IKZF4_HUMAN - dbPTM
IKZF4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IKZF4_HUMAN
UniProt AC Q9H2S9
Protein Name Zinc finger protein Eos
Gene Name IKZF4
Organism Homo sapiens (Human).
Sequence Length 585
Subcellular Localization Nucleus .
Protein Description DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity)..
Protein Sequence MHTPPALPRRFQGGGRVRTPGSHRQGKDNLERDPSGGCVPDFLPQAQDSNHFIMESLFCESSGDSSLEKEFLGAPVGPSVSTPNSQHSSPSRSLSANSIKVEMYSDEESSRLLGPDERLLEKDDSVIVEDSLSEPLGYCDGSGPEPHSPGGIRLPNGKLKCDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCNYACRRRDALTGHLRTHSVSSPTVGKPYKCNYCGRSYKQQSTLEEHKERCHNYLQSLSTEAQALAGQPGDEIRDLEMVPDSMLHSSSERPTFIDRLANSLTKRKRSTPQKFVGEKQMRFSLSDLPYDVNSGGYEKDVELVAHHSLEPGFGSSLAFVGAEHLRPLRLPPTNCISELTPVISSVYTQMQPLPGRLELPGSREAGEGPEDLADGGPLLYRPRGPLTDPGASPSNGCQDSTDTESNHEDRVAGVVSLPQGPPPQPPPTIVVGRHSPAYAKEDPKPQEGLLRGTPGPSKEVLRVVGESGEPVKAFKCEHCRILFLDHVMFTIHMGCHGFRDPFECNICGYHSQDRYEFSSHIVRGEHKVG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MHTPPALPRR
-----CCCCCCCCCC
29.6628674151
22PhosphorylationGRVRTPGSHRQGKDN
CCCCCCCCCCCCCCC
19.39-
79PhosphorylationLGAPVGPSVSTPNSQ
CCCCCCCCCCCCCCC
23.8328450419
81PhosphorylationAPVGPSVSTPNSQHS
CCCCCCCCCCCCCCC
42.3528450419
82PhosphorylationPVGPSVSTPNSQHSS
CCCCCCCCCCCCCCC
25.0828450419
85PhosphorylationPSVSTPNSQHSSPSR
CCCCCCCCCCCCCCC
30.3928450419
88PhosphorylationSTPNSQHSSPSRSLS
CCCCCCCCCCCCCCC
35.9928450419
89PhosphorylationTPNSQHSSPSRSLSA
CCCCCCCCCCCCCCC
25.4428450419
91PhosphorylationNSQHSSPSRSLSANS
CCCCCCCCCCCCCCC
36.1328450419
100SumoylationSLSANSIKVEMYSDE
CCCCCCEEEEEECHH
31.7828112733
104PhosphorylationNSIKVEMYSDEESSR
CCEEEEEECHHHHHH
10.2427732954
105PhosphorylationSIKVEMYSDEESSRL
CEEEEEECHHHHHHH
36.9223401153
109PhosphorylationEMYSDEESSRLLGPD
EEECHHHHHHHCCCC
20.7930108239
110PhosphorylationMYSDEESSRLLGPDE
EECHHHHHHHCCCCH
30.1730108239
125PhosphorylationRLLEKDDSVIVEDSL
HHHHCCCCEEEECCC
24.71-
133PhosphorylationVIVEDSLSEPLGYCD
EEEECCCCCCCCCCC
40.9130108239
138PhosphorylationSLSEPLGYCDGSGPE
CCCCCCCCCCCCCCC
8.6127732954
142PhosphorylationPLGYCDGSGPEPHSP
CCCCCCCCCCCCCCC
37.6130108239
148PhosphorylationGSGPEPHSPGGIRLP
CCCCCCCCCCCEECC
35.6430108239
158AcetylationGIRLPNGKLKCDVCG
CEECCCCCEEECCCE
51.9523749302
182PhosphorylationMVHKRSHTGERPFHC
EEECCCCCCCCCCCC
41.82-
195PhosphorylationHCNQCGASFTQKGNL
CCCCCCCCEECCCCC
17.7017924679
207UbiquitinationGNLLRHIKLHSGEKP
CCCEEEEEECCCCCC
33.74-
210PhosphorylationLRHIKLHSGEKPFKC
EEEEEECCCCCCCCC
60.1123401153
