PRD16_HUMAN - dbPTM
PRD16_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PRD16_HUMAN
UniProt AC Q9HAZ2
Protein Name PR domain zinc finger protein 16 {ECO:0000305}
Gene Name PRDM16 {ECO:0000312|HGNC:HGNC:14000}
Organism Homo sapiens (Human).
Sequence Length 1276
Subcellular Localization Nucleus .
Protein Description Binds DNA and functions as a transcriptional regulator. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells. Functions also as a repressor of TGF-beta signaling. Isoform 4 may regulate granulocytes differentiation..
Protein Sequence MRSKARARKLAKSDGDVVNNMYEPNRDLLASHSAEDEAEDSAMSPIPVGPPSPFPTSEDFTPKEGSPYEAPVYIPEDIPIPADFELRESSIPGAGLGVWAKRKMEAGERLGPCVVVPRAAAKETDFGWEQILTDVEVSPQEGCITKISEDLGSEKFCVDANQAGAGSWLKYIRVACSCDDQNLTMCQISEQIYYKVIKDIEPGEELLVHVKEGVYPLGTVPPGLDEEPTFRCDECDELFQSKLDLRRHKKYTCGSVGAALYEGLAEELKPEGLGGGSGQAHECKDCERMFPNKYSLEQHMVIHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKRFECENCVKVFTDPSNLQRHIRSQHVGARAHACPDCGKTFATSSGLKQHKHIHSTVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHYTPGGIFAPGLPLTPSPMMDKAKPSPSLNHASLGFNEYFPSRPHPGSLPFSTAPPTFPALTPGFPGIFPPSLYPRPPLLPPTSLLKSPLNHTQDAKLPSPLGNPALPLVSAVSNSSQGTTAAAGPEEKFESRLEDSCVEKLKTRSSDMSDGSDFEDVNTTTGTDLDTTTGTGSDLDSDVDSDPDKDKGKGKSAEGQPKFGGGLAPPGAPNSVAEVPVFYSQHSFFPPPDEQLLTATGAAGDSIKAIASIAEKYFGPGFMGMQEKKLGSLPYHSAFPFQFLPNFPHSLYPFTDRALAHNLLVKAEPKSPRDALKVGGPSAECPFDLTTKPKDVKPILPMPKGPSAPASGEEQPLDLSIGSRARASQNGGGREPRKNHVYGERKLGAGEGLPQVCPARMPQQPPLHYAKPSPFFMDPIYSRVEKRKVTDPVGALKEKYLRPSPLLFHPQMSAIETMTEKLESFAAMKADSGSSLQPLPHHPFNFRSPPPTLSDPILRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKEKPFKCHLCNRCFGQQTNLDRHLKKHEHENAPVSQHPGVLTNHLGTSASSPTSESDNHALLDEKEDSYFSEIRNFIANSEMNQASTRTEKRADMQIVDGSAQCPGLASEKQEDVEEEDDDDLEEDDEDSLAGKSQDDTVSPAPEPQAAYEDEEDEEPAASLAVGFDHTRRCAEDHEGGLLALEPMPTFGKGLDLRRAAEEAFEVKDVLNSTLDSEALKHTLCRQAKNQAYAMMLSLSEDTPLHTPSQGSLDAWLKVTGATSESGAFHPINHL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
31PhosphorylationPNRDLLASHSAEDEA
CCHHHHHCCCCCCHH		20.2529449344
33PhosphorylationRDLLASHSAEDEAED
HHHHHCCCCCCHHHH		30.7529449344
41PhosphorylationAEDEAEDSAMSPIPV
CCCHHHHCCCCCCCC		19.8529449344
44PhosphorylationEAEDSAMSPIPVGPP
HHHHCCCCCCCCCCC		21.2829449344
52PhosphorylationPIPVGPPSPFPTSED
CCCCCCCCCCCCCCC		42.1629449344
56PhosphorylationGPPSPFPTSEDFTPK
CCCCCCCCCCCCCCC		45.1629449344
57PhosphorylationPPSPFPTSEDFTPKE
CCCCCCCCCCCCCCC		35.0929449344
61PhosphorylationFPTSEDFTPKEGSPY
CCCCCCCCCCCCCCC		45.8629449344
66PhosphorylationDFTPKEGSPYEAPVY
CCCCCCCCCCCCCEE		25.9626657352
193PhosphorylationCQISEQIYYKVIKDI
EEEHHHHHHHHHCCC		9.27-
194PhosphorylationQISEQIYYKVIKDIE
EEHHHHHHHHHCCCC		10.62-
321SumoylationCPKAFNWKSNLIRHQ
CCCCCCCCHHHHHHH		30.48-
321SumoylationCPKAFNWKSNLIRHQ
CCCCCCCCHHHHHHH		30.48-
379PhosphorylationGKTFATSSGLKQHKH
CCEEECCCCHHHCCC		43.7325159151
382SumoylationFATSSGLKQHKHIHS
EECCCCHHHCCCHHH		54.61-
382SumoylationFATSSGLKQHKHIHS
EECCCCHHHCCCHHH		54.61-
402PhosphorylationICEVCHKSYTQFSNL
HHHHHCCHHHHHHHH		15.11-
421PhosphorylationRMHADCRTQIKCKDC
