KINH_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KINH_MOUSE
• UniProt AC: Q61768
• Protein Name: Kinesin-1 heavy chain
• Gene Name: Kif5b
• Organism: Mus musculus (Mouse).
• Sequence Length: 963
• Subcellular Localization: Cytoplasm, cytoskeleton . Uniformly distributed between soma and neurites in hippocampal neurons.
• Protein Description: Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. May be involved in the mechanisms of growth arrest induced by exposure to DNA-damaging drugs or by cellular senescence. [PubMed: 9657148 Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner]
• Protein Sequence: MADPAECNIKVMCRFRPLNESEVNRGDKYVAKFQGEDTVMIASKPYAFDRVFQSSTSQEQVYNDCAKKIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPEGMGIIPRIVQDIFNYIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGSTYVPYRDSKMTRILQDSLGGNCRTTIVICCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKTLRNTIQWLENELNRWRNGETVPIDEQFDKEKANLEAFTADKDIAITSDKPAAAVGMAGSFTDAERRKCEEELAKLYKQLDDKDEEINQQSQLVEKLKTQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKLKEMTNHQKKRAAEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKMEENEKELAACQLRISQHEAKIKSLTEYLQNVEQKKRQLEESVDSLGEELVQLRAQEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLRDEVEAKEKLITDLQDQNQKMVLEQERLRVEHERLKATDQEKSRKLHELTVMQDRREQARQDLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSAEVDSDDTGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENASRDRKRYQQEVDRIKEAVRSKNMARRGHSAQIAKPIRPGQHPAASPTHPGTVRGGGSFVQNNQPVGLRGGGGKQS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADPAECNI ------CCCHHHCCE	31.34	-
10	Acetylation	DPAECNIKVMCRFRP CHHHCCEEEEEEECC	15.21	23806337
44	Acetylation	DTVMIASKPYAFDRV CEEEEECCCCCHHHH	32.78	23954790
65	S-nitrosylation	QEQVYNDCAKKIVKD HHHHHHHHHHHHHHH	5.49	21278135
65	S-nitrosocysteine	QEQVYNDCAKKIVKD HHHHHHHHHHHHHHH	5.49	-
154	Phosphorylation	DVSKTNLSVHEDKNR CHHCCCCCCCCCCCC	24.41	-
159	Acetylation	NLSVHEDKNRVPYVK CCCCCCCCCCCCCCC	43.60	23806337
166	Ubiquitination	KNRVPYVKGCTERFV CCCCCCCCCCCCCEE	42.28	-
175	Phosphorylation	CTERFVCSPDEVMDT CCCCEEECHHHHHHC	30.04	-
226	Ubiquitination	TEQKLSGKLYLVDLA CHHHHCCEEEEEECC	30.49	-
237	Ubiquitination	VDLAGSEKVSKTGAE EECCCCCCCCCCCCC	54.21	-
240	Ubiquitination	AGSEKVSKTGAEGAV CCCCCCCCCCCCCCH	54.70	-
252	Ubiquitination	GAVLDEAKNINKSLS CCHHHHHHHHHHHHH	57.20	-
272	Phosphorylation	ISALAEGSTYVPYRD HHHHHCCCCCCCCCC	14.20	20531401
273	Phosphorylation	SALAEGSTYVPYRDS HHHHCCCCCCCCCCC	39.12	20531401
346	Acetylation	QWKKKYEKEKEKNKT HHHHHHHHHHHHCHH	71.62	6568327
357	Phosphorylation	KNKTLRNTIQWLENE HCHHHHHHHHHHHHH	14.22	18779572
382	Acetylation	PIDEQFDKEKANLEA CCCHHCCHHHHCHHH	63.50	23236377
400	Phosphorylation	DKDIAITSDKPAAAV CCCEEECCCCCCHHH	37.21	29899451
412	Phosphorylation	AAVGMAGSFTDAERR HHHHCCCCCCHHHHH	18.55	30352176
414	Phosphorylation	VGMAGSFTDAERRKC HHCCCCCCHHHHHHH	35.68	29472430
