NEXN_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NEXN_MOUSE
• UniProt AC: Q7TPW1
• Protein Name: Nexilin
• Gene Name: Nexn {ECO:0000312|MGI:MGI:1916060}
• Organism: Mus musculus (Mouse).
• Sequence Length: 607
• Subcellular Localization: Cytoplasm, cytoskeleton . Cell junction, adherens junction . Cytoplasm, myofibril, sarcomere, Z line . Localizes to the cell-matrix AJ. Not found at the cell-cell AJ.
• Protein Description: Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity..
• Protein Sequence: MNDVSQKAEIKEMLASDDEEESSPKIEKAYVPKLTGTVKGKFDEMEKHRQEEQRKRTEEERKRRIEQDLLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPAKSYKTPGKTKDPEDLDREEGNGRTNHEEDKMRYEEECRVLKEAKCLSLVMDDETEAKKESHFPGKLKSTFEELERQRQENRKKQAEEEARRRLEEERRSFEEARRHMVNEEDENQDRETVFKEYRPGKLKLSFEEIERQRREDEKRKAEEEARRRIEEEKAAFAEARRSMVLDDDSPEIYKTVSQESLTPGKLEINFEQLLRQKMEEERRRTEEERRHKLEMEKQEFEQLRQEMGKEEEENESFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEVQKKIEEERAKRRAIDLEIKEREAENFHEDDDVDVRPAKKSESPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQKEIDAALQKKREDEEEEEGSIVNGSTTEDEEQTRSGAPWFKKPLRNTSVVDSEPVRFTVKVTGEPKPEITWWFEGEILQDGEDYQYIERGETYCLYLPETFPEDGGEYMCKAVNNKGSAASTCILTIEMDDY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Oxidation	QKAEIKEMLASDDEE HHHHHHHHHCCCCCC	3.00	17242355
16	Phosphorylation	EIKEMLASDDEEESS HHHHHHCCCCCCCCC	41.45	25521595
22	Phosphorylation	ASDDEEESSPKIEKA CCCCCCCCCCCHHHH	56.04	26824392
23	Phosphorylation	SDDEEESSPKIEKAY CCCCCCCCCCHHHHH	33.23	25521595
30	Phosphorylation	SPKIEKAYVPKLTGT CCCHHHHHHCCCCCC	28.49	29514104
35	Phosphorylation	KAYVPKLTGTVKGKF HHHHCCCCCCCCCCH	36.61	23140645
37	Phosphorylation	YVPKLTGTVKGKFDE HHCCCCCCCCCCHHH	17.51	23140645
92	Phosphorylation	QIEDINNTGTESASE HHHHHHCCCCCCCCC	40.78	21659605
94	Phosphorylation	EDINNTGTESASEEG HHHHCCCCCCCCCCC	25.40	26824392
96	Phosphorylation	INNTGTESASEEGDD HHCCCCCCCCCCCCC	36.61	26824392
98	Phosphorylation	NTGTESASEEGDDSL CCCCCCCCCCCCCCE	45.52	23649490
104	Phosphorylation	ASEEGDDSLLITVVP CCCCCCCCEEEEEEE	29.80	24453211
159	Phosphorylation	LKEAKCLSLVMDDET HHHHHHHEEEECCCC	28.52	21082442
172	Phosphorylation	ETEAKKESHFPGKLK CCHHHHHHCCCCCHH	39.03	-
211	Phosphorylation	RLEEERRSFEEARRH HHHHHHHHHHHHHHH	43.14	26824392
244	Phosphorylation	RPGKLKLSFEEIERQ CCCCEEECHHHHHHH	29.08	22817900
281	Phosphorylation	AFAEARRSMVLDDDS HHHHHHHHHCCCCCC	14.00	25521595
288	Phosphorylation	SMVLDDDSPEIYKTV HHCCCCCCHHHHHHC	31.28	27180971
292	Phosphorylation	DDDSPEIYKTVSQES CCCCHHHHHHCCHHH	10.03	27742792
294	Phosphorylation	DSPEIYKTVSQESLT CCHHHHHHCCHHHCC	14.39	26160508
296	Phosphorylation	PEIYKTVSQESLTPG HHHHHHCCHHHCCCC	33.20	25521595
299	Phosphorylation	YKTVSQESLTPGKLE HHHCCHHHCCCCEEE	29.88	25521595
301	Phosphorylation	TVSQESLTPGKLEIN HCCHHHCCCCEEEEC	39.00	26824392
371	Phosphorylation	ELIKLKRSGSIQAKN HHHHHHHCCCCCCCC	34.99	26824392
373	Phosphorylation	IKLKRSGSIQAKNLK HHHHHCCCCCCCCHH	16.87	24453211
436	Phosphorylation	RPAKKSESPFTHKVN CCCCCCCCCCCCCCC	32.19	24899341
439	Phosphorylation	KKSESPFTHKVNMKA CCCCCCCCCCCCHHH	24.95	23737553
476	Ubiquitination	LRMQFEQKEIDAALQ HHHHHHHHHHHHHHH	49.81	-
495	Phosphorylation	DEEEEEGSIVNGSTT CCCCCCCCCCCCCCC	27.00	25521595
500	Phosphorylation	EGSIVNGSTTEDEEQ CCCCCCCCCCCCHHH	27.27	26824392
501	Phosphorylation	GSIVNGSTTEDEEQT CCCCCCCCCCCHHHH	35.29	23737553
502	Phosphorylation	SIVNGSTTEDEEQTR CCCCCCCCCCHHHHC	43.04	26824392
508	Phosphorylation	TTEDEEQTRSGAPWF CCCCHHHHCCCCCCC	30.04	27742792
522	Phosphorylation	FKKPLRNTSVVDSEP CCCCCCCCCCCCCCC	19.23	28066266
523	Phosphorylation	KKPLRNTSVVDSEPV CCCCCCCCCCCCCCE	24.56	24899341

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NEXN_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NEXN_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NEXN_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NEXN_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, AND MASSSPECTROMETRY.
PubMed: 17203969