dbPTM

RBM27_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RBM27_HUMAN
UniProt AC	Q9P2N5
Protein Name	RNA-binding protein 27
Gene Name	RBM27
Organism	Homo sapiens (Human).
Sequence Length	1060
Subcellular Localization	Cytoplasm. Nucleus speckle. Incorporated into the nuclear speckles and to speckles proximal to the nuclear periphery. Also localizes to punctate structures in the cytoplasm termed cytospeckles (By similarity)..
Protein Description
Protein Sequence	MLIEDVDALKSWLAKLLEPICDADPSALANYVVALVKKDKPEKELKAFCADQLDVFLQKETSGFVDKLFESLYTKNYLPLLEPVKPEPKPLVQEKEEIKEEVFQEPAEEERDGRKKKYPSPQKTRSESSERRTREKKREDGKWRDYDRYYERNELYREKYDWRRGRSKSRSKSRGLSRSRSRSRGRSKDRDPNRNVEHRERSKFKSERNDLESSYVPVSAPPPNSSEQYSSGAQSIPSTVTVIAPAHHSENTTESWSNYYNNHSSSNSFGRNLPPKRRCRDYDERGFCVLGDLCQFDHGNDPLVVDEVALPSMIPFPPPPPGLPPPPPPGMLMPPMPGPGPGPGPGPGPGPGPGPGPGHSMRLPVPQGHGQPPPSVVLPIPRPPITQSSLINSRDQPGTSAVPNLASVGTRLPPPLPQNLLYTVSERQPMYSREHGAAASERLQLGTPPPLLAARLVPPRNLMGSSIGYHTSVSSPTPLVPDTYEPDGYNPEAPSITSSGRSQYRQFFSRTQTQRPNLIGLTSGDMDVNPRAANIVIQTEPPVPVSINSNITRVVLEPDSRKRAMSGLEGPLTKKPWLGKQGNNNQNKPGFLRKNQYTNTKLEVKKIPQELNNITKLNEHFSKFGTIVNIQVAFKGDPEAALIQYLTNEEARKAISSTEAVLNNRFIRVLWHRENNEQPTLQSSAQLLLQQQQTLSHLSQQHHHLPQHLHQQQVLVAQSAPSTVHGGIQKMMSKPQTSGAYVLNKVPVKHRLGHAGGNQSDASHLLNQSGGAGEDCQIFSTPGHPKMIYSSSNLKTPSKLCSGSKSHDVQEVLKKKQEAMKLQQDMRKKRQEVLEKQIECQKMLISKLEKNKNMKPEERANIMKTLKELGEKISQLKDELKTSSAVSTPSKVKTKTEAQKELLDTELDLHKRLSSGEDTTELRKKLSQLQVEAARLGILPVGRGKTMSSQGRGRGRGRGGRGRGSLNHMVVDHRPKALTVGGFIEEEKEDLLQHFSTANQGPKFKDRRLQISWHKPKVPSISTETEEEEVKEEETETSDLFLPDDDDEDEDEYESRSWRR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
59	Ubiquitination	QLDVFLQKETSGFVD HHHHHHHHHCCCHHH	66.17	29967540
67	Acetylation	ETSGFVDKLFESLYT HCCCHHHHHHHHHHC	50.18	26051181
71	Phosphorylation	FVDKLFESLYTKNYL HHHHHHHHHHCCCCH	21.24	24719451
73	Phosphorylation	DKLFESLYTKNYLPL HHHHHHHHCCCCHHH	25.58	24719451
77	Phosphorylation	ESLYTKNYLPLLEPV HHHHCCCCHHHCCCC	15.97	21406692
85	Sumoylation	LPLLEPVKPEPKPLV HHHCCCCCCCCCCCC	55.14	-
85	Sumoylation	LPLLEPVKPEPKPLV HHHCCCCCCCCCCCC	55.14	-
99	Sumoylation	VQEKEEIKEEVFQEP CCCHHHHHHHHHHCC	51.61	-
99	Sumoylation	VQEKEEIKEEVFQEP CCCHHHHHHHHHHCC	51.61	-
118	Phosphorylation	RDGRKKKYPSPQKTR CCCCCCCCCCCCCCC	20.16	30266825
120	Phosphorylation	GRKKKYPSPQKTRSE CCCCCCCCCCCCCCC	36.55	28176443
128	Phosphorylation	PQKTRSESSERRTRE CCCCCCCCHHHHHHH	38.45	29743597
146	Phosphorylation	EDGKWRDYDRYYERN HCCCCCCHHHHHHHH	8.18	22817900
149	Phosphorylation	KWRDYDRYYERNELY CCCCHHHHHHHHHHH	13.54	28796482
150	Phosphorylation	WRDYDRYYERNELYR CCCHHHHHHHHHHHH	14.87	28796482
