dbPTM

AKAP2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	AKAP2_MOUSE
UniProt AC	O54931
Protein Name	A-kinase anchor protein 2
Gene Name	Akap2
Organism	Mus musculus (Mouse).
Sequence Length	893
Subcellular Localization
Protein Description	Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP..
Protein Sequence	MEIGVSVAECKSVPGVTSTPHSKDHSSPFYSPSHNGLLADHHESLDNDVAREIQYLDEVLEANCCDSSVDGTYNGISSPEPGAAILVSSLGSPAHSVTEAEPTEKASGRQVPPHIELSRSPSDRMAEGERANGHSTDQPQDLLGNSLQAPASPSSSTSSHCSSRDGEFTLTTLKKEAKFELRAFHEDKKPSKLFEEDEREKEQFCVRKVRPSEEMIELEKERRELIRSQAVKKNPGIAAKWWNPPQEKTIEEQLDEEHLESHRKYKERKEKRAQQEQLQLQQQQQQQLQQQQLQQQQLQQQQLQQQLQQQQLSTSQPCTAPAAHKHLDGIEHTKEDVVTEQIDFSAARKQFQLMENSRQTLAKGQSTPRLFSIKPYYKPLGSIHSDKPPTILRPATVGGTLEDGGTQAAKEQKAPCVSESQSAGAGPANAATQGKEGPYSEPSKRGPLSKLWAEDGEFTSARAVLTVVKDEDHGILDQFSRSVNVSLTQEELDSGLDELSVRSQDTTVLETLSNDFSMDNISDSGASNETPSALQENSLADFSLPQTPQTDNPSEGREGVSKSFSDHGFYSPSSTLGDSPSVDDPLEYQAGLLVQNAIQQAIAEQVDKAEAHTSKEGSEQQEPEATVEEAGSQTPGSEKPQGMFAPPQVSSPVQEKRDILPKNLPAEDRALREKGPSQPPTAAQPSGPVNMEETRPEGGYFSKYSEAAELRSTASLLATQESDVMVGPFKLRSRKQRTLSMIEEEIRAAQEREEELKRQRQVRQSTPSPRAKNAPSLPSRTTCYKTAPGKIEKVKPPPSPTTEGPSLQPDLAPEEAAGTQRPKNLMQTLMEDYETHKSKRRERMDDSSYTSKLLSCKVTSEVLEATRVNRRKSALALRWEAGIYANQEEEDNE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	VSVAECKSVPGVTST CCHHHCCCCCCCCCC	45.24	23684622
17	Phosphorylation	CKSVPGVTSTPHSKD CCCCCCCCCCCCCCC	32.57	25777480
18	Phosphorylation	KSVPGVTSTPHSKDH CCCCCCCCCCCCCCC	37.22	23684622
19	Phosphorylation	SVPGVTSTPHSKDHS CCCCCCCCCCCCCCC	18.69	24899341
22	Phosphorylation	GVTSTPHSKDHSSPF CCCCCCCCCCCCCCC	40.77	27149854
26	Phosphorylation	TPHSKDHSSPFYSPS CCCCCCCCCCCCCCC	50.25	27742792
27	Phosphorylation	PHSKDHSSPFYSPSH CCCCCCCCCCCCCCC	18.66	29899451
30	Phosphorylation	KDHSSPFYSPSHNGL CCCCCCCCCCCCCCC	24.05	27742792
31	Phosphorylation	DHSSPFYSPSHNGLL CCCCCCCCCCCCCCC	21.95	26824392
33	Phosphorylation	SSPFYSPSHNGLLAD CCCCCCCCCCCCCCC	24.52	27742792
44	Phosphorylation	LLADHHESLDNDVAR CCCCCHHHCCHHHHH	36.34	27742792
73	Phosphorylation	DSSVDGTYNGISSPE CCCCCCCCCCCCCCC	19.54	10391015
118	Phosphorylation	VPPHIELSRSPSDRM CCCCEEECCCHHHHH	20.23	24068923
120	Phosphorylation	PHIELSRSPSDRMAE CCEEECCCHHHHHHC	25.94	24068923
122	Phosphorylation	IELSRSPSDRMAEGE EEECCCHHHHHHCCC	38.81	9378289
135	Phosphorylation	GERANGHSTDQPQDL CCCCCCCCCCCCHHH	34.77	25619855
136	Phosphorylation	ERANGHSTDQPQDLL CCCCCCCCCCCHHHC	32.74	25619855
146	Phosphorylation	PQDLLGNSLQAPASP CHHHCCCCCCCCCCC	21.76	25619855
152	Phosphorylation	NSLQAPASPSSSTSS CCCCCCCCCCCCCCC	25.02	27087446
