CTBP1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CTBP1_MOUSE
• UniProt AC: O88712
• Protein Name: C-terminal-binding protein 1
• Gene Name: Ctbp1
• Organism: Mus musculus (Mouse).
• Sequence Length: 441
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation..
• Protein Sequence: MGSSHLLNKGLPLGVRPPIMNGPMHPRPLVALLDGRDCTVEMPILKDVATVAFCDAQSTQEIHEKVLNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFDNIDIKSAGDLGIAVCNVPAASVEETADSTLCHILNLYRRTTWLHQALREGTRVQSVEQIREVASGAARIRGETLGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSDGIERALGLQRVSTLQDLLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKALAQALKEGRIRGAALDVHESEPFSFSQGPLKDAPNLICTPHAAWYSEQASIEMREEAAREIRRAITGRIPDSLKNCVNKDHLTAATHWASMDPAVVHPELNGAAYSRYPPGVVSVAPTGIPAAVEGIVPSAMSLSHGLPPVAHPPHAPSPGQTVKPEADRDHTSDQL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MGSSHLLNKGL ----CCCHHHHCCCC	16.66	25338131
54	S-nitrosocysteine	DVATVAFCDAQSTQE CCEEEEECCCCCHHH	2.82	-
54	S-nitrosylation	DVATVAFCDAQSTQE CCEEEEECCCCCHHH	2.82	21278135
158	Phosphorylation	REGTRVQSVEQIREV HHCCCCCCHHHHHHH	25.43	-
264	Phosphorylation	QGAFLVNTARGGLVD CCCEEEECCCCCCCC	15.39	21454597
273	Ubiquitination	RGGLVDEKALAQALK CCCCCCHHHHHHHHH	44.21	22790023
280	Ubiquitination	KALAQALKEGRIRGA HHHHHHHHHCCCCCE	62.23	22790023
294	Phosphorylation	AALDVHESEPFSFSQ EEEEECCCCCCCCCC	35.37	25338131
298	Phosphorylation	VHESEPFSFSQGPLK ECCCCCCCCCCCCCC	34.40	25338131
300	Phosphorylation	ESEPFSFSQGPLKDA CCCCCCCCCCCCCCC	32.79	25338131
340	Phosphorylation	REIRRAITGRIPDSL HHHHHHHHCCCCHHH	21.30	29899451
423	Phosphorylation	AHPPHAPSPGQTVKP CCCCCCCCCCCCCCC	42.31	23649490

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
176	T	Phosphorylation	Kinase	AKT1	P31750	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
423	S	Phosphorylation	Phosphorylation by HIPK2 on Ser-423 induces proteasomal degradation (By similarity).	-
429	K	Sumoylation	Sumoylation on Lys-429 is promoted by the E3 SUMO-protein ligase CBX4.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CTBP1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HIC1_HUMAN	HIC1	physical	12052894
IKZF4_HUMAN	IKZF4	physical	12444977
HDAC2_MOUSE	Hdac2	physical	20211142
HDAC9_MOUSE	Hdac9	physical	20211142
CTBP2_HUMAN	CTBP2	physical	16702210
GLIS2_MOUSE	Glis2	physical	16326862

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.