173	Phosphorylation	RSKSRSKSRGLSRSR CCCCHHHHHCCCHHH	32.59	28102081
177	Phosphorylation	RSKSRGLSRSRSRSR HHHHHCCCHHHHHHC	30.91	28102081
179	Phosphorylation	KSRGLSRSRSRSRGR HHHCCCHHHHHHCCC	31.09	28102081
181	Phosphorylation	RGLSRSRSRSRGRSK HCCCHHHHHHCCCCC	35.54	28102081
183	O-linked_Glycosylation	LSRSRSRSRGRSKDR CCHHHHHHCCCCCCC	40.09	30379171
187	O-linked_Glycosylation	RSRSRGRSKDRDPNR HHHHCCCCCCCCCCC	41.55	30379171
187	Phosphorylation	RSRSRGRSKDRDPNR HHHHCCCCCCCCCCC	41.55	24719451
388	Phosphorylation	PRPPITQSSLINSRD CCCCCCHHHHHCCCC	20.61	-
399	Phosphorylation	NSRDQPGTSAVPNLA CCCCCCCCCCCCCCC	21.86	27732954
400	Phosphorylation	SRDQPGTSAVPNLAS CCCCCCCCCCCCCCC	32.93	23663014
407	O-linked_Glycosylation	SAVPNLASVGTRLPP CCCCCCCCCCCCCCC	25.01	30379171
407	Phosphorylation	SAVPNLASVGTRLPP CCCCCCCCCCCCCCC	25.01	23663014
410	Phosphorylation	PNLASVGTRLPPPLP CCCCCCCCCCCCCCC	27.20	23663014
411	Dimethylation	NLASVGTRLPPPLPQ CCCCCCCCCCCCCCC	38.99	-
411	Methylation	NLASVGTRLPPPLPQ CCCCCCCCCCCCCCC	38.99	80702909
422	Phosphorylation	PLPQNLLYTVSERQP CCCCCCEEEEHHCCC	14.30	27642862
427	Methylation	LLYTVSERQPMYSRE CEEEEHHCCCCCCCC	38.09	115490687
433	Methylation	ERQPMYSREHGAAAS HCCCCCCCCCCCCHH	23.57	115490695
442	Methylation	HGAAASERLQLGTPP CCCCHHHHHCCCCCC	25.82	115368757
447	Phosphorylation	SERLQLGTPPPLLAA HHHHCCCCCCCCHHH	41.01	29255136
455	Methylation	PPPLLAARLVPPRNL CCCCHHHHCCCCHHC	30.52	24129315
465	Phosphorylation	PPRNLMGSSIGYHTS CCHHCCCCCCCCCCC	12.57	28450419
466	Phosphorylation	PRNLMGSSIGYHTSV CHHCCCCCCCCCCCC	17.82	28450419
469	Phosphorylation	LMGSSIGYHTSVSSP CCCCCCCCCCCCCCC	10.56	28450419
471	Phosphorylation	GSSIGYHTSVSSPTP CCCCCCCCCCCCCCC	23.49	28450419
472	Phosphorylation	SSIGYHTSVSSPTPL CCCCCCCCCCCCCCC	13.49	28450419
474	Phosphorylation	IGYHTSVSSPTPLVP CCCCCCCCCCCCCCC	30.30	26657352
475	Phosphorylation	GYHTSVSSPTPLVPD CCCCCCCCCCCCCCC	30.55	29496963
477	Phosphorylation	HTSVSSPTPLVPDTY CCCCCCCCCCCCCCC	31.07	28450419
483	Phosphorylation	PTPLVPDTYEPDGYN CCCCCCCCCCCCCCC	24.58	28450419
484	Phosphorylation	TPLVPDTYEPDGYNP CCCCCCCCCCCCCCC	32.61	28450419
489	Phosphorylation	DTYEPDGYNPEAPSI CCCCCCCCCCCCCCC	34.62	28450419
502	Phosphorylation	SITSSGRSQYRQFFS CCCCCCHHHHHHHHH	34.78	19369195
505	Methylation	SSGRSQYRQFFSRTQ CCCHHHHHHHHHCCC	21.13	115490719
511	Phosphorylation	YRQFFSRTQTQRPNL HHHHHHCCCCCCCCE	34.47	28555341
513	Phosphorylation	QFFSRTQTQRPNLIG HHHHCCCCCCCCEEE	26.40	28555341
522	O-linked_Glycosylation	RPNLIGLTSGDMDVN CCCEEECCCCCCCCC	26.00	30379171
