dbPTM

SNX8_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SNX8_MOUSE
UniProt AC	Q8CFD4
Protein Name	Sorting nexin-8
Gene Name	Snx8
Organism	Mus musculus (Mouse).
Sequence Length	459
Subcellular Localization	Early endosome membrane Peripheral membrane protein Cytoplasmic side. Colocalizes with retromer components..
Protein Description	May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network (By similarity)..
Protein Sequence	MTGRAMDPLPSPAVAAAAEAEADEEADPPATGPRTSQVTEWRALDPGRMQMPQGNPLLLSYTLQELLAKDTVQVELIPEKKGLFLKHVEYEVSSQRFKSSVYRRYNDFVVFHEVLLHKFPYRMVPALPPKRVLGADREFIEGRRRALKRFINLVARHPPFSEDVLLKLFLSFSGSDVQHKLKEAAQCVGDEFMNCKLAARAKDFLPADIQTQFAMSRELIRNVYNSFYKLRDRAERIASRAIDNAADLLIFGKELSALGSDTTPLPSWAALHLSTWGSLKQALKGLSVEFALLADRAAQQGKKEENDVVEKLNLFLDLLQSYKDLCERHEKGVLHKHQRALHKYGLMKRQMMSAAHGREPESVEQLESRIVEQENVIQTMELRNYFSLYCLHQETQLVHVYLPLTSHILGAFVNSQIQGHKEMSKVWNDLKPKLSCLFAGPHSVLTPPRSPQEDGVCPH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
99	Phosphorylation	VSSQRFKSSVYRRYN ECCHHHHHHHHHHHC	23.48	22871156
196	Ubiquitination	GDEFMNCKLAARAKD CHHHHHCHHHHHCHH	35.84	22790023
425	Acetylation	QGHKEMSKVWNDLKP HCHHHHHHHHHHHHH	50.38	7719755
435	Phosphorylation	NDLKPKLSCLFAGPH HHHHHHHEEEECCCC	18.20	25159016
443	Phosphorylation	CLFAGPHSVLTPPRS EEECCCCCCCCCCCC	23.19	25159016
446	Phosphorylation	AGPHSVLTPPRSPQE CCCCCCCCCCCCCCC	29.14	26824392
450	Phosphorylation	SVLTPPRSPQEDGVC CCCCCCCCCCCCCCC	36.39	26824392

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SNX8_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SNX8_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SNX8_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SNX8_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SNX8_MOUSE

Related Literatures of Post-Translational Modification