dbPTM

HNRPU_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HNRPU_MOUSE
UniProt AC	Q8VEK3
Protein Name	Heterogeneous nuclear ribonucleoprotein U {ECO:0000312\|MGI:MGI:1858195}
Gene Name	Hnrnpu {ECO:0000312\|MGI:MGI:1858195}
Organism	Mus musculus (Mouse).
Sequence Length	800
Subcellular Localization	Nucleus . Nucleus matrix . Chromosome . Nucleus speckle . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, spindle pole . Midbody . Cytop
Protein Description	DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organization, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression. [PubMed: 20833368]
Protein Sequence	MSSSPVNVKKLKVSELKEELKKRRLSDKGLKADLMDRLQAALDNEAGGRPAMEPGNGSLDLGGDAAGRSGAGLEQEAAAGAEDDEEEEGIAALDGDQMELGEENGAAGAADAGAMEEEEAASEDENGDDQGFQEGEDELGDEEEGAGDENGHGEQQSQPPAAAAQQQPSQQRGAGKEAAGKSSGPTSLFAVTVAPPGARQGQQQAGGDGKTEQKGGDKKRGVKRPREDHGRGYFEYIEENKYSRAKSPQPPVEEEDEHFDDTVVCLDTYNCDLHFKISRDRLSASSLTMESFAFLWAGGRASYGVSKGKVCFEMKVTEKIPVRHLYTKDIDIHEVRIGWSLTTSGMLLGEEEFSYGYSLKGIKTCNCETEDYGEKFDENDVITCFANFETDEVELSYAKNGQDLGVAFKISKEVLADRPLFPHVLCHNCAVEFNFGQKEKPYFPIPEDCTFIQNVPLEDRVRGPKGPEEKKDCEVVMMIGLPGAGKTTWVTKHAAENPGKYNILGTNTIMDKMMVAGFKKQMADTGKLNTLLQRAPQCLGKFIEIAARKKRNFILDQTNVSAAAQRRKMCLFAGFQRKAVVVCPKDEDYKQRTQKKAEVEGKDLPEHAVLKMKGNFTLPEVAECFDEITYVELQKEEAQKLLEQYKEESKKALPPEKKQNTGSKKSNKNKSGKNQFNRGGGHRGRGGFNMRGGNFRGGAPGNRGGYNRRGNMPQRGGGGGSGGIGYPYPRGPVFPGRGGYSNRGNYNRGGMPNRGNYNQNFRGRGNNRGYKNQSQGYNQWQQGQFWGQKPWSQHYHQGYY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSSPVNVK ------CCCCCCCHH	39.25	23684622
2	Acetylation	------MSSSPVNVK ------CCCCCCCHH	39.25	-
2	Phosphorylation	------MSSSPVNVK ------CCCCCCCHH	39.25	23527152
3	Phosphorylation	-----MSSSPVNVKK -----CCCCCCCHHH	37.04	25266776
3	Phosphorylation	-----MSSSPVNVKK -----CCCCCCCHHH	37.04	27742792
4	Phosphorylation	----MSSSPVNVKKL ----CCCCCCCHHHC	26.09	25266776
4	Phosphorylation	----MSSSPVNVKKL ----CCCCCCCHHHC	26.09	23527152
12	Ubiquitination	PVNVKKLKVSELKEE CCCHHHCCHHHHHHH	53.23	27667366
17	Acetylation	KLKVSELKEELKKRR HCCHHHHHHHHHHCC	45.12	-
17	Ubiquitination	KLKVSELKEELKKRR HCCHHHHHHHHHHCC	45.12	-
17	Acetylation	KLKVSELKEELKKRR HCCHHHHHHHHHHCC	45.12	23806337
17	Ubiquitination	KLKVSELKEELKKRR HCCHHHHHHHHHHCC	45.12	27667366
21	Acetylation	SELKEELKKRRLSDK HHHHHHHHHCCCCCC	47.73	-
21	Acetylation	SELKEELKKRRLSDK HHHHHHHHHCCCCCC	47.73	23806337
26	Phosphorylation	ELKKRRLSDKGLKAD HHHHCCCCCCCCCHH	35.15	25266776
26	Phosphorylation	ELKKRRLSDKGLKAD HHHHCCCCCCCCCHH	35.15	25338131
