SMC5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SMC5_MOUSE
• UniProt AC: Q8CG46
• Protein Name: Structural maintenance of chromosomes protein 5
• Gene Name: Smc5
• Organism: Mus musculus (Mouse).
• Sequence Length: 1101
• Subcellular Localization: Nucleus . Chromosome . Nucleus, PML body . Chromosome, telomere . Colocalizes with SMC6 on the X-Y chromosome pair within the sex vesicle during late pachytene/diplotene (PubMed:11408570). Associates with chromatin. Localizes to PML nuclear bodies in
• Protein Description: Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6 (By similarity)..
• Protein Sequence: MATPSGKAAPPNPQVSKRSLPRDASSEVPSKRKNSNPLPTLPRPSGTFVEGSIVRIAMENFLTYDICEVSPGPHLNMIIGANGTGKSSIVCAICLGLAGKPAFMGRADKVGFFVKRGCSKGLVEIELFRTSGNLIITREIDVIKNQSFWFINKKPVTQKIVEEQVAALNIQVGNLCQFLPQDKVGEFAKLSKIELLEATEKSVGPPEMHRYHCELKNFREKEKQLETSCKEKTEYLEKMVQRNERYKQDVERFYERKRHLDLIEMLEAKRPWVEYENVRQEYEGVKLIRDRVKEEVRKLKEGQIPMTRRIEEIDRQRHTLEVRIKEKSTDIKEASQKCKQRQDLIERKDRQIKELQQALTVKQNEELDRQKRISNTRKMIEDLQSELKTAENCENLQPQIDTVTNDLRRVQEEKALCEGEIIDKQREKEMLEKQRRSVSDHITRFDNLMNQKEDKLRQRYRDTYDAVLWLRNNRDRFKQRVCEPIMLTINMKDNKNAKYVENHISSNDLRAFVFESQEDMEIFLREVRDNKKLRVNAVIAPKISYADKAPSRSLNDLKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTERTRERIERVIQETRLKQIYTAEEKYVLKTSVYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEMNRQLEAVDSGLAALRDTNRHLELKDNELRLKKKELLERKTRKRQLEQKISSKLASIRLMEQDTCNLEEEERKASTKIKEINVQKAKLVTELTGLVKICTSFQIQKVDLILQNTTVISEKNKLEADYMASSSQLRVTEQQFIELDDNRQRLLQKCKELMKKARQVCNLSADQAVPQEFQTQVPTIPNGHSSSPPMAFQDLPNTLDEIDALLTEERSRASCFTGLNPSVVEEYSKREVEIQQLTEELQGKKVELDEYRENISQVKERWLNPLKELVEKINEKFSNFFSSMQCAGEVDLHTENEEDYDKYGIRIRVKFRSSTQLHELTPHHQSGGERSVSTMLYLMALQELNRCPFRVVDEINQGMDPINERRVFEMVVNTACKENTSQYFFITPKLLQNLPYSEKMTVLFVYNGPHMLEPNRWNLKAFQRRRRRITFTQPQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Phosphorylation	RSLPRDASSEVPSKR CCCCCCCCCCCCCCC	31.18	29514104
35	Phosphorylation	VPSKRKNSNPLPTLP CCCCCCCCCCCCCCC	42.74	25159016
437	Phosphorylation	MLEKQRRSVSDHITR HHHHHHHHHHHHHHH	28.32	27841257
439	Phosphorylation	EKQRRSVSDHITRFD HHHHHHHHHHHHHHH	25.39	27841257
452	Ubiquitination	FDNLMNQKEDKLRQR HHHHHCHHHHHHHHH	63.98	22790023
558	Ubiquitination	SRSLNDLKQYGFFSY CCCHHHHHHCCHHHH	44.32	22790023
629	Ubiquitination	KTSVYSNKVISSNTS EEEECCCCCCCCCCC	34.70	22790023
717	Phosphorylation	KISSKLASIRLMEQD HHHHHHHHHHHHHCC	20.76	24719451
791	Phosphorylation	LEADYMASSSQLRVT HHHHHHCCHHCCEEC	17.62	29899451
793	Phosphorylation	ADYMASSSQLRVTEQ HHHHCCHHCCEECHH	30.64	26370283
1096	Phosphorylation	QRRRRRITFTQPQ-- HHHHHCCEECCCC--	20.86	22006019

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SMC5_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SMC5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SMC5_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SMC5_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.