KIF5A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KIF5A_MOUSE
• UniProt AC: P33175
• Protein Name: Kinesin heavy chain isoform 5A
• Gene Name: Kif5a
• Organism: Mus musculus (Mouse).
• Sequence Length: 1027
• Subcellular Localization: Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Concentrated in the cell body of the neurons, particularly in the perinuclear region.
• Protein Description: Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). [PubMed: 12682084 Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons]
• Protein Sequence: MAETNNECSIKVLCRFRPLNQAEILRGDKFIPIFQGDDSVIIGGKPYVFDRVFPPNTTQEQVYHACAMQIVKDVLAGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIARDIFNHIYSMDENLEFHIKVSYFEIYLDKIRDLLDVTKTNLSVHEDKNRVPFVKGCTERFVSSPEEILDVIDEGKSNRHVAVTNMNEHSSRSHSIFLINIKQENVETEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGTKSYVPYRDSKMTRILQDSLGGNCRTTMFICCSPSSYNDAETKSTLMFGQRAKTIKNTASVNLELTAEQWKKKYEKEKEKTKAQKETIAKLEAELSRWRNGENVPETERLAGEDSALGAELCEETPVNDNSSIVVRIAPEERQKYEEEIRRLYKQLDDKDDEINQQSQLIEKLKQQMLDQEELLVSTRGDNEKVQRELSHLQSENDAAKDEVKEVLQALEELAVNYDQKSQEVEEKSQQNQLLVDELSQKVATMLSLESELQRLQEVSGHQRKRIAEVLNGLMRDLSEFSVIVGNGEIKLPVEISGAIEEEFTVARLYISKIKSEVKSVVKRCRQLENLQVECHRKMEVTGRELSSCQLLISQHEAKIRSLTEYMQTVELKKRHLEESYDSLSDELARLQAHETVHEVALKDKEPDTQDAEEVKKALELQMENHREAHHRQLARLRDEINEKQKTIDELKDLNQKLQLELEKLQADYERLKNEENEKSAKLQELTFLYERHEQSKQDLKGLEETVARELQTLHNLRKLFVQDVTTRVKKSAEMEPEDSGGIHSQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALEGALKEAKEGAMKDKRRYQQEVDRIKEAVRYKSSGKRGHSAQIAKPVRPGHYPASSPTNPYGTRSPECISYTNNLFQNYQNLHLQAAPSSTSDMYFASSGATSVAPLASYQKANMDNGNATDINDNRSDLPCGYEAEDQAKLFPLHQETAAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAETNNECS ------CCCCCCCCE	43.56	-
47	Phosphorylation	VIIGGKPYVFDRVFP EEECCEEEEECCCCC	19.75	28576409
57	Phosphorylation	DRVFPPNTTQEQVYH CCCCCCCCCHHHHHH	35.31	28576409
58	Phosphorylation	RVFPPNTTQEQVYHA CCCCCCCCHHHHHHH	36.43	28576409
63	Phosphorylation	NTTQEQVYHACAMQI CCCHHHHHHHHHHHH	5.38	28576409
78	Phosphorylation	VKDVLAGYNGTIFAY HHHHHCCCCCEEEEE	12.57	22817900
99	Ubiquitination	KTHTMEGKLHDPQLM CEEEEECEECCHHHH	29.37	-
188	Ubiquitination	LDVIDEGKSNRHVAV HHHHHCCCCCCEEEE	42.37	22790023
227	Ubiquitination	TEQKLSGKLYLVDLA CHHHHCCEEEEEECC	30.49	-
238	Ubiquitination	VDLAGSEKVSKTGAE EECCCCCCCCCCCCC	54.21	-
241	Ubiquitination	AGSEKVSKTGAEGAV CCCCCCCCCCCCCCH	54.70	-
253	Ubiquitination	GAVLDEAKNINKSLS CCHHHHHHHHHHHHH	57.20	-
258	Phosphorylation	EAKNINKSLSALGNV HHHHHHHHHHHHHHH	24.06	29899451
305	Phosphorylation	TTMFICCSPSSYNDA EEEEEEECCHHCCCH	24.33	-
326	Phosphorylation	MFGQRAKTIKNTASV HHCHHCCCCCCCCCC	35.88	-
348	Acetylation	QWKKKYEKEKEKTKA HHHHHHHHHHHHHHH	71.62	6569443
397	Phosphorylation	GAELCEETPVNDNSS CHHHCCCCCCCCCCC	15.39	22817900
660	Phosphorylation	KKRHLEESYDSLSDE HHHHHHHCHHHHHHH	25.51	29899451
806	Phosphorylation	KLFVQDVTTRVKKSA HHHHHHHHHHHHHHC	19.71	-
807	Phosphorylation	LFVQDVTTRVKKSAE HHHHHHHHHHHHHCC	33.06	-
829	Ubiquitination	GIHSQKQKISFLENN CCCCHHHHHHHHHHH	47.56	-
842	Ubiquitination	NNLEQLTKVHKQLVR HHHHHHHHHHHHHHH	51.43	-
868	Phosphorylation	LEKRLRATAERVKAL HHHHHHHHHHHHHHH	23.71	-
930	Phosphorylation	RPGHYPASSPTNPYG CCCCCCCCCCCCCCC	32.14	29899451
931	Phosphorylation	PGHYPASSPTNPYGT CCCCCCCCCCCCCCC	37.54	19060867
933	Phosphorylation	HYPASSPTNPYGTRS CCCCCCCCCCCCCCC	51.26	29899451
936	Phosphorylation	ASSPTNPYGTRSPEC CCCCCCCCCCCCHHH	32.95	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KIF5A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KIF5A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KIF5A_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KINH_MOUSE	Kif5b	physical	15834408
KIF5C_MOUSE	Kif5c	physical	15834408
KCNC1_MOUSE	Kcnc1	physical	21106837
KINH_MOUSE	Kif5b	physical	10964943
KIF5C_MOUSE	Kif5c	physical	10964943

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.