UniProt ID | IKZF4_HUMAN | |
---|---|---|
UniProt AC | Q9H2S9 | |
Protein Name | Zinc finger protein Eos | |
Gene Name | IKZF4 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 585 | |
Subcellular Localization | Nucleus . | |
Protein Description | DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity).. | |
Protein Sequence | MHTPPALPRRFQGGGRVRTPGSHRQGKDNLERDPSGGCVPDFLPQAQDSNHFIMESLFCESSGDSSLEKEFLGAPVGPSVSTPNSQHSSPSRSLSANSIKVEMYSDEESSRLLGPDERLLEKDDSVIVEDSLSEPLGYCDGSGPEPHSPGGIRLPNGKLKCDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCNYACRRRDALTGHLRTHSVSSPTVGKPYKCNYCGRSYKQQSTLEEHKERCHNYLQSLSTEAQALAGQPGDEIRDLEMVPDSMLHSSSERPTFIDRLANSLTKRKRSTPQKFVGEKQMRFSLSDLPYDVNSGGYEKDVELVAHHSLEPGFGSSLAFVGAEHLRPLRLPPTNCISELTPVISSVYTQMQPLPGRLELPGSREAGEGPEDLADGGPLLYRPRGPLTDPGASPSNGCQDSTDTESNHEDRVAGVVSLPQGPPPQPPPTIVVGRHSPAYAKEDPKPQEGLLRGTPGPSKEVLRVVGESGEPVKAFKCEHCRILFLDHVMFTIHMGCHGFRDPFECNICGYHSQDRYEFSSHIVRGEHKVG | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
3 | Phosphorylation | -----MHTPPALPRR -----CCCCCCCCCC | 29.66 | 28674151 | |
22 | Phosphorylation | GRVRTPGSHRQGKDN CCCCCCCCCCCCCCC | 19.39 | - | |
79 | Phosphorylation | LGAPVGPSVSTPNSQ CCCCCCCCCCCCCCC | 23.83 | 28450419 | |
81 | Phosphorylation | APVGPSVSTPNSQHS CCCCCCCCCCCCCCC | 42.35 | 28450419 | |
82 | Phosphorylation | PVGPSVSTPNSQHSS CCCCCCCCCCCCCCC | 25.08 | 28450419 | |
85 | Phosphorylation | PSVSTPNSQHSSPSR CCCCCCCCCCCCCCC | 30.39 | 28450419 | |
88 | Phosphorylation | STPNSQHSSPSRSLS CCCCCCCCCCCCCCC | 35.99 | 28450419 | |
89 | Phosphorylation | TPNSQHSSPSRSLSA CCCCCCCCCCCCCCC | 25.44 | 28450419 | |
91 | Phosphorylation | NSQHSSPSRSLSANS CCCCCCCCCCCCCCC | 36.13 | 28450419 | |
100 | Sumoylation | SLSANSIKVEMYSDE CCCCCCEEEEEECHH | 31.78 | 28112733 | |
104 | Phosphorylation | NSIKVEMYSDEESSR CCEEEEEECHHHHHH | 10.24 | 27732954 | |
105 | Phosphorylation | SIKVEMYSDEESSRL CEEEEEECHHHHHHH | 36.92 | 23401153 | |
109 | Phosphorylation | EMYSDEESSRLLGPD EEECHHHHHHHCCCC | 20.79 | 30108239 | |
110 | Phosphorylation | MYSDEESSRLLGPDE EECHHHHHHHCCCCH | 30.17 | 30108239 | |
125 | Phosphorylation | RLLEKDDSVIVEDSL HHHHCCCCEEEECCC | 24.71 | - | |
133 | Phosphorylation | VIVEDSLSEPLGYCD EEEECCCCCCCCCCC | 40.91 | 30108239 | |
138 | Phosphorylation | SLSEPLGYCDGSGPE CCCCCCCCCCCCCCC | 8.61 | 27732954 | |
142 | Phosphorylation | PLGYCDGSGPEPHSP CCCCCCCCCCCCCCC | 37.61 | 30108239 | |
148 | Phosphorylation | GSGPEPHSPGGIRLP CCCCCCCCCCCEECC | 35.64 | 30108239 | |
158 | Acetylation | GIRLPNGKLKCDVCG CEECCCCCEEECCCE | 51.95 | 23749302 | |
182 | Phosphorylation | MVHKRSHTGERPFHC EEECCCCCCCCCCCC | 41.82 | - | |
195 | Phosphorylation | HCNQCGASFTQKGNL CCCCCCCCEECCCCC | 17.70 | 17924679 | |
207 | Ubiquitination | GNLLRHIKLHSGEKP CCCEEEEEECCCCCC | 33.74 | - | |
210 | Phosphorylation | LRHIKLHSGEKPFKC EEEEEECCCCCCCCC | 60.11 | 23401153 | |
