NH2L1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NH2L1_MOUSE
• UniProt AC: Q9D0T1
• Protein Name: NHP2-like protein 1
• Gene Name: Snu13 {ECO:0000250|UniProtKB:P55769}
• Organism: Mus musculus (Mouse).
• Sequence Length: 128
• Subcellular Localization: Nucleus . Nucleus, nucleolus . Concentrated in the dense fibrillar component of the nucleolus.
• Protein Description: Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding..
• Protein Sequence: MTEADVNPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANEATKTLNRGISEFIVMAADAEPLEIILHLPLLCEDKNVPYVFVRSKQALGRACGVSRPVIACSVTIKEGSQLKQQIQSIQQSIERLLV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MTEADVNP -------CCCCCCCC	7.44	-
2	Acetylation	------MTEADVNPK ------CCCCCCCCC	39.62	-
2	Phosphorylation	------MTEADVNPK ------CCCCCCCCC	39.62	28576409
11	Phosphorylation	ADVNPKAYPLADAHL CCCCCCHHCHHHHHH	12.61	29514104
20	Acetylation	LADAHLTKKLLDLVQ HHHHHHHHHHHHHHH	48.02	7692055
20	Malonylation	LADAHLTKKLLDLVQ HHHHHHHHHHHHHHH	48.02	26320211
21	Acetylation	ADAHLTKKLLDLVQQ HHHHHHHHHHHHHHH	49.39	23806337
21	Ubiquitination	ADAHLTKKLLDLVQQ HHHHHHHHHHHHHHH	49.39	-
21	Malonylation	ADAHLTKKLLDLVQQ HHHHHHHHHHHHHHH	49.39	26320211
29	Phosphorylation	LLDLVQQSCNYKQLR HHHHHHHHCCHHHHH	6.29	26643407
30	S-palmitoylation	LDLVQQSCNYKQLRK HHHHHHHCCHHHHHH	5.84	28526873
32	Phosphorylation	LVQQSCNYKQLRKGA HHHHHCCHHHHHHHH	12.39	26643407
33	Ubiquitination	VQQSCNYKQLRKGAN HHHHCCHHHHHHHHH	28.94	22790023
33	Acetylation	VQQSCNYKQLRKGAN HHHHCCHHHHHHHHH	28.94	22826441
43	Phosphorylation	RKGANEATKTLNRGI HHHHHHHHHHHHHHH	20.55	20531401
44	Ubiquitination	KGANEATKTLNRGIS HHHHHHHHHHHHHHH	59.05	27667366
102	S-nitrosocysteine	VSRPVIACSVTIKEG CCCCEEEEEEEECCC	2.00	-
102	S-nitrosylation	VSRPVIACSVTIKEG CCCCEEEEEEEECCC	2.00	20925432
113	Ubiquitination	IKEGSQLKQQIQSIQ ECCCHHHHHHHHHHH	32.30	22790023
118	Phosphorylation	QLKQQIQSIQQSIER HHHHHHHHHHHHHHH	24.80	25619855
122	Phosphorylation	QIQSIQQSIERLLV- HHHHHHHHHHHHCC-	15.27	27087446

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NH2L1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NH2L1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NH2L1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GAR1_HUMAN	GAR1	physical	20360068
NOP58_HUMAN	NOP58	physical	20360068
NOP56_HUMAN	NOP56	physical	20360068
IPO5_HUMAN	IPO5	physical	20360068
WAP53_HUMAN	WRAP53	physical	20360068
PABP4_HUMAN	PABPC4	physical	20360068
MOV10_HUMAN	MOV10	physical	20360068
SMD1_HUMAN	SNRPD1	physical	20360068
SART3_HUMAN	SART3	physical	20360068
U3IP2_HUMAN	RRP9	physical	20360068
C1QBP_HUMAN	C1QBP	physical	20360068
FBRL_HUMAN	FBL	physical	20360068
RSMB_HUMAN	SNRPB	physical	20360068
SMD3_HUMAN	SNRPD3	physical	20360068
DDX21_HUMAN	DDX21	physical	20360068
NOLC1_HUMAN	NOLC1	physical	20360068
RUXE_HUMAN	SNRPE	physical	20360068
TADBP_HUMAN	TARDBP	physical	20360068
SMD2_HUMAN	SNRPD2	physical	20360068
PABP1_HUMAN	PABPC1	physical	20360068
IMA5_HUMAN	KPNA1	physical	20360068
RUVB1_HUMAN	RUVBL1	physical	20360068
RUVB2_HUMAN	RUVBL2	physical	20360068
DHX15_HUMAN	DHX15	physical	20360068
NHP2_HUMAN	NHP2	physical	20360068
NUFP1_HUMAN	NUFIP1	physical	20360068
ZNHI3_HUMAN	ZNHIT3	physical	20360068
NH2L1_HUMAN	NHP2L1	physical	20360068
DKC1_HUMAN	DKC1	physical	20360068
DHX9_HUMAN	DHX9	physical	20360068
IMA1_HUMAN	KPNA2	physical	20360068
HNRPF_HUMAN	HNRNPF	physical	20360068
NOP10_HUMAN	NOP10	physical	20360068
LA_HUMAN	SSB	physical	20360068
COIL_HUMAN	COIL	physical	20360068
NPA1P_HUMAN	URB1	physical	20360068
IMB1_HUMAN	KPNB1	physical	20360068
BCD1_HUMAN	ZNHIT6	physical	20360068
RL1D1_HUMAN	RSL1D1	physical	20360068
HNRL1_HUMAN	HNRNPUL1	physical	20360068
LARP7_HUMAN	LARP7	physical	20360068
TGS1_HUMAN	TGS1	physical	20360068
IMA7_HUMAN	KPNA6	physical	20360068
WDR43_HUMAN	WDR43	physical	20360068
DHX30_HUMAN	DHX30	physical	20360068

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.