| UniProt ID | ELP1_MOUSE | |
|---|---|---|
| UniProt AC | Q7TT37 | |
| Protein Name | Elongator complex protein 1 | |
| Gene Name | Elp1 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 1333 | |
| Subcellular Localization | Cytoplasm . Nucleus . | |
| Protein Description | May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK).; Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration. Involved in neurogenesis. [PubMed: 19185337 Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation] | |
| Protein Sequence | MRNLKLHRTLEFRDIQAPGKPQCFCLRAEQGTVLIGSERGLTEVDPVRREVKTEISLVAEGFLPEDGSGCIVGIQDLLDQESVCVATASGDVIVCNLSTQQLECVGSVASGISVMSWSPDQELLLLATAQQTLIMMTKDFEVIAEEQIHQDDFGEGKFVTVGWGSKQTQFHGSEGRPTAFPVQLPENALPWDDRRPHITWRGDGQYFAVSVVCRQTEARKIRVWNREFALQSTSESVPGLGPALAWKPSGSLIASTQDKPNQQDVVFFEKNGLLHGHFTLPFLKDEVKVNDLLWNADSSVLAIWLEDLPKEDSSTLKSYVQLWTVGNYHWYLKQSLPFSTTGKNQIVSLLWDPVTPCRLHVLCTGWRYLCCDWHWTTDRSSGNSANDLANVAVIDGNRVLVTVFRQTVVPPPMCTYRLLIPHPVNQVIFSAHLGNDLAVLDASNQISVYKCGDKPNMDSTVKLGAVGGNGFKVPLTTPHLEKRYSIQFGNNEEEEEEEVNALQLSFLTWVEDDTFLAISYSHSSSQSIIHHLTVTHSEVDEEQGQLDVSSSVTVDGVVIGLCCCSKTKSLAVQLADGQVLKYLWESPSLAVEPWKNSEGIPVRFVHPCTQMEVATIGGEECVLGLTDRCRFFINDTEVASNITSFAVCDDFLLVTTHSHTCQVFSLSGASLKMLQAALSGSHEASGEILRKVERGSRIVTVVPQDTKLILQMPRGNLEVVHHRALVLAQIRKWLDKLMFKEAFECMRKLRINLNLIHDHNPKVFLENVETFVKQIDSVNHINLFFTELREEDVTKTMYPPPITKSVQVSTHPDGKKLDLICDAMRAAMEAINPRKFCLSILTSHVKKTTPELEIVLQKVQELQGNLPFDPESVSVEEALKYLLLLVDVNELFNHSLGTYDFNLVLMVAEKSQKDPKEYLPFLNTLKKMETNYQRFTIDKYLKRYEKALGHLSKCGPEYFTECLNLIKDKNLYKEALKLYRPDSPQYQAVSMAYGEHLMQEHLYEPAGLVFARCGAQEKALEAFLACGSWQQALCVAAQLQMSKDKVAGLARTLAGKLVEQRKHSEAATVLEQYAQDYEEAVLLLLEGSAWEEALRLVYKYDRVDIIETSVKPSILEAQKNYMDFLDSETATFIRHKNRLQVVRALRRQAPQVHVDHEVAHGPESDLFSETSSIMSGSEMSGRYSHSNSRISARSSKNRRKAERKKHSLKEGSPLEGLALLEALSEVVQSVEKLKDEVRAILKVLFLFEFEEQAKELQRAFESTLQLMERAVPEIWTPAGQQSSTTPVLGPSSTANSITASYQQQKTCVPALDAGVYMPPKMDPRSQWKLSLLE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 165 | Phosphorylation | FVTVGWGSKQTQFHG EEEEEECCCCCEECC | 18.32 | 29514104 | |
| 655 | Phosphorylation | CDDFLLVTTHSHTCQ ECCEEEEECCCCCEE | 20.82 | - | |
| 667 | Phosphorylation | TCQVFSLSGASLKML CEEEEEECHHHHHHH | 30.99 | 23737553 | |
| 670 | Phosphorylation | VFSLSGASLKMLQAA EEEECHHHHHHHHHH | 31.86 | 23737553 | |
| 707 | Acetylation | TVVPQDTKLILQMPR EECCCCCEEEEECCC | 41.65 | 23236377 | |
| 805 | Phosphorylation | YPPPITKSVQVSTHP CCCCCCCEEEEEECC | 14.77 | - | |
| 930 | Phosphorylation | NTLKKMETNYQRFTI HHHHHHHHHHHHHHH | 35.41 | 23684622 | |
| 936 | Phosphorylation | ETNYQRFTIDKYLKR HHHHHHHHHHHHHHH | 30.38 | 23684622 | |
| 1172 | Phosphorylation | DLFSETSSIMSGSEM HCCCCCCCCCCCCCC | 29.72 | - | |
| 1175 | Phosphorylation | SETSSIMSGSEMSGR CCCCCCCCCCCCCCC | 37.18 | 25338131 | |
| 1188 | Phosphorylation | GRYSHSNSRISARSS CCCCCCCCCCCCCHH | 33.72 | 30635358 | |
| 1191 | Phosphorylation | SHSNSRISARSSKNR CCCCCCCCCCHHHHH | 19.27 | 30635358 | |
| 1224 | Phosphorylation | LALLEALSEVVQSVE HHHHHHHHHHHHHHH | 35.08 | 27180971 | |
| 1229 | Phosphorylation | ALSEVVQSVEKLKDE HHHHHHHHHHHHHHH | 22.19 | 27180971 | |
| 1284 | Phosphorylation | PAGQQSSTTPVLGPS CCCCCCCCCCCCCCC | 40.13 | 22006019 | |
| 1293 | Phosphorylation | PVLGPSSTANSITAS CCCCCCCCCCCCCCC | 33.91 | 24453211 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ELP1_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ELP1_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ELP1_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of ELP1_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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