154	Phosphorylation	LQAPASPSSSTSSHC CCCCCCCCCCCCCCC	34.13	25619855
155	Phosphorylation	QAPASPSSSTSSHCS CCCCCCCCCCCCCCC	40.81	25619855
156	Phosphorylation	APASPSSSTSSHCSS CCCCCCCCCCCCCCC	36.32	25619855
157	Phosphorylation	PASPSSSTSSHCSSR CCCCCCCCCCCCCCC	35.88	25619855
158	Phosphorylation	ASPSSSTSSHCSSRD CCCCCCCCCCCCCCC	21.74	25619855
159	Phosphorylation	SPSSSTSSHCSSRDG CCCCCCCCCCCCCCC	28.71	25619855
162	Phosphorylation	SSTSSHCSSRDGEFT CCCCCCCCCCCCEEE	24.00	25619855
163	Phosphorylation	STSSHCSSRDGEFTL CCCCCCCCCCCEEEE	39.52	25619855
169	Phosphorylation	SSRDGEFTLTTLKKE CCCCCEEEEEHHHHH	20.92	29514104
172	Phosphorylation	DGEFTLTTLKKEAKF CCEEEEEHHHHHHHH	39.43	29514104
191	Phosphorylation	FHEDKKPSKLFEEDE HCCCCCHHHCCCCCH	51.36	51459121
212	Phosphorylation	CVRKVRPSEEMIELE EEEECCCCHHHHHHH	35.31	25338131
249	Phosphorylation	WNPPQEKTIEEQLDE CCCCCCCCHHHHCCH	32.63	19367708
357	Phosphorylation	QFQLMENSRQTLAKG HHHHHHHHHHHHHCC	16.68	-
366	Phosphorylation	QTLAKGQSTPRLFSI HHHHCCCCCCCCEEE	49.39	26643407
367	Phosphorylation	TLAKGQSTPRLFSIK HHHCCCCCCCCEEEC	12.44	26643407
416	S-nitrosocysteine	AKEQKAPCVSESQSA HHHHCCCCCCHHHCC	6.68	-
416	S-nitrosylation	AKEQKAPCVSESQSA HHHHCCCCCCHHHCC	6.68	21278135
439	Phosphorylation	TQGKEGPYSEPSKRG HCCCCCCCCCCCCCC	36.20	20116462
469	Ubiquitination	RAVLTVVKDEDHGIL EEEEEEEECCCCCHH	51.57	-
482	Phosphorylation	ILDQFSRSVNVSLTQ HHHHHHCEECCCCCH	19.49	25619855
486	Phosphorylation	FSRSVNVSLTQEELD HHCEECCCCCHHHHH	22.09	26824392
488	Phosphorylation	RSVNVSLTQEELDSG CEECCCCCHHHHHCC	26.82	25619855
494	Phosphorylation	LTQEELDSGLDELSV CCHHHHHCCCCEEHH	54.61	26824392
500	Phosphorylation	DSGLDELSVRSQDTT HCCCCEEHHHCCCCC	17.28	25619855
503	Phosphorylation	LDELSVRSQDTTVLE CCEEHHHCCCCCHHH	30.19	23649490
506	Phosphorylation	LSVRSQDTTVLETLS EHHHCCCCCHHHHHC	15.92	23649490
507	Phosphorylation	SVRSQDTTVLETLSN HHHCCCCCHHHHHCC	31.23	23649490
511	Phosphorylation	QDTTVLETLSNDFSM CCCCHHHHHCCCCCC	31.18	23649490
513	Phosphorylation	TTVLETLSNDFSMDN CCHHHHHCCCCCCCC	41.60	23649490
517	Phosphorylation	ETLSNDFSMDNISDS HHHCCCCCCCCCCCC	28.26	23649490
522	Phosphorylation	DFSMDNISDSGASNE CCCCCCCCCCCCCCC	31.79	23737553
524	Phosphorylation	SMDNISDSGASNETP CCCCCCCCCCCCCCC	29.48	23737553
527	Phosphorylation	NISDSGASNETPSAL CCCCCCCCCCCCCHH	38.43	23737553
530	Phosphorylation	DSGASNETPSALQEN CCCCCCCCCCHHHHC	27.13	23737553
532	Phosphorylation	GASNETPSALQENSL CCCCCCCCHHHHCCC	49.37	23737553
538	Phosphorylation	PSALQENSLADFSLP CCHHHHCCCCCCCCC	24.96	23649490
543	Phosphorylation	ENSLADFSLPQTPQT HCCCCCCCCCCCCCC	39.42	23649490
547	Phosphorylation	ADFSLPQTPQTDNPS CCCCCCCCCCCCCCC	18.54	23737553