28	Acetylation	KKRRLSDKGLKADLM HHCCCCCCCCCHHHH	63.87	-
28	Acetylation	KKRRLSDKGLKADLM HHCCCCCCCCCHHHH	63.87	23806337
28	Malonylation	KKRRLSDKGLKADLM HHCCCCCCCCCHHHH	63.87	26320211
31	Acetylation	RLSDKGLKADLMDRL CCCCCCCCHHHHHHH	48.82	-
31	Ubiquitination	RLSDKGLKADLMDRL CCCCCCCCHHHHHHH	48.82	-
31	Acetylation	RLSDKGLKADLMDRL CCCCCCCCHHHHHHH	48.82	22826441
31	Malonylation	RLSDKGLKADLMDRL CCCCCCCCHHHHHHH	48.82	26320211
31	Ubiquitination	RLSDKGLKADLMDRL CCCCCCCCHHHHHHH	48.82	27667366
58	Phosphorylation	AMEPGNGSLDLGGDA CCCCCCCCCCCCCCC	23.78	25521595
58	Phosphorylation	AMEPGNGSLDLGGDA CCCCCCCCCCCCCCC	23.78	25521595
122	Phosphorylation	MEEEEAASEDENGDD HHHHHHHHCCCCCCC	53.26	-
122	Phosphorylation	MEEEEAASEDENGDD HHHHHHHHCCCCCCC	53.26	-
181	Acetylation	AGKEAAGKSSGPTSL CCHHHCCCCCCCCCE	36.40	-
181	Ubiquitination	AGKEAAGKSSGPTSL CCHHHCCCCCCCCCE	36.40	-
181	Acetylation	AGKEAAGKSSGPTSL CCHHHCCCCCCCCCE	36.40	23806337
181	Malonylation	AGKEAAGKSSGPTSL CCHHHCCCCCCCCCE	36.40	26320211
181	Ubiquitination	AGKEAAGKSSGPTSL CCHHHCCCCCCCCCE	36.40	-
182	Phosphorylation	GKEAAGKSSGPTSLF CHHHCCCCCCCCCEE	39.34	18846507
182	ADP-ribosylation	GKEAAGKSSGPTSLF CHHHCCCCCCCCCEE	39.34	-
182	Phosphorylation	GKEAAGKSSGPTSLF CHHHCCCCCCCCCEE	39.34	25521595
183	Phosphorylation	KEAAGKSSGPTSLFA HHHCCCCCCCCCEEE	52.88	18846507
183	Phosphorylation	KEAAGKSSGPTSLFA HHHCCCCCCCCCEEE	52.88	23984901
186	Phosphorylation	AGKSSGPTSLFAVTV CCCCCCCCCEEEEEE	41.40	21183079
186	Phosphorylation	AGKSSGPTSLFAVTV CCCCCCCCCEEEEEE	41.40	25521595
187	Phosphorylation	GKSSGPTSLFAVTVA CCCCCCCCEEEEEEC	25.32	25266776
187	Phosphorylation	GKSSGPTSLFAVTVA CCCCCCCCEEEEEEC	25.32	25521595
192	Phosphorylation	PTSLFAVTVAPPGAR CCCEEEEEECCCCCC	13.92	-
192	Phosphorylation	PTSLFAVTVAPPGAR CCCEEEEEECCCCCC	13.92	25619855
210	Acetylation	QQAGGDGKTEQKGGD CCCCCCCCCCCCCCC	54.34	1908651
210	Ubiquitination	QQAGGDGKTEQKGGD CCCCCCCCCCCCCCC	54.34	27667366
231	Citrullination	RPREDHGRGYFEYIE CCCHHCCCCHHHHHH	32.97	-
231	Citrullination	RPREDHGRGYFEYIE CCCHHCCCCHHHHHH	32.97	24463520
236	Phosphorylation	HGRGYFEYIEENKYS CCCCHHHHHHCCCCC	12.06	-
236	Phosphorylation	HGRGYFEYIEENKYS CCCCHHHHHHCCCCC	12.06	26026062
241	Acetylation	FEYIEENKYSRAKSP HHHHHCCCCCCCCCC	48.13	-
241	Ubiquitination	FEYIEENKYSRAKSP HHHHHCCCCCCCCCC	48.13	-
241	Acetylation	FEYIEENKYSRAKSP HHHHHCCCCCCCCCC	48.13	23806337
241	Ubiquitination	FEYIEENKYSRAKSP HHHHHCCCCCCCCCC	48.13	-
