MIRO1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MIRO1_MOUSE
• UniProt AC: Q8BG51
• Protein Name: Mitochondrial Rho GTPase 1
• Gene Name: Rhot1
• Organism: Mus musculus (Mouse).
• Sequence Length: 631
• Subcellular Localization: Mitochondrion outer membrane; Single-pass type IV membrane protein. Colocalizes with MGARP and RHOT2 at the mitochondria..
• Protein Description: Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity)..
• Protein Sequence: MRAGRVRPLRASDMKKDVRILLVGEPRVGKTSLIMSLVSEEFPEEVPPRAEEITIPADVTPERVPTHIVDYSEAEQSDEQLHQEISQANVICIVYAVNNKHSIDKVTSRWIPLINERTDKDSRLPLILVGNKSDLVEYSSMETILPIMNQYTEIETCVECSAKNLKNISELFYYAQKAVLHPTGPLYCPEEKEMKPACIKALTRIFKISDQDNDGTLNDAELNFFQRICFNTPLAPQALEDVKNVVRKHLSDGVADSGLTLRGFLFLHTLFIQRGRHETTWTVLRRFGYDDDLDLTPEYLFPLLKIPPDCTTELNHHAYLFLQSTFDKHDLDRDCALSPDELKDLFQVFPYIPWGPDVNNTVCTNERGWITYQGFLSQWTLTTYLDVQRCLEYLGYLGYSILTEQESQASAITVTRDKKIDLQKKQTQRNVFRCNVIGVKGCGKTGVLQSLLGRNLMRQKKIRDDHKSYYAINTVYVYGQEKYLLLHDISESEFLTEAETICDVVCLVYDVTNPKSFEYCARIFKQHFMDSRIPCLIVAAKSDLHEVKQEHSISPTDFCRKHKMPPPQAFTCNTADAPSKDIFVKLTTMAMYPHVTQADLKSSTFWLRASFGATVFAVVGFAMYRALLKQR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
105	Malonylation	NNKHSIDKVTSRWIP CCCCCCHHHHHCEEH	45.82	26320211
166 (in isoform 2)	Ubiquitination	-	62.72	22790023
166	Ubiquitination	ECSAKNLKNISELFY HHCCCCCCCHHHHHH	62.72	22790023
188	S-palmitoylation	HPTGPLYCPEEKEMK CCCCCCCCCCHHHCH	4.50	28526873
195	Ubiquitination	CPEEKEMKPACIKAL CCCHHHCHHHHHHHH	30.47	22790023
195 (in isoform 2)	Ubiquitination	-	30.47	22790023
200 (in isoform 2)	Ubiquitination	-	36.91	22790023
200	Ubiquitination	EMKPACIKALTRIFK HCHHHHHHHHHHHHH	36.91	22790023
207	Ubiquitination	KALTRIFKISDQDND HHHHHHHHCCCCCCC	38.64	22790023
207 (in isoform 2)	Ubiquitination	-	38.64	22790023
229	S-palmitoylation	LNFFQRICFNTPLAP HHHHHHHHHCCCCCH	2.04	28526873
232	Phosphorylation	FQRICFNTPLAPQAL HHHHHHCCCCCHHHH	10.22	-
251	Phosphorylation	NVVRKHLSDGVADSG HHHHHHCCCCCCCCC	31.85	20139300
257	Phosphorylation	LSDGVADSGLTLRGF CCCCCCCCCCCHHHH	26.43	20139300
338	Phosphorylation	LDRDCALSPDELKDL CCCCCCCCHHHHHHH	16.27	22324799
525	Ubiquitination	EYCARIFKQHFMDSR HHHHHHHHHHCCCCC	40.26	-
525	Malonylation	EYCARIFKQHFMDSR HHHHHHHHHHCCCCC	40.26	26320211
525 (in isoform 2)	Ubiquitination	-	40.26	22790023
535	S-nitrosylation	FMDSRIPCLIVAAKS CCCCCCCEEEEEECC	3.64	21278135
535	S-palmitoylation	FMDSRIPCLIVAAKS CCCCCCCEEEEEECC	3.64	28526873
535	S-nitrosocysteine	FMDSRIPCLIVAAKS CCCCCCCEEEEEECC	3.64	-
572	S-nitrosylation	PPPQAFTCNTADAPS CCCCCEECCCCCCCC	3.26	21278135
572	S-nitrosocysteine	PPPQAFTCNTADAPS CCCCCEECCCCCCCC	3.26	-
592 (in isoform 4)	Phosphorylation	-	4.81	23140645
592 (in isoform 2)	Phosphorylation	-	4.81	29472430
597 (in isoform 4)	Phosphorylation	-	31.61	29472430
597 (in isoform 2)	Phosphorylation	-	31.61	29472430
600 (in isoform 4)	Phosphorylation	-	6.94	26060331
600 (in isoform 2)	Phosphorylation	-	6.94	26060331
602 (in isoform 4)	Phosphorylation	-	41.74	23140645
602 (in isoform 2)	Phosphorylation	-	41.74	23140645

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MIRO1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MIRO1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MIRO1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MIRO1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.