RUXE_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RUXE_MOUSE
• UniProt AC: P62305
• Protein Name: Small nuclear ribonucleoprotein E
• Gene Name: Snrpe
• Organism: Mus musculus (Mouse).
• Sequence Length: 92
• Subcellular Localization: Cytoplasm, cytosol. Nucleus. SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes..
• Protein Description: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development (By similarity)..
• Protein Sequence: MAYRGQGQKVQKVMVQPINLIFRYLQNRSRIQVWLYEQVNMRIEGCIIGFDEYMNLVLDDAEEIHSKTKSRKQLGRIMLKGDNITLLQSVSN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Ubiquitination	GQGQKVQKVMVQPIN CCCCCCEEEEEEHHH	34.97	22790023
66	Phosphorylation	DDAEEIHSKTKSRKQ CCHHHHHHHCCCHHH	47.91	18779572
67	Ubiquitination	DAEEIHSKTKSRKQL CHHHHHHHCCCHHHH	45.90	-
69	Ubiquitination	EEIHSKTKSRKQLGR HHHHHHCCCHHHHCC	52.58	-
85	Phosphorylation	MLKGDNITLLQSVSN EEECCCEEEEEECCC	27.89	20531401
89	Phosphorylation	DNITLLQSVSN---- CCEEEEEECCC----	27.73	20531401
91	Phosphorylation	ITLLQSVSN------ EEEEEECCC------	41.91	20531401

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RUXE_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RUXE_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RUXE_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RUXE_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.