PLOD2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLOD2_MOUSE
• UniProt AC: Q9R0B9
• Protein Name: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
• Gene Name: Plod2
• Organism: Mus musculus (Mouse).
• Sequence Length: 737
• Subcellular Localization: Rough endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side.
• Protein Description: Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links..
• Protein Sequence: MGDRGARPGRLMPMLALLSWAAGLGVAEETPGRIPADKLLVITVATKENDGFHRFMNSAKYFNYTVKVLGQGQEWRGGDGMNSIGGGQKVRLLKEAMEHYASQEDLVILFTECFDVVFAGGPEEVLKKFQKTNHKIVFAADGLLWPDKRLADKYPVVHIGKRYLNSGGFIGYAPYISRLVQQWNLQDNDDDQLFYTKVYIDPLKREAFNITLDHKCKIFQALNGATDEVVLKFENGKSRVKNTFYETLPVAINGNGPTKILLNYFGNYVPNSWTQENGCALCDVDTIDLSTVDVPPKVTLGVFIEQPTPFLPRFLNLLLTLDYPKEALQLFIHNKEVYHEKDIKVFVDKAKHDISSIKIVGPEENLSQAEARNMGMDFCRQDEKCDYYFSVDADVVLTNPRTLKFLIEQNRKIIAPLVTRHGKLWSNFWGALSPDGYYARSEDYVDIVQGNRVGIWNVPYMANVYLIQGKTLRSEMNERNYFVRDKLDPDMALCRNARDMGVFMYISNRHEFGRLISTANYNTSHLNNDFWQIFENPVDWKEKYINRDYSKIFTENIVEQPCPDVFWFPIFSERACDELVEEMEHYGKWSGGKHHDSRISGGYENVPTDDIHMKQIGLENVWLHFIREFIAPVTLKVFAGYYTKGFALLNFVVKYSPERQRSLRPHHDASTFTINIALNNVGEDFQGGGCKFLRYNCSIESPRKGWSFMHPGRLTHLHEGLPVKNGTRYIAVSFIDP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
63	N-linked_Glycosylation	MNSAKYFNYTVKVLG HHHCEECEEEEEECC	28.60	-
153	Acetylation	PDKRLADKYPVVHIG CCHHHHHCCCEEEEC	45.94	22826441
172	Phosphorylation	NSGGFIGYAPYISRL CCCCCCCHHHHHHHH	10.29	26643407
175	Phosphorylation	GFIGYAPYISRLVQQ CCCCHHHHHHHHHHH	11.89	26643407
177	Phosphorylation	IGYAPYISRLVQQWN CCHHHHHHHHHHHHC	17.45	26643407
209	N-linked_Glycosylation	PLKREAFNITLDHKC CCCHHHHCCCHHHHC	33.12	-
320	Phosphorylation	RFLNLLLTLDYPKEA HHHHHHHHCCCCHHH	19.97	-
323	Phosphorylation	NLLLTLDYPKEALQL HHHHHCCCCHHHHHH	21.22	-
365	N-linked_Glycosylation	KIVGPEENLSQAEAR EEECCHHCCCHHHHH	43.24	-
367	Phosphorylation	VGPEENLSQAEARNM ECCHHCCCHHHHHHH	38.64	-
522	N-linked_Glycosylation	LISTANYNTSHLNND HHHHCCCCCCCCCCC	34.61	-
554	Phosphorylation	RDYSKIFTENIVEQP CCHHHHHHHCCCCCC	31.43	-
696	N-linked_Glycosylation	GCKFLRYNCSIESPR CCEEEEEECEECCCC	13.46	-
704	Succinylation	CSIESPRKGWSFMHP CEECCCCCCCCCCCC	69.02	23806337
704	Succinylation	CSIESPRKGWSFMHP CEECCCCCCCCCCCC	69.02	-
704	Acetylation	CSIESPRKGWSFMHP CEECCCCCCCCCCCC	69.02	23806337
725	N-linked_Glycosylation	HEGLPVKNGTRYIAV ECCCCCCCCCEEEEE	58.25	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLOD2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLOD2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLOD2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PLOD2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.