213SumoylationIKLHSGEKPFKCPFC
EEECCCCCCCCCCCC
60.32-
213UbiquitinationIKLHSGEKPFKCPFC
EEECCCCCCCCCCCC
60.32-
213SumoylationIKLHSGEKPFKCPFC
EEECCCCCCCCCCCC
60.32-
213AcetylationIKLHSGEKPFKCPFC
EEECCCCCCCCCCCC
60.3223749302
236PhosphorylationALTGHLRTHSVSSPT
HHHCCCCCCCCCCCC
25.5129978859
238PhosphorylationTGHLRTHSVSSPTVG
HCCCCCCCCCCCCCC
24.0729978859
240PhosphorylationHLRTHSVSSPTVGKP
CCCCCCCCCCCCCCC
33.3523401153
241PhosphorylationLRTHSVSSPTVGKPY
CCCCCCCCCCCCCCE
23.5728450419
243PhosphorylationTHSVSSPTVGKPYKC
CCCCCCCCCCCCEEC
43.7828450419
248PhosphorylationSPTVGKPYKCNYCGR
CCCCCCCEECCCCCC
31.4923186163
252PhosphorylationGKPYKCNYCGRSYKQ
CCCEECCCCCCCCCC
13.02-
311PhosphorylationHSSSERPTFIDRLAN
CCCCCCCHHHHHHHH
39.1726074081
319PhosphorylationFIDRLANSLTKRKRS
HHHHHHHHHHHCCCC
31.6326074081
321PhosphorylationDRLANSLTKRKRSTP
HHHHHHHHHCCCCCC
28.7326074081
326PhosphorylationSLTKRKRSTPQKFVG
HHHHCCCCCCCHHCC
47.6926074081
327PhosphorylationLTKRKRSTPQKFVGE
HHHCCCCCCCHHCCC
33.5026074081
335AcetylationPQKFVGEKQMRFSLS
CCHHCCCEEECEEHH
43.39-
340PhosphorylationGEKQMRFSLSDLPYD
CCEEECEEHHHCCCC
19.3227251275
342PhosphorylationKQMRFSLSDLPYDVN
EEECEEHHHCCCCCC
35.5827251275
484PhosphorylationPPPQPPPTIVVGRHS
CCCCCCCEEEECCCC
31.9823186163
491PhosphorylationTIVVGRHSPAYAKED
EEEECCCCCCCCCCC
15.1826657352
494PhosphorylationVGRHSPAYAKEDPKP
ECCCCCCCCCCCCCC
22.9129691806
500SumoylationAYAKEDPKPQEGLLR
CCCCCCCCCCCCCCC
72.2028112733
500SumoylationAYAKEDPKPQEGLLR
CCCCCCCCCCCCCCC
72.20-
509PhosphorylationQEGLLRGTPGPSKEV
CCCCCCCCCCCCHHH
20.7327251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IKZF4_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IKZF4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IKZF4_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SIN3A_HUMANSIN3Aphysical
12015313
SIN3B_HUMANSIN3Bphysical
12015313
CHD4_HUMANCHD4physical
12015313
HDAC2_HUMANHDAC2physical
12015313
HDAC4_HUMANHDAC4physical
12015313
HDAC5_HUMANHDAC5physical
12015313
HDAC7_HUMANHDAC7physical
12015313
IKZF1_HUMANIKZF1physical
10218586
IKZF4_HUMANIKZF4physical
10218586
CTBP1_HUMANCTBP1physical
12444977
IKZF5_HUMANIKZF5physical
10978333
FOXP3_HUMANFOXP3physical
19696312
FHL2_HUMANFHL2physical
18255255
IKBA_HUMANNFKBIAphysical
18255255

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IKZF4_HUMAN

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Related Literatures of Post-Translational Modification

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