dbPTM

DMXL1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DMXL1_MOUSE
UniProt AC	Q6PNC0
Protein Name	DmX-like protein 1
Gene Name	Dmxl1
Organism	Mus musculus (Mouse).
Sequence Length	3013
Subcellular Localization
Protein Description
Protein Sequence	MNLHQVLTGAVNPGDHCFAVGSVGEQRFTAYASGCDIVILGSNFERLQIIPGAKHGNIQVGCVDCSMQQGKIAASYGNVISVFEPVSLPKKRKNLEFYSQWQKSGQFFLDSIAHNITWDPAGNRLLTGSSCLQLWCNSRKQTEDENPDKTDLNFGNWMCIWHCKTASQVHLMKFSPDGEFFATAGKDDCLLKVWYNVENWRPAVTSPDKNSEKQSQGEIDFSFVYLAHPRAVNGFSWRKTSKYMPRASVCNVLLTCCKDNVCRLWVETFLPNDCFLYGSDCNHWCEPVSLTNNLKRNASSKDRVQSALEVNLRPFRRGRSRSLALVAHTGYLPHQQDPHHAHRNTPLHANALCHFHIAASINPATDIPLLPSITSLSLNENEEKCGPFVVHWLNNKELHFTLSMEVFLQQLRKSFEQPSSEASVEDSIQADLKSDEELDDGVDDLKINHEKKELDEDKMLPSSSFTPLSSAAVDHQIEVLLSEWSKNADMLFSIHPMDGSLLVWHVDWLDEYQPGMFRQVQVSFVSRIPVAFPTGDANSLCKSIVMYACTKNVDLAIQQGKQRPTGLTRSTSMLISSAHSKSSNNLKLSIFTPNVMMISKHADGSLNQWLVSFAEESAFSTVLSISHKSRYCGHRFHLNDLACHSVLPLLLTTSHHNALRTPNVGNQKQAHDAVNTEECSLAQQNKSNVDMAFQDPNAIYSELILWRVDPVGPLSFSGGVSELARINSLHVSAFSNVAWLPTLIPSYCLGAYCNSPSACFVASDGQYLRLYEAVIDAKKLLYELSNPEISKYVGEVFNIVSQQSTARPGCIIALDSITKLHGRKTQLLHVFQEDFILNNLEKKRLGVDNILLDSDSSCNGFSEKFYLVVIECTEDNRSLLRMWDLHLRSTPVSLDERIDTKISEASWLPEEHYSSSPEKILSPFSQKFQACRANLQSTSKLSLFSEMVYSKELDLPEGVEIISVKPSAGHLSSSSIYPVCSAPYLLATSCSDDKVRFWRCRVTNGESATSKNGKLDVVYVWEEWPLLIEDGLENNSSVTVPGRPVEVSCAHTSRLAVAYKQPTGNSRSQEFVMHVSIFECESTGGSCWILEQTIHLDELSTVLDSGISIDSNLVAYNKQETYLVSKESITSNTKHLVHLDWMSREDGSHILTVGIGSKLFMYGPMAGKVQDQTGKENQAFPLWDSTKIVPLSKFVLLRSVDLVSSVEGAPPFPVSLSWVRDGILVVGMDCEMHVYSQWQPSNKQEPVISESYNGSTPSILSLIKQSNSSSSGLHPPKKTLTRSMTSLAQKICGKKSIFDPSVDMEDSGLFEAAHVLSPTLPQYHPLQLLELMDLGKVRRAKAILSHLVKCIAGEVVALNEAESNHERRLRSLTISASGSTTRDPQAFNKADSRDYTEIDSVPPLPLYALLAADDDSYCSSLEKTGSESSLKKSKQLSKESYDELFQTSVLMSDNHMLETDEENTQPRVIDLSQYSPTYFGPEHAQVLSGHLLHSSLPGLTRMEQMSLMALADTIATTSTDIGESRDRNQGGETLDECGLKFLLAVRLHTFLTTSLPAYRAQLLHQGLSTGHFAWAFHSVAEEELLNMLPAMQKDDPTWSELRAMGVGWWVRNARILRRCIEKVAKAAFHRNNDPLDAAIFYLAMKKKAVIWGLYRSQKDTKMTQFFGHNFEEERWRKAALKNAFSLLGKQRFEHSAAFFLLGGCLKDAIEVCLEKLNDIQLALVIARLFESEFDKSATYKSILRKKVLGIGSPASELSSSSINAHHDPFLRSMAHWILEDYSAALETLIKQPVTEDEDQVMMSACNPIVFNFYNYLRTHPLLLRRHFGSSSETFSTHMTLAGKSGLAGTINLSERRLFFTTASAHLKAGCPMLALEVLSKMPKVSKKAKPCCRGSSFLTSKDSSLKLDVREDKCCAADWSPSLTNGLESSSEGSSERHSHSTLSFDWSQPSVVFQDDSLELKWDSDNDEENEDPPISMKEIRPLQRKTVKEIDELSSYTDSLSTLDENDILNPSEDIIAVQLKFRACLKILTVELRTLSTGYEIDGGKLRYQLYHWLEKEVVALQRTCDFCSDADQLQTTFSQSADESGSTEDADDLHHQTKVKQLRESFQEKRQWLLKYQSLLRMFLSYCVLHGSHGGGLASVRMELILLLQESQQETAEPIFSNPLSEQTSVPLLFACTASAKTVVANPLLHLSNLTHDILHAIINFDSPPHPDSQTNKVYVMHTLAASLSACIYQCLCGSHNYSSFQTNQFTGMVYQTVLLAHRHSLRTGSLDESVTPNTSPAQWPGINFLIQLLNSSGEEAQSGLTVLLCEILTAVYLSLFIHGLATHSSNELFRIVAHPLNEKMWSAVFGGGAHVPSKGQANSKALSVEGEKQNRHISPSKVSARESPVSSSSGNQEPPAVKEKFVPPELSIWDYFIAKPFLPPSQSRAEYDSEESLESDDEEEEDDDDALPSGLQLHEHSNSNSFSWSLMRLAMVQLVLNNLKTFYPFAGHDLAELPVSSPLCHAVLKTLQCWEQVLLRRLEIHGGPPQNYISSHTSEENVSAGPAILRHKALLEPTNTPFKSKNHLALSVKRLWQYLVKQEEIQETFIRNIFTKKRCLNEIEADLGYPGGKARIIHKESDIITAFAVNRANRNCIAIASSHDVQELDVSAILATQIYTWVDDDTETETKGSEDFLVIHARDDLSAVQGSTPYTHSNPGTPINMPWLGSTQTGRGASVMLKKAINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQITCFRSGGNSRITRMRFNYQGNKFGIVDADGYLSLYQTNWKCCPVTGSMPKPYLAWQCHNKTANDFVFVSSSSLIATAGLSSDNRNICLWDTLVAPANSLVHAFTCHDSGATVLAYAPKHQLLISGGRKGFTCIFDLRQRQQRQLFQSHDSPVKAIAIDPTEEYFVTGSAEGNIKIWSLSSFSLLHTFINEHARQSIFRNIGTGVMQIETGPANHIFSCGADGTMKMRILPDQFSPLNEVLKNDVKFML

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
138	Phosphorylation	CLQLWCNSRKQTEDE HHHHHHCCCCCCCCC	37.40	-
205	Phosphorylation	ENWRPAVTSPDKNSE CCCCCCCCCCCCCCC	36.33	25521595
206	Phosphorylation	NWRPAVTSPDKNSEK CCCCCCCCCCCCCCC	25.22	25521595
211	Phosphorylation	VTSPDKNSEKQSQGE CCCCCCCCCCCCCCE	52.49	22817900
248	Phosphorylation	SKYMPRASVCNVLLT CCCCCHHHHHHHHHH	28.60	22802335
255	Phosphorylation	SVCNVLLTCCKDNVC HHHHHHHHHHCCCCH	16.23	22802335
299	Phosphorylation	NNLKRNASSKDRVQS HHHCCCCCCHHHHHH	41.28	24719451
322	Phosphorylation	FRRGRSRSLALVAHT CCCCCCCCEEEEEEC	21.17	24719451
419	Phosphorylation	RKSFEQPSSEASVED HHHCCCCCCCCCHHH	40.27	25619855
420	Phosphorylation	KSFEQPSSEASVEDS HHCCCCCCCCCHHHH	43.81	25619855
423	Phosphorylation	EQPSSEASVEDSIQA CCCCCCCCHHHHHHH	23.22	25619855
427	Phosphorylation	SEASVEDSIQADLKS CCCCHHHHHHHHCCC	11.77	25619855
434	Phosphorylation	SIQADLKSDEELDDG HHHHHCCCHHHCCCC	58.51	25521595
570	Phosphorylation	RPTGLTRSTSMLISS CCCCCCHHHHHHHHC	21.43	27742792
571	Phosphorylation	PTGLTRSTSMLISSA CCCCCHHHHHHHHCC	18.18	28833060
572	Phosphorylation	TGLTRSTSMLISSAH CCCCHHHHHHHHCCC	16.91	26824392
576	Phosphorylation	RSTSMLISSAHSKSS HHHHHHHHCCCCCCC	19.94	28833060
577	Phosphorylation	STSMLISSAHSKSSN HHHHHHHCCCCCCCC	24.02	28833060
580	Phosphorylation	MLISSAHSKSSNNLK HHHHCCCCCCCCCCE	33.67	20531401
645	Phosphorylation	LNDLACHSVLPLLLT HHHHHHHHHHHHHHC	25.82	21183079
652	Phosphorylation	SVLPLLLTTSHHNAL HHHHHHHCCCCCCCC	26.65	26060331
653	Phosphorylation	VLPLLLTTSHHNALR HHHHHHCCCCCCCCC	26.49	26060331