523	O-linked_Glycosylation	PNLIGLTSGDMDVNP CCEEECCCCCCCCCH	37.53	30379171
523	Phosphorylation	PNLIGLTSGDMDVNP CCEEECCCCCCCCCH	37.53	28555341
539	O-linked_Glycosylation	AANIVIQTEPPVPVS HCCEEEECCCCCCEE	39.06	30379171
546	O-linked_Glycosylation	TEPPVPVSINSNITR CCCCCCEECCCCCEE	15.24	31492838
562	Ubiquitination	VLEPDSRKRAMSGLE EECCCCHHHHHCCCC	48.76	-
566	Phosphorylation	DSRKRAMSGLEGPLT CCHHHHHCCCCCCCC	38.96	29255136
574	Ubiquitination	GLEGPLTKKPWLGKQ CCCCCCCCCCCCCCC	65.60	33845483
575	Acetylation	LEGPLTKKPWLGKQG CCCCCCCCCCCCCCC	35.87	26051181
588	Acetylation	QGNNNQNKPGFLRKN CCCCCCCCCCCCCCC	36.43	26051181
598	Ubiquitination	FLRKNQYTNTKLEVK CCCCCCCCCCCEEEE	27.01	18655026
599	Ubiquitination	LRKNQYTNTKLEVKK CCCCCCCCCCEEEEC	30.22	18655026
601	Acetylation	KNQYTNTKLEVKKIP CCCCCCCCEEEECCC	44.73	26051181
641	Ubiquitination	FKGDPEAALIQYLTN ECCCHHHHHHHHHCC	11.97	18655026
642	Ubiquitination	KGDPEAALIQYLTNE CCCHHHHHHHHHCCH	3.02	18655026
647	Phosphorylation	AALIQYLTNEEARKA HHHHHHHCCHHHHHH	35.33	-
653	Ubiquitination	LTNEEARKAISSTEA HCCHHHHHHHHHHHH	58.06	18655026
654	Ubiquitination	TNEEARKAISSTEAV CCHHHHHHHHHHHHH	11.01	18655026
656	Phosphorylation	EEARKAISSTEAVLN HHHHHHHHHHHHHHH	35.75	29255136
657	Phosphorylation	EARKAISSTEAVLNN HHHHHHHHHHHHHHH	24.93	28387310
658	Phosphorylation	ARKAISSTEAVLNNR HHHHHHHHHHHHHHH	22.60	29255136
733	Phosphorylation	GGIQKMMSKPQTSGA HHHHHHHCCCCCCCC	37.37	28555341
734	"N6,N6-dimethyllysine"	GIQKMMSKPQTSGAY HHHHHHCCCCCCCCE	24.21	-
734	Acetylation	GIQKMMSKPQTSGAY HHHHHHCCCCCCCCE	24.21	25953088
734	Methylation	GIQKMMSKPQTSGAY HHHHHHCCCCCCCCE	24.21	23644510
738	O-linked_Glycosylation	MMSKPQTSGAYVLNK HHCCCCCCCCEEECC	19.04	31492838
738	Phosphorylation	MMSKPQTSGAYVLNK HHCCCCCCCCEEECC	19.04	28555341
741	Phosphorylation	KPQTSGAYVLNKVPV CCCCCCCEEECCCCC	14.70	27642862
760	Phosphorylation	GHAGGNQSDASHLLN CCCCCCHHHHHHHHH	38.86	29083192
763	Phosphorylation	GGNQSDASHLLNQSG CCCHHHHHHHHHCCC	21.47	30576142
769	Phosphorylation	ASHLLNQSGGAGEDC HHHHHHCCCCCCCCC	37.81	30576142
780	Phosphorylation	GEDCQIFSTPGHPKM CCCCEEECCCCCCCE	35.01	25159151
781	Phosphorylation	EDCQIFSTPGHPKMI CCCEEECCCCCCCEE	23.65	25159151
786	Ubiquitination	FSTPGHPKMIYSSSN ECCCCCCCEEECCCC	32.05	29967540
789	Phosphorylation	PGHPKMIYSSSNLKT CCCCCEEECCCCCCC	10.05	25159151
790	Phosphorylation	GHPKMIYSSSNLKTP CCCCEEECCCCCCCC	19.16	23186163
791	Phosphorylation	HPKMIYSSSNLKTPS CCCEEECCCCCCCCH	13.28	21712546
792	Phosphorylation	PKMIYSSSNLKTPSK CCEEECCCCCCCCHH	40.00	22199227
796	Phosphorylation	YSSSNLKTPSKLCSG ECCCCCCCCHHHCCC	35.64	25159151