242	Phosphorylation	EYIEENKYSRAKSPQ HHHHCCCCCCCCCCC	18.25	23684622
242	Phosphorylation	EYIEENKYSRAKSPQ HHHHCCCCCCCCCCC	18.25	17947660
243	Phosphorylation	YIEENKYSRAKSPQP HHHCCCCCCCCCCCC	27.63	21183079
243	Phosphorylation	YIEENKYSRAKSPQP HHHCCCCCCCCCCCC	27.63	19060867
247	Phosphorylation	NKYSRAKSPQPPVEE CCCCCCCCCCCCCCC	27.99	19144319
247	Phosphorylation	NKYSRAKSPQPPVEE CCCCCCCCCCCCCCC	27.99	27087446
262	Phosphorylation	EDEHFDDTVVCLDTY CCCCCCCEEEEEECC	19.38	25266776
262	Phosphorylation	EDEHFDDTVVCLDTY CCCCCCCEEEEEECC	19.38	25521595
268	Phosphorylation	DTVVCLDTYNCDLHF CEEEEEECCCCCEEE	12.04	19060867
268	Phosphorylation	DTVVCLDTYNCDLHF CEEEEEECCCCCEEE	12.04	25619855
269	Phosphorylation	TVVCLDTYNCDLHFK EEEEEECCCCCEEEE	17.29	25619855
285	Phosphorylation	SRDRLSASSLTMESF CCCCCCCCCCCHHHH	23.62	21183079
285	Phosphorylation	SRDRLSASSLTMESF CCCCCCCCCCCHHHH	23.62	21183079
291	Phosphorylation	ASSLTMESFAFLWAG CCCCCHHHHHHHHHC	15.85	21183079
291	Phosphorylation	ASSLTMESFAFLWAG CCCCCHHHHHHHHHC	15.85	22817900
303	Phosphorylation	WAGGRASYGVSKGKV HHCCCHHCCCCCCCE	22.14	-
307	Ubiquitination	RASYGVSKGKVCFEM CHHCCCCCCCEEEEE	61.41	27667366
311	S-nitrosocysteine	GVSKGKVCFEMKVTE CCCCCCEEEEEEECC	2.45	-
311	S-nitrosylation	GVSKGKVCFEMKVTE CCCCCCEEEEEEECC	2.45	21278135
319	Acetylation	FEMKVTEKIPVRHLY EEEEECCCCCCCEEE	42.83	-
319	Succinylation	FEMKVTEKIPVRHLY EEEEECCCCCCCEEE	42.83	-
319	Ubiquitination	FEMKVTEKIPVRHLY EEEEECCCCCCCEEE	42.83	-
319	Acetylation	FEMKVTEKIPVRHLY EEEEECCCCCCCEEE	42.83	23806337
319	Succinylation	FEMKVTEKIPVRHLY EEEEECCCCCCCEEE	42.83	23806337
319	Ubiquitination	FEMKVTEKIPVRHLY EEEEECCCCCCCEEE	42.83	27667366
328	Acetylation	PVRHLYTKDIDIHEV CCCEEEECCCEEEEE	38.85	-
328	Succinylation	PVRHLYTKDIDIHEV CCCEEEECCCEEEEE	38.85	-
328	Ubiquitination	PVRHLYTKDIDIHEV CCCEEEECCCEEEEE	38.85	-
328	Acetylation	PVRHLYTKDIDIHEV CCCEEEECCCEEEEE	38.85	23806337
328	Succinylation	PVRHLYTKDIDIHEV CCCEEEECCCEEEEE	38.85	23806337
328	Ubiquitination	PVRHLYTKDIDIHEV CCCEEEECCCEEEEE	38.85	27667366
363	Ubiquitination	GYSLKGIKTCNCETE CEECCCEEECCCCCC	56.55	-
363	Ubiquitination	GYSLKGIKTCNCETE CEECCCEEECCCCCC	56.55	-
440	Acetylation	FNFGQKEKPYFPIPE ECCCCCCCCCCCCCC	52.64	-
440	Ubiquitination	FNFGQKEKPYFPIPE ECCCCCCCCCCCCCC	52.64	-
440	Acetylation	FNFGQKEKPYFPIPE ECCCCCCCCCCCCCC	52.64	22826441
440	Ubiquitination	FNFGQKEKPYFPIPE ECCCCCCCCCCCCCC	52.64	-
449	S-nitrosocysteine	YFPIPEDCTFIQNVP CCCCCCCCCEEECCC	2.97	-
449	S-nitrosylation	YFPIPEDCTFIQNVP CCCCCCCCCEEECCC	2.97	20925432
