IKZF5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IKZF5_HUMAN
• UniProt AC: Q9H5V7
• Protein Name: Zinc finger protein Pegasus
• Gene Name: IKZF5
• Organism: Homo sapiens (Human).
• Sequence Length: 419
• Subcellular Localization: Nucleus .
• Protein Description: DNA-binding protein that binds to the 5'GNNTGTNG-3' core sequence. Transcriptional repressor..
• Protein Sequence: MGEKKPEPLDFVKDFQEYLTQQTHHVNMISGSVSGDKEAEALQGAGTDGDQNGLDHPSVEVSLDENSGMLVDGFERTFDGKLKCRYCNYASKGTARLIEHIRIHTGEKPHRCHLCPFASAYERHLEAHMRSHTGEKPYKCELCSFRCSDRSNLSHHRRRKHKMVPIKGTRSSLSSKKMWGVLQKKTSNLGYSRRALINLSPPSMVVQKPDYLNDFTHEIPNIQTDSYESMAKTTPTGGLPRDPQELMVDNPLNQLSTLAGQLSSLPPENQNPASPDVVPCPDEKPFMIQQPSTQAVVSAVSASIPQSSSPTSPEPRPSHSQRNYSPVAGPSSEPSAHTSTPSIGNSQPSTPAPALPVQDPQLLHHCQHCDMYFADNILYTIHMGCHGYENPFQCNICGCKCKNKYDFACHFARGQHNQH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Sumoylation	---MGEKKPEPLDFV ---CCCCCCCCCHHH	50.76	28112733
5	Sumoylation	---MGEKKPEPLDFV ---CCCCCCCCCHHH	50.76	-
30	Phosphorylation	THHVNMISGSVSGDK CCCEEEECCCCCCHH	17.78	27251275
32	Phosphorylation	HVNMISGSVSGDKEA CEEEECCCCCCHHHH	13.30	27251275
86	Phosphorylation	DGKLKCRYCNYASKG CCEEEECCCCCCCHH	8.43	-
92	Ubiquitination	RYCNYASKGTARLIE CCCCCCCHHHHHHEE	52.70	-
133	Phosphorylation	EAHMRSHTGEKPYKC HHHHHHCCCCCCEEE	48.56	24719451
144	Phosphorylation	PYKCELCSFRCSDRS CEEEEECEEECCCCC	28.49	24719451
167	Ubiquitination	KHKMVPIKGTRSSLS CCCCEECCCCCHHHC	48.43	29967540
171	Phosphorylation	VPIKGTRSSLSSKKM EECCCCCHHHCCHHH	35.15	26437602
172	Phosphorylation	PIKGTRSSLSSKKMW ECCCCCHHHCCHHHH	29.04	26437602
177	Sumoylation	RSSLSSKKMWGVLQK CHHHCCHHHHHHHHH	41.66	-
177	Sumoylation	RSSLSSKKMWGVLQK CHHHCCHHHHHHHHH	41.66	-
185	Sumoylation	MWGVLQKKTSNLGYS HHHHHHHHHCCCCCC	44.20	28112733
186	Phosphorylation	WGVLQKKTSNLGYSR HHHHHHHHCCCCCCC	29.86	27732954
187	Phosphorylation	GVLQKKTSNLGYSRR HHHHHHHCCCCCCCE	38.65	27732954
200	Phosphorylation	RRALINLSPPSMVVQ CEEEHHCCCCCCEEC	30.21	29116813
203	Phosphorylation	LINLSPPSMVVQKPD EHHCCCCCCEECCCC	27.82	25159151
216	Phosphorylation	PDYLNDFTHEIPNIQ CCCHHCCCCCCCCCC	22.82	28348404
233	Phosphorylation	SYESMAKTTPTGGLP CHHHHHCCCCCCCCC	28.59	28857561
234	Phosphorylation	YESMAKTTPTGGLPR HHHHHCCCCCCCCCC	20.39	21815630
236	Phosphorylation	SMAKTTPTGGLPRDP HHHCCCCCCCCCCCH	41.61	27732954
263	Phosphorylation	STLAGQLSSLPPENQ HHHHHHHHCCCCCCC	23.18	26074081
264	Phosphorylation	TLAGQLSSLPPENQN HHHHHHHCCCCCCCC	54.19	26074081
274	Phosphorylation	PENQNPASPDVVPCP CCCCCCCCCCCCCCC	23.92	26074081
292	Phosphorylation	PFMIQQPSTQAVVSA CCEEECCCHHHHHHH	28.90	23090842
293	Phosphorylation	FMIQQPSTQAVVSAV CEEECCCHHHHHHHH	27.51	23090842
298	Phosphorylation	PSTQAVVSAVSASIP CCHHHHHHHHHCCCC	19.16	23090842
301	Phosphorylation	QAVVSAVSASIPQSS HHHHHHHHCCCCCCC	18.93	27251275
