BOP1_MOUSE - dbPTM
BOP1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID BOP1_MOUSE
UniProt AC P97452
Protein Name Ribosome biogenesis protein BOP1 {ECO:0000255|HAMAP-Rule:MF_03027}
Gene Name Bop1
Organism Mus musculus (Mouse).
Sequence Length 732
Subcellular Localization Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein Description Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome..
Protein Sequence MAGACGKPHMSPASLPGKRRLEPDQELQIQEPPLLSDPDSSLSDSEESVFSGLEDLGSDSSEEDTEGVAGSSGDEDNHRAEETSEELAQAAPLCSRTEEAGALAQDEYEEDSSDEEDIRNTVGNVPLAWYDEFPHVGYDLDGKRIYKPLRTRDELDQFLDKMDDPDFWRTVQDKMTGRDLRLTDEQVALVHRLQRGQFGDSGFNPYEPAVDFFSGDIMIHPVTNRPADKRSFIPSLVEKEKVSRMVHAIKMGWIKPRRPHDPTPSFYDLWAQEDPNAVLGRHKMHVPAPKLALPGHAESYNPPPEYLPTEEERSAWMQQEPVERKLNFLPQKFPSLRTVPAYSRFIQERFERCLDLYLCPRQRKMRVNVDPEDLIPKLPRPRDLQPFPVCQALVYRGHSDLVRCLSVSPGGQWLASGSDDGTLKLWEVATARCMKTVHVGGVVRSIAWNPNPTICLVAAAMDDAVLLLNPALGDRLLVGSTDQLLEAFTPPEEPALQPARWLEVSEEEHQRGLRLRICHSKPVTQVTWHGRGDYLAVVLSSQEHTQVLLHQVSRRRSQSPFRRSHGQVQCVAFHPSRPFLLVASQRSIRIYHLLRQELTKKLMPNCKWVSSMAVHPAGDNIICGSYDSKLVWFDLDLSTKPYKVLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGMVYNDLLQNPLLVPVKVLKGHTLTRDLGVLDVAFHPTQPWVFSSGADGTIRLFS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Acetylation-MAGACGKPHMSPAS
-CCCCCCCCCCCCCC		31.4723806337
11PhosphorylationACGKPHMSPASLPGK
CCCCCCCCCCCCCCC		17.8026824392
14PhosphorylationKPHMSPASLPGKRRL
CCCCCCCCCCCCCCC		38.1830352176
36PhosphorylationIQEPPLLSDPDSSLS
CCCCCCCCCCCCCCC		55.5722817900
83PhosphorylationDNHRAEETSEELAQA
CCCCCHHHHHHHHHH		32.7021743459
84PhosphorylationNHRAEETSEELAQAA
CCCCHHHHHHHHHHH		32.1421743459
97PhosphorylationAAPLCSRTEEAGALA
HHHHCCHHHHHCHHC		23.1425619855
108PhosphorylationGALAQDEYEEDSSDE
CHHCCCCCCCCCCCH		32.6725619855
112PhosphorylationQDEYEEDSSDEEDIR
CCCCCCCCCCHHHHH		42.8627087446
113PhosphorylationDEYEEDSSDEEDIRN
CCCCCCCCCHHHHHH		62.4527087446
121PhosphorylationDEEDIRNTVGNVPLA
CHHHHHHHHCCCCEE		21.6822345495
130PhosphorylationGNVPLAWYDEFPHVG
CCCCEEEECCCCCCE		10.4522345495
138PhosphorylationDEFPHVGYDLDGKRI
CCCCCCEECCCCCEE		16.5522345495
332UbiquitinationKLNFLPQKFPSLRTV
HHCCCCCCCCCCCCC		58.2522790023
395PhosphorylationPVCQALVYRGHSDLV
CHHHHHEECCCCCCE		16.2426026062
408PhosphorylationLVRCLSVSPGGQWLA
CEEEEEECCCCCEEE		17.9126643407
416PhosphorylationPGGQWLASGSDDGTL
CCCCEEECCCCCCCE		36.3426643407
418PhosphorylationGQWLASGSDDGTLKL
CCEEECCCCCCCEEH		29.9926643407
422PhosphorylationASGSDDGTLKLWEVA
ECCCCCCCEEHHHHH		27.9326643407
534PhosphorylationTWHGRGDYLAVVLSS
EECCCCCEEEEEEEC		10.2129109428
545PhosphorylationVLSSQEHTQVLLHQV
EEECHHHHHHHHHHH		21.4429109428
557PhosphorylationHQVSRRRSQSPFRRS
HHHHHHCCCCCCCCC		32.9529472430
559PhosphorylationVSRRRSQSPFRRSHG
HHHHCCCCCCCCCCC		27.5329895711
576PhosphorylationQCVAFHPSRPFLLVA
EEEEECCCCCEEEEE		43.9721183079
584PhosphorylationRPFLLVASQRSIRIY
CCEEEEEEHHHHHHH		20.7422817900
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of BOP1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of BOP1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of BOP1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of BOP1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of BOP1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-112 AND SER-113, ANDMASS SPECTROMETRY.

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