ATAD3_MOUSE - dbPTM
ATAD3_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ATAD3_MOUSE
UniProt AC Q925I1
Protein Name ATPase family AAA domain-containing protein 3
Gene Name Atad3
Organism Mus musculus (Mouse).
Sequence Length 591
Subcellular Localization Mitochondrion inner membrane
Single-pass membrane protein. Mitochondrion matrix, mitochondrion nucleoid. In the mitochondrial inner membrane, enriched in sites with the potential to form contacts with the outer membrane. The N-terminal domain intera
Protein Description Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important role in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability. Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis (By similarity)..
Protein Sequence MSWLFGIKGPKGEGTGPPLPLPPAQPGAEGGGDRGAGDRPSPKDKWSNFDPTGLERAAKAARELEHSRHAKEALSLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRVQAEERRKTLTEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAIRRATVEREMELRHKNEMLRVEAEARARAKADRENADIIREQIRLKAAEHRQTILESIRTAGTLLGEGFRAFVTDWDKVTATVAGLTLLAVGVYSAKNATSVAGRYIEARLGKPSLVRETSRISVLEALRHPIQVSRRLVSRPQDALEGVILSPSLEARVRDIAIATRNTKKNKSLYRNVLMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGREGVTAMHKVFDWASTSRRGLLLFVDEADAFLRKRATEKISEDLRATLNAFLHRTGQHSSKFMLVLASNQPEQFDWAINDRIDEMVCFALPQREERERLVRMYFDKYVLKPATEGKQRLKVAQFDYGKKCSEVAQLTEGMSGREIAQLAVAWQAMAYSSEDGVLTEAMMDARVQDAVQQHQQKMQWLKVERPDSQTNKPPHPSLLSC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSWLFGIKG
------CCCCCCCCC		32.27-
8SuccinylationMSWLFGIKGPKGEGT
CCCCCCCCCCCCCCC		70.3323954790
41PhosphorylationRGAGDRPSPKDKWSN
CCCCCCCCCCCCCCC		45.5422817900
45MalonylationDRPSPKDKWSNFDPT
CCCCCCCCCCCCCHH		59.6626320211
71AcetylationLEHSRHAKEALSLAQ
HHHHHHHHHHHHHHH		37.087969809
134AcetylationARAQYQDKLARQRYE
HHHHHHHHHHHHHHH		28.6423201123
134MalonylationARAQYQDKLARQRYE
HHHHHHHHHHHHHHH		28.6426320211
197MalonylationAEARARAKADRENAD
HHHHHHHHHHHHHHH		45.3126320211
320PhosphorylationALEGVILSPSLEARV
HHCCCEECHHHHHHH		11.0026824392
322PhosphorylationEGVILSPSLEARVRD
CCCEECHHHHHHHHH		35.1528066266
358PhosphorylationGPPGTGKTLFAKKLA
CCCCCCHHHHHHHHH		28.5821454597
362AcetylationTGKTLFAKKLALHSG
CCHHHHHHHHHHCCC		40.7723201123
372PhosphorylationALHSGMDYAIMTGGD
HHCCCCCEEEECCCC		6.8021149613
376PhosphorylationGMDYAIMTGGDVAPM
CCCEEEECCCCCCCC		31.7221149613
393AcetylationEGVTAMHKVFDWAST
CCCHHHHHHHCHHHC		31.3523201123
423GlutarylationLRKRATEKISEDLRA
HHHHHHHHHCHHHHH		47.3724703693
423AcetylationLRKRATEKISEDLRA
HHHHHHHHHCHHHHH		47.3723806337
423SuccinylationLRKRATEKISEDLRA
HHHHHHHHHCHHHHH		47.3723806337
425PhosphorylationKRATEKISEDLRATL
HHHHHHHCHHHHHHH		35.8025159016
471S-palmitoylationDRIDEMVCFALPQRE
HCCCHHHHHCCCCHH		1.2728526873
490SuccinylationLVRMYFDKYVLKPAT
HHHHHHHHHCCCCCC		27.62-
490SuccinylationLVRMYFDKYVLKPAT
HHHHHHHHHCCCCCC		27.6223806337
490AcetylationLVRMYFDKYVLKPAT
HHHHHHHHHCCCCCC		27.6223576753
494AcetylationYFDKYVLKPATEGKQ
HHHHHCCCCCCCCCH		23.6723576753
494SuccinylationYFDKYVLKPATEGKQ
HHHHHCCCCCCCCCH		23.6724315375
512AcetylationVAQFDYGKKCSEVAQ
EEEECCCCCHHHHHH		44.3623576753
512SuccinylationVAQFDYGKKCSEVAQ
EEEECCCCCHHHHHH		44.3623954790
513AcetylationAQFDYGKKCSEVAQL
EEECCCCCHHHHHHH		38.332390999
567AcetylationAVQQHQQKMQWLKVE
HHHHHHHHCCCCEEC		26.8723201123
578PhosphorylationLKVERPDSQTNKPPH
CEECCCCCCCCCCCC		41.40-
580PhosphorylationVERPDSQTNKPPHPS
ECCCCCCCCCCCCCH		49.51-
587PhosphorylationTNKPPHPSLLSC---
CCCCCCCHHCCC---		38.6229472430
590PhosphorylationPPHPSLLSC------
CCCCHHCCC------		24.0729472430
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ATAD3_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ATAD3_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ATAD3_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ATAD3_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ATAD3_MOUSE

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Substrate and functional diversity of lysine acetylation revealed bya proteomics survey.";
Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T.,Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.;
Mol. Cell 23:607-618(2006).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-490 AND LYS-512, AND MASSSPECTROMETRY.

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