420	Ubiquitination	FTDAERRKCEEELAK CCHHHHHHHHHHHHH	52.82	22790023
502	Phosphorylation	LEELAVNYDQKSQEV HHHHHCCCCCCCHHH	17.10	29899451
516	Phosphorylation	VEDKTKEYELLSDEL HHHHHHHHHHHHHHH	17.27	25367039
539	Ubiquitination	SIDAELQKLKEMTNH HHHHHHHHHHHHCHH	74.32	22790023
557	Phosphorylation	RAAEMMASLLKDLAE HHHHHHHHHHHHHHH	19.15	18779572
606	Acetylation	SEVKTMVKRCKQLES HHHHHHHHHHHHHHH	41.05	7619049
609	Acetylation	KTMVKRCKQLESTQT HHHHHHHHHHHHHCC	63.05	7619059
613	Phosphorylation	KRCKQLESTQTESNK HHHHHHHHHCCHHHH	34.11	23737553
614	Phosphorylation	RCKQLESTQTESNKK HHHHHHHHCCHHHHH	30.09	23737553
616	Phosphorylation	KQLESTQTESNKKME HHHHHHCCHHHHHHH	41.28	23737553
618	Phosphorylation	LESTQTESNKKMEEN HHHHCCHHHHHHHHH	58.29	23737553
666	Phosphorylation	QLEESVDSLGEELVQ HHHHHHHHHHHHHHH	35.80	25338131
717	Phosphorylation	ETHQKQISSLRDEVE HHHHHHHHHHHHHHH	22.33	18779572
718	Phosphorylation	THQKQISSLRDEVEA HHHHHHHHHHHHHHH	29.11	25159016
801	Ubiquitination	QTLHNLRKLFVQDLA HHHHHHHHHHHHHHH	49.82	22790023
819	Phosphorylation	KKSAEVDSDDTGGSA HHHCCCCCCCCCCCH	42.43	25521595
822	Phosphorylation	AEVDSDDTGGSAAQK CCCCCCCCCCCHHHH	48.73	30635358
825	Phosphorylation	DSDDTGGSAAQKQKI CCCCCCCCHHHHHHH	23.06	30635358
831	Ubiquitination	GSAAQKQKISFLENN CCHHHHHHHHHHHHC	47.56	-
844	Ubiquitination	NNLEQLTKVHKQLVR HCHHHHHHHHHHHHH	51.43	-
870	Phosphorylation	LEKRLRATAERVKAL HHHHHHHHHHHHHHH	23.71	18779572
917	Phosphorylation	NMARRGHSAQIAKPI CHHHCCCCCCCCCCC	25.37	25777480
933	Phosphorylation	PGQHPAASPTHPGTV CCCCCCCCCCCCCCC	32.22	26824392
935	Phosphorylation	QHPAASPTHPGTVRG CCCCCCCCCCCCCCC	37.90	25168779
939	Phosphorylation	ASPTHPGTVRGGGSF CCCCCCCCCCCCCCC	16.10	21149613
945	Phosphorylation	GTVRGGGSFVQNNQP CCCCCCCCCCCCCCC	26.06	25521595
956	Methylation	NNQPVGLRGGGGKQS CCCCCCCCCCCCCCC	35.46	24129315
963	Phosphorylation	RGGGGKQS------- CCCCCCCC-------	45.75	25890499

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
175	S	Phosphorylation	Kinase	MAPK10	P53779	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KINH_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KINH_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KIF5A_MOUSE	Kif5a	physical	15834408
KIF5C_MOUSE	Kif5c	physical	15834408
DAXX_MOUSE	Daxx	physical	18932217
KINH_MOUSE	Kif5b	physical	10964943
KIF5A_MOUSE	Kif5a	physical	10964943
KIF5C_MOUSE	Kif5c	physical	10964943
FMR1_HUMAN	FMR1	physical	26496610
KLC1_HUMAN	KLC1	physical	26496610
XPR1_HUMAN	XPR1	physical	26496610
CSN2_HUMAN	COPS2	physical	26496610
RHGBA_HUMAN	ARHGAP11A	physical	26496610
SUN1_HUMAN	SUN1	physical	26496610
VPS8_HUMAN	VPS8	physical	26496610
KDIS_HUMAN	KIDINS220	physical	26496610
KLC2_HUMAN	KLC2	physical	26496610
KLC4_HUMAN	KLC4	physical	26496610
KLC3_HUMAN	KLC3	physical	26496610
LYSM2_HUMAN	LYSMD2	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.