303	Phosphorylation	VVSAVSASIPQSSSP HHHHHHCCCCCCCCC	27.56	21406692
307	Phosphorylation	VSASIPQSSSPTSPE HHCCCCCCCCCCCCC	27.68	21406692
308	Phosphorylation	SASIPQSSSPTSPEP HCCCCCCCCCCCCCC	34.78	21406692
309	Phosphorylation	ASIPQSSSPTSPEPR CCCCCCCCCCCCCCC	37.13	21406692
311	Phosphorylation	IPQSSSPTSPEPRPS CCCCCCCCCCCCCCC	59.88	21406692
312	Phosphorylation	PQSSSPTSPEPRPSH CCCCCCCCCCCCCCC	30.56	30576142
318	Phosphorylation	TSPEPRPSHSQRNYS CCCCCCCCCCCCCCC	36.73	21406692
320	Phosphorylation	PEPRPSHSQRNYSPV CCCCCCCCCCCCCCC	34.86	21406692

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IKZF5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IKZF5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IKZF5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IKZF5_HUMAN	IKZF5	physical	16189514
IKZF4_HUMAN	IKZF4	physical	10978333
IKZF5_HUMAN	IKZF5	physical	10978333
IKZF1_HUMAN	IKZF1	physical	10978333
IKZF3_HUMAN	IKZF3	physical	10978333
IKZF5_HUMAN	IKZF5	physical	25416956
CHD8_HUMAN	CHD8	physical	28514442
MIB2_HUMAN	MIB2	physical	28514442
ZC3H3_HUMAN	ZC3H3	physical	28514442
IKZF2_HUMAN	IKZF2	physical	28514442
IKZF3_HUMAN	IKZF3	physical	28514442
AHDC1_HUMAN	AHDC1	physical	28514442
CCD77_HUMAN	CCDC77	physical	28514442
TF7L2_HUMAN	TCF7L2	physical	28514442
Z518B_HUMAN	ZNF518B	physical	28514442
ZZZ3_HUMAN	ZZZ3	physical	28514442
TAD2A_HUMAN	TADA2A	physical	28514442
MBIP1_HUMAN	MBIP	physical	28514442
KAT2B_HUMAN	KAT2B	physical	28514442
YETS2_HUMAN	YEATS2	physical	28514442
MCM10_HUMAN	MCM10	physical	28514442
PEX14_HUMAN	PEX14	physical	28514442
MOONR_HUMAN	KIAA0753	physical	28514442
M18BP_HUMAN	MIS18BP1	physical	28514442
CSR2B_HUMAN	CSRP2BP	physical	28514442
IKZF4_HUMAN	IKZF4	physical	28514442
ELF2_HUMAN	ELF2	physical	28514442
UTP11_HUMAN	UTP11L	physical	28514442
DYH14_HUMAN	DNAH14	physical	28514442
KAT2A_HUMAN	KAT2A	physical	28514442
TADA3_HUMAN	TADA3	physical	28514442
RHG19_HUMAN	ARHGAP19	physical	28514442
ODFP2_HUMAN	ODF2	physical	28514442
LIN54_HUMAN	LIN54	physical	28514442
SLTM_HUMAN	SLTM	physical	28514442
CCNB1_HUMAN	CCNB1	physical	28514442
FBX11_HUMAN	FBXO11	physical	28514442
CKS2_HUMAN	CKS2	physical	28514442
SGF29_HUMAN	CCDC101	physical	28514442
CKS1_HUMAN	CKS1B	physical	28514442
RL36L_HUMAN	RPL36AL	physical	28514442
CEP44_HUMAN	CEP44	physical	28514442
RM30_HUMAN	MRPL30	physical	28514442
WIZ_HUMAN	WIZ	physical	28514442
NOL6_HUMAN	NOL6	physical	28514442
LRIF1_HUMAN	LRIF1	physical	28514442
TIGD5_HUMAN	TIGD5	physical	28514442
TRI27_HUMAN	TRIM27	physical	28514442
THA11_HUMAN	THAP11	physical	28514442
RPA49_HUMAN	POLR1E	physical	28514442
UBE2O_HUMAN	UBE2O	physical	28514442
RBM27_HUMAN	RBM27	physical	28514442
GGPPS_HUMAN	GGPS1	physical	28514442
CDK1_HUMAN	CDK1	physical	28514442
PDLI7_HUMAN	PDLIM7	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.