SERC_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SERC_MOUSE
• UniProt AC: Q99K85
• Protein Name: Phosphoserine aminotransferase
• Gene Name: Psat1
• Organism: Mus musculus (Mouse).
• Sequence Length: 370
• Protein Description: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine..
• Protein Sequence: MEATKQVVNFGPGPAKLPHSVLLEIQKQLLDYRGLGISVLEMSHRSSDFAKIIGNTENLVRELLAVPNNYKVIFVQGGGSGQFSAVPLNLIGLKAGRSADYVVTGAWSAKAAEEAKKFGTVNIVHPKLGSYTKIPDPSTWNLNPDASYVYFCANETVHGVEFDFVPDVKGAVLVCDMSSNFLSRPVDVSKFGVIFAGAQKNVGSAGVTVVIVRDDLLGFSLRECPSVLDYKVQAGNNSLYNTPPCFSIYVMGMVLEWIKNNGGAAAMEKLSSIKSQMIYEIIDNSQGFYVCPVERQNRSRMNIPFRIGNAKGDEALEKRFLDKAVELNMISLKGHRSVGGIRASLYNAVTTEDVEKLAAFMKNFLEMHQL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEATKQVV -------CCCCEECE	7.74	-
4	Phosphorylation	----MEATKQVVNFG ----CCCCEECEECC	14.54	-
5	Acetylation	---MEATKQVVNFGP ---CCCCEECEECCC	48.41	22826441
16	Ubiquitination	NFGPGPAKLPHSVLL ECCCCCCCCCHHHHH	66.73	-
20	Phosphorylation	GPAKLPHSVLLEIQK CCCCCCHHHHHHHHH	16.72	29899451
27	Ubiquitination	SVLLEIQKQLLDYRG HHHHHHHHHHHHCCC	48.88	-
38	Phosphorylation	DYRGLGISVLEMSHR HCCCCCCEEEECCCC	20.89	29899451
43	Phosphorylation	GISVLEMSHRSSDFA CCEEEECCCCCCCHH	13.33	26239621
46	Phosphorylation	VLEMSHRSSDFAKII EEECCCCCCCHHHHH	28.92	26239621
47	Phosphorylation	LEMSHRSSDFAKIIG EECCCCCCCHHHHHC	36.38	26239621
51	Ubiquitination	HRSSDFAKIIGNTEN CCCCCHHHHHCCHHH	34.55	-
51	Acetylation	HRSSDFAKIIGNTEN CCCCCHHHHHCCHHH	34.55	-
71	Ubiquitination	LAVPNNYKVIFVQGG HCCCCCEEEEEEECC	30.86	-
110	Ubiquitination	VTGAWSAKAAEEAKK EECCCCHHHHHHHHH	42.48	-
116	Acetylation	AKAAEEAKKFGTVNI HHHHHHHHHHCCEEE	52.49	30987107
127	Acetylation	TVNIVHPKLGSYTKI CEEEECCCCCCCCCC	51.07	23806337
175	Glutathionylation	VKGAVLVCDMSSNFL CCCEEEEEECCCCHH	2.96	24333276
200	N6-(pyridoxal phosphate)lysine	VIFAGAQKNVGSAGV EEEEECCCCCCCCCE	53.73	-
200	Other	VIFAGAQKNVGSAGV EEEEECCCCCCCCCE	53.73	-
224	Glutathionylation	LGFSLRECPSVLDYK CCCCCCCCCCCCEEE	2.17	24333276
269	Acetylation	GGAAAMEKLSSIKSQ CHHHHHHHHHHCCHH	40.35	-
269	Ubiquitination	GGAAAMEKLSSIKSQ CHHHHHHHHHHCCHH	40.35	-
291	Glutathionylation	NSQGFYVCPVERQNR CCCCEEEEEECCCCC	1.81	24333276
318	Acetylation	KGDEALEKRFLDKAV CCCHHHHHHHHHHHH	49.66	15611925
323	Ubiquitination	LEKRFLDKAVELNMI HHHHHHHHHHHHEEE	57.38	-
323	Acetylation	LEKRFLDKAVELNMI HHHHHHHHHHHHEEE	57.38	-
331	Phosphorylation	AVELNMISLKGHRSV HHHHEEEECCCCCCC	17.17	26824392
333	Ubiquitination	ELNMISLKGHRSVGG HHEEEECCCCCCCCC	45.97	-
333	Acetylation	ELNMISLKGHRSVGG HHEEEECCCCCCCCC	45.97	-
337	Phosphorylation	ISLKGHRSVGGIRAS EECCCCCCCCCHHHH	21.31	25777480
344	Phosphorylation	SVGGIRASLYNAVTT CCCCHHHHHCCCCCH	22.87	26824392
346	Phosphorylation	GGIRASLYNAVTTED CCHHHHHCCCCCHHH	9.89	25619855
350	Phosphorylation	ASLYNAVTTEDVEKL HHHCCCCCHHHHHHH	23.27	25619855
351	Phosphorylation	SLYNAVTTEDVEKLA HHCCCCCHHHHHHHH	24.48	25777480
362	Ubiquitination	EKLAAFMKNFLEMHQ HHHHHHHHHHHHHHC	37.79	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SERC_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SERC_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SERC_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SERC_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.