CCCCCCCCEEEECCC		40.76-
433PhosphorylationKDCGQMFSTTSSLNK
CCCHHCCCCCHHHHH		25.9825159151
434PhosphorylationDCGQMFSTTSSLNKH
CCHHCCCCCHHHHHH		21.31-
435PhosphorylationCGQMFSTTSSLNKHR
CHHCCCCCHHHHHHH		18.34-
437PhosphorylationQMFSTTSSLNKHRRF
HCCCCCHHHHHHHHH		33.5925627689
464PhosphorylationFAPGLPLTPSPMMDK
CCCCCCCCCCCCCCC		21.5622199227
466PhosphorylationPGLPLTPSPMMDKAK
CCCCCCCCCCCCCCC		21.8622199227
533PhosphorylationPPLLPPTSLLKSPLN
CCCCCCCHHHCCCCC		37.1624719451
537PhosphorylationPPTSLLKSPLNHTQD
CCCHHHCCCCCCCCC		34.2925849741
549PhosphorylationTQDAKLPSPLGNPAL
CCCCCCCCCCCCCCH		43.1026657352
568 (in isoform 4)Sumoylation-27.29-
581PhosphorylationGPEEKFESRLEDSCV
CCHHHHHHHHHHHHH		45.35-
586PhosphorylationFESRLEDSCVEKLKT
HHHHHHHHHHHHHHH		15.64-
611PhosphorylationFEDVNTTTGTDLDTT
CCCCCCCCCCCCCCC		35.73-
698PhosphorylationDSIKAIASIAEKYFG
HHHHHHHHHHHHHHC		19.0723403867
752SumoylationLAHNLLVKAEPKSPR
HHHCCEEECCCCCHH		47.18-
778 (in isoform 2)Ubiquitination-44.8521906983
778 (in isoform 1)Ubiquitination-44.8521906983
778UbiquitinationCPFDLTTKPKDVKPI
CCCCCCCCCCCCCCC		44.852190698
779 (in isoform 3)Ubiquitination-35.6721906983
868PhosphorylationFFMDPIYSRVEKRKV
CCCCHHHHHHHHCCC		30.4824719451
876PhosphorylationRVEKRKVTDPVGALK
HHHHCCCCCCCHHHH		37.3125159151
899PhosphorylationLLFHPQMSAIETMTE
CCCCCCCHHHHHHHH		22.3522210691
905PhosphorylationMSAIETMTEKLESFA
CHHHHHHHHHHHHHH		37.0722210691
915AcetylationLESFAAMKADSGSSL
HHHHHHHCCCCCCCC		44.297826195
974PhosphorylationTRHLRTHTGEQPYRC
HHHHHHCCCCCCEEC		41.6321857030
987PhosphorylationRCKYCDRSFSISSNL
ECCCCCCCCCCCHHH		15.3023312004
989PhosphorylationKYCDRSFSISSNLQR
CCCCCCCCCCHHHHH		23.8623312004
1051PhosphorylationLTNHLGTSASSPTSE
EECCCCCCCCCCCCC		25.1024247654
1089PhosphorylationNSEMNQASTRTEKRA
CHHHHHCCCHHCHHC		14.52-
1090PhosphorylationSEMNQASTRTEKRAD
HHHHHCCCHHCHHCC		44.63-
1194AcetylationEPMPTFGKGLDLRRA
EECCCCCCCCHHHHH		52.707973251
1215PhosphorylationVKDVLNSTLDSEALK
HHHHHHHCCCHHHHH		33.2526657352
1239PhosphorylationQAYAMMLSLSEDTPL
HHHHHHHHHCCCCCC		16.3829759185
1241PhosphorylationYAMMLSLSEDTPLHT
HHHHHHHCCCCCCCC		30.0129759185
1244PhosphorylationMLSLSEDTPLHTPSQ
HHHHCCCCCCCCCCC		24.5722210691
1248PhosphorylationSEDTPLHTPSQGSLD
CCCCCCCCCCCCCCC		32.1122210691
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PRD16_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PRD16_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PRD16_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SMAD2_HUMANSMAD2physical
19049980
SMAD3_HUMANSMAD3physical
19049980
SKI_HUMANSKIphysical
19049980
CTBP2_MOUSECtbp2physical
21516122
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615373Left ventricular non-compaction 8 (LVNC8)
615373Cardiomyopathy, dilated 1LL (CMD1LL)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PRD16_HUMAN

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Related Literatures of Post-Translational Modification

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