492	Acetylation	GKTTWVTKHAAENPG CCCEEECCCCCCCCC	22.94	-
492	Ubiquitination	GKTTWVTKHAAENPG CCCEEECCCCCCCCC	22.94	-
492	Acetylation	GKTTWVTKHAAENPG CCCEEECCCCCCCCC	22.94	22826441
492	Ubiquitination	GKTTWVTKHAAENPG CCCEEECCCCCCCCC	22.94	-
500	Acetylation	HAAENPGKYNILGTN CCCCCCCCCCCCCCC	36.06	-
500	Ubiquitination	HAAENPGKYNILGTN CCCCCCCCCCCCCCC	36.06	-
500	Acetylation	HAAENPGKYNILGTN CCCCCCCCCCCCCCC	36.06	22826441
500	Ubiquitination	HAAENPGKYNILGTN CCCCCCCCCCCCCCC	36.06	27667366
506	Phosphorylation	GKYNILGTNTIMDKM CCCCCCCCCCHHHHH	26.24	25890499
508	Phosphorylation	YNILGTNTIMDKMMV CCCCCCCCHHHHHHH	19.95	25890499
519	Acetylation	KMMVAGFKKQMADTG HHHHHCHHHHHCCCC	40.97	-
519	Succinylation	KMMVAGFKKQMADTG HHHHHCHHHHHCCCC	40.97	-
519	Acetylation	KMMVAGFKKQMADTG HHHHHCHHHHHCCCC	40.97	23806337
519	Succinylation	KMMVAGFKKQMADTG HHHHHCHHHHHCCCC	40.97	23806337
527	Acetylation	KQMADTGKLNTLLQR HHHCCCCHHHHHHHH	40.43	-
527	Ubiquitination	KQMADTGKLNTLLQR HHHCCCCHHHHHHHH	40.43	-
527	Acetylation	KQMADTGKLNTLLQR HHHCCCCHHHHHHHH	40.43	23806337
527	Malonylation	KQMADTGKLNTLLQR HHHCCCCHHHHHHHH	40.43	26320211
527	Ubiquitination	KQMADTGKLNTLLQR HHHCCCCHHHHHHHH	40.43	-
538	Glutathionylation	LLQRAPQCLGKFIEI HHHHHHHHHHHHHHH	5.42	24333276
541	Acetylation	RAPQCLGKFIEIAAR HHHHHHHHHHHHHHH	30.16	-
541	Succinylation	RAPQCLGKFIEIAAR HHHHHHHHHHHHHHH	30.16	-
541	Ubiquitination	RAPQCLGKFIEIAAR HHHHHHHHHHHHHHH	30.16	-
541	Acetylation	RAPQCLGKFIEIAAR HHHHHHHHHHHHHHH	30.16	23806337
541	Succinylation	RAPQCLGKFIEIAAR HHHHHHHHHHHHHHH	30.16	23806337
541	Ubiquitination	RAPQCLGKFIEIAAR HHHHHHHHHHHHHHH	30.16	-
550	Ubiquitination	IEIAARKKRNFILDQ HHHHHHHCCCEEECC	47.20	-
550	Ubiquitination	IEIAARKKRNFILDQ HHHHHHHCCCEEECC	47.20	-
558	Phosphorylation	RNFILDQTNVSAAAQ CCEEECCCCHHHHHH	36.94	-
558	Phosphorylation	RNFILDQTNVSAAAQ CCEEECCCCHHHHHH	36.94	24759943
561	Phosphorylation	ILDQTNVSAAAQRRK EECCCCHHHHHHHHH	17.79	24759943
568	Acetylation	SAAAQRRKMCLFAGF HHHHHHHHHHHHCCC	35.83	-
568	Acetylation	SAAAQRRKMCLFAGF HHHHHHHHHHHHCCC	35.83	22826441
578	Acetylation	LFAGFQRKAVVVCPK HHCCCEEEEEEECCC	34.45	-
578	Acetylation	LFAGFQRKAVVVCPK HHCCCEEEEEEECCC	34.45	22826441
583	S-nitrosocysteine	QRKAVVVCPKDEDYK EEEEEEECCCCHHHH	2.04	-
583	Glutathionylation	QRKAVVVCPKDEDYK EEEEEEECCCCHHHH	2.04	24333276
583	S-nitrosylation	QRKAVVVCPKDEDYK EEEEEEECCCCHHHH	2.04	20925432
585	Acetylation	KAVVVCPKDEDYKQR EEEEECCCCHHHHHH	69.49	-