654	Phosphorylation	LPLLLTTSHHNALRT HHHHHCCCCCCCCCC	19.95	26060331
661	Phosphorylation	SHHNALRTPNVGNQK CCCCCCCCCCCCCCC	21.77	26824392
854	Phosphorylation	VDNILLDSDSSCNGF CCEEEECCCCCCCCC	39.08	29899451
856	Phosphorylation	NILLDSDSSCNGFSE EEEECCCCCCCCCCC	40.52	29899451
857	Phosphorylation	ILLDSDSSCNGFSEK EEECCCCCCCCCCCC	19.32	29899451
901	Ubiquitination	LDERIDTKISEASWL HHHHHCCCCHHHHCC	40.25	-
903	Phosphorylation	ERIDTKISEASWLPE HHHCCCCHHHHCCCH	28.76	25777480
906	Phosphorylation	DTKISEASWLPEEHY CCCCHHHHCCCHHHC	25.70	24925903
913	Phosphorylation	SWLPEEHYSSSPEKI HCCCHHHCCCCHHHH	17.33	24925903
914	Phosphorylation	WLPEEHYSSSPEKIL CCCHHHCCCCHHHHC	26.67	24925903
915	Phosphorylation	LPEEHYSSSPEKILS CCHHHCCCCHHHHCC	42.62	24925903
916	Phosphorylation	PEEHYSSSPEKILSP CHHHCCCCHHHHCCH	31.01	25521595
922	Phosphorylation	SSPEKILSPFSQKFQ CCHHHHCCHHHHHHH	27.63	26824392
925	Phosphorylation	EKILSPFSQKFQACR HHHCCHHHHHHHHHH	35.53	23984901
927	Ubiquitination	ILSPFSQKFQACRAN HCCHHHHHHHHHHHH	37.94	-
1003	Phosphorylation	RFWRCRVTNGESATS EEEEEEEECCCCCCC	20.39	25338131
1007	Phosphorylation	CRVTNGESATSKNGK EEEECCCCCCCCCCC	37.94	25338131
1126	Ubiquitination	QETYLVSKESITSNT CCEEEEEHHHHCCCC	48.26	-
1249	Phosphorylation	NKQEPVISESYNGST CCCCCCEEECCCCCC	22.26	27180971
1251	Phosphorylation	QEPVISESYNGSTPS CCCCEEECCCCCCHH	19.67	23140645
1252	Phosphorylation	EPVISESYNGSTPSI CCCEEECCCCCCHHH	21.35	22817900
1255	Phosphorylation	ISESYNGSTPSILSL EEECCCCCCHHHHHH	33.24	21082442
1256	Phosphorylation	SESYNGSTPSILSLI EECCCCCCHHHHHHH	23.58	26643407
1258	Phosphorylation	SYNGSTPSILSLIKQ CCCCCCHHHHHHHHH	35.93	23140645
1261	Phosphorylation	GSTPSILSLIKQSNS CCCHHHHHHHHHCCC	26.78	26643407
1266	Phosphorylation	ILSLIKQSNSSSSGL HHHHHHHCCCCCCCC	33.41	29899451
1268	Phosphorylation	SLIKQSNSSSSGLHP HHHHHCCCCCCCCCC	36.52	25338131
1269	Phosphorylation	LIKQSNSSSSGLHPP HHHHCCCCCCCCCCC	32.54	30352176
1279	Phosphorylation	GLHPPKKTLTRSMTS CCCCCHHHHHHHHHH	39.22	26643407
1281	Phosphorylation	HPPKKTLTRSMTSLA CCCHHHHHHHHHHHH	26.40	29899451
1283	Phosphorylation	PKKTLTRSMTSLAQK CHHHHHHHHHHHHHH	22.60	25521595
1285	Phosphorylation	KTLTRSMTSLAQKIC HHHHHHHHHHHHHHH	23.10	22942356
1286	Phosphorylation	TLTRSMTSLAQKICG HHHHHHHHHHHHHHC	17.05	22324799
1371	Phosphorylation	NHERRLRSLTISASG HHHHHHHEEEEECCC	34.16	22705319
1375	Phosphorylation	RLRSLTISASGSTTR HHHEEEEECCCCCCC	15.90	22705319
1377	Phosphorylation	RSLTISASGSTTRDP HEEEEECCCCCCCCH	26.87	29514104
