733
879	Sumoylation	ASGENKSKDESQSLL CCCCCCCHHHHHHHH	68.10	28112733
884	Phosphorylation	KSKDESQSLLRRRRG CCHHHHHHHHHHHCC	38.35	24719451
886	Phosphorylation	KDESQSLLRRRRGSG HHHHHHHHHHHCCCC	4.92	-
892	Phosphorylation	LLRRRRGSGVFCANC HHHHHCCCCCCCCCC	29.94	25463755
896	Phosphorylation	RRGSGVFCANCLTTK HCCCCCCCCCCCCCC	2.18	32645325
898	Phosphorylation	GSGVFCANCLTTKTS CCCCCCCCCCCCCCC	23.63	32645325
901	Phosphorylation	VFCANCLTTKTSLWR CCCCCCCCCCCCCEE	28.57	27486199
902	Phosphorylation	FCANCLTTKTSLWRK CCCCCCCCCCCCEEC	21.26	27486199
905	Phosphorylation	NCLTTKTSLWRKNAN CCCCCCCCCEECCCC	27.73	17081983
925	Sumoylation	NACGLYQKLHSTPRP CHHHHHHHHCCCCCC	34.31	28112733
928	Phosphorylation	GLYQKLHSTPRPLNI HHHHHHCCCCCCCCH	51.01	25159151
929	Phosphorylation	LYQKLHSTPRPLNII HHHHHCCCCCCCCHH	16.75	25159151
937	Sumoylation	PRPLNIIKQNNGEQI CCCCCHHCCCCHHHH	43.08	28112733
941	Phosphorylation	NIIKQNNGEQIIRRR CHHCCCCHHHHHHHH	35.42	24719451
942	Phosphorylation	IIKQNNGEQIIRRRT HHCCCCHHHHHHHHH	40.50	27251275
965	Sumoylation	LQAEQLNKQQRGSNE HHHHHHHHHHCCCCH	57.30	28112733
970	Phosphorylation	LNKQQRGSNEEQVNG HHHHHCCCCHHHCCC	43.17	23927012
978	Phosphorylation	NEEQVNGSPLERRSE CHHHCCCCCCHHHCC	22.55	30278072
983	Phosphorylation	NGSPLERRSEDHLTE CCCCCHHHCCCCCCH	34.71	27251275
984	Phosphorylation	GSPLERRSEDHLTES CCCCHHHCCCCCCHH	54.30	24719451
991	Phosphorylation	SEDHLTESHQREIPL CCCCCCHHHCCCCCC	21.49	24719451
997	Phosphorylation	ESHQREIPLPSLSKY HHHCCCCCCCCCCHH	33.20	24719451
1003	Sumoylation	IPLPSLSKYEAQGSL CCCCCCCHHHCCCCC	53.02	-
1003	Sumoylation	IPLPSLSKYEAQGSL CCCCCCCHHHCCCCC	53.02	28112733
1009	Phosphorylation	SKYEAQGSLTKSHSA CHHHCCCCCCCCCCC	22.30	25159151
1011	Phosphorylation	YEAQGSLTKSHSAQQ HHCCCCCCCCCCCCC	32.00	25627689
1012	Sumoylation	EAQGSLTKSHSAQQP HCCCCCCCCCCCCCC	52.01	28112733
1013	Phosphorylation	AQGSLTKSHSAQQPV CCCCCCCCCCCCCCE	19.89	22115753
1015	Phosphorylation	GSLTKSHSAQQPVLV CCCCCCCCCCCCEEE	34.56	28348404
1016	Sumoylation	SLTKSHSAQQPVLVS CCCCCCCCCCCEEEE	13.45	-
1022	Phosphorylation	SAQQPVLVSQTLDIH CCCCCEEEEEEECHH	3.97	24719451
1025	Phosphorylation	QPVLVSQTLDIHKRM CCEEEEEEECHHHHC	20.92	28555341
1026	Phosphorylation	PVLVSQTLDIHKRMQ CEEEEEEECHHHHCC	4.52	24719451
1028	Phosphorylation	LVSQTLDIHKRMQPL EEEEEECHHHHCCCE	4.67	27251275
1030	Sumoylation	SQTLDIHKRMQPLHI EEEECHHHHCCCEEE	50.31	28112733
1040	Sumoylation	QPLHIQIKSPQESTG CCEEEEECCCCCCCC	39.44	28112733
1041	Phosphorylation	PLHIQIKSPQESTGD CEEEEECCCCCCCCC	33.18	30278072
1045	Phosphorylation	QIKSPQESTGDPGNS EECCCCCCCCCCCCC	32.23	30576142
1046	Phosphorylation	IKSPQESTGDPGNSS ECCCCCCCCCCCCCC	44.87	23532336
1052	Phosphorylation	STGDPGNSSSVSEGK CCCCCCCCCCCCCCC	29.88	23186163
1053	Phosphorylation	TGDPGNSSSVSEGKG CCCCCCCCCCCCCCC	38.47	28450419
1054	Phosphorylation	GDPGNSSSVSEGKGS CCCCCCCCCCCCCCC	29.50	28450419
1056	Phosphorylation	PGNSSSVSEGKGSSE CCCCCCCCCCCCCCC	42.45	25849741