585	Acetylation	KAVVVCPKDEDYKQR EEEEECCCCHHHHHH	69.49	22826441
602	Acetylation	KKAEVEGKDLPEHAV HHHHHCCCCCCCHHE	42.45	-
602	Ubiquitination	KKAEVEGKDLPEHAV HHHHHCCCCCCCHHE	42.45	-
602	Acetylation	KKAEVEGKDLPEHAV HHHHHCCCCCCCHHE	42.45	23806337
602	Ubiquitination	KKAEVEGKDLPEHAV HHHHHCCCCCCCHHE	42.45	-
611	Acetylation	LPEHAVLKMKGNFTL CCCHHEEEEECCCCH	31.78	-
611	Succinylation	LPEHAVLKMKGNFTL CCCHHEEEEECCCCH	31.78	-
611	Ubiquitination	LPEHAVLKMKGNFTL CCCHHEEEEECCCCH	31.78	-
611	Acetylation	LPEHAVLKMKGNFTL CCCHHEEEEECCCCH	31.78	23806337
611	Malonylation	LPEHAVLKMKGNFTL CCCHHEEEEECCCCH	31.78	26320211
611	Succinylation	LPEHAVLKMKGNFTL CCCHHEEEEECCCCH	31.78	23806337
611	Ubiquitination	LPEHAVLKMKGNFTL CCCHHEEEEECCCCH	31.78	27667366
640	Ubiquitination	LQKEEAQKLLEQYKE CCHHHHHHHHHHHHH	63.19	-
640	Ubiquitination	LQKEEAQKLLEQYKE CCHHHHHHHHHHHHH	63.19	27667366
646	Acetylation	QKLLEQYKEESKKAL HHHHHHHHHHHHHCC	55.49	-
646	Acetylation	QKLLEQYKEESKKAL HHHHHHHHHHHHHCC	55.49	23806337
650	Ubiquitination	EQYKEESKKALPPEK HHHHHHHHHCCCHHH	45.40	-
651	Acetylation	QYKEESKKALPPEKK HHHHHHHHCCCHHHH	65.52	129149
657	Ubiquitination	KKALPPEKKQNTGSK HHCCCHHHHCCCCCC	66.49	27667366
666	Phosphorylation	QNTGSKKSNKNKSGK CCCCCCCCCCCCCCC	57.69	-
666	Phosphorylation	QNTGSKKSNKNKSGK CCCCCCCCCCCCCCC	57.69	22802335
673	Malonylation	SNKNKSGKNQFNRGG CCCCCCCCCCCCCCC	55.45	26320211
673	Ubiquitination	SNKNKSGKNQFNRGG CCCCCCCCCCCCCCC	55.45	27667366
678	Dimethylation	SGKNQFNRGGGHRGR CCCCCCCCCCCCCCC	46.55	-
678	Methylation	SGKNQFNRGGGHRGR CCCCCCCCCCCCCCC	46.55	30759979
683	Dimethylation	FNRGGGHRGRGGFNM CCCCCCCCCCCCCCC	39.52	-
683	Methylation	FNRGGGHRGRGGFNM CCCCCCCCCCCCCCC	39.52	54540525
685	Dimethylation	RGGGHRGRGGFNMRG CCCCCCCCCCCCCCC	41.86	-
685	Methylation	RGGGHRGRGGFNMRG CCCCCCCCCCCCCCC	41.86	24395555
691	Dimethylation	GRGGFNMRGGNFRGG CCCCCCCCCCCCCCC	51.47	-
691	Methylation	GRGGFNMRGGNFRGG CCCCCCCCCCCCCCC	51.47	24129315
696	Dimethylation	NMRGGNFRGGAPGNR CCCCCCCCCCCCCCC	46.78	-
696	Methylation	NMRGGNFRGGAPGNR CCCCCCCCCCCCCCC	46.78	24129315
703	Dimethylation	RGGAPGNRGGYNRRG CCCCCCCCCCCCCCC	45.92	-
703	Methylation	RGGAPGNRGGYNRRG CCCCCCCCCCCCCCC	45.92	24129315
708	Methylation	GNRGGYNRRGNMPQR CCCCCCCCCCCCCCC	39.12	24395603
709	Asymmetric dimethylarginine	NRGGYNRRGNMPQRG CCCCCCCCCCCCCCC	36.88	-
709	Methylation	NRGGYNRRGNMPQRG CCCCCCCCCCCCCCC	36.88	24129315
715	Asymmetric dimethylarginine	RRGNMPQRGGGGGSG CCCCCCCCCCCCCCC	39.59	-
715	Methylation	RRGNMPQRGGGGGSG CCCCCCCCCCCCCCC	39.59	24129315