1379	Phosphorylation	LTISASGSTTRDPQA EEEECCCCCCCCHHH	24.90	29899451
1381	Phosphorylation	ISASGSTTRDPQAFN EECCCCCCCCHHHHC	34.47	29899451
1392	Phosphorylation	QAFNKADSRDYTEID HHHCCCCCCCCCCCC	31.73	29899451
1395	Phosphorylation	NKADSRDYTEIDSVP CCCCCCCCCCCCCCC	12.74	29899451
1396	Phosphorylation	KADSRDYTEIDSVPP CCCCCCCCCCCCCCC	30.65	29899451
1416	Phosphorylation	LLAADDDSYCSSLEK HHHCCCCCCHHCHHH	34.73	29899451
1426	Phosphorylation	SSLEKTGSESSLKKS HCHHHHCCHHHHHHH	39.27	27681418
1428	Phosphorylation	LEKTGSESSLKKSKQ HHHHCCHHHHHHHHH	42.54	27681418
1429	Phosphorylation	EKTGSESSLKKSKQL HHHCCHHHHHHHHHC	39.91	27681418
1452	Phosphorylation	FQTSVLMSDNHMLET HHHHHHHCCCCCCCC	30.97	-
1681	Ubiquitination	RWRKAALKNAFSLLG HHHHHHHHHHHHHHC	41.31	-
1752	Phosphorylation	KKVLGIGSPASELSS HHHHCCCCCHHHHCC	18.51	29899451
1829	Phosphorylation	LLRRHFGSSSETFST HHHHHCCCCCCCEEH	29.73	22817900
1830	Phosphorylation	LRRHFGSSSETFSTH HHHHCCCCCCCEEHH	32.35	22817900
1831	Phosphorylation	RRHFGSSSETFSTHM HHHCCCCCCCEEHHH	42.21	19060867
1833	Phosphorylation	HFGSSSETFSTHMTL HCCCCCCCEEHHHHH	25.49	21183079
1835	Phosphorylation	GSSSETFSTHMTLAG CCCCCCEEHHHHHCC	25.48	27149854
1836	Phosphorylation	SSSETFSTHMTLAGK CCCCCEEHHHHHCCC	16.10	27149854
1839	Phosphorylation	ETFSTHMTLAGKSGL CCEEHHHHHCCCCCC	13.07	27149854
1885	Phosphorylation	LSKMPKVSKKAKPCC HHCCCCCCCCCCCCC	34.27	28059163
1895	Phosphorylation	AKPCCRGSSFLTSKD CCCCCCCCCCCCCCC	9.88	29176673
1896	Phosphorylation	KPCCRGSSFLTSKDS CCCCCCCCCCCCCCC	27.40	27742792
1899	Phosphorylation	CRGSSFLTSKDSSLK CCCCCCCCCCCCCCC	31.55	29899451
1900	Phosphorylation	RGSSFLTSKDSSLKL CCCCCCCCCCCCCCE	36.29	27742792
1903	Phosphorylation	SFLTSKDSSLKLDVR CCCCCCCCCCCEEEC	41.11	25521595
1904	Phosphorylation	FLTSKDSSLKLDVRE CCCCCCCCCCEEECC	39.39	27742792
1920	Phosphorylation	KCCAADWSPSLTNGL CCCCCCCCHHHCCCC	12.73	26745281
1922	Phosphorylation	CAADWSPSLTNGLES CCCCCCHHHCCCCCC	42.16	23984901
1924	Phosphorylation	ADWSPSLTNGLESSS CCCCHHHCCCCCCCC	31.42	23984901
1929	Phosphorylation	SLTNGLESSSEGSSE HHCCCCCCCCCCCCC	44.18	23984901
1930	Phosphorylation	LTNGLESSSEGSSER HCCCCCCCCCCCCCC	24.04	23984901
1931	Phosphorylation	TNGLESSSEGSSERH CCCCCCCCCCCCCCC	56.08	23984901
1934	Phosphorylation	LESSSEGSSERHSHS CCCCCCCCCCCCCCC	25.60	23984901
1965	Phosphorylation	SLELKWDSDNDEENE CEEEECCCCCCCCCC	36.88	27742792
1977	Phosphorylation	ENEDPPISMKEIRPL CCCCCCCCHHHCHHC	29.58	25619855
2079	Phosphorylation	SDADQLQTTFSQSAD CCHHHHHHHHCCCCC	38.10	30635358
