| UniProt ID | MYO1C_MOUSE | |
|---|---|---|
| UniProt AC | Q9WTI7 | |
| Protein Name | Unconventional myosin-Ic | |
| Gene Name | Myo1c | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 1063 | |
| Subcellular Localization |
Cytoplasm. Cell membrane Peripheral membrane protein Cytoplasmic side. Cell projection, stereocilium membrane. Cytoplasmic vesicle. Cell projection, ruffle. Colocalizes with CABP1 and CIB1 at cell margin, membrane ruffles and punctate regions on th |
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| Protein Description | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which then are moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes.; Isoform 3 is involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation.. | |
| Protein Sequence | MALQVELIPTGEIIRVVHPHRPCKLALGSDGVRVTMESALTARDRVGVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPPHLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVVHQNHGERNFHVFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVMRKALSVIDFTEDEVEDLLSIVASVLHLGNIHFAADEDSNAQVTTENQLKYLTRLLGVEGTTLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVRKINRSLASKDAESPSWRSTTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVEEKFKGIISILDEECLRPGEATDLTFLEKLEDTVKPHPHFLTHKLADQKTRKSLDRGEFRLLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCSSMNPIMAQCFDKSELSDKKRPETVATQFKMSLLQLVEILRSKEPAYIRCIKPNDAKQPGRFDEVLIRHQVKYLGLMENLRVRRAGFAYRRKYEAFLQRYKSLCPETWPMWAGRPQDGVAVLVRHLGYKPEEYKMGRTKIFIRFPKTLFATEDSLEVRRQSLATKIQAAWRGFHWRQKFLRVKRSAICIQSWWRGTLGRRKAAKRKWAAQTIRRLIRGFILRHSPRCPENAFFLDHVRASFLLNLRRQLPRNVLDTSWPTPPPALREASELLRELCMKNMVWKYCRSISPEWKQQLQQKAVASEIFKGKKDNYPQSVPRLFISTRLGTEEISPRVLQSLGSEPIQYAVPVVKYDRKGYKPRPRQLLLTPSAVVIVEDAKVKQRIDYANLTGISVSSLSDSLFVLHVQREDNKQKGDVVLQSDHVIETLTKTALSADRVNNININQGSITFAGGPGRDGIIDFTSGSELLITKAKNGHLAVVAPRLNSR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 (in isoform 2) | Acetylation | - | 38.07 | - | |
| 3 (in isoform 3) | Phosphorylation | - | 9.98 | - | |
| 6 (in isoform 3) | Phosphorylation | - | 28.20 | 26239621 | |
| 10 (in isoform 3) | Phosphorylation | - | 40.22 | 30635358 | |
| 188 | Ubiquitination | LEAFGNAKTLRNDNS HHHHCCCCCCCCCCC | 52.68 | 22790023 | |
| 196 | Phosphorylation | TLRNDNSSRFGKYMD CCCCCCCCCCEEEEE | 37.57 | 26824392 | |
| 269 | Acetylation | QSYLYLVKGQCAKVS CCEEEEEECCEEECC | 40.44 | 22826441 | |
| 281 | Ubiquitination | KVSSINDKSDWKVMR ECCCCCCHHHHHHHH | 45.91 | 22790023 | |
| 281 | Acetylation | KVSSINDKSDWKVMR ECCCCCCHHHHHHHH | 45.91 | 22826441 | |
| 361 | Ubiquitination | THRKIIAKGEELLSP HCCCHHHCCCHHCCC | 57.35 | 22790023 | |
| 373 | Phosphorylation | LSPLNLEQAAYARDA CCCCCHHHHHHHHHH | 34.16 | 19144319 | |
| 376 | Phosphorylation | LNLEQAAYARDALAK CCHHHHHHHHHHHHH | 12.75 | 26060331 | |
| 383 | Methylation | YARDALAKAVYSRTF HHHHHHHHHHHHHHH | 38.95 | - | |
| 383 | Ubiquitination | YARDALAKAVYSRTF HHHHHHHHHHHHHHH | 38.95 | 22790023 | |
