KCNC1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCNC1_MOUSE
• UniProt AC: P15388
• Protein Name: Potassium voltage-gated channel subfamily C member 1
• Gene Name: Kcnc1 {ECO:0000312|MGI:MGI:96667}
• Organism: Mus musculus (Mouse).
• Sequence Length: 511
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. [PubMed: 2599109]
• Protein Sequence: MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYIEGVCVVWFTFEFLMRVVFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTCPLAQEEILEINRAGRKPLRGMSI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Phosphorylation	LAEPDAHSHFDYDPR ECCCCCCCCCCCCCC	27.80	25521595
48	Phosphorylation	DAHSHFDYDPRADEF CCCCCCCCCCCCCCC	27.23	25521595
130	Phosphorylation	GGAPLDNSADDADAD CCCCCCCCCCCCCCC	32.51	25521595
142	Phosphorylation	DADGPGDSGDGEDEL CCCCCCCCCCCHHHH	44.70	29899451
158	Phosphorylation	MTKRLALSDSPDGRP HHHHHECCCCCCCCC	30.36	24925903
160	Phosphorylation	KRLALSDSPDGRPGG HHHECCCCCCCCCCC	22.86	24925903
220	N-linked_Glycosylation	ERFNPIVNKTEIENV HHHCCCCCHHHEECC	46.37	-
222	Phosphorylation	FNPIVNKTEIENVRN HCCCCCHHHEECCCC	36.67	27600695
229	N-linked_Glycosylation	TEIENVRNGTQVRYY HHEECCCCCCEEEEE	54.29	-
231	Phosphorylation	IENVRNGTQVRYYRE EECCCCCCEEEEEEE	27.69	27600695
235	Phosphorylation	RNGTQVRYYREAETE CCCCEEEEEEEHHHH	14.18	-
236	Phosphorylation	NGTQVRYYREAETEA CCCEEEEEEEHHHHH	7.45	-
468	Phosphorylation	PRPPQLGSPNYCKSV CCCCCCCCCCCHHHH	20.68	22324799
471	Phosphorylation	PQLGSPNYCKSVVNS CCCCCCCCHHHHHCC	12.49	22817900
474	Phosphorylation	GSPNYCKSVVNSPHH CCCCCHHHHHCCCCC	27.95	24925903
474 (in isoform 3)	Phosphorylation	-	27.95	29899451
478	Phosphorylation	YCKSVVNSPHHSTQS CHHHHHCCCCCCCCC	17.63	24925903
478 (in isoform 3)	Phosphorylation	-	17.63	29899451
482 (in isoform 3)	Phosphorylation	-	25.71	29899451
482	Phosphorylation	VVNSPHHSTQSDTCP HHCCCCCCCCCCCCC	25.71	24925903
483	Phosphorylation	VNSPHHSTQSDTCPL HCCCCCCCCCCCCCC	27.95	24925903
483 (in isoform 3)	Phosphorylation	-	27.95	29899451
485	Phosphorylation	SPHHSTQSDTCPLAQ CCCCCCCCCCCCCCH	34.67	24925903
485 (in isoform 3)	Phosphorylation	-	34.67	29899451
487	Phosphorylation	HHSTQSDTCPLAQEE CCCCCCCCCCCCHHH	22.67	24925903
527	Phosphorylation	----------------------- -----------------------		18056256
527 (in isoform 3)	Phosphorylation	-		18056256
527	Phosphorylation	----------------------- -----------------------		18056256
535 (in isoform 3)	Phosphorylation	-		29899451
570	Phosphorylation	------------------------------------------------------------------ ------------------------------------------------------------------		-
570 (in isoform 3)	Phosphorylation	-		20415495
570	Phosphorylation	------------------------------------------------------------------ ------------------------------------------------------------------		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KCNC1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCNC1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCNC1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KIF5A_MOUSE	Kif5a	physical	21106837
KINH_MOUSE	Kif5b	physical	21106837
KCNC1_MOUSE	Kcnc1	physical	12091563

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.