2080	Phosphorylation	DADQLQTTFSQSADE CHHHHHHHHCCCCCC	14.34	30635358
2082	Phosphorylation	DQLQTTFSQSADESG HHHHHHHCCCCCCCC	22.57	30635358
2084	Phosphorylation	LQTTFSQSADESGST HHHHHCCCCCCCCCC	36.17	30635358
2088	Phosphorylation	FSQSADESGSTEDAD HCCCCCCCCCCCCHH	38.29	30635358
2090	Phosphorylation	QSADESGSTEDADDL CCCCCCCCCCCHHHH	37.59	19060867
2091	Phosphorylation	SADESGSTEDADDLH CCCCCCCCCCHHHHH	41.22	19060867
2101	Phosphorylation	ADDLHHQTKVKQLRE HHHHHHHHHHHHHHH	33.19	30635358
2372	Phosphorylation	QANSKALSVEGEKQN CCCCCCEEECCCCCC	24.00	29899451
2383	Phosphorylation	EKQNRHISPSKVSAR CCCCCCCCHHHCCCC	19.59	29895711
2385	Phosphorylation	QNRHISPSKVSARES CCCCCCHHHCCCCCC	38.61	21454597
2388	Phosphorylation	HISPSKVSARESPVS CCCHHHCCCCCCCCC	25.91	25619855
2392	Phosphorylation	SKVSARESPVSSSSG HHCCCCCCCCCCCCC	25.66	25619855
2395	Phosphorylation	SARESPVSSSSGNQE CCCCCCCCCCCCCCC	28.08	25619855
2396	Phosphorylation	ARESPVSSSSGNQEP CCCCCCCCCCCCCCC	28.85	25619855
2397	Phosphorylation	RESPVSSSSGNQEPP CCCCCCCCCCCCCCC	34.46	25619855
2398	Phosphorylation	ESPVSSSSGNQEPPA CCCCCCCCCCCCCCC	43.65	25619855
2430	Phosphorylation	AKPFLPPSQSRAEYD CCCCCCCCCCCCCCC	38.56	20415495
2432	Phosphorylation	PFLPPSQSRAEYDSE CCCCCCCCCCCCCCH	37.48	20415495
2537	Phosphorylation	HGGPPQNYISSHTSE CCCCCHHHCCCCCCC	9.27	29899451
2539	Phosphorylation	GPPQNYISSHTSEEN CCCHHHCCCCCCCCC	13.00	29899451
2540	Phosphorylation	PPQNYISSHTSEENV CCHHHCCCCCCCCCC	22.64	29899451
2542	Phosphorylation	QNYISSHTSEENVSA HHHCCCCCCCCCCCC	39.52	21183079
2543	Phosphorylation	NYISSHTSEENVSAG HHCCCCCCCCCCCCC	37.17	22807455
2548	Phosphorylation	HTSEENVSAGPAILR CCCCCCCCCCHHHHC	38.81	20415495
2727	Acetylation	RGASVMLKKAINNVR CCHHHHHHHHHHHHH	23.28	24062335
2727	Succinylation	RGASVMLKKAINNVR CCHHHHHHHHHHHHH	23.28	26388266
2960	Phosphorylation	INEHARQSIFRNIGT CHHHHHHHHHHHHCC	20.38	30387612
2999	Phosphorylation	RILPDQFSPLNEVLK EECCCCCCCHHHHHH	23.89	22324799
3006	Ubiquitination	SPLNEVLKNDVKFML CCHHHHHHHCCCCCC	57.17	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DMXL1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DMXL1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DMXL1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of DMXL1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DMXL1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-434, AND MASSSPECTROMETRY.	19144319 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-915, AND MASSSPECTROMETRY.	17242355 [Abstract]