| 404 | Ubiquitination | INRSLASKDAESPSW HHHHHHCCCCCCCCH | 56.18 | 22790023 | |
| 404 | Acetylation | INRSLASKDAESPSW HHHHHHCCCCCCCCH | 56.18 | 23806337 | |
| 408 | Phosphorylation | LASKDAESPSWRSTT HHCCCCCCCCHHHHH | 26.42 | 27087446 | |
| 410 | Phosphorylation | SKDAESPSWRSTTVL CCCCCCCCHHHHHHH | 44.38 | 22324799 | |
| 480 | Glutathionylation | YFNNKIICDLVEEKF HHCCEEHHHHHHHHH | 3.64 | 24333276 | |
| 486 | Ubiquitination | ICDLVEEKFKGIISI HHHHHHHHHCCHHHH | 38.58 | 22790023 | |
| 486 | Acetylation | ICDLVEEKFKGIISI HHHHHHHHHCCHHHH | 38.58 | 23806337 | |
| 498 | Glutathionylation | ISILDEECLRPGEAT HHHCCHHHCCCCCCC | 3.53 | 24333276 | |
| 536 | Phosphorylation | ADQKTRKSLDRGEFR CCHHHHHCCCCCCEE | 32.01 | 25263469 | |
| 594 | Acetylation | DKSELSDKKRPETVA CHHHHCCCCCHHHHH | 47.51 | 19849379 | |
| 595 | Ubiquitination | KSELSDKKRPETVAT HHHHCCCCCHHHHHH | 77.50 | 22790023 | |
| 595 | Acetylation | KSELSDKKRPETVAT HHHHCCCCCHHHHHH | 77.50 | 19849387 | |
| 617 | Phosphorylation | QLVEILRSKEPAYIR HHHHHHHCCCCCEEE | 37.62 | 19144319 | |
| 618 | Ubiquitination | LVEILRSKEPAYIRC HHHHHHCCCCCEEEE | 62.37 | 22790023 | |
| 647 | Acetylation | VLIRHQVKYLGLMEN HHHHHHHHHHHHHHH | 28.34 | 22826441 | |
| 729 | Phosphorylation | TLFATEDSLEVRRQS CCEECCCCHHHHHHH | 21.87 | 29514104 | |
| 736 | Phosphorylation | SLEVRRQSLATKIQA CHHHHHHHHHHHHHH | 20.40 | 27149854 | |
| 739 | Phosphorylation | VRRQSLATKIQAAWR HHHHHHHHHHHHHHC | 33.69 | 28066266 | |
| 740 | Ubiquitination | RRQSLATKIQAAWRG HHHHHHHHHHHHHCC | 27.49 | 22790023 | |
| 763 | S-nitrosylation | RVKRSAICIQSWWRG HHCHHHHHHHHHHCC | 2.01 | 20925432 | |
| 763 | S-nitrosocysteine | RVKRSAICIQSWWRG HHCHHHHHHHHHHCC | 2.01 | - | |
| 799 | Phosphorylation | RGFILRHSPRCPENA HHHHHHCCCCCCCCC | 13.96 | 27717184 | |
| 802 | S-nitrosylation | ILRHSPRCPENAFFL HHHCCCCCCCCCCHH | 5.87 | 20925432 | |
| 802 | S-nitrosocysteine | ILRHSPRCPENAFFL HHHCCCCCCCCCCHH | 5.87 | - | |
| 815 | Phosphorylation | FLDHVRASFLLNLRR HHHHHHHHHHHHHHH | 13.08 | 24899341 | |
| 862 | Phosphorylation | MVWKYCRSISPEWKQ HHHHHHHHCCHHHHH | 24.69 | 26643407 | |
| 864 | Phosphorylation | WKYCRSISPEWKQQL HHHHHHCCHHHHHHH | 20.29 | 26824392 | |
| 868 | Ubiquitination | RSISPEWKQQLQQKA HHCCHHHHHHHHHHH | 26.89 | 22790023 | |
| 916 | Phosphorylation | RVLQSLGSEPIQYAV HHHHHCCCCCCEEEE | 45.55 | 29514104 | |
| 1039 | Phosphorylation | DGIIDFTSGSELLIT CCEEECCCCCEEEEE | 40.07 | 23737553 | |
| 1041 | Phosphorylation | IIDFTSGSELLITKA EEECCCCCEEEEEEC | 25.49 | 26824392 | |
| 1046 | Phosphorylation | SGSELLITKAKNGHL CCCEEEEEECCCCCE | 25.56 | 23737553 | |
| 1062 | Phosphorylation | VVAPRLNSR------ EEECCCCCC------ | 43.91 | 22324799 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 1020 | S | Phosphorylation | Kinase | GSK3B | Q9WV60 | PSP |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MYO1C_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MYO1C_MOUSE !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-408, AND MASSSPECTROMETRY. | |