550	Phosphorylation	SLPQTPQTDNPSEGR CCCCCCCCCCCCCCC	38.66	23737553
554	Phosphorylation	TPQTDNPSEGREGVS CCCCCCCCCCCCCCC	59.96	23737553
588	Phosphorylation	SVDDPLEYQAGLLVQ CCCCHHHHHHHHHHH	16.02	28059163
618	Phosphorylation	AHTSKEGSEQQEPEA HHCCCCCCCCCCCCC	33.07	22942356
626	Phosphorylation	EQQEPEATVEEAGSQ CCCCCCCCHHHHCCC	27.13	26643407
632	Phosphorylation	ATVEEAGSQTPGSEK CCHHHHCCCCCCCCC	37.62	26160508
634	Phosphorylation	VEEAGSQTPGSEKPQ HHHHCCCCCCCCCCC	31.17	26824392
637	Phosphorylation	AGSQTPGSEKPQGMF HCCCCCCCCCCCCCC	43.58	26160508
650	Phosphorylation	MFAPPQVSSPVQEKR CCCCCCCCCCHHHHH	24.55	26824392
651	Phosphorylation	FAPPQVSSPVQEKRD CCCCCCCCCHHHHHC	30.18	26824392
662	Acetylation	EKRDILPKNLPAEDR HHHCCCCCCCCHHHH	68.61	23806337
700	Phosphorylation	ETRPEGGYFSKYSEA CCCCCCCCCCCHHHH	18.61	29514104
702	Phosphorylation	RPEGGYFSKYSEAAE CCCCCCCCCHHHHHH	23.38	29514104
704	Phosphorylation	EGGYFSKYSEAAELR CCCCCCCHHHHHHHH	15.56	29514104
722	Phosphorylation	SLLATQESDVMVGPF HHHHCCCCCCCCCCC	26.20	29514104
738	Phosphorylation	LRSRKQRTLSMIEEE CCCCCHHHHHHHHHH	22.23	25521595
740	Phosphorylation	SRKQRTLSMIEEEIR CCCHHHHHHHHHHHH	19.66	25521595
747	Dimethylation	SMIEEEIRAAQEREE HHHHHHHHHHHHHHH	27.44	-
765	Phosphorylation	RQRQVRQSTPSPRAK HHHHHHHCCCCCCCC	31.55	23737553
766	Phosphorylation	QRQVRQSTPSPRAKN HHHHHHCCCCCCCCC	21.32	23737553
768	Phosphorylation	QVRQSTPSPRAKNAP HHHHCCCCCCCCCCC	27.40	23737553
776	Phosphorylation	PRAKNAPSLPSRTTC CCCCCCCCCCCCCCE	50.96	18779572
779	Phosphorylation	KNAPSLPSRTTCYKT CCCCCCCCCCCEEEC	47.77	18779572
784	Phosphorylation	LPSRTTCYKTAPGKI CCCCCCEEECCCCCE	14.85	29514104
784 (in isoform 3)	Phosphorylation	-	14.85	29514104
799	Phosphorylation	EKVKPPPSPTTEGPS EECCCCCCCCCCCCC	40.42	25521595
801	Phosphorylation	VKPPPSPTTEGPSLQ CCCCCCCCCCCCCCC	41.64	25521595
802	Phosphorylation	KPPPSPTTEGPSLQP CCCCCCCCCCCCCCC	42.18	25521595
806	Phosphorylation	SPTTEGPSLQPDLAP CCCCCCCCCCCCCCH	50.96	27742792
819	Phosphorylation	APEEAAGTQRPKNLM CHHHHCCCCCCHHHH	19.37	25619855
873	Phosphorylation	TRVNRRKSALALRWE HCCCCHHHHHHHHHH	27.06	7658505
884	Phosphorylation	LRWEAGIYANQEEED HHHHHCCCCCCCCCC	9.89	75251

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of AKAP2_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of AKAP2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of AKAP2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of AKAP2_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of AKAP2_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-799, AND MASSSPECTROMETRY.	19131326 [Abstract]