PPIB_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PPIB_MOUSE
• UniProt AC: P24369
• Protein Name: Peptidyl-prolyl cis-trans isomerase B
• Gene Name: Ppib
• Organism: Mus musculus (Mouse).
• Sequence Length: 216
• Subcellular Localization: Endoplasmic reticulum lumen . Melanosome .
• Protein Description: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding..
• Protein Sequence: MLRLSERNMKVLFAAALIVGSVVFLLLPGPSVANDKKKGPKVTVKVYFDLQIGDESVGRVVFGLFGKTVPKTVDNFVALATGEKGFGYKNSKFHRVIKDFMIQGGDFTRGDGTGGKSIYGERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTSWLDGKHVVFGKVLEGMDVVRKVESTKTDSRDKPLKDVIIVDSGKIEVEKPFAIAKE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
67	Acetylation	VVFGLFGKTVPKTVD EEEEECCCCCCCCHH	38.73	23806337
67	Succinylation	VVFGLFGKTVPKTVD EEEEECCCCCCCCHH	38.73	23806337
71	Acetylation	LFGKTVPKTVDNFVA ECCCCCCCCHHCEEH	57.77	22826441
84	Succinylation	VALATGEKGFGYKNS EHHHCCCCCCCCCCC	61.97	22790023
84	Ubiquitination	VALATGEKGFGYKNS EHHHCCCCCCCCCCC	61.97	-
84	Acetylation	VALATGEKGFGYKNS EHHHCCCCCCCCCCC	61.97	22826441
89	Succinylation	GEKGFGYKNSKFHRV CCCCCCCCCCCHHHH	55.94	23954790
89	Acetylation	GEKGFGYKNSKFHRV CCCCCCCCCCCHHHH	55.94	6568837
98	Succinylation	SKFHRVIKDFMIQGG CCHHHHEECCEEECC	41.90	23954790
98	Acetylation	SKFHRVIKDFMIQGG CCHHHHEECCEEECC	41.90	22826441
108	Phosphorylation	MIQGGDFTRGDGTGG EEECCCCCCCCCCCC	38.18	22817900
116	Acetylation	RGDGTGGKSIYGERF CCCCCCCCCCCCCCC	34.72	23806337
116	Succinylation	RGDGTGGKSIYGERF CCCCCCCCCCCCCCC	34.72	23806337
129	Acetylation	RFPDENFKLKHYGPG CCCCCCCCCCEECCC	69.11	23864654
131	Acetylation	PDENFKLKHYGPGWV CCCCCCCCEECCCEE	35.06	22826441
158	Succinylation	QFFITTVKTSWLDGK EEEEEEEEEEECCCC	34.45	23954790
165	Acetylation	KTSWLDGKHVVFGKV EEEECCCCCEEEEEE	32.66	23806337
165	Succinylation	KTSWLDGKHVVFGKV EEEECCCCCEEEEEE	32.66	23806337
165	Ubiquitination	KTSWLDGKHVVFGKV EEEECCCCCEEEEEE	32.66	-
171	Acetylation	GKHVVFGKVLEGMDV CCCEEEEEEEECCHH	31.98	22826441
186	Acetylation	VRKVESTKTDSRDKP EEEEECCCCCCCCCC	60.66	23864654
187	Phosphorylation	RKVESTKTDSRDKPL EEEECCCCCCCCCCC	39.02	-
192	Acetylation	TKTDSRDKPLKDVII CCCCCCCCCCCEEEE	51.65	23806337
192	Succinylation	TKTDSRDKPLKDVII CCCCCCCCCCCEEEE	51.65	23806337
209	Succinylation	SGKIEVEKPFAIAKE CCCEEEECCEEEECC	51.08	23806337
209	Ubiquitination	SGKIEVEKPFAIAKE CCCEEEECCEEEECC	51.08	-
209	Succinylation	SGKIEVEKPFAIAKE CCCEEEECCEEEECC	51.08	-
209	Acetylation	SGKIEVEKPFAIAKE CCCEEEECCEEEECC	51.08	23806337
215	Acetylation	EKPFAIAKE------ ECCEEEECC------	58.82	23864654
215	Succinylation	EKPFAIAKE------ ECCEEEECC------	58.82	23954790

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PPIB_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PPIB_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PPIB_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PPIB_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.