213 | Sumoylation | IKLHSGEKPFKCPFC EEECCCCCCCCCCCC | 60.32 | - | |
213 | Ubiquitination | IKLHSGEKPFKCPFC EEECCCCCCCCCCCC | 60.32 | - | |
213 | Sumoylation | IKLHSGEKPFKCPFC EEECCCCCCCCCCCC | 60.32 | - | |
213 | Acetylation | IKLHSGEKPFKCPFC EEECCCCCCCCCCCC | 60.32 | 23749302 | |
236 | Phosphorylation | ALTGHLRTHSVSSPT HHHCCCCCCCCCCCC | 25.51 | 29978859 | |
238 | Phosphorylation | TGHLRTHSVSSPTVG HCCCCCCCCCCCCCC | 24.07 | 29978859 | |
240 | Phosphorylation | HLRTHSVSSPTVGKP CCCCCCCCCCCCCCC | 33.35 | 23401153 | |
241 | Phosphorylation | LRTHSVSSPTVGKPY CCCCCCCCCCCCCCE | 23.57 | 28450419 | |
243 | Phosphorylation | THSVSSPTVGKPYKC CCCCCCCCCCCCEEC | 43.78 | 28450419 | |
248 | Phosphorylation | SPTVGKPYKCNYCGR CCCCCCCEECCCCCC | 31.49 | 23186163 | |
252 | Phosphorylation | GKPYKCNYCGRSYKQ CCCEECCCCCCCCCC | 13.02 | - | |
311 | Phosphorylation | HSSSERPTFIDRLAN CCCCCCCHHHHHHHH | 39.17 | 26074081 | |
319 | Phosphorylation | FIDRLANSLTKRKRS HHHHHHHHHHHCCCC | 31.63 | 26074081 | |
321 | Phosphorylation | DRLANSLTKRKRSTP HHHHHHHHHCCCCCC | 28.73 | 26074081 | |
326 | Phosphorylation | SLTKRKRSTPQKFVG HHHHCCCCCCCHHCC | 47.69 | 26074081 | |
327 | Phosphorylation | LTKRKRSTPQKFVGE HHHCCCCCCCHHCCC | 33.50 | 26074081 | |
335 | Acetylation | PQKFVGEKQMRFSLS CCHHCCCEEECEEHH | 43.39 | - | |
340 | Phosphorylation | GEKQMRFSLSDLPYD CCEEECEEHHHCCCC | 19.32 | 27251275 | |
342 | Phosphorylation | KQMRFSLSDLPYDVN EEECEEHHHCCCCCC | 35.58 | 27251275 | |
484 | Phosphorylation | PPPQPPPTIVVGRHS CCCCCCCEEEECCCC | 31.98 | 23186163 | |
491 | Phosphorylation | TIVVGRHSPAYAKED EEEECCCCCCCCCCC | 15.18 | 26657352 | |
494 | Phosphorylation | VGRHSPAYAKEDPKP ECCCCCCCCCCCCCC | 22.91 | 29691806 | |
500 | Sumoylation | AYAKEDPKPQEGLLR CCCCCCCCCCCCCCC | 72.20 | 28112733 | |
500 | Sumoylation | AYAKEDPKPQEGLLR CCCCCCCCCCCCCCC | 72.20 | - | |
509 | Phosphorylation | QEGLLRGTPGPSKEV CCCCCCCCCCCCHHH | 20.73 | 27251275 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of IKZF4_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of IKZF4_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of IKZF4_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
SIN3A_HUMAN | SIN3A | physical | 12015313 | |
SIN3B_HUMAN | SIN3B | physical | 12015313 | |
CHD4_HUMAN | CHD4 | physical | 12015313 | |
HDAC2_HUMAN | HDAC2 | physical | 12015313 | |
HDAC4_HUMAN | HDAC4 | physical | 12015313 | |
HDAC5_HUMAN | HDAC5 | physical | 12015313 | |
HDAC7_HUMAN | HDAC7 | physical | 12015313 | |
IKZF1_HUMAN | IKZF1 | physical | 10218586 | |
IKZF4_HUMAN | IKZF4 | physical | 10218586 | |
CTBP1_HUMAN | CTBP1 | physical | 12444977 | |
IKZF5_HUMAN | IKZF5 | physical | 10978333 | |
FOXP3_HUMAN | FOXP3 | physical | 19696312 | |
FHL2_HUMAN | FHL2 | physical | 18255255 | |
IKBA_HUMAN | NFKBIA | physical | 18255255 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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