726	Phosphorylation	GGSGGIGYPYPRGPV CCCCCCCCCCCCCCC	9.55	29899451
730	Asymmetric dimethylarginine	GIGYPYPRGPVFPGR CCCCCCCCCCCCCCC	57.09	-
730	Methylation	GIGYPYPRGPVFPGR CCCCCCCCCCCCCCC	57.09	-
737	Asymmetric dimethylarginine	RGPVFPGRGGYSNRG CCCCCCCCCCCCCCC	35.28	-
737	Methylation	RGPVFPGRGGYSNRG CCCCCCCCCCCCCCC	35.28	24129315
743	Dimethylation	GRGGYSNRGNYNRGG CCCCCCCCCCCCCCC	28.88	-
743	Methylation	GRGGYSNRGNYNRGG CCCCCCCCCCCCCCC	28.88	24395615
748	Dimethylation	SNRGNYNRGGMPNRG CCCCCCCCCCCCCCC	32.46	-
748	Methylation	SNRGNYNRGGMPNRG CCCCCCCCCCCCCCC	32.46	24395627
754	Dimethylation	NRGGMPNRGNYNQNF CCCCCCCCCCCCCCC	28.94	-
754	Methylation	NRGGMPNRGNYNQNF CCCCCCCCCCCCCCC	28.94	24384415
762	Methylation	GNYNQNFRGRGNNRG CCCCCCCCCCCCCCC	41.26	24383493
771	Ubiquitination	RGNNRGYKNQSQGYN CCCCCCCCCCCCCCC	51.87	-
774	Phosphorylation	NRGYKNQSQGYNQWQ CCCCCCCCCCCCCHH	34.66	25367039
777	Phosphorylation	YKNQSQGYNQWQQGQ CCCCCCCCCCHHCCC	9.13	25367039
789	Acetylation	QGQFWGQKPWSQHYH CCCCCCCCCHHHCCC	44.51	22826441
789	Ubiquitination	QGQFWGQKPWSQHYH CCCCCCCCCHHHCCC	44.51	-
792	Phosphorylation	FWGQKPWSQHYHQGY CCCCCCHHHCCCCCC	18.66	26643407
795	Phosphorylation	QKPWSQHYHQGYY-- CCCHHHCCCCCCC--	6.54	25367039
799	Phosphorylation	SQHYHQGYY------ HHCCCCCCC------	10.22	26643407
800	Phosphorylation	QHYHQGYY------- HCCCCCCC-------	20.92	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HNRPU_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
58	S	Phosphorylation	17242355
Phosphorylated on Ser-58 by PLK1 and dephosphorylated by protein phosphatase 2A (PP2A) in mitosis.
709	R	Methylation	24129315
Arg-709 and Arg-715 are dimethylated, probably to asymmetric dimethylarginine.
715	R	Methylation	24129315
Arg-709 and Arg-715 are dimethylated, probably to asymmetric dimethylarginine.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HNRPU_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
RPB1_MOUSE	Polr2a	physical	21235343

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HNRPU_MOUSE

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations."; Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.; Mol. Cell. Proteomics 5:914-922(2006). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, AND MASS SPECTROMETRY.	16452087 [Abstract]
Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58 AND SER-247, AND MASSSPECTROMETRY.	19367708 [Abstract]

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