1061	Phosphorylation	SVSEGKGSSERGSPI CCCCCCCCCCCCCCH	32.29	26055452
1062	Phosphorylation	VSEGKGSSERGSPIE CCCCCCCCCCCCCHH	39.73	26055452
1066	Phosphorylation	KGSSERGSPIEKYMR CCCCCCCCCHHHHCC	29.00	28355574
1069	Phosphorylation	SERGSPIEKYMRPAK CCCCCCHHHHCCCCC	41.33	27251275
1070	Sumoylation	ERGSPIEKYMRPAKH CCCCCHHHHCCCCCC	45.10	28112733
1074	Phosphorylation	PIEKYMRPAKHPNYS CHHHHCCCCCCCCCC	29.18	24719451
1075	Phosphorylation	IEKYMRPAKHPNYSP HHHHCCCCCCCCCCC	16.66	24719451
1079	Phosphorylation	MRPAKHPNYSPPGSP CCCCCCCCCCCCCCC	50.03	24719451
1080	Phosphorylation	RPAKHPNYSPPGSPI CCCCCCCCCCCCCCC	27.31	30266825
1081	Phosphorylation	PAKHPNYSPPGSPIE CCCCCCCCCCCCCCC	31.12	23401153
1085	Phosphorylation	PNYSPPGSPIEKYQY CCCCCCCCCCCCCCC	28.60	23927012
1093	Phosphorylation	PIEKYQYPLFGLPFV CCCCCCCCCCCCCCC	12.99	17081983
1094	Phosphorylation	IEKYQYPLFGLPFVH CCCCCCCCCCCCCCC	4.53	17081983
1098	Phosphorylation	QYPLFGLPFVHNDFQ CCCCCCCCCCCCCCC	29.59	17081983
1192	Sumoylation	TKAPPNVKNEGPLNV CCCCCCCCCCCCCCE	56.79	-
1192	Sumoylation	TKAPPNVKNEGPLNV CCCCCCCCCCCCCCE	56.79	17391059
1201	Sumoylation	EGPLNVVKTEKVDRS CCCCCEEEEEECCCC	46.84	-
1201	Sumoylation	EGPLNVVKTEKVDRS CCCCCEEEEEECCCC	46.84	25114211
1202	Phosphorylation	GPLNVVKTEKVDRST CCCCEEEEEECCCCC	29.45	-
1205	Sumoylation	NVVKTEKVDRSTQDE CEEEEEECCCCCHHH	6.35	-
1208	Phosphorylation	KTEKVDRSTQDELST EEEECCCCCHHHHHH	26.42	-
1209	Phosphorylation	TEKVDRSTQDELSTK EEECCCCCHHHHHHC	40.72	-
1214	Phosphorylation	RSTQDELSTKCVHCG CCCHHHHHHCCCCCC	24.63	-
1214	Sumoylation	RSTQDELSTKCVHCG CCCHHHHHHCCCCCC	24.63	-
1215	Phosphorylation	STQDELSTKCVHCGI CCHHHHHHCCCCCCE	40.88	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TRPS1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
1201	K	Sumoylation		17391059
Sumoylation on Lys-1201 is the major site.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TRPS1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
UBC9_HUMAN	UBE2I	physical	17391059
SUMO1_HUMAN	SUMO1	physical	17391059

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
190350	Tricho-rhino-phalangeal syndrome 1 (TRPS1)
150230	Tricho-rhino-phalangeal syndrome 2 (TRPS2)
190351	Tricho-rhino-phalangeal syndrome 3 (TRPS3)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TRPS1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-157; SER-178; SER-184;SER-978 AND SER-1066, AND MASS SPECTROMETRY.	19413330 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127; SER-892; SER-1081AND SER-1085, AND MASS SPECTROMETRY.	17081983 [Abstract]
Sumoylation
Reference	PubMed
"SUMOylation modulates transcriptional repression by TRPS1."; Kaiser F.J., Ludecke H.J., Weger S.; Biol. Chem. 388:381-390(2007). Cited for: SUMOYLATION AT LYS-1192 AND LYS-1201, FUNCTION, AND MUTAGENESIS OFLYS-1192 AND LYS-1201.	17391059 [Abstract]

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