798	Phosphorylation	SSNLKTPSKLCSGSK CCCCCCCHHHCCCCC	43.42	28450419
799	Acetylation	SNLKTPSKLCSGSKS CCCCCCHHHCCCCCC	55.50	25953088
802	Phosphorylation	KTPSKLCSGSKSHDV CCCHHHCCCCCCCCH	57.44	21712546
804	Phosphorylation	PSKLCSGSKSHDVQE CHHHCCCCCCCCHHH	18.07	21712546
806	Phosphorylation	KLCSGSKSHDVQEVL HHCCCCCCCCHHHHH	26.98	28555341
814	Methylation	HDVQEVLKKKQEAMK CCHHHHHHHHHHHHH	64.20	115976419
815	Methylation	DVQEVLKKKQEAMKL CHHHHHHHHHHHHHH	56.37	115976427
836	Acetylation	KRQEVLEKQIECQKM HHHHHHHHHHHHHHH	53.03	26051181
842	Acetylation	EKQIECQKMLISKLE HHHHHHHHHHHHHHH	47.54	26051181
847	Acetylation	CQKMLISKLEKNKNM HHHHHHHHHHHCCCC	54.38	26051181
850	Acetylation	MLISKLEKNKNMKPE HHHHHHHHCCCCCHH	81.37	19812171
852	Acetylation	ISKLEKNKNMKPEER HHHHHHCCCCCHHHH	70.28	19812179
867	Ubiquitination	ANIMKTLKELGEKIS HHHHHHHHHHHHHHH	57.00	30230243
874	Phosphorylation	KELGEKISQLKDELK HHHHHHHHHHHHHHH	40.29	24719451
882	Phosphorylation	QLKDELKTSSAVSTP HHHHHHHHCCCCCCC	40.30	22199227
883	Phosphorylation	LKDELKTSSAVSTPS HHHHHHHCCCCCCCH	18.08	22199227
884	Phosphorylation	KDELKTSSAVSTPSK HHHHHHCCCCCCCHH	37.61	26055452
887	Phosphorylation	LKTSSAVSTPSKVKT HHHCCCCCCCHHCCC	34.03	22199227
888	Phosphorylation	KTSSAVSTPSKVKTK HHCCCCCCCHHCCCH	25.61	25159151
890	Phosphorylation	SSAVSTPSKVKTKTE CCCCCCCHHCCCHHH	50.60	30576142
891	Acetylation	SAVSTPSKVKTKTEA CCCCCCHHCCCHHHH	49.29	25953088
900	Ubiquitination	KTKTEAQKELLDTEL CCHHHHHHHHHHHHH	58.33	29967540
904	Ubiquitination	EAQKELLDTELDLHK HHHHHHHHHHHHHHH	51.24	21890473
905	Phosphorylation	AQKELLDTELDLHKR HHHHHHHHHHHHHHH	38.12	28387310
905	Ubiquitination	AQKELLDTELDLHKR HHHHHHHHHHHHHHH	38.12	21890473
911	Acetylation	DTELDLHKRLSSGED HHHHHHHHHHCCCCC	63.43	26051181
911	Ubiquitination	DTELDLHKRLSSGED HHHHHHHHHHCCCCC	63.43	29967540
914	Phosphorylation	LDLHKRLSSGEDTTE HHHHHHHCCCCCHHH	40.09	29255136
915	Phosphorylation	DLHKRLSSGEDTTEL HHHHHHCCCCCHHHH	51.28	29255136
919	Phosphorylation	RLSSGEDTTELRKKL HHCCCCCHHHHHHHH	20.19	29255136
920	Phosphorylation	LSSGEDTTELRKKLS HCCCCCHHHHHHHHH	45.40	29255136
925	Ubiquitination	DTTELRKKLSQLQVE CHHHHHHHHHHHHHH	47.11	29967540
927	Phosphorylation	TELRKKLSQLQVEAA HHHHHHHHHHHHHHH	37.41	29978859
935	Methylation	QLQVEAARLGILPVG HHHHHHHHHCCEEEC	40.26	115490711
943	Dimethylation	LGILPVGRGKTMSSQ HCCEEECCCCCCCCC	43.60	-
943	Methylation	LGILPVGRGKTMSSQ HCCEEECCCCCCCCC	43.60	26494069
945	Methylation	ILPVGRGKTMSSQGR CEEECCCCCCCCCCC	39.43	116265617
948	Ubiquitination	VGRGKTMSSQGRGRG ECCCCCCCCCCCCCC	25.41	21890473
949	Ubiquitination	GRGKTMSSQGRGRGR CCCCCCCCCCCCCCC	26.32	21890473
963	Methylation	RGRGGRGRGSLNHMV CCCCCCCCCCCCEEE	30.11	115490703
988	Ubiquitination	GGFIEEEKEDLLQHF CCCCHHHHHHHHHHH	60.86	29967540
991	Ubiquitination	IEEEKEDLLQHFSTA CHHHHHHHHHHHHCC	5.34	21890473
992	Ubiquitination	EEEKEDLLQHFSTAN HHHHHHHHHHHHCCC	6.02	21890473
1003	Ubiquitination	STANQGPKFKDRRLQ HCCCCCCCCCCCCEE	72.39	21890473
1004	Ubiquitination	TANQGPKFKDRRLQI CCCCCCCCCCCCEEE	12.85	21890473
1012	Phosphorylation	KDRRLQISWHKPKVP CCCCEEEEECCCCCC	15.35	23401153
1015	Acetylation	RLQISWHKPKVPSIS CEEEEECCCCCCCCC	40.03	25953088
1020	Phosphorylation	WHKPKVPSISTETEE ECCCCCCCCCCCCCH	31.96	28355574
1022	Phosphorylation	KPKVPSISTETEEEE CCCCCCCCCCCCHHH	25.24	25159151
1023	Phosphorylation	PKVPSISTETEEEEV CCCCCCCCCCCHHHH	45.30	21815630
1025	Phosphorylation	VPSISTETEEEEVKE CCCCCCCCCHHHHHH	49.11	29496963
1031	Sumoylation	ETEEEEVKEEETETS CCCHHHHHHHHCCCC	63.79	-
1035	Phosphorylation	EEVKEEETETSDLFL HHHHHHHCCCCCCCC	48.09	30624053
1037	Phosphorylation	VKEEETETSDLFLPD HHHHHCCCCCCCCCC	34.65	30624053
1038	Phosphorylation	KEEETETSDLFLPDD HHHHCCCCCCCCCCC	26.53	30624053
1053	Phosphorylation	DDEDEDEYESRSWRR CCCCHHHHHHHCCCC	31.37	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RBM27_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RBM27_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RBM27_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MPLKI_HUMAN	MPLKIP	physical	22939629
UBL4A_HUMAN	UBL4A	physical	22939629
VDAC3_HUMAN	VDAC3	physical	22939629
TAGL_HUMAN	TAGLN	physical	22939629
RM53_HUMAN	MRPL53	physical	22939629
TIM44_HUMAN	TIMM44	physical	22939629
ZC11A_HUMAN	ZC3H11A	physical	22939629
TBL2_HUMAN	TBL2	physical	22939629
RT28_HUMAN	MRPS28	physical	22939629
NCBP1_HUMAN	NCBP1	physical	26344197
PCF11_HUMAN	PCF11	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RBM27_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-447 AND SER-566, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-447, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-447, AND MASSSPECTROMETRY.	18220336 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-447, AND MASSSPECTROMETRY.	16964243 [Abstract]
Ubiquitylation
Reference	PubMed
"Proteomic analysis of ubiquitinated proteins in normal hepatocytecell line Chang liver cells."; Tan F., Lu L., Cai Y., Wang J., Xie Y., Wang L., Gong Y., Xu B.-E.,Wu J., Luo Y., Qiang B., Yuan J., Sun X., Peng X.; Proteomics 8:2885-2896(2008). Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-653, AND MASSSPECTROMETRY.	18655026 [Abstract]