GLIS2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GLIS2_MOUSE
• UniProt AC: Q8VDL9
• Protein Name: Zinc finger protein GLIS2
• Gene Name: Glis2
• Organism: Mus musculus (Mouse).
• Sequence Length: 521
• Subcellular Localization: Nucleus speckle. Cytoplasm.
• Protein Description: Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway. Represses the Hedgehog-dependent expression of Wnt4. Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition. Represses transcriptional activation by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation..
• Protein Sequence: MHSLDEPLDLKLSITKLRAAREKRERTLGVVRHHALHRELGLVDDSPAPGSPGSPPPGFLLNPKFPEKVDGRFSAAPLVDLSLSPPSGLDSPNGSSSLSPECQGNGDLPPLPTAVDFQPLRYLDGVPSSFQFFLPLGSGGALHLPASSFLPPPKDKCLSPELPLAKQLVCRWAKCNQLFELLQDLVDHVNDHHVKPEQDARYCCHWEGCARHGRGFNARYKMLIHIRTHTNEKPHRCPTCNKSFSRLENLKIHNRSHTGEKPYVCPYEGCNKRYSNSSDRFKHTRTHYVDKPYYCKMPGCHKRYTDPSSLRKHIKAHGHFVSHEQQELLQLRPPPKPPLPTPDSGSYVSGAQIIIPNPAALFGGPSLPGLPLPLPPGPLDLSALACGNGGGGGGGIGPGLPGSVLPLNLAKNPLLPSPFGAGGLGLPVVSLLGGSAGSKAEGEKGRGSVPARVLGLEDHKTPLERTERSRSRPSPDGLPLLPGTVLDLSTGNSAASSPEVLTPGWVVIPPGSVLLKPAVVN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MHSLDEPLDL -----CCCCCCCHHH	35.90	21454597
15	Phosphorylation	LDLKLSITKLRAARE HHHHHHHHHHHHHHH	22.20	21454597
46	Phosphorylation	ELGLVDDSPAPGSPG HHCCCCCCCCCCCCC	20.63	25168779
51	Phosphorylation	DDSPAPGSPGSPPPG CCCCCCCCCCCCCCC	25.65	26643407
54	Phosphorylation	PAPGSPGSPPPGFLL CCCCCCCCCCCCCCC	37.30	26824392
159	Phosphorylation	PPKDKCLSPELPLAK CCCCCCCCCCCHHHH	26.29	28066266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GLIS2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GLIS2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GLIS2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CTBP1_MOUSE	Ctbp1	physical	16326862

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.