dbPTM

TMCO1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TMCO1_MOUSE
UniProt AC	Q921L3
Protein Name	Calcium load-activated calcium channel {ECO:0000250\|UniProtKB:Q9UM00}
Gene Name	Tmco1 {ECO:0000312\|MGI:MGI:1921173}
Organism	Mus musculus (Mouse).
Sequence Length	188
Subcellular Localization	Endoplasmic reticulum membrane Multi-pass membrane protein . Golgi apparatus membrane Multi-pass membrane protein . The first transmembrane region is required for localization to the endoplasmic reticulum.
Protein Description	Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. [PubMed: 27212239 In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store]
Protein Sequence	MSTMFADTLLIVFISVCTALLAEGITWVLVYRTDKYKRLKAEVEKQSKKLEKKKETITESAGRQQKKKIERQEEKLKNNNRDLSMVRMKSMFAIGFCFTALMGMFNSIFDGRVVAKLPFTPLSYIQGLSHRNLLGDDTTDCSFIFLYILCTMSIRQNIQKILGLAPSRAATKQAGGFLGPPPPSGKFS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
58	Phosphorylation	EKKKETITESAGRQQ HHHHHHHHHHHHHHH	31.16	28066266
60	Phosphorylation	KKETITESAGRQQKK HHHHHHHHHHHHHHH	27.63	28066266
116	Ubiquitination	FDGRVVAKLPFTPLS HCCCEEEECCCCCHH	45.12	-
184	Phosphorylation	FLGPPPPSGKFS--- CCCCCCCCCCCC---	61.46	26643407
188	Phosphorylation	PPPSGKFS------- CCCCCCCC-------	42.68	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TMCO1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TMCO1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TMCO1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of TMCO1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TMCO1_MOUSE

Related Literatures of Post-Translational Modification