RL8_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RL8_MOUSE
• UniProt AC: P62918
• Protein Name: 60S ribosomal protein L8
• Gene Name: Rpl8
• Organism: Mus musculus (Mouse).
• Sequence Length: 257
• Subcellular Localization: Cytoplasm .
• Protein Description: Component of the large ribosomal subunit..
• Protein Sequence: MGRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIHDPGRGAPLAKVVFRDPYRFKKRTELFIAAEGIHTGQFVYCGKKAQLNIGNVLPVGTMPEGTIVCCLEEKPGDRGKLARASGNYATVISHNPETKKTRVKLPSGSKKVISSANRAVVGVVAGGGRIDKPILKAGRAYHKYKAKRNCWPRVRGVAMNPVEHPFGGGNHQHIGKPSTIRRDAPAGRKVGLIAARRTGRLRGTKTVQEKEN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	GQRKGAGSVFRAHVK CCCCCCCHHHHHHHC	19.97	24453211
46	Ubiquitination	GYIKGIVKDIIHDPG CCCHHHHHHHHCCCC	41.09	-
46	Acetylation	GYIKGIVKDIIHDPG CCCHHHHHHHHCCCC	41.09	23806337
60	Succinylation	GRGAPLAKVVFRDPY CCCCCCHHEEECCCC	46.76	23806337
60	Acetylation	GRGAPLAKVVFRDPY CCCCCCHHEEECCCC	46.76	23806337
67	Phosphorylation	KVVFRDPYRFKKRTE HEEECCCCCCCCCEE	32.73	29514104
92	Acetylation	GQFVYCGKKAQLNIG CCEEECCCCEEEECC	41.18	2387935
93	Acetylation	QFVYCGKKAQLNIGN CEEECCCCEEEECCC	27.01	7630765
114	S-palmitoylation	MPEGTIVCCLEEKPG CCCCEEEEECCCCCC	1.61	28526873
114	Glutathionylation	MPEGTIVCCLEEKPG CCCCEEEEECCCCCC	1.61	24333276
115	Glutathionylation	PEGTIVCCLEEKPGD CCCEEEEECCCCCCC	3.57	24333276
130	Phosphorylation	RGKLARASGNYATVI CCHHHHHCCCEEEEE	23.24	28066266
133	Phosphorylation	LARASGNYATVISHN HHHHCCCEEEEEECC	13.74	29514104
138	Phosphorylation	GNYATVISHNPETKK CCEEEEEECCCCCCC	16.93	25338131
144	Ubiquitination	ISHNPETKKTRVKLP EECCCCCCCEEEECC	50.95	-
144	Malonylation	ISHNPETKKTRVKLP EECCCCCCCEEEECC	50.95	26320211
144	Acetylation	ISHNPETKKTRVKLP EECCCCCCCEEEECC	50.95	23201123
145	Ubiquitination	SHNPETKKTRVKLPS ECCCCCCCEEEECCC	49.32	-
145	Acetylation	SHNPETKKTRVKLPS ECCCCCCCEEEECCC	49.32	2381893
149	Malonylation	ETKKTRVKLPSGSKK CCCCEEEECCCCCCE	51.92	26320211
152	Phosphorylation	KTRVKLPSGSKKVIS CEEEECCCCCCEEHH	67.16	29176673
154	Phosphorylation	RVKLPSGSKKVISSA EEECCCCCCEEHHCC	33.37	29176673
155	Acetylation	VKLPSGSKKVISSAN EECCCCCCEEHHCCC	55.36	7630775
177	Acetylation	AGGGRIDKPILKAGR ECCCCCCHHHHHCHH	31.42	23201123
195	Glutathionylation	KYKAKRNCWPRVRGV HHHCCCCCCCCCCCE	6.50	24333276
195	S-nitrosylation	KYKAKRNCWPRVRGV HHHCCCCCCCCCCCE	6.50	21278135
195	S-nitrosocysteine	KYKAKRNCWPRVRGV HHHCCCCCCCCCCCE	6.50	-
216	Hydroxylation	HPFGGGNHQHIGKPS CCCCCCCCCCCCCCC	24.70	-
251	Phosphorylation	GRLRGTKTVQEKEN- CCCCCCCCHHHCCC-	27.53	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RL8_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
216	H	Hydroxylation	Hydroxylated on His-216 by RIOX1